A novel series of glucagon receptor antagonists with reduced molecular weight and lipophilicity

Bioorganic and Medicinal Chemistry Letters

Volumn 22, Issue 1, 2012, Pages 415-420

  Filipski, Kevin J ^a   Bian, Jianwei ^a   Ebner, David C ^a   Lee, Esther C Y ^a   Li, Jian Cheng ^a   Sammons, Matthew F ^a   Wright, Stephen W ^a   Stevens, Benjamin D ^a   Didiuk, Mary T ^a   Tu, Meihua ^a   Perreault, Christian ^a   Brown, Janice ^a   Atkinson, Karen ^a   Tan, Beijing ^a   Salatto, Christopher T ^a   Litchfield, John ^a   Pfefferkorn, Jeffrey A ^a   Guzman Perez, Angel ^a  

^a PFIZER INC   (United States)

Author keywords

Aminopyrazole; Diabetes; Glucagon receptor antagonist; Pyrazole ether

Indexed keywords

AMINOPYRAZOLE; GLUCAGON; GLUCAGON RECEPTOR ANTAGONIST; GLUCOSE; PYRAZOLE DERIVATIVE; PYRAZOLE ETHER; RECEPTOR BLOCKING AGENT; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DRUG CLEARANCE; DRUG PENETRATION; DRUG POTENCY; DRUG SOLUBILITY; DRUG STRUCTURE; DRUG SYNTHESIS; LIPOPHILICITY; MOLECULAR WEIGHT; NONHUMAN; RAT;

ANIMALS; CHEMISTRY, PHARMACEUTICAL; DIABETES MELLITUS; DOGS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DESIGN; ETHER, ETHYL; GLUCAGON; GLUCOSE; HUMANS; KINETICS; MODELS, CHEMICAL; MOLECULAR WEIGHT; PYRAZOLES; RATS; RECEPTORS, GLUCAGON; TEMPERATURE;

CANIS FAMILIARIS; RATTUS;

EID: 84655161328     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2011.10.113     Document Type: Article

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