Bioinformatics Analyses Reveal Age-Specific Neuroimmune Modulation as a Target for Treatment of High Ethanol Drinking

Alcoholism: Clinical and Experimental Research

Volumn 38, Issue 2, 2014, Pages 428-437

  Agrawal, Rajiv G ^a   Owen, Julie A ^a   Levin, Patricia S ^b   Hewetson, Aveline ^a   Berman, Ari E ^b   Franklin, Scott R ^a   Hogue, Ryan J ^a   Chen, Yukun ^a   Walz, Chris ^b   Colvard, Benjamin D ^b   Nguyen, Jonathan ^b   Velasquez, Oscar ^b   Al Hasan, Yazan ^a   Blednov, Yuri A ^b   Fowler, Anna Kate ^a   Syapin, Peter J ^a   Bergeson, Susan E ^a  

^a TEXAS TECH UNIVERSITY HEALTH SCIENCES CENTER SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF TEXAS AT AUSTIN   (United States)

Author keywords

Alcoholism; Bioinformatics; Drinking in Dark; FVB NJ C57BL 6J F1 Mouse; Medications Development; Minocycline

Indexed keywords

ALCOHOL; MINOCYCLINE; SODIUM CHLORIDE;

ADOLESCENT; ADULT; AGE; ALCOHOL BLOOD LEVEL; ALCOHOL CONSUMPTION; ALCOHOL METABOLISM; ALCOHOLISM; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BIOINFORMATICS; COMPUTER MODEL; CONTROLLED STUDY; DRINKING BEHAVIOR; ELIMINATION REACTION; FEMALE; GENE EXPRESSION; IMMUNOMODULATION; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; SEX DIFFERENCE;

MUS;

ALCOHOLISM; BIOINFORMATICS; DRINKING-IN-DARK; FVB/NJ × C57BL/6J F1 MOUSE; MEDICATIONS DEVELOPMENT; MINOCYCLINE;

AGING; ALCOHOLISM; ANIMALS; ANTI-BACTERIAL AGENTS; CENTRAL NERVOUS SYSTEM DEPRESSANTS; COMPUTATIONAL BIOLOGY; ETHANOL; FEMALE; MALE; MICE; MICE, INBRED C57BL; MINOCYCLINE; NEUROIMMUNOMODULATION; SEX CHARACTERISTICS;

EID: 84893685617     PISSN: 01456008     EISSN: 15300277     Source Type: Journal    
DOI: 10.1111/acer.12288     Document Type: Article

References (67)

