Necroptosis is active in children with inflammatory bowel disease and contributes to heighten intestinal inflammation

American Journal of Gastroenterology

Volumn 109, Issue 2, 2014, Pages 279-287

  Pierdomenico, Maria ^a   Negroni, Anna ^a   Stronati, Laura ^a   Vitali, Roberta ^a   Prete, Enrica ^a   Bertin, John ^b   Gough, Peter J ^b   Aloi, Marina ^c   Cucchiara, Salvatore ^c  

^a ENEA   (Italy)

^b GLAXOSMITHKLINE   (United States)

^c SAPIENZA UNIVERSITY OF ROME   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ADOLESCENT; AGE FACTORS; BIOPSY, NEEDLE; BLOTTING, WESTERN; CASPASE 8; CELL DEATH; CELL SURVIVAL; CHILD; CHILD, PRESCHOOL; COHORT STUDIES; COLITIS, ULCERATIVE; COLON; CROHN DISEASE; DISEASE PROGRESSION; FEMALE; GENE EXPRESSION REGULATION; HUMANS; ILEUM; IMMUNOHISTOCHEMISTRY; INFLAMMATORY BOWEL DISEASES; MALE; PROSPECTIVE STUDIES; PROTEIN KINASES; REAL-TIME POLYMERASE CHAIN REACTION; RECEPTOR-INTERACTING PROTEIN SERINE-THREONINE KINASES; RISK ASSESSMENT; SEVERITY OF ILLNESS INDEX; SIGNAL TRANSDUCTION; STATISTICS, NONPARAMETRIC;

EID: 84893726744     PISSN: 00029270     EISSN: 15720241     Source Type: Journal    
DOI: 10.1038/ajg.2013.403     Document Type: Article

References (35)

