Protective effect of Et-1 receptor antagonist bosentan on paracetamol induced acute liver toxicity in rats

European Journal of Pharmacology

Volumn 726, Issue 1, 2014, Pages 87-95

  Yayla, Muhammed ^a   Halici, Zekai ^a   Unal, Bunyami ^a   Bayir, Yasin ^b   Akpinar, Erol ^a   Gocer, Fatma ^a  

^a ATATURK UNIVERSITY   (Turkey)

^b ATATÜRK UNIVERSITY   (Turkey)

Author keywords

Bosentan; ET 1; Hepatotoxicity; Paracetamol; Rat

Indexed keywords

ALANINE AMINOTRANSFERASE; ANTIOXIDANT; ASPARTATE AMINOTRANSFERASE; BOSENTAN; ENDOTHELIN 1; ENDOTHELIN RECEPTOR; ENDOTHELIN RECEPTOR ANTAGONIST; PARACETAMOL; SULFONAMIDE; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL; BLOOD; CELL PROTECTION; DOSE RESPONSE; DRUG EFFECTS; DRUG-INDUCED LIVER INJURY; ENZYMOLOGY; FEMALE; LIVER; METABOLISM; OXIDATIVE STRESS; RAT; TOXICITY;

ACETAMINOPHEN; ALANINE TRANSAMINASE; ANIMALS; ANTIOXIDANTS; ASPARTATE AMINOTRANSFERASES; CYTOPROTECTION; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG-INDUCED LIVER INJURY; ENDOTHELIN RECEPTOR ANTAGONISTS; ENDOTHELIN-1; FEMALE; LIVER; OXIDATIVE STRESS; RATS; RECEPTORS, ENDOTHELIN; SULFONAMIDES; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84893698707     PISSN: 00142999     EISSN: 18790712     Source Type: Journal    
DOI: 10.1016/j.ejphar.2014.01.022     Document Type: Article

References (56)

