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Bioorganic and Medicinal Chemistry Letters

Volumn 24, Issue 3, 2014, Pages 839-844

Identification of a novel conformationally constrained glucagon receptor antagonist

(18) Lee, Esther C Y a Tu, Meihua a Stevens, Benjamin D a Bian, Jianwei a Aspnes, Gary a Perreault, Christian a Sammons, Matthew F a Wright, Stephen W a Litchfield, John a Kalgutkar, Amit S a Sharma, Raman a Didiuk, Mary T a Ebner, David C a Filipski, Kevin J a Brown, Janice a Atkinson, Karen a Pfefferkorn, Jeffrey A a Guzman Perez, Angel a

a PFIZER INC (United States)

Author keywords

Diabetes mellitus; Glucagon receptor antagonist; Metabolite; Physicochemical properties

Indexed keywords

CYTOCHROME P450; GLUCAGON RECEPTOR; GLUCAGON RECEPTOR ANTAGONIST; UNCLASSIFIED DRUG;

ARTICLE; DRUG CLEARANCE; DRUG CONFORMATION; DRUG IDENTIFICATION; DRUG METABOLISM; ENANTIOMER; ENANTIOSELECTIVITY; HUMAN; IN VITRO STUDY; IN VIVO STUDY; LIPOPHILICITY; NONHUMAN; OXIDATION;

DIABETES MELLITUS; GLUCAGON RECEPTOR ANTAGONIST; METABOLITE; PHYSICOCHEMICAL PROPERTIES;

ADMINISTRATION, INTRAVENOUS; ADMINISTRATION, ORAL; ANIMALS; BENZAMIDES; CELLS, CULTURED; DOGS; LIGANDS; MOLECULAR CONFORMATION; MOLECULAR STRUCTURE; OXIDATION-REDUCTION; PROTEIN BINDING; PYRIMIDINES; RATS; RATS, WISTAR; RECEPTORS, GLUCAGON; STEREOISOMERISM;

EID: 84893686968 PISSN: 0960894X EISSN: 14643405 Source Type: Journal
DOI: 10.1016/j.bmcl.2013.12.090 Document Type: Article

Times cited : (17)

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