A synthetic hydrazone derivative acts as an apoptotic inducer with chemopreventive activity on a tongue cancer cell line

Asian Pacific Journal of Cancer Prevention

Volumn 12, Issue 1, 2011, Pages 259-263

  Zulkepli, N ^a   Saad, Nur Ayunie ^a   Rou, Karen Voon Kai ^a   Sulaiman, Wan Nur Hidayati Wan ^a   Salhin, Abdussalam ^a   Seeni, Azman ^a,b  

^a SCHOOL OF PHYSICS   (Malaysia)

^b ADVANCED MEDICAL AND DENTAL INSTITUTE   (Malaysia)

Author keywords

Apoptosis; Chemoprevention; Hydrazones; Tongue cancer cells

Indexed keywords

EID: 79958735625     PISSN: 15137368     EISSN: 2476762X     Source Type: Journal    
DOI: None     Document Type: Article

References (12)

1. Cocco MT, Congiu C, Lilliu V, et al.(2005). Synthesis and in vitro antitumoral activity of new hydrazinopyrimidine-5-carbonitrile derivatives. Bioorg Med Chem, 14, 366-72.
2. Gursoy A, Karali N.(2003). Synthesis and primary cytotoxicity evaluation of 3-[[(6-Chloro-3-phenyl-4(3H)-quinazolinone -2-yl)mercaptoacetyl]hydrazono]-5-fluoro-1H-2-indolinone. Eur J Med Chem, 38, 633-43.
3. Gursoy E, Guzeldemirci-Ulusoy N.(2007). Synthesis and primary cytotoxicity evaluation of new imidazo [2,1-b] thiazole derivatives. Eur J Med Chem, 42, 320-6.
4. Jordan MA.(2002). Mechanism of action of antitumor drugs that interacts with microtubules and tubulin. Curr Med Chem Anticancer gents, 2, 1-17.
5. Khuri FR, Lippman SM, Spitz MR, et al.(1997). Molecular epidemiology and retinoid chemoprevention of head and neck cancer. J Natl Cancer Inst, 89, 199-211.
6. Rollas S, Kucukguzel SG.(2007). Biological activities of hydrazone derivatives. Molecules, 12, 1910-39.
7. Sporn MB, Suh N.(2002). Chemoprevention: an essential approach to controlling cancer. Nat Rev Cancer, 2, 537-43.
8. Terzioglu N, Gursoy A.(2003). Synthesis and anticancer evaluation of some new hydrazone derivatives of (2,6-Dimethyl-N'-(2-hydroxyphenylmethylidene)imidazo[2,1-b][1,3,4] thiadiazole-5-carbohydrazide. Eur J Med Chem, 38, 781-6.
9. Thompson CB.(1995). Apoptosis in the pathogenesis and treatment of disease. Science, 267, 1456-62.
10. Tsao AS, Kim ES, Hong WK.(2004). Chemoprevention of cancer. CA Cancer J Clin, 54, 150-80.
11. Vicini P, Incerti M, Doytchinova I, et al.(2006). Synthesis and antiproliferative activity of benzo[d]isothiazole hydrazones. Eur J Med Chem, 41, 624-32.
12. Zhang H, Drewe J, Tseng B, et al.(2004). Discovery and SAR of indole-2-carboxylic acid benzylidenehydrazides as a new series of potent apoptosis inducers using cell based HTS assay. Bioorg Med Chem, 12, 3649-55.