1. Chen L, Park SM, Turner JR et al. Cell death in the colonic epithelium during infl ammatory bowel diseases: CD95/Fas and beyond. Infl amm Bowel Dis 2010; 16: 1071-6.
2. G ü nther C, Neumann H, Neurath MF et al. Apoptosis, necrosis and necroptosis: cell death regulation in the intestinal epithelium. Gut 2013; 62: 1062-71.
3. Han J, Zhong CQ, Zhang DW. Programmed necrosis: backup to and competitor with apoptosis in the immune system. Nat Immunol 2011; 12: 1143-9.
4. Tang X, Degterev A, Jagtap P et al. Structure-activity relationship study of novel necroptosis inhibitors. Bioorg Med Chem Lett 2005; 15: 5039-44.
5. Tait SW, Green DR. Caspase-independent cell death: leaving the set without the fi nal cut. Oncogene 2008; 27: 6452-61.
6. Christofferson DE, Yuan J. Necroptosis as an alternative form of programmed cell death. Curr Opin Cell Biol 2010; 22: 263-8.
7. Yuan J, Kroemer G. Alternative cell death mechanisms in development and beyond. Genes Dev 2010; 24: 2592-602.
8. Vandenabeele P, Galluzzi L, Vanden Berghe T et al. Molecular mechanisms of necroptosis: an ordered cellular explosion. Nat Rev Mol Cell Biol 2010; 11: 700-14.
9. Berghe TV, Vanlangenakker N, Parthoens E et al. Necroptosis, necrosis and secondary necrosis converge on similar cellular disintegration features. Cell Death Differ 2010; 17: 922-30.
10. Golstein P, Kroemer G. Cell death by necrosis: towards a molecular defi nition. Trends Biochem Sci 2007; 32: 37-43.
11. Kono H, Rock KL. How dying cells alert the immune system to danger. Nat Rev Immunol 2008; 8: 279-89.
12. Rock KL, Kono H. The infl ammatory response to cell death. Annu Rev Pathol 2008; 3: 99-126. Review.
13. He S, Liang Y, Shao F et al. Toll-like receptors activate programmed necrosis in macrophages through a receptor-interacting kinase-3-mediated pathway. Proc Natl Acad Sci USA 2011; 108: 20054-9.
14. Feoktistova M, Geserick P, Kellert B et al. cIAPs block ripoptosome formation, a RIP1/caspase-8 containing intracellular cell death complex diff erentially regulated by cFLIP isoforms. Mol Cell 2011; 43: 449-63.
15. Upton JW, Kaiser WJ, Mocarski ES. Virus inhibition of RIP3-dependent necrosis. Cell Host Microbe 2010; 7: 302-13.
16. Martinon F, Gaide O, Petrilli V et al. NALP infl ammasomes: a central role in innate immunity. Semin Immunopathol 2007; 29: 213-29.
17. Kalai M, Van Loo G, Vanden Berghe T et al. Tipping the balance between necrosis and apoptosis in human and murine cells treated with interferon and dsRNA. Cell Death Diff er 2002; 9: 981-94.
18. Cho YS, Challa S, Moquin D et al. Phosphorylation-driven assembly of the RIP1-RIP3 complex regulates programmed necrosis and virus-induced infl ammation. Cell 2009; 137: 1112-23.
19. He S, Wang L, Miao L et al. Receptor interacting protein kinase-3 determines cellular necrotic response to TNF-α. Cell 2009; 137: 1100-11.
20. Zhang DW, Shao J, Lin J et al. RIP3, an energy metabolism regulator that switches TNF-induced cell death from apoptosis to necrosis. Science 2009; 325: 332-6.
21. Vandenabeele P, Declercq W, Van Herreweghe F et al. The role of the kinases RIP1 and RIP3 in TNF-induced necrosis. Sci Signal 2010; 115: 1-8.
22. Zhao J, Jitkaew S, Cai Z et al. Mixed lineage kinase domain-like is a key receptor interacting protein 3 downstream component of TNF-induced necrosis. Proc Natl Acad Sci USA 2012; 109: 5322-7.
23. Sun L, Wang H, Wang Z et al. Mixed lineage kinase domain-like protein mediates necrosis signaling downstream of RIP3 kinase. Cell 2012; 148: 213-27.
24. Gunther C, Martini E, Wittkopf N et al. Caspase-8 regulates TNF-alphainduced epithelial necroptosis and terminal ileitis. Nature 2011; 477: 335-9.
25. Welz PS, Wullaert A, Vlantis K et al. FADD prevents RIP3-mediated epithelial cell necrosis and chronic intestinal infl ammation. Nature 2011; 477: 330-4.
26. Bousvaros A, Antonioli DA, Colletti RB et al. North American Society for Pediatric Gastroenterology, Hepatology and Nutrition; Colitis Foundation of America. Differentiating ulcerative colitis from Crohn disease in children and young adults: report of a working group of the North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition and the Crohn's and Colitis Foundation of America. J Pediatr Gastroenterol Nutr 2007; 44: 653-74.
27. Hyams JS, Mandel F, Ferry GD et al. Development and validation of a pediatric Crohn's disease activity index. J Pediatr Gastroenterol Nutr 1991; 12: 439-47.
28. Turner D, Otley AR, Mack D et al. Development, validation, and evaluation of a pediatric ulcerative colitis activity index: a prospective multicenter study. Gastroenterology 2007; 133: 423-32.
29. Hitomi J, Christofferson DE, Ng A et al. Identifi cation of a molecular signaling network that regulates a cellular necrotic cell death pathway. Cell 2008; 135: 1311-23.
30. Th apa RJ, Basagoudanavar SH, Nogusa S et al. NF-kappaB protects cells from gamma interferon-induced RIP1-dependent necroptosis. Mol Cell Biol 2011; 31: 2934-46.
31. Vanlangenakker N, Vanden Berghe T, Vandenabeele P. Many stimuli pull the necrotic trigger, an overview. Cell Death Differ 2012; 19: 75-86.
32. Degterev A, Hitomi J, Germscheid M et al. Identifi cation of RIP1 kinase as a specifi c cellular target of necrostatin. Nat Chem Biol 2008; 4: 313-21.
33. Kaczmarek A, Vandenabeele P, Krysko DV. Necroptosis: the release of damage-associated molecular patterns and its physiological relevance. Immunity 2013; 38: 209-23.
34. Harris HE, Andersson U, Pisetsky DS. HMGB1: a multifunctional alarmin driving autoimmune and infl ammatory disease. Nat Rev Rheumatol 2012; 8: 195-202.
35. Vitali R, Stronati L, Negroni A et al. Fecal HMGB1 is a novel marker of intestinal mucosal infl ammation in pediatric infl ammatory bowel disease. Am J Gastroenterol 2011; 106: 2029.