Design, synthesis and biological evaluation of (E)-2-(2-arylhydrazinyl) quinoxalines, a promising and potent new class of anticancer agents

Bioorganic and Medicinal Chemistry Letters

Volumn 24, Issue 3, 2014, Pages 934-939

  Rodrigues, Felipe A R ^a   Bomfim, Igor Da S ^a   Cavalcanti, Bruno C ^a   Pessoa, Claudia Do Ó ^a   Wardell, James L ^b,c   Wardell, Solange M S V ^d   Pinheiro, Alessandra C ^b   Kaiser, Carlos Roland ^e   Nogueira, Thais C M ^b,e   Low, John N ^c   Gomes, Ligia R ^f   De Souza, Marcus V N ^b  

^a FEDERAL UNIVERSITY OF CEARÁ   (Brazil)

^b INSTITUTO OSWALDO CRUZ   (Brazil)

^c UNIVERSITY OF ABERDEEN   (United Kingdom)

^d CHEMSOL   (United Kingdom)

^e FEDERAL UNIVERSITY OF RIO DE JANEIRO   (Brazil)

^f UNIVERSITY OF PORTO   (Portugal)

Author keywords

Antitumor activity; Drugs; Hydrazone; Quinoxaline

Indexed keywords

2 (2 ARYLHYDRAZINYL)QUINOXALINE; ANTINEOPLASTIC AGENT; DOXORUBICIN; IRON; LIGAND; QUINOXALINE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CANCER CELL CULTURE; CRYSTAL STRUCTURE; DRUG CYTOTOXICITY; DRUG DESIGN; DRUG SCREENING; DRUG SYNTHESIS; HUMAN; HUMAN CELL; HYDROGEN BOND; IC 50; STRUCTURE ACTIVITY RELATION;

ANTITUMOR ACTIVITY; DRUGS; HYDRAZONE; QUINOXALINE;

ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; CELL PROLIFERATION; COORDINATION COMPLEXES; DOXORUBICIN; DRUG DESIGN; HUMANS; HYDROGEN BONDING; INHIBITORY CONCENTRATION 50; IRON; LIGANDS; QUINOXALINES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84893689406     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2013.12.074     Document Type: Article

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