Correlation between overexpression and amino acid substitution of the PmrAB locus and colistin resistance in Acinetobacter baumannii

International Journal of Antimicrobial Agents

Volumn 37, Issue 6, 2011, Pages 525-530

  Park, Young Kyoung ^a   Choi, Ji Young ^a   Shin, Dongwoo ^a   Ko, Kwan Soo ^a  

^a Sungkyunkwan University School of Medicine   (South Korea)

Author keywords

Acinetobacter baumannii; Colistin; PmrAB; Real time PCR

Indexed keywords

COLISTIN;

ACINETOBACTER BAUMANNII; AMINO ACID SUBSTITUTION; ANTIBIOTIC RESISTANCE; ANTIBIOTIC SENSITIVITY; ARTICLE; BACTERIAL GENE; BACTERIAL STRAIN; BACTERIUM ISOLATE; CONTROLLED STUDY; GENE EXPRESSION; GENE LOCUS; GENE OVEREXPRESSION; GENE SEQUENCE; GENETIC POLYMORPHISM; IN VITRO STUDY; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; PMRA GENE; PMRB GENE; PMRC GENE; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; REAL TIME POLYMERASE CHAIN REACTION;

ACINETOBACTER BAUMANNII; AMINO ACID SUBSTITUTION; ANTI-BACTERIAL AGENTS; BACTERIAL PROTEINS; COLISTIN; DRUG RESISTANCE, BACTERIAL; GENE EXPRESSION; GENE EXPRESSION PROFILING; HUMANS; TRANSCRIPTION FACTORS;

EID: 79955485381     PISSN: 09248579     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijantimicag.2011.02.008     Document Type: Article

References (17)

1. Y.K. Park, K.R. Peck, H.S. Cheong, D.R. Chung, J.H. Song, and K.S. Ko Extreme drug resistance in Acinetobacter baumannii infections in intensive care units, South Korea Emerg Infect Dis 15 2009 1325 1327
2. R.L. Nation, and J. Li Colistin in the 21st century Curr Opin Infect Dis 22 2010 535 543
3. J.S. Gunn, S.S. Ryan, J.C. Van Velkinburgh, R.K. Ernst, and S.I. Miller Genetic functional analysis of a PmrA-PmrB-regulated locus necessary for lipopolysaccharide modification, antimicrobial peptide resistance, and oral virulence of Salmonella enterica serovar Typhimurium Infect Immun 68 2000 6139 6146
4. S.M. Moskowitz, R.K. Ernst, and S.I. Miller PmrAB, a two-component regulatory system of Pseudomonas aeruginosa that modulates resistance to cationic antimicrobial peptides and addition of aminoarabinose to lipid A J Bacteriol 186 2004 575 579 (Pubitemid 38076447)
5. S. Sun, A. Negrea, M. Rhen, and D.I. Andersson Genetic analysis of colistin resistance in Salmonella enterica serovar Typhimurium Antimicrob Agents Chemother 53 2009 2298 2305
6. M.D. Adams, G.C. Nickel, S. Bajaksouzian, H. Lavender, A.R. Murthy, and M.R. Jacobs Resistance to colistin in Acinetobacter baumannii associated with mutations in the PmrAB two-component system Antimicrob Agents Chemother 53 2009 3628 3634
7. J.H. Moffatt, M. Harper, P. Harrison, J.D. Hale, E. Vinogradov, and T. Seemann Colistin resistance in Acinetobacter baumannii is mediated by complete loss of lipopolysaccharide production Antimicrob Agents Chemother 54 2010 4971 4977
8. S.G. Bartual, H. Seifert, C. Hippler, M.A.D. Luzon, H. Wisplinghoff, and F. Rodriguez-Valera Development of a multilocus sequence typing scheme for characterization of clinical isolates of Acinetobacter baumannii J Clin Microbiol 43 2005 4382 4390 (Pubitemid 41298217)
9. Clinical and Laboratory Standards Institute. Performance standards for antimicrobial susceptibility testing; 19th informational supplement. Document M100-S19. Wayne, PA: CLSI; 2009.
10. A. Antoniadou, F. Kontopidou, G. Poulakou, E. Koratzanis, I. Galani, and E. Papadomichelakis Colistin-resistant isolates of Klebsiella pneumoniae emerging in intensive care unit patients: first report of a multiclonal cluster J Antimicrob Chemother 60 2007 1163 1167
11. H.K. Johansen, S.M. Moskowitz, O. Ciofu, T. Pressler, and N. Høiby Spread of colistin resistant non-mucoid Pseudomonas aeruginosa among chronically infected Danish cystic fibrosis patients J Cyst Fibros 7 2008 391 397
12. K.S. Ko, J.Y. Suh, K.T. Kwon, S.I. Jung, K.H. Park, and C.I. Kang High rates of resistance to colistin and polymyxin B in subgroups of Acinetobacter baumannii isolates from Korea J Antimicrob Chemother 60 2007 1163 1167 (Pubitemid 47617772)
13. N. Abraham, and D.H. Kwon A single amino acid substitution in PmrB is associated with polymyxin B resistance in clinical isolate of Pseudomonas aeruginosa FEMS Micobiol Lett 298 2009 249 254
14. K. Barrow, and D.H. Kwon Alterations in two-component regulatory systems of phoPQ and pmrAB are associated with polymyxin B resistance in clinical isolates of Pseudomonas aeruginosa Antimicrob Agents Chemother 53 2009 5150 5154
15. M.D. Adams, K. Goglin, N. Molyneaux, K.M. Hujer, H. Lavender, and J.J. Jamison Comparative genome sequence analysis of multidrug-resistant Acinetobacter baumannii J Bacteriol 190 2008 8053 8064
16. L. Fernández, W.J. Gooderham, M. Bains, J.B. McPhee, I. Wiegand, and R.E. Hancock Adaptive resistance to the 'last hope' antibiotics polymyxin B and colistin in Pseudomonas aeruginosa is mediated by the novel two-component regulatory system ParR-ParS Antimicrob Agents Chemother 54 2010 3372 3382
17. A.Y. Mitrophanov, M.W. Jewett, T.J. Hadley, and E.A. Groisman Evolution and dynamics of regulatory architectures controlling polymyxin B resistance in enteric bacteria PLoS Genet 4 2008 e1000233