Delay and stability of central venous administration of norepinephrine in children: A bench study

European Journal of Pediatrics

Volumn 173, Issue 1, 2014, Pages 69-73

  Oualha, Mehdi ^a,b   Capelo, Mikaël ^a   Spreux Varoquaux, Odile ^c   Drouet Chaillou, Isabelle ^d   Tréluyer, Jean Marc ^a,b   Hubert, Philippe ^a   Lesage, Fabrice ^a  

^a HÔPITAL NECKER ENFANTS MALADES   (France)

^b Université de Versailles Saint Quentin en Yvelines ^*  (France)

^c LABORATOIRE DES SCIENCES DU CLIMAT ET DE L ENVIRONNEMENT   (France)

^d CENTRE HOSPITALIER DE VERSAILLES   (France)

Author keywords

Central venous catheter; Children; Dead volume; Delivery delay; Infusion stability; Norepinephrine

Indexed keywords

NORADRENALIN;

ARTICLE; CENTRAL VENOUS CATHETER; CONTINUOUS INFUSION; DOSE CALCULATION; DRUG DELIVERY SYSTEM; EXPERIMENTAL STUDY; FLOW RATE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; INFUSION RATE; PRIORITY JOURNAL; THERAPY DELAY;

ADRENERGIC ALPHA-AGONISTS; CATHETERIZATION, CENTRAL VENOUS; CHILD; HUMANS; INFUSIONS, INTRAVENOUS; NOREPINEPHRINE;

EID: 84893681868     PISSN: 03406199     EISSN: 14321076     Source Type: Journal    
DOI: 10.1007/s00431-013-2121-5     Document Type: Article

References (14)

1. Bartels K, Moss DR, Peterfreund RA (2009) An analysis of drug delivery dynamics via a pediatric central venous infusion system: quantification of delays in achieving intended doses. Anesth Analg 109(4):1156-1161
2. Capes DF, Dunster KR, Sunderland VB et al (1995) Fluctuations in syringe-pump infusions: association with blood pressure variations in infants. Am J Health Syst Pharm 52(15):1646-1653
3. Cook RI (2000) Syringe pump assemblies and the natural history of clinical technology. Can J Anaesth 47(10):929-935
4. Décaudin B, Dewulf S, Lannoy D et al (2009) Impact of multiaccess infusion devices on in vitro drug delivery during multi-infusion therapy. Anesth Analg 109(4):1147-1155
5. Guillemin A, Troupel S, Galli A (1988) Determination of catecholamines in plasma by high-performance liquid chromatography. Clin Chem 34(9):1913-1914
6. Hoellein L, Holzgrabe U (2012) Ficts and facts of epinephrine and norepinephrine stability in injectable solutions. Int J Pharm 434(1-2):468-480
7. Hutton P, Thornberry EA (1986) Factors affecting delivery of drug through extension tubing. Br J Anaesth 58:1141-1148
8. Lovich MA, Doles J, Peterfreund RA (2005) The impact of carrier flow rate and infusion set dead-volume on the dynamics of intravenous drug delivery. Anesth Analg 100(4):1048-1055
9. Lovich MA, Kinnealley ME, Sims NM et al (2006) The delivery of drugs to patients by continuous intravenous infusion: modeling predicts potential dose fluctuations depending on flow rates and infusion system dead volume. Anesth Analg 102(4):1147-1153
10. Lovich MA, Peterfreund GL, Sims NM et al (2007) Central venous catheter infusions: a laboratory model shows large differences in drug delivery dynamics related to catheter dead volume. Crit Care Med 35(12):2792-2798
11. Moss DR, Bartels K, Peterfreund GL et al (2009) An in vitro analysis of central venous drug delivery by continuous infusion: the effect of manifold design and port selection. Anesth Analg 109(5):1524-1529
12. Neff T, Fischer J, Fehr S et al (2001) Start-up delays of infusion syringe pumps. Paediatr Anaesth 11:561-565
13. Neff SB, Neff TA, Gerber S et al (2007) Flow rate, syringe size and architecture are critical to start-up performance of syringe pumps. Eur J Anaesthesiol 24:602-608
14. Weiss M, Bänziger O, Neff T et al (2000) Influence of infusion line compliance on drug delivery rate during acute line loop formation. Intensive Care Med 26:776-779