1. M.B. Ahmed, and M.R. Khater Evaluation of the protective potential of Ambrosia maritima extract on acetaminophen-induced liver damage J. Ethnopharmacol. 75 2001 169 174 (Pubitemid 32297729)
2. R.J. Barst, D. Ivy, J. Dingemanse, A. Widlitz, K. Schmitt, A. Doran, D. Bingaman, N. Nguyen, M. Gaitonde, and P.L. van Giersbergen Pharmacokinetics, safety, and efficacy of bosentan in pediatric patients with pulmonary arterial hypertension Clin. Pharmacol. Ther. 73 2003 372 382 (Pubitemid 36403597)
3. J.S. Beckman, and W.H. Koppenol Nitric oxide, superoxide, and peroxynitrite: the good, the bad, and ugly Am. J. Physiol. 271 1996 C1424 C1437
4. J.G. Bessems, and N.P. Vermeulen Paracetamol (acetaminophen)-induced toxicity: molecular and biochemical mechanisms, analogues and protective approaches Crit. Rev. Toxicol. 31 2001 55 138 (Pubitemid 32157805)
5. M. Black Acetaminophen hepatotoxicity Gastroenterology 78 1980 382 392 (Pubitemid 10132373)
6. C.A. Bradham, J. Plumpe, M.P. Manns, D.A. Brenner, and C. Trautwein Mechanisms of hepatic toxicity. I. TNF-induced liver injury Am. J. Physiol. 275 1998 G387 G392
7. J. Brok, N. Buckley, and C. Gluud Interventions for paracetamol (acetaminophen) overdose Cochrane Database Syst. Rev. 2006 3328
8. T.H. Cheng, N.L. Shih, C.H. Chen, H. Lin, J.C. Liu, H.H. Chao, J.Y. Liou, Y.L. Chen, H.W. Tsai, Y.S. Chen, C.F. Cheng, and J.J. Chen Role of mitogen-activated protein kinase pathway in reactive oxygen species-mediated endothelin-1-induced beta-myosin heavy chain gene expression and cardiomyocyte hypertrophy J. Biomed. Sci. 12 2005 123 133 (Pubitemid 40576770)
9. H. Chiu, C.R. Gardner, D.M. Dambach, J.A. Brittingham, S.K. Durham, J.D. Laskin, and D.L. Laskin Role of p55 tumor necrosis factor receptor 1 in acetaminophen-induced antioxidant defense Am. J. Physiol. Gastrointest. Liver Physiol. 285 2003 G959 G966
10. L.J. Chun, M.J. Tong, R.W. Busuttil, and J.R. Hiatt Acetaminophen hepatotoxicity and acute liver failure J. Clin. Gastroenterol. 43 2009 342 349
11. M. Clozel, V. Breu, G.A. Gray, and B.M. Loffler In vivo pharmacology of Ro 46-2005, the first synthetic nonpeptide endothelin receptor antagonist: implications for endothelin physiology J. Cardiovasc. Pharmacol. 22 Suppl 8 1993 S377 S379
12. P. Conte Fde, C. Barja-Fidalgo, W.A. Verri Jr., F.Q. Cunha, G.A. Rae, C. Penido, and M.G. Henriques Endothelins modulate inflammatory reaction in zymosan-induced arthritis: participation of LTB4, TNF-alpha, and CXCL-1 J. Leukoc. Biol. 84 2008 652 660
13. D.G. Davidson, and W.N. Eastham Acute liver necrosis following overdose of paracetamol Br. Med. J. 2 1966 497 499
14. N. Dhaun, I.M. Macintyre, V. Melville, P. Lilitkarntakul, N.R. Johnston, J. Goddard, and D.J. Webb Blood pressure-independent reduction in proteinuria and arterial stiffness after acute endothelin-a receptor antagonism in chronic kidney disease Hypertension 54 2009 113 119
15. P.B. Donate, T.M. Cunha, W.A. Verri Jr., C.M. Junta, F.O. Lima, S.M. Vieira, R.S. Peres, K.F. Bombonato-Prado, P. Louzada Jr., S.H. Ferreira, E.A. Donadi, G.A. Passos, and F.Q. Cunha Bosentan, an endothelin receptor antagonist, ameliorates collagen-induced arthritis: the role of TNF-alpha in the induction of endothelin system genes Inflammation Res.: Off. J. Eur. Histamine Res. Soc. 61 2012 337 348
16. H. Ehrenreich, R.W. Anderson, C.H. Fox, P. Rieckmann, G.S. Hoffman, W.D. Travis, J.E. Coligan, J.H. Kehrl, and A.S. Fauci Endothelins, peptides with potent vasoactive properties, are produced by human macrophages J. Exp. Med. 172 1990 1741 1748
17. C. Eriksson, A. Gustavsson, T. Kronvall, and C. Tysk Hepatotoxicity by bosentan in a patient with portopulmonary hypertension: a case-report and review of the literature J. Gastrointest. Liver Dis.: JGLD 20 2011 77 80
18. K. Fattinger, C. Funk, M. Pantze, C. Weber, J. Reichen, B. Stieger, and P.J. Meier The endothelin antagonist bosentan inhibits the canalicular bile salt export pump: a potential mechanism for hepatic adverse reactions Clin. Pharmacol. Ther. 69 2001 223 231 (Pubitemid 32382504)