1. Agrawal RG, Hewetson A, George CM, Syapin PJ, Bergeson SE (2011) Minocycline reduces ethanol drinking. Brain Behav Immun 25(Suppl 1):S165-S169.
2. Ai Z, Wang J, Xu Y, Teng Y (2013) Bioinformatics analysis reveals potential candidate drugs for cervical cancer. J Obstet Gynaecol Res 39:1052-1058.
3. Aloisi F (2001) Immune function of microglia. Glia 36:165-179.
4. Anton RF, O'Malley SS, Ciraulo DA, Cisler RA, Couper D, Donovan DM, Gastfriend DR, Hosking JD, Johnson BA, Locastro JS, Longabaugh R, Mason BJ, Mattson ME, Miller WR, Pettinati HM, Randall CL, Swift R, Weiss RD, Williams LD, Zweben A (2006) Combined pharmacotherapies and behavioral interventions for alcohol dependence: the COMBINE study: a randomized controlled trial. JAMA 295:2003-2017.
5. Babor TF, Hofmann M, Delboca FK, Hesselbrock V, Meyer RE, Dolinsky ZS, Rounsaville B (1992) Types of alcoholics, I. Evidence for an empirically derived typology based on indicators of vulnerability and severity. Arch Gen Psychiatry 49:599-608.
6. Bahrami F, Morris DL, Pourgholami MH (2012) Tetracyclines: drugs with huge therapeutic potential. Mini Rev Med Chem 12:44-52.
7. Benjamini Y, Hochberg Y (1995) Controlling the false discovery rate: a practical and powerful approach to multiple testing. J Roy Stat Soc Ser B 57:289-300.
8. Bennett ME, McCrady BS, Johnson V, Pandina RJ (1999) Problem drinking from young adulthood to adulthood: patterns, predictors and outcomes. J Stud Alcohol 60:605-614.
9. Blednov YA, Benavidez JM, Geil C, Perra S, Morikawa H, Harris RA (2011) Activation of inflammatory signaling by lipopolysaccharide produces a prolonged increase of voluntary alcohol intake in mice. Brain Behav Immun 25(Suppl 1):S92-S105.
10. Blednov YA, Bergeson SE, Walker D, Ferreira VMM, Kuziel WA, Harris RA (2005a) Perturbation of chemokine networks by gene deletion alters the reinforcing actions of ethanol. Behav Brain Res 165:110-125.
11. Blednov YA, Metten P, Finn DA, Rhodes JS, Bergeson SE, Harris RA, Crabbe JC (2005b) Hybrid C57BL/6J × FVB/NJ mice drink more alcohol than do C57BL/6J mice. Alcohol Clin Exp Res 29:1949-1958.
12. Blednov YA, Ponomarev I, Geil C, Bergeson S, Koob GF, Harris RA (2012) Neuroimmune regulation of alcohol consumption: behavioral validation of genes obtained from genomic studies. Addict Biol 17:108-120.
13. Brown SA, D'Amico EJ (2001) Outcomes of alcohol treatment for adolescents. Recent Dev Alcohol 15:307-327.
14. Brown SA, Tapert SF (2004) Adolescence and the trajectory of alcohol use: basic to clinical studies. Ann N Y Acad Sci 1021:234-244.
15. Cippitelli A, Damadzic R, Frankola K, Goldstein A, Thorsell A, Singley E, Eskay RL, Heilig M (2010) Alcohol-induced neurodegeneration, suppression of transforming growth factor-beta, and cognitive impairment in rats: prevention by group II metabotropic glutamate receptor activation. Biol Psychiatry 67:823-830.
16. Corona AW, Huang Y, O'Connor JC, Dantzer R, Kelley KW, Popovich PG, Godbout JP (2010) Fractalkine receptor (CX3CR1) deficiency sensitizes mice to the behavioral changes induced by lipopolysaccharide. J Neuroinflammation 7:93.
17. Crews FT (2012) Immune function genes, genetics, and the neurobiology of addiction. Alcohol Res 34:355-361.
18. Crews FT, Nixon K (2009) Mechanisms of neurodegeneration and regeneration in alcoholism. Alcohol Alcohol 44:115-127.
19. Daniels GM, Buck KJ (2002) Expression profiling identifies strain-specific changes associated with ethanol withdrawal in mice. Genes Brain Behav 1:35-45.
20. Davis RL, Syapin PJ (2005) Interactions of alcohol and nitric-oxide synthase in the brain. Brain Res Brain Res Rev 49:494-504.
21. Dawes MA, Johnson BA (2004) Pharmacotherapeutic trials in adolescent alcohol use disorders: opportunities and challenges. Alcohol Alcohol 39:166-177.
22. Edenberg HJ, Strother WN, McClintick JN, Tian H, Stephens M, Jerome RE, Lumeng L, Li TK, McBride WJ (2005) Gene expression in the hippocampus of inbred alcohol-preferring and -nonpreferring rats. Genes Brain Behav 4:20-30.
23. Fernandez-Lizarbe S, Pascual M, Guerri C (2009) Critical role of TLR4 response in the activation of microglia induced by ethanol. J Immunol 183:4733-4744.
24. Finn DA, Snelling C, Fretwell AM, Tanchuck MA, Underwood L, Cole M, Crabbe JC, Roberts AJ (2007) Increased drinking during withdrawal from intermittent ethanol exposure is blocked by the CRF receptor antagonist D-Phe-CRF(12-41). Alcohol Clin Exp Res 31:939-949.
25. Garrido-Mesa N, Zarzuelo A, Galvez J (2013) What is behind the non-antibiotic properties of minocycline? Pharmacol Res 67:18-30.
