Central venous catheter infusions: A laboratory model shows large differences in drug delivery dynamics related to catheter dead volume

Critical Care Medicine

Volumn 35, Issue 12, 2007, Pages 2792-2798

  Lovich, Mark A ^a   Peterfreund, Gregory L ^b   Sims, Nathaniel M ^b   Peterfreund, Robert A ^b  

^a ST ELIZABETH'S MEDICAL CENTER   (United States)

^b MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

Central venous catheter; Drug infusion, dead volume; Medication safety

Indexed keywords

DRUG CARRIER; METHYLENE BLUE;

ARTICLE; CENTRAL VENOUS CATHETER; CONTINUOUS INFUSION; DRUG DELIVERY SYSTEM; INFUSION RATE; PHARMACODYNAMICS; PRIORITY JOURNAL; PULMONARY ARTERY CATHETER; QUANTITATIVE ANALYSIS; STEADY STATE;

EID: 36448996189     PISSN: 00903493     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.CCM.0000295587.04882.4F     Document Type: Article

References (12)

1. Geater RE, Leff RD, Roberts RJ: Factors affecting drug delivery from a syringe-pump infusion set. Am J Hosp Pharm 1985; 42:2510-2513
2. Kubajak CA, Leff RD, Roberts RJ: Influence of physical characteristics of intravenous systems on drug delivery. Dev Pharmacol Ther 1988; 11:189-195
3. Lovich MA, Doles J, Peterfreund RA: The impact of carrier flow rate and infusion set dead-volume on the dynamics of intravenous drug delivery. Anesth Analg 2005; 100:1048-1055
4. Lovich MA, Kinnealley ME, Sims NM, et al: The delivery of drugs to patients by continuous intravenous infusion: Modeling predicts potential dose fluctuations depending on flow rates and infusion system dead volume. Anesth Analg 2006; 102:1147-1153
5. Neff T, Fischer J, Fehr S, et al: Start-up delays of infusion syringe pumps. Paediatr Anaesth 2001; 11:561-565
6. Rooke GA, Bowdle TA: Syringe pumps for infusion of vasoactive drugs: Mechanical idiosyncrasies and recommended operating procedures. Anesth Analg 1994; 78:150-156
7. Dull RO, Peterfreund RA: Variations in the composition of spinal anesthetic solutions: The effects of drug addition order and preparation methods. Anesth Analg 1998; 87:1326-1330
8. Leff RD, Holstad SG, Kubajak CA, et al: Altered drug infusion rates during syringe-pump infusion. Am J Hosp Pharm 1986; 43:2241-2242
9. Ng GA, Martin W, Rankin AC: Imaging of adenosine bolus transit following intravenous administration: Insights into antiarrhythmic efficacy. Heart 1999; 82:163-169
10. McLintic AJ, Martin W, Tweddel AC: The influence of arm position and cardiac output on bolus clearance from the arm. Anaesthesia 1992; 47:838-841
11. Francois CJ, Shors SM, Bonow RO, et al: Analysis of cardiopulmonary transit times at contrast material-enhanced MR imaging in patients with heart disease. Radiology 2003; 227:447-452
12. Kohn LT, Corrigan J, Donaldson MS: Building a Safer Health System. Washington DC, National Academies Press, 2000