19. P.J. Ferret, R. Hammoud, M. Tulliez, A. Tran, H. Trebeden, P. Jaffray, B. Malassagne, Y. Calmus, B. Weill, and F. Batteux Detoxification of reactive oxygen species by a nonpeptidyl mimic of superoxide dismutase cures acetaminophen-induced acute liver failure in the mouse Hepatology 33 2001 1173 1180 (Pubitemid 32378217)
20. A.A. Fouad, and I. Jresat Hepatoprotective effect of coenzyme Q10 in rats with acetaminophen toxicity Environ. Toxicol. Pharmacol. 33 2012 158 167
21. N. Galie, M. Beghetti, M.A. Gatzoulis, J. Granton, R.M. Berger, A. Lauer, E. Chiossi, M. Landzberg Bosentan Randomized Trial of Endothelin Antagonist Therapy, I. Bosentan therapy in patients with Eisenmenger syndrome: a multicenter, double-blind, randomized, placebo-controlled study Circulation 114 2006 48 54 (Pubitemid 44305274)
22. N. Galie, A. Manes, and A. Branzi The endothelin system in pulmonary arterial hypertension Cardiovasc. Res. 61 2004 227 237 (Pubitemid 38091763)
23. K. Gamze, H.M. Mehmet, F. Deveci, T. Turgut, F. Ilhan, and I. Ozercan Effect of bosentan on the production of proinflammatory cytokines in a rat model of emphysema Exp. Mol. Med. 39 2007 614 620 (Pubitemid 350106818)
24. C.R. Gandhi, K. Stephenson, and M.S. Olson Endothelin, a potent peptide agonist in the liver J. Biol. Chem. 265 1990 17432 17435
25. C. Gardner, and D. Laskin Sinusoidal cells in liver injury and repair S. Sahu, Hepatotoxicity: From Genomics to in Vitro and in Vivo Models 2007 John Wiley & Sons, Ltd West Sussex 341 370
26. A. Helmy, R. Jalan, D.E. Newby, N.R. Johnston, P.C. Hayes, and D.J. Webb Altered peripheral vascular responses to exogenous and endogenous endothelin-1 in patients with well-compensated cirrhosis Hepatology 33 2001 826 831 (Pubitemid 32246631)
27. J.A. Hinson, A.B. Reid, S.S. McCullough, and L.P. James Acetaminophen-induced hepatotoxicity: role of metabolic activation, reactive oxygen/nitrogen species, and mitochondrial permeability transition Drug Metab. Rev. 36 2004 805 822 (Pubitemid 39453075)
28. M.M. Hoeper Liver toxicity: the Achilles× heel of endothelin receptor antagonist therapy Eur Respir J 34 2009 529 530
29. O.L. Hung, and L. Nelson Tintinalli×s Emergency Medicine: A Comprehensive Study Guide 6 ed. 2004 McGraw-Hill New York
30. H. Jaeschke Glutathione disulfide formation and oxidant stress during acetaminophen-induced hepatotoxicity in mice in vivo: the protective effect of allopurinol J. Pharmacol. Exp. Ther. 255 1990 935 941
31. L.P. James, S.S. McCullough, T.R. Knight, H. Jaeschke, and J.A. Hinson Acetaminophen toxicity in mice lacking NADPH oxidase activity: role of peroxynitrite formation and mitochondrial oxidant stress Free Radic. Res. 37 2003 1289 1297 (Pubitemid 37441712)
32. D.J. Jollow, S.S. Thorgeirsson, W.Z. Potter, M. Hashimoto, and J.R. Mitchell Acetaminophen-induced hepatic necrosis. VI. Metabolic disposition of toxic and nontoxic doses of acetaminophen Pharmacology 12 1974 251 271
33. E. Karakus, Z. Halici, A. Albayrak, B. Polat, Y. Bayir, I. Kiki, E. Cadirci, A. Topcu, and S. Aksak Agomelatine: an antidepressant with new potent hepatoprotective effects on paracetamol-induced liver damage in rats Hum. Exp. Toxicol. 32 2013 846 857
34. D.C. Kemp, M.J. Zamek-Gliszczynski, and K.L. Brouwer Xenobiotics inhibit hepatic uptake and biliary excretion of taurocholate in rat hepatocytes Toxicol. Sci.: Off. J. Soc. Toxicol. 83 2005 207 214 (Pubitemid 40227890)
35. A.M. Larson, J. Polson, R.J. Fontana, T.J. Davern, E. Lalani, L.S. Hynan, J.S. Reisch, F.V. Schiodt, G. Ostapowicz, A.O. Shakil, W.M. Lee, and Acute Liver Failure Study G. Acetaminophen-induced acute liver failure: results of a United States multicenter, prospective study Hepatology 42 2005 1364 1372 (Pubitemid 43260039)
36. D. Laskin, and C. Gardner Nonparenchymal cells, inflammatory macrophages, and hepatotoxicity N. Kaplowitz, L. DeLeve, Drug-Induced Liver Disease 2007 Informa Heatlthcare New York 159 184
