Mutations and expression of PmrAB and PhoPQ related with colistin resistance in Pseudomonas aeruginosa clinical isolates

Diagnostic Microbiology and Infectious Disease

Volumn 78, Issue 3, 2014, Pages 271-276

  Lee, Ji Young ^a   Ko, Kwan Soo ^a,b  

^a Sungkyunkwan University School of Medicine   (South Korea)

^b Asia Pacific Foundation for Infectious Diseases (APFID)   (South Korea)

Author keywords

Colistin; PhoPQ; PmrAB; Pseudomonas aeruginosa

Indexed keywords

COLISTIN; PHOPQ; PMRAB; PSEUDOMONAS AERUGINOSA;

AMINO ACID SUBSTITUTION; ANTI-BACTERIAL AGENTS; BACTERIAL PROTEINS; COLISTIN; DRUG RESISTANCE, BACTERIAL; GENE EXPRESSION REGULATION, BACTERIAL; HUMANS; MICROBIAL SENSITIVITY TESTS; MUTATION; PSEUDOMONAS AERUGINOSA; REPUBLIC OF KOREA; TRANSCRIPTION FACTORS;

EID: 84893715511     PISSN: 07328893     EISSN: 18790070     Source Type: Journal    
DOI: 10.1016/j.diagmicrobio.2013.11.027     Document Type: Article

References (22)

1. Abraham N., Kwon D.H. A single amino acid substitution in PmrB is associated with polymyxin B resistance in clinical isolate of Pseudomonas aeruginosa. FEMS Microbiol Lett 2009, 298:249-254.
2. Adams M.D., Nickel G.C., Bajaksouzian S., Lavender H., Murthy A.R., Jacobs M.R., et al. Resistance to colistin in Acinetobacter baumannii associated with mutations in the PmrAB two-component system. Antimicrob Agents Chemother 2009, 53:3628-3634.
3. Barrow K., Kwon D.H. Alterations in two-component regulatory systems of phoPQ and pmrAB are associated with polymyxin B resistance in clinical isolates of Pseudomonas aeruginosa. Antimicrob Agents Chemother 2009, 53:5150-5154.
4. Cheng H.Y., Chen Y.F., Peng H.L. Molecular characterization of the PhoPQ-PmrD-PmrAB mediated pathway regulating polymyxin B resistance in Klebsiella pneumoniae CG43. J Biomed Sci 2010, 17:60.
5. Clinical and Laboratory Standards Institute (CLSI) Performance standards for antimicrobial susceptibility testing; 21th informational supplement (M100-S21) 2011, CLSI, Wayne, PA.
6. Dumas J.L., van Delden C., Perron K., Köhler T. Analysis of antibiotic resistance gene expression in Pseudomonas aeruginosa by quantitative real-time-PCR. FEMS Microbiol Lett 2006, 254:217-225.
7. Falagas M.E., Rafailidis P.I., Matthaiou D.K., Virtzili S., Nikita D., Michalopoulos A. Pandrug-resistant Klebsiella pneumonia, Pseudomonas aeruginosa, and Acinetobacter baumannii infections: characteristics and outcome in a series of 28 patients. Int J Antimicrob Agents 2008, 32:450-454.
8. Falagas M.E., Rafailidis P.I., Matthaiou D.K. Resistance to polymyxins: mechanisms, frequency and treatment options. Drug Resist Updat 2010, 13:132-138.
9. Fernández L., Gooderham W.J., Bains M., McPhee J.B., Wiegand I., Hancock R.E. Adaptive resistance to the "last hope" antibiotics polymyxin B and colistin in Pseudomonas aeruginosa is mediated by the novel two-component regulatory system ParR-ParS. Antimicrob Agents Chemother 2010, 54:3372-3382.
10. Fernández L., Jenssen H., Bains M., Wiegand I., Gooderham W.J., Hancock R.E. The two-component system CprRS senses cationic peptides and triggers adaptive resistance in Pseudomonas aeruginosa independently of ParRS. Antimicrob Agents Chemother 2012, 56:6212-6222.
11. Gunn J.S. The Salmonella PmrAB regulon: lipopolysaccharide modifications, antimicrobial peptide resistance and more. Trends Microbiol 2008, 16:284-290.
12. Landman D., Bratu S., Alam M., Quale J. Citywide emergence of Pseudomonas aeruginosa strains with reduced susceptibility to polymyxin B. J Antimicrob Chemother 2005, 55:954-957.
13. Lee J.Y., Song J.H., Ko K.S. Identification of nonclonal Pseudomonas aeruginosa isolates with reduced colistin susceptibility in Korea. Microb Drug Resist 2011, 17:299-304.
14. Lee J.Y., Lim M.H., Heo S.T., Ko K.S. Repeated isolation of Pseudomonas aeruginosa isolates resistant to both polymyxins and carbapenems from 1 patient. Diagn Microbiol Infect Dis 2012, 72:267-271.
15. Lister P.D., Wolter D.J., Hanson N.D. Antibacterial-resistant Pseudomonas aeruginosa: clinical impact and complex regulation of chromosomally encoded resistance mechanisms. Clin Microbiol Rev 2009, 22:582-610.
16. Llobet E., Campos M.A., Giménez P., Moranta D., Bengoechea J.A. Analysis of the networks controlling the antimicrobial-peptide-dependent induction of Klebsiella pneumoniae virulence factors. Infect Immunol 2011, 79:3718-3732.
17. 2+-induced gene regulation in Pseudomonas aeruginosa. J Bacteriol 2006, 188:3995-4006.
18. Moskowitz S.M., Ernst R.K., Miller S.I. PmrAB, a two-component regulatory system of Pseudomonas aeruginosa that modulates resistance to cationic antimicrobial peptides and addition of aminoarabinose to lipid A. J Bacteriol 2004, 186:575-579.
19. Muller C., Plésiat P., Jeannot K. A two-component regulatory system interconnects resistance to polymyxins, aminoglycosides, fluoroquinolones, and β-lactams in Pseudomonas aeruginosa. Antimicrob Agents Chemother 2011, 55:1211-1221.
20. Park Y.K., Choi J.Y., Shin D., Ko K.S. Correlation between overexpression and amino acid substitution of the PmrAB locus and colistin resistance in Acinetobacter baumannii. Int J Antimicrob Agents 2011, 37:525-530.
21. Schurek K.N., Sampaio J.L.M., Kiffer C.R.V., Sinto S., Mendes C.M.F., Hancock R.E.W. Involvement of pmrAB and phoPQ in polymyxin B adaptation and inducible resistance in non-cystic fibrosis clinical isolates of Pseudomonas aeruginosa. Antimicrob Agents Chemother 2009, 53:4345-4351.
22. Wang C.Y., Jerng J.S., Chen K.Y., Lee L.N., Yu C.J., Hsueh P.R., et al. Pandrug-resistant Pseudomonas aeruginosa among hospitalized patients: clinical features, risk-factors and outcomes. Clin Microbiol Infect 2006, 12:63-68.