Genetic variants affecting alternative splicing of human cholesteryl ester transfer protein

Biochemical and Biophysical Research Communications

Volumn 443, Issue 4, 2014, Pages 1270-1274

  Suhy, Adam ^a   Hartmann, Katherine ^a   Newman, Leslie ^a   Papp, Audrey ^a   Toneff, Thomas ^b   Hook, Vivian ^b   Sadee, Wolfgang ^a  

^a THE OHIO STATE UNIVERSITY WEXNER MEDICAL CENTER   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Alternative splicing; CETP levels in liver and plasma; Cholesteryl ester transfer protein; Coronary artery disease; Statin

Indexed keywords

CARRIER PROTEIN; CHOLESTEROL ESTER CARRIER PROTEIN; MESSENGER RNA; UNCLASSIFIED DRUG;

ALTERNATIVE RNA SPLICING; ARTICLE; CONTROLLED STUDY; EMBRYO; EXON; GENE AMPLIFICATION; GENE CONSTRUCT; GENE FREQUENCY; GENETIC VARIABILITY; GENOTYPE; HEREDITY; HUMAN; HUMAN CELL; IN VITRO STUDY; LIVER; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION;

ALTERNATIVE SPLICING; CETP LEVELS IN LIVER AND PLASMA; CHOLESTERYL ESTER TRANSFER PROTEIN; CORONARY ARTERY DISEASE; STATIN;

ALLELES; ALTERNATIVE SPLICING; CHOLESTEROL ESTER TRANSFER PROTEINS; ENHANCER ELEMENTS, GENETIC; EXONS; GENETIC VARIATION; HEK293 CELLS; HEP G2 CELLS; HUMANS; INTRONS; LIVER; POLYMORPHISM, SINGLE NUCLEOTIDE; RNA SPLICE SITES; RNA, MESSENGER;

EID: 84893731832     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2013.12.127     Document Type: Article

References (18)

1. A.I. Su, T. Wiltshire, S. Batalov, H. Lapp, K.A. Ching, and D. Block et al. A gene atlas of the mouse and human protein-encoding transcriptomes Proc. Natl. Acad. Sci. U.S.A. 101 2004 6062 6067 (Pubitemid 38520528)
2. D.J. Gordon, J.L. Probstfield, R.J. Garrison, J.D. Neaton, W.P. Castelli, and J.D. Knoke et al. High-density lipoprotein cholesterol and cardiovascular disease. Four prospective American studies Circulation 79 1989 8 15 (Pubitemid 19043669)
3. V.L. Roger, A.S. Go, D.M. Lloyd-Jones, E.J. Benjamin, J.D. Berry, and W.B. Borden et al. Heart disease and stroke statistics-2012 update: a report from the American Heart Association Circulation 125 2012 e2 e220
4. R.K. Murray, D.K. Granner, and V.W. Rodwell Harper's Biochemistry 27th ed. 2006 Appleton & Lange Stamford
5. J.J. Regieli, J.W. Jukema, D.E. Grobbee, J.J.P. Kastelein, J.A. Kuivenhoven, and A.H. Zwinderman et al. CETP genotype predicts increased mortality in statin-treated men with proven cardiovascular disease: an adverse pharmacogenetic interaction Eur. Heart J. 29 2008 2792 2799
6. M. Nagano, S. Yamashita, K.-I. Hirano, M. Takano, T. Maruyama, and M. Ishihara et al. Molecular mechanisms of cholesteryl ester transfer protein deficiency in Japanese J. Atheroscler. Thromb. 11 2004 110 121
7. M. Corbex, O. Poirier, F. Fumeron, D. Betoulle, A. Evans, and J.B. Ruidavets et al. Extensive association analysis between the CETP gene and coronary heart disease phenotypes reveals several putative functional polymorphisms and gene-environment interaction Genet. Epidemiol. 19 2000 64 80 (Pubitemid 30445638)
8. E. Frisdal, A.H.E.M. Klerkx, W. Le Goff, M.W.T. Tanck, J.-P. Lagarde, and J.W. Jukema et al. Functional interaction between -629C/A, -971G/A and -1337C/T polymorphisms in the CETP gene is a major determinant of promoter activity and plasma CETP concentration in the REGRESS Study Hum. Mol. Genet. 14 2005 2607 2618 (Pubitemid 41300635)
9. A.C. Papp, J.K. Pinsonneault, D. Wang, L.C. Newman, Y. Gong, and J.A. Johnson et al. Cholesteryl Ester Transfer Protein (CETP) polymorphisms affect mRNA splicing, HDL levels, and sex-dependent cardiovascular risk PLoS One 7 2012 e31930
10. M.G.G. Marmot, G.D.D. Smith, S. Stansfeld, C. Patel, F. North, and J. Head et al. Health inequalities among British civil servants: the Whitehall II study Lancet 337 1991 1387 1393
11. S.M. Boekholdt, F.M. Sacks, J.W. Jukema, J. Shepherd, D.J. Freeman, and D. McMahon et al. Cholesteryl ester transfer protein TaqIB variant, high-density lipoprotein cholesterol levels, cardiovascular risk, and efficacy of pravastatin treatment: individual patient meta-analysis of 13,677 subjects Circulation 111 2005 278 287 (Pubitemid 40165333)
12. J. Kuivenhoven The role of a common variant of the cholesteryl ester transfer protein gene in the progression of coronary atherosclerosis N. Engl. J. Med. 338 1998 86 93 (Pubitemid 28042271)
13. M.J. Barber, L.M. Mangravite, C.L. Hyde, D.I. Chasman, J.D. Smith, and C.A. McCarty et al. Genome-wide association of lipid-lowering response to statins in combined study populations PLoS One 5 2010 e9763
14. M. Leusink, N.C. Onland-Moret, F.W. Asselbergs, B. Ding, S. Kotti, and N.R. van Zuydam et al. Cholesteryl ester transfer protein polymorphisms, statin use, and their impact on cholesterol levels and cardiovascular events Clin. Pharmacol. Ther. 2013
15. A. Inazu, E.M. Quinet, S. Wang, M.L. Brown, S. Stevenson, and M.L. Barr et al. Alternative splicing of the mRNA encoding the human cholesteryl ester transfer protein Biochemistry 31 1992 2352 2358
16. L. Mende-Mueller, and T. Toneff Tissue-specific proteolysis of Huntingtin (htt) in human brain: evidence of enhanced levels of N-and C-terminal htt fragments in Huntington's disease striatum J. Neurosci. 21 2001 1830 1837 (Pubitemid 32221366)
17. T. Toneff, L. Funkelstein, C. Mosier, A. Abagyan, M. Ziegler, and V. Hook Beta-amyloid peptides undergo regulated co-secretion with neuropeptide and catecholamine neurotransmitters Peptides 46 2013 126 135
18. C.J. Pepine, E.M. Handberg, R.M. Cooper-DeHoff, R.G. Marks, P. Kowey, and F.H. Messerli et al. A calcium antagonist vs a non-calcium antagonist hypertension treatment strategy for patients with coronary artery disease. The International Verapamil-Trandolapril Study (INVEST): a randomized controlled trial JAMA 290 2003 2805 2816 (Pubitemid 37509488)