메뉴 건너뛰기




Volumn 21, Issue 2, 2014, Pages 188-194

Why commercialization of gene therapy stalled; Examining the life cycles of gene therapy technologies

Author keywords

Biotechnology; Capital investment; Drug development; Innovation; Technology life cycles

Indexed keywords

BIOMETRY; BIOTECHNOLOGY; GENETIC THERAPY; HUMANS;

EID: 84893717170     PISSN: 09697128     EISSN: 14765462     Source Type: Journal    
DOI: 10.1038/gt.2013.72     Document Type: Article
Times cited : (23)

References (50)
  • 1
    • 0015492624 scopus 로고
    • Gene therapy for human genetic disease?
    • Friedmann T, Roblin R. Gene therapy for human genetic disease? Science 1972; 175: 949-955.
    • (1972) Science , vol.175 , pp. 949-955
    • Friedmann, T.1    Roblin, R.2
  • 5
    • 35148817461 scopus 로고    scopus 로고
    • Gene therapy clinical trials worldwide to 2007 - An update
    • Edelstein ML, Abedi MR, Wixon J. Gene therapy clinical trials worldwide to 2007 - an update. J Gene Med 2007; 9: 833-842.
    • (2007) J Gene Med , vol.9 , pp. 833-842
    • Edelstein, M.L.1    Abedi, M.R.2    Wixon, J.3
  • 9
    • 84878581647 scopus 로고    scopus 로고
    • Three-year follow-up after unilateral subretinal delivery of adeno-associated virus in patients with Leber congenital Amaurosis type 2
    • Testa F, Maguire AM, Rossi S, Pierce EA, Melillo P, Marshall K et al. Three-year follow-up after unilateral subretinal delivery of adeno-associated virus in patients with Leber congenital Amaurosis type 2. Ophthalmology 2013; 120: 1283-1291.
    • (2013) Ophthalmology , vol.120 , pp. 1283-1291
    • Testa, F.1    Maguire, A.M.2    Rossi, S.3    Pierce, E.A.4    Melillo, P.5    Marshall, K.6
  • 11
    • 70449337791 scopus 로고    scopus 로고
    • Medicine. A comeback for gene therapy
    • Naldini L. Medicine. A comeback for gene therapy. Science 2009; 326: 805-806.
    • (2009) Science , vol.326 , pp. 805-806
    • Naldini, L.1
  • 12
    • 0031180356 scopus 로고    scopus 로고
    • Critical issues in gene therapy commercialization
    • Persidis A, Tomczyk MS. Critical issues in gene therapy commercialization. Nat Biotechnol 1997; 15: 689-690.
    • (1997) Nat Biotechnol , vol.15 , pp. 689-690
    • Persidis, A.1    Tomczyk, M.S.2
  • 13
    • 33751562430 scopus 로고    scopus 로고
    • Chinese gene therapy. Splicing out the West?
    • Guo J, Xin H. Chinese gene therapy. Splicing out the West? Science 2006; 314: 1232-1235.
    • (2006) Science , vol.314 , pp. 1232-1235
    • Guo, J.1    Xin, H.2
  • 14
    • 84874141721 scopus 로고    scopus 로고
    • Therapeutic angiogenesis in treatment of patients with chronic obliterating diseases of lower limb arteries
    • IuV C, Staroverov I, Nersesian E, Isaev A, Deev R. [Therapeutic angiogenesis in treatment of patients with chronic obliterating diseases of lower limb arteries]. Angiol Sosud Khir 2011; 18: 19-27.
    • (2011) Angiol Sosud Khir , vol.18 , pp. 19-27
    • Iuv, C.1    Staroverov, I.2    Nersesian, E.3    Isaev, A.4    Deev, R.5
  • 15
    • 84869040765 scopus 로고    scopus 로고
    • Europe gives gene therapy the green light
    • Gruber K. Europe gives gene therapy the green light. Lancet 2012; 380: e10.
    • (2012) Lancet , vol.380
    • Gruber, K.1
  • 16
    • 84871991715 scopus 로고    scopus 로고
    • Gene therapy enters the pharma market: The short story of a long journey
    • Buning H. Gene therapy enters the pharma market: the short story of a long journey. EMBO Mol Med 2013; 5: 1-3.
    • (2013) EMBO Mol Med , vol.5 , pp. 1-3
    • Buning, H.1
  • 17
    • 84875962928 scopus 로고    scopus 로고
    • Efficacy and long-term safety of alipogene tiparvovec (AAV1-LPLS447X) gene therapy for lipoprotein lipase deficiency: An open-label trial