26. Gehrmann J, Matsumoto Y, Kreutzberg GW (1995) Microglia: intrinsic immuneffector cell of the brain. Brain Res Brain Res Rev 20:269-287.
27. Grant BF, Dawson DA (1997) Age at onset of alcohol use and its association with DSM-IV alcohol abuse and dependence: results from the National Longitudinal Alcohol Epidemiologic Survey. J Subst Abuse 9:103-110.
28. Greenfield SF, Pettinati HM, O'Malley S, Randall PK, Randall CL (2010) Gender differences in alcohol treatment: an analysis of outcome from the COMBINE study. Alcohol Clin Exp Res 34:1803-1812.
29. Guasti L, Richardson D, Jhaveri M, Eldeeb K, Barrett D, Elphick MR, Alexander SP, Kendall D, Michael GJ, Chapman V (2009) Minocycline treatment inhibits microglial activation and alters spinal levels of endocannabinoids in a rat model of neuropathic pain. Mol Pain 5:35.
30. Henry CJ, Huang Y, Wynne A, Hanke M, Himler J, Bailey MT, Sheridan JF, Godbout JP (2008) Minocycline attenuates lipopolysaccharide (LPS)-induced neuroinflammation, sickness behavior, and anhedonia. J Neuroinflammation 5:15.
31. Homsi S, Federico F, Croci N, Palmier B, Plotkine M, Marchand-Leroux C, Jafarian-Tehrani M (2009) Minocycline effects on cerebral edema: relations with inflammatory and oxidative stress markers following traumatic brain injury in mice. Brain Res 1291:122-132.
32. Huang TY, Chu HC, Lin YL, Lin CK, Hsieh TY, Chang WK, Chao YC, Liao CL (2009) Minocycline attenuates experimental colitis in mice by blocking expression of inducible nitric oxide synthase and matrix metalloproteinases. Toxicol Appl Pharmacol 237:69-82.
33. Johnson BA, Ait-Daoud N, Bowden CL, Diclemente CC, Roache JD, Lawson K, Javors MA, Ma JZ (2003) Oral topiramate for treatment of alcohol dependence: a randomised controlled trial. Lancet 361:1677-1685.
34. Kapsimali M, Kloosterman WP, De Bruijn E, Rosa F, Plasterk RH, Wilson SW (2007) MicroRNAs show a wide diversity of expression profiles in the developing and mature central nervous system. Genome Biol 8:R173.
35. Kerns RT, Miles MF (2008) Microarray analysis of ethanol-induced changes in gene expression. Methods Mol Biol 447:395-410.
36. Key J, Hodgson S, Omar RZ, Jensen TK, Thompson SG, Boobis AR, Davies DS, Elliott P (2006) Meta-analysis of studies of alcohol and breast cancer with consideration of the methodological issues. Cancer Causes Control 17:759-770.
37. Kielian T, Esen N, Liu S, Phulwani NK, Syed MM, Phillips N, Nishina K, Cheung AL, Schwartzman JD, Ruhe JJ (2007) Minocycline modulates neuroinflammation independently of its antimicrobial activity in staphylococcus aureus-induced brain abscess. Am J Pathol 171:1199-1214.
38. Kloppenburg M, Brinkman BM, De Rooij-Dijk HH, Miltenburg AM, Daha MR, Breedveld FC, Dijkmans BA, Verweij C (1996) The tetracycline derivative minocycline differentially affects cytokine production by monocytes and T lymphocytes. Antimicrob Agents Chemother 40:934-940.
39. Kobayashi K, Imagama S, Ohgomori T, Hirano K, Uchimura K, Sakamoto K, Hirakawa A, Takeuchi H, Suzumura A, Ishiguro N, Kadomatsu K (2013) Minocycline selectively inhibits M1 polarization of microglia. Cell Death Dis 4:e525.
40. Kranzler HR, Van Kirk J (2001) Efficacy of naltrexone and acamprosate for alcoholism treatment: a meta-analysis. Alcohol Clin Exp Res 25:1335-1341.
41. Lewohl JM, Wang L, Miles MF, Zhang L, Dodd PR, Harris RA (2000) Gene expression in human alcoholism: microarray analysis of frontal cortex. Alcohol Clin Exp Res 24:1873-1882.
42. Liu J, Yang AR, Kelly T, Puche A, Esoga C, June HL Jr, Elnabawi A, Merchenthaler I, Sieghart W, June HL Sr, Aurelian L (2011) Binge alcohol drinking is associated with GABAA alpha2-regulated Toll-like receptor 4 (TLR4) expression in the central amygdala. Proc Natl Acad Sci U S A 108:4465-4470.
43. Medina KL, McQueeny T, Nagel BJ, Hanson KL, Schweinsburg AD, Tapert SF (2008) Prefrontal cortex volumes in adolescents with alcohol use disorders: unique gender effects. Alcohol Clin Exp Res 32:386-394.
44. Melon LC, Wray KN, Moore EM, Boehm SL II (2013) Sex and age differences in heavy binge drinking and its effects on alcohol responsivity following abstinence. Pharmacol Biochem Behav 104:177-187.
45. Mulligan MK, Ponomarev I, Boehm SL II, Owen JA, Levin PS, Berman AE, Blednov YA, Crabbe JC, Williams RW, Miles MF, Bergeson SE (2008) Alcohol trait and transcriptional genomic analysis of C57BL/6 substrains. Genes Brain Behav 7:677-689.