37. D.L. Laskin Macrophages and inflammatory mediators in chemical toxicity: a battle of forces Chem. Res. Toxicol. 22 2009 1376 1385
38. J.R. Mitchell, D.J. Jollow, W.Z. Potter, D.C. Davis, J.R. Gillette, and B.B. Brodie Acetaminophen-induced hepatic necrosis. I. Role of drug metabolism J. Pharmacol. Exp. Ther. 187 1973 185 194
39. J.R. Mitchell, D.J. Jollow, W.Z. Potter, J.R. Gillette, and B.B. Brodie Acetaminophen-induced hepatic necrosis. IV. Protective role of glutathione J. Pharmacol. Exp. Ther. 187 1973 211 217
40. D. Nakae, K. Yamamoto, H. Yoshiji, T. Kinugasa, H. Maruyama, J.L. Farber, and Y. Konishi Liposome-encapsulated superoxide dismutase prevents liver necrosis induced by acetaminophen Am. J. Pathol. 136 1990 787 795 (Pubitemid 20142315)
41. S.D. Nelson Molecular mechanisms of the hepatotoxicity caused by acetaminophen Semin. Liver Dis. 10 1990 267 278
42. W.A. Pryor, and G.L. Squadrito The chemistry of peroxynitrite: a product from the reaction of nitric oxide with superoxide Am. J. Physiol. 268 1995 L699 L722
43. M.G. Rajesh, and M.S. Latha Preliminary evaluation of the antihepatotoxic activity of Kamilari, a polyherbal formulation J. Ethnopharmacol. 91 2004 99 104 (Pubitemid 38270235)
44. H. Ruetten, and C. Thiemermann Endothelin-1 stimulates the biosynthesis of tumour necrosis factor in macrophages: ET-receptors, signal transduction and inhibition by dexamethasone J. Physiol. Pharmacol.: Off. J. Pol. Physiol. Soc. 48 1997 675 688 (Pubitemid 28055595)
45. R. Sallie, J.M. Tredger, and R. Williams Drugs and the liver. Part 1: testing liver function Biopharm. Drug Dispos. 12 1991 251 259
46. S. Sherlock, and J. Dooley Diseases of Liver and Biliary System 11 ed. 2002 Blackwell Scientific Publications Oxford
47. M.S. Siobal Pulmonary vasodilators Respir. Care 52 2007 885 899
48. O. Sitbon, V. Gressin, R. Speich, P.S. Macdonald, M. Opravil, D.A. Cooper, T. Fourme, M. Humbert, J.F. Delfraissy, and G. Simonneau Bosentan for the treatment of human immunodeficiency virus-associated pulmonary arterial hypertension Am. J. Respir. Crit. Care Med. 170 2004 1212 1217 (Pubitemid 39577380)
49. C. Srinivasan, W.M. Williams, M.B. Ray, and T.S. Chen Prevention of acetaminophen-induced liver toxicity by 2(R,S)-n-propylthiazolidine-4(R)- carboxylic acid in mice Biochem. Pharmacol. 61 2001 245 252 (Pubitemid 32121789)
50. M.K.E. Uzkeser, A. Albayrak, I. Kiki, Y. Bayir, E. Cadirci, D. Unal, Z. Halici, and A. Karadeniz Protective effect of Panax ginseng against N-acetyl-p-aminophenol-induced hepatotoxicity in rats Afr. J. Pharm. Pharmacol. 6 2012 2634 2642
51. J.L. Wallace Acetaminophen hepatotoxicity: NO to the rescue Br. J. Pharmacol. 143 2004 1 2 (Pubitemid 39280017)
52. M. Wendel, A. Petzold, R. Koslowski, M. Kasper, A. Augstein, L. Knels, J.U. Bleyl, and T. Koch Localization of endothelin receptors in bleomycin-induced pulmonary fibrosis in the rat Histochem. Cell Biol. 122 2004 507 517 (Pubitemid 40379020)
53. H. Xu, L. Lin, and W.J. Yuan Antiarrhythmic effect of endothelin-A receptor antagonist on acute ischemic arrhythmia in isolated rat heart Acta Pharmacol. Sin. 24 2003 37 44 (Pubitemid 36090774)
54. K. Yamanaka, A. Hasegawa, R. Sawamura, and S. Okada Cellular response to oxidative damage in lung induced by the administration of dimethylarsinic acid, a major metabolite of inorganic arsenics, in mice Toxicol. Appl. Pharmacol. 108 1991 205 213
55. M. Yanagisawa, H. Kurihara, S. Kimura, Y. Tomobe, M. Kobayashi, Y. Mitsui, Y. Yazaki, K. Goto, and T. Masaki A novel potent vasoconstrictor peptide produced by vascular endothelial cells Nature 332 1988 411 415 (Pubitemid 18090241)
56. C.M. Zanatta, F.V. Veronese, S. Loreto Mda, D.A. Sortica, V.N. Carpio, M.I. Eldeweiss, V.D. da Silva, T.G. Lopes, J.L. Gross, and L.H. Canani Endothelin-1 and endothelin a receptor immunoreactivity is increased in patients with diabetic nephropathy Renal Failure 34 2012 308 315