    • Gaudet D, Methot J, Dery S, Brisson D, Essiembre C, Tremblay G et al. Efficacy and long-term safety of alipogene tiparvovec (AAV1-LPLS447X) gene therapy for lipoprotein lipase deficiency: an open-label trial. Gene Ther 2013; 20: 361-369.
    • (2013) Gene Ther , vol.20 , pp. 361-369
    • Gaudet, D.1    Methot, J.2    Dery, S.3    Brisson, D.4    Essiembre, C.5    Tremblay, G.6
  • 19
    • 82755181916 scopus 로고    scopus 로고
    • Safety and efficacy of a xenogeneic DNA vaccine encoding for human tyrosinase as adjunctive treatment for oral malignant melanoma in dogs following surgical excision of the primary tumor
    • Grosenbaugh DA, Leard AT, Bergman PJ, Klein MK, Meleo K, Susaneck S et al. Safety and efficacy of a xenogeneic DNA vaccine encoding for human tyrosinase as adjunctive treatment for oral malignant melanoma in dogs following surgical excision of the primary tumor. Am J Vet Res 2011; 72: 1631-1638.
    • (2011) Am J Vet Res , vol.72 , pp. 1631-1638
    • Grosenbaugh, D.A.1    Leard, A.T.2    Bergman, P.J.3    Klein, M.K.4    Meleo, K.5    Susaneck, S.6
  • 21
    • 84865703844 scopus 로고    scopus 로고
    • Effects of administration of two growth hormone-releasing hormone plasmids to gilts on sow and litter performance for the subsequent three gestations
    • Brown PA, Khan AS, Draghia-Akli R, Pope MA, Bodles-Brakhop AM, Kern DR. Effects of administration of two growth hormone-releasing hormone plasmids to gilts on sow and litter performance for the subsequent three gestations. Am J Vet Res 2012; 73: 1428-1434.
    • (2012) Am J Vet Res , vol.73 , pp. 1428-1434
    • Brown, P.A.1    Khan, A.S.2    Draghia-Akli, R.3    Pope, M.A.4    Bodles-Brakhop, A.M.5    Kern, D.R.6
  • 23
    • 4344645978 scopus 로고    scopus 로고
    • Can the pharmaceutical industry reduce attrition rates?
    • Kola I, Landis J. Can the pharmaceutical industry reduce attrition rates? Nat Rev Drug Discov 2004; 3: 711-716.
    • (2004) Nat Rev Drug Discov , vol.3 , pp. 711-716
    • Kola, I.1    Landis, J.2
  • 25
    • 36949015479 scopus 로고
    • Speeding products to market: Waiting time to first product introduction in new firms
    • Schoonhoven CB, Eisenhardt KM, Lyman K. Speeding products to market: Waiting time to first product introduction in new firms. AdminSci Quart 1990 177-207.
    • (1990) AdminSci Quart , pp. 177-207
    • Schoonhoven, C.B.1    Eisenhardt, K.M.2    Lyman, K.3
  • 26
    • 80051502652 scopus 로고    scopus 로고
    • Efficacy of three vaccines in protecting western Scrub-Jays (Aphelocoma californica) from experimental infection with West Nile virus: Implications for vaccination of island Scrub-Jays (Aphelocoma insularis)
    • Wheeler SS, Langevin S, Woods L, Carroll BD, Vickers W, Morrison SA et al. Efficacy of three vaccines in protecting western Scrub-Jays (Aphelocoma californica) from experimental infection with West Nile virus: Implications for vaccination of island Scrub-Jays (Aphelocoma insularis). Vector Borne Zoonotic Dis 2011; 11: 1069-1080.
    • (2011) Vector Borne Zoonotic Dis , vol.11 , pp. 1069-1080
    • Wheeler, S.S.1    Langevin, S.2    Woods, L.3    Carroll, B.D.4    Vickers, W.5    Morrison, S.A.6
  • 27
    • 84867390775 scopus 로고    scopus 로고
    • Patterns of technological innovation in biotech
    • McNamee LM, Ledley FD. Patterns of technological innovation in biotech. Nat Biotechnol 2012; 30: 937-943.
    • (2012) Nat Biotechnol , vol.30 , pp. 937-943
    • McNamee, L.M.1    Ledley, F.D.2
  • 28
    • 0029854711 scopus 로고    scopus 로고
    • Ten years of orthoclone OKT3 (muromonab-CD3): A review
    • Smith SL. Ten years of orthoclone OKT3 (muromonab-CD3): a review. J Transpl Coord 1996; 6: 109-119.
    • (1996) J Transpl Coord , vol.6 , pp. 109-119
    • Smith, S.L.1
  • 30
    • 84860896956 scopus 로고    scopus 로고
    • Marketed therapeutic antibodies compendium
