Design, synthesis, and biological evaluation of a series of piperazine ureas as fatty acid amide hydrolase inhibitors

Bioorganic and Medicinal Chemistry

Volumn 22, Issue 4, 2014, Pages 1468-1478

  Kono, Mitsunori ^a   Matsumoto, Takahiro ^a   Imaeda, Toshihiro ^a   Kawamura, Toru ^a   Fujimoto, Shinji ^a   Kosugi, Yohei ^a   Odani, Tomoyuki ^a   Shimizu, Yuji ^a   Matsui, Hideki ^a   Shimojo, Masato ^a   Kori, Masakuni ^a  

^a TAKEDA PHARMACEUTICAL COMPANY LIMITED   (Japan)

Author keywords

Arachidonoylethanolamide; Fatty acid amide hydrolase inhibitors; Inflammatory pain; Neuropathic pain; Piperazine ureas

Indexed keywords

ARACHIDONOYLETHANOLAMIDE; FATTY ACID AMIDE HYDROLASE INHIBITORS; INFLAMMATORY PAIN; NEUROPATHIC PAIN; PIPERAZINE UREAS;

ADMINISTRATION, ORAL; AMIDOHYDROLASES; ANALGESICS; ANIMALS; BRAIN; DISEASE MODELS, ANIMAL; DRUG DESIGN; ENZYME INHIBITORS; HALF-LIFE; MALE; MICE; MICE, INBRED ICR; PAIN; PIPERAZINES; PYRIDAZINES; PYRIMIDINES; RATS; RATS, SPRAGUE-DAWLEY; UREA;

EID: 84893764017     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2013.12.023     Document Type: Article

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