46. Mulligan MK, Ponomarev I, Hitzemann RJ, Belknap JK, Tabakoff B, Harris RA, Crabbe JC, Blednov YA, Grahame NJ, Phillips TJ, Finn DA, Hoffman PL, Iyer VR, Koob GF, Bergeson SE (2006) Toward understanding the genetics of alcohol drinking through transcriptome meta-analysis. Proc Natl Acad Sci USA 103:6368-6373.
47. Mulligan MK, Rhodes JS, Crabbe JC, Mayfield RD, Adron Harris R, Ponomarev I (2011) Molecular profiles of drinking alcohol to intoxication in C57BL/6J mice. Alcohol Clin Exp Res 35:659-670.
48. Nikodemova M, Lee J, Fabry Z, Duncan ID (2010) Minocycline attenuates experimental autoimmune encephalomyelitis in rats by reducing T cell infiltration into the spinal cord. J Neuroimmunol 219:33-37.
49. Orio L, Llopis N, Torres E, Izco M, O'shea E, Colado MI (2010) A study on the mechanisms by which minocycline protects against MDMA ('ecstasy')-induced neurotoxicity of 5-HT cortical neurons. Neurotox Res 18:187-199.
50. Plane JM, Shen Y, Pleasure DE, Deng W (2010) Prospects for minocycline neuroprotection. Arch Neurol 67:1442-1448.
51. Qin HW, Wilson CA, Lee SJ, Zhao XY, Benveniste EN (2005) LPS induces CD40 gene expression through the activation of NF-kappa B and STAT-1 alpha in macrophages and microglia. Blood 106:3114-3122.
52. R Development Core Team (2006) R: A Language and Environment for Statistical Computing. R Foundation for Statistical Computing, Vienna, Austria. Available at: http://www.R-project.org. Accessed December 2, 2006.
53. Raivich G, Bohatschek M, Kloss CU, Werner A, Jones LL, Kreutzberg GW (1999) Neuroglial activation repertoire in the injured brain: graded response, molecular mechanisms and cues to physiological function. Brain Res Brain Res Rev 30:77-105.
54. Rhodes JS, Best K, Belknap JK, Finn DA, Crabbe JC (2005) Evaluation of a simple model of ethanol drinking to intoxication in C57BL/6J mice. Physiol Behav 84:53-63.
55. Scheffel J, Regen T, Van Rossum D, Seifert S, Ribes S, Nau R, Parsa R, Harris RA, Boddeke HW, Chuang HN, Pukrop T, Wessels JT, Jurgens T, Merkler D, Bruck W, Schnaars M, Simons M, Kettenmann H, Hanisch UK (2012) Toll-like receptor activation reveals developmental reorganization and unmasks responder subsets of microglia. Glia 60:1930-1943.
56. Sewell KL, Breedveld F, Furrie E, O'brien J, Brinckerhoff C, Dynesius-Trentham R, Nosaka Y, Trentham DE (1996) The effect of minocycline in rat models of inflammatory arthritis: correlation of arthritis suppression with enhanced T cell calcium flux. Cell Immunol 167:195-204.
57. Soliman GM, Choi AO, Maysinger D, Winnik FM (2010) Minocycline block copolymer micelles and their anti-inflammatory effects on microglia. Macromol Biosci 10:278-288.
58. Squeglia LM, Sorg SF, Schweinsburg AD, Wetherill RR, Pulido C, Tapert SF (2012) Binge drinking differentially affects adolescent male and female brain morphometry. Psychopharmacology 220:529-539.
59. Sullivan EV, Zahr NM (2008) Neuroinflammation as a neurotoxic mechanism in alcoholism: commentary on "Increased MCP-1 and microglia in various regions of human alcoholic brain". Exp Neurol 213:10-17.
60. Tabakoff B, Bhave SV, Hoffman PL (2003) Selective breeding, quantitative trait locus analysis, and gene arrays identify candidate genes for complex drug-related behaviors. J Neurosci 23:4491-4498.
61. Urbano-Marquez A, Estruch R, Fernandez-Sola J, Nicolas JM, Pare JC, Rubin E (1995) The greater risk of alcoholic cardiomyopathy and myopathy in women compared with men. JAMA 274:149-154.
62. Volpicelli JR, Alterman AI, Hayashida M, O'brien CP (1992) Naltrexone in the treatment of alcohol dependence. Arch Gen Psychiatry 49:876-880.
63. Yang LP, Zhu XA, Tso MO (2007) Minocycline and sulforaphane inhibited lipopolysaccharide-mediated retinal microglial activation. Mol Vis 13: 1083-1093.
64. Yoon SY, Patel D, Dougherty PM (2012) Minocycline blocks lipopolysaccharide induced hyperalgesia by suppression of microglia but not astrocytes. Neuroscience 221:214-224.
65. Zhang B, Kirov S, Snoddy J (2005) WebGestalt: an integrated system for exploring gene sets in various biological contexts. Nucleic Acids Res 33:W741-W748.
66. Zhang Z, Zhang ZY, Wu Y, Schluesener HJ (2012) Immunolocalization of Toll-like receptors 2 and 4 as well as their endogenous ligand, heat shock protein 70, in rat traumatic brain injury. NeuroImmunomodulation 19:10-19.
67. Zhao P, Waxman SG, Hains BC (2007) Extracellular signal-regulated kinase-regulated microglia-neuron signaling by prostaglandin E2 contributes to pain after spinal cord injury. J Neurosci 27:2357-2368.