    • Reichert JM. Marketed therapeutic antibodies compendium. MAbs 2012; 4: 413-415.
    • (2012) MAbs , vol.4 , pp. 413-415
    • Reichert, J.M.1
  • 31
    • 14844293113 scopus 로고    scopus 로고
    • Emergence of a scientific and commercial research and development infrastructure for human gene therapy
    • Crofts C, Krimsky S. Emergence of a scientific and commercial research and development infrastructure for human gene therapy. Hum Gene Ther 2005; 16: 169-177.
    • (2005) Hum Gene Ther , vol.16 , pp. 169-177
    • Crofts, C.1    Krimsky, S.2
  • 34
    • 0037497338 scopus 로고    scopus 로고
    • Harmful potential of viral vectors fuels doubts over gene therapy
    • Check E. Harmful potential of viral vectors fuels doubts over gene therapy. Nature 2003; 423: 573-574.
    • (2003) Nature , vol.423 , pp. 573-574
    • Check, E.1
  • 36
    • 84862070065 scopus 로고    scopus 로고
    • Private and public 'cradle to maturity' financing patterns of US biotech ventures (1970-2001)
    • Morgan Jr IW, Abetti PA. Private and public 'cradle to maturity' financing patterns of US biotech ventures (1970-2001). J PE 2004; 7: 9-25.
    • (2004) J PE , vol.7 , pp. 9-25
    • Morgan Jr., I.W.1    Abetti, P.A.2
  • 38
    • 79751506542 scopus 로고    scopus 로고
    • Gene therapy finds its niche
    • Sheridan C. Gene therapy finds its niche. Nat Biotechnol 2011; 29: 121-128.
    • (2011) Nat Biotechnol , vol.29 , pp. 121-128
    • Sheridan, C.1
  • 39
    • 34249723130 scopus 로고    scopus 로고
    • Genzyme: 15 years of cell and gene therapy research
    • De Bie C. Genzyme: 15 years of cell and gene therapy research. Regen Med 2007; 2: 95-97.
    • (2007) Regen Med , vol.2 , pp. 95-97
    • De Bie, C.1
  • 40
    • 0030768112 scopus 로고    scopus 로고
    • Architecture of R&D-a conceptual framework for collaboration
    • Cavalla D. Architecture of R&D-a conceptual framework for collaboration. Drug Discov Today 1997; 2: 200-205.
    • (1997) Drug Discov Today , vol.2 , pp. 200-205
    • Cavalla, D.1
  • 42
    • 34249314179 scopus 로고    scopus 로고
    • Organizational scope and investment: Evidence from the drug development strategies and performance of biopharmaceutical firms
    • NBER Working Paper No. 10933
    • Guedj I, Scharfstein D. Organizational scope and investment: evidence from the drug development strategies and performance of biopharmaceutical firms. National Bureau of Economic Research 2004; NBER Working Paper No. 10933.
    • (2004) National Bureau of Economic Research
    • Guedj, I.1    Scharfstein, D.2
  • 44
    • 0030342338 scopus 로고    scopus 로고
    • Financing gene therapy beyond phase II
    • Michael A. Financing gene therapy beyond phase II. Gene Ther 1996; 3: 1035.
    • (1996) Gene Ther , vol.3 , pp. 1035
    • Michael, A.1
  • 46
    • 70350765132 scopus 로고    scopus 로고
    • Can literature analysis identify innovation drivers in drug discovery?
    • Agarwal P, Searls DB. Can literature analysis identify innovation drivers in drug discovery? Nat Rev Drug Discov 2009; 8: 865-878.
    • (2009) Nat Rev Drug Discov , vol.8 , pp. 865-878
    • Agarwal, P.1    Searls, D.B.2
  • 47
    • 0000931294 scopus 로고    scopus 로고
    • The growth of the cell death field: An analysis from the ISI-Science citation index
    • Garfield E, Melino G. The growth of the cell death field: an analysis from the ISI-Science citation index. Cell Death Differ 1997; 4: 352-361.
    • (1997) Cell Death Differ , vol.4 , pp. 352-361
    • Garfield, E.1    Melino, G.2
  • 48
    • 70249091815 scopus 로고    scopus 로고
    • Trends in biotech literature 2008
    • Marshall A. Trends in biotech literature 2008. Nat Biotechnol 2009; 27: 789.
    • (2009) Nat Biotechnol , vol.27 , pp. 789
    • Marshall, A.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.