Obese and diabetic KKAy mice show increased mortality but improved cardiac function following myocardial infarction

Cardiovascular Pathology

Volumn 22, Issue 6, 2013, Pages 481-487

  Heaberlin, James R ^a   Ma, Yonggang ^c   Zhang, Jianhua ^a   Ahuja, Seema S ^a,b   Lindsey, Merry L ^a,c,d   Halade, Ganesh V ^a  

^a UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO   (United States)

^b UNIVERSITY OF TEXAS AT SAN ANTONIO   (United States)

^c UNIVERSITY OF MISSISSIPPI SCHOOL OF MEDICINE   (United States)

^d G V SONNY MONTGOMERY VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

Diabetes; Extracellular matrix; Heart failure; Inflammation; Myocardial infarction; Obesity

Indexed keywords

COLLAGEN TYPE 1; GLUCOSE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; EXTRACELLULAR MATRIX; FEMALE; GLUCOSE BLOOD LEVEL; HEART FUNCTION; HEART INFARCTION; HEART INFARCTION SIZE; IMMUNOHISTOCHEMISTRY; MACROPHAGE; MALE; MORTALITY; MOUSE; NEOVASCULARIZATION (PATHOLOGY); NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; OBESITY; PRIORITY JOURNAL; SURVIVAL; TRANSTHORACIC ECHOCARDIOGRAPHY;

DIABETES; EXTRACELLULAR MATRIX; HEART FAILURE; INFLAMMATION; MYOCARDIAL INFARCTION; OBESITY;

ANIMALS; BLOOD GLUCOSE; COLLAGEN TYPE I; COLLAGEN TYPE III; DIABETES MELLITUS, TYPE 2; DISEASE MODELS, ANIMAL; FEMALE; MACROPHAGES; MALE; MICE; MICE, MUTANT STRAINS; MYOCARDIAL CONTRACTION; MYOCARDIAL INFARCTION; MYOCARDIUM; NEOVASCULARIZATION, PHYSIOLOGIC; OBESITY; TIME FACTORS; VENTRICULAR FUNCTION, LEFT; VENTRICULAR REMODELING;

EID: 84893672871     PISSN: 10548807     EISSN: 18791336     Source Type: Journal    
DOI: 10.1016/j.carpath.2013.06.002     Document Type: Article

References (30)

1. Flegal KM, Carroll MD, Kit BK, Ogden CL. Prevalence of obesity and trends in the distribution of body mass index among US adults, 1999-2010. JAMA 2012;307:491-7.
2. Eckel RH, Grundy SM, Zimmet PZ. The metabolic syndrome. Lancet 2005;365:1415-28.
3. Calle EE, Thun MJ, Petrelli JM, Rodriguez C, Heath CW. Body-mass index and mortality in a prospective cohort of U. S. adults. N Engl J Med 1999;341:1097-105.
4. Peeters A, Barendregt JJ, Willekens F, Mackenbach JP, Al Mamun A, Bonneux L. Obesity in adulthood and its consequences for life expectancy: a life-table analysis. Ann Intern Med 2003;138:24-32.
5. Bucholz EM, Rathore SS, Reid KJ, Jones PG, Chan PS, Rich MW, et al. Body mass index and mortality in acute myocardial infarction patients. Am J Med 2012;125:796-803.
6. Kalantar-Zadeh K, Anker SD, Coats AJ, Horwich TB, Fonarow GC. Obesity paradox as a component of reverse epidemiology in heart failure. Arch Intern Med 2005;165:1797 [author reply-8].
7. Nakamura M, Yamada K. Studies on a diabetic (KK) strain of the mouse. Diabetologia 1967;3:212-21.
8. Iwatsuka H, Shino A, Suzuoki Z. General survey of diabetic features of yellow KK mice. Endocrinol Jpn 1970;17:23-35.
9. Zamilpa R, Lopez EF, Chiao YA, Dai Q, Escobar GP, Hakala K, et al. Proteomic analysis identifies in vivo candidate matrix metalloproteinase-9 substrates in the left ventricle post-myocardial infarction. Proteomics 2010;10:2214-23.
10. Michael LH, Ballantyne CM, Zachariah JP, Gould KE, Pocius JS, Taffet GE, et al. Myocardial infarction and remodeling in mice: effect of reperfusion. Am J Physiol 1999;277:H660-8.
11. Chiao YA, Dai Q, Zhang J, Lin J, Lopez EF, Ahuja SS, et al. Multi-analyte profiling reveals matrix metalloproteinase-9 and monocyte chemotactic protein-1 as plasma biomarkers of cardiac aging. Circ Cardiovasc Genet 2011;4:455-62.
12. Lindsey ML, Escobar GP, Dobrucki LW, Goshorn DK, Bouges S, Mingoia JT, et al. Matrix metalloproteinase-9 gene deletion facilitates angiogenesis after myocardial infarction. Am J Physiol Heart Circ Physiol 2006;290:H232-9.
13. Naruko T, Ueda M, Haze K, Van Der Wal AC, Van Der Loos CM, Itoh A, et al. Neutrophil infiltration of culprit lesions in acute coronary syndromes. Circulation 2002;106:2894-900.
14. Ukena C, Dobre D, Mahfoud F, Kindermann I, Lamiral Z, Tala S, et al. Hypo- and hyperglycemia predict outcome in patients with left ventricular dysfunction after acute myocardial infarction: data from EPHESUS. J Card Fail 2012;18:439-45.
15. Nahrendorf M, Pittet MJ, Swirski FK. Monocytes: protagonists of infarct inflammation and repair after myocardial infarction. Circulation 2010;121:2437-45.
16. Frangogiannis NG. Regulation of the inflammatory response in cardiac repair. Circ Res 2012;110:159-73.
17. Antoniades C, Bakogiannis C, Tousoulis D, Antonopoulos AS, Stefanadis C. The CD40/CD40 ligand system: linking inflammation with atherothrombosis. JAm Coll Cardiol 2009;54:669-77.
18. Jugdutt BI. Ventricular remodeling after infarction and the extracellular collagen matrix: when is enough enough? Circulation 2003;108:1395-403.
19. Kocher AA, Schuster MD, Szabolcs MJ, Takuma S, Burkhoff D, Wang J, et al. Neovascularization of ischemic myocardium by human bone-marrow-derived angioblasts prevents cardiomyocyte apoptosis, reduces remodeling and improves cardiac function. Nat Med 2001;7:430-6.
20. De Boer RA, Doehner W, Van Der Horst IC, Anker SD, Babalis D, Roughton M, et al. Influence of diabetes mellitus and hyperglycemia on prognosis in patients > or =70 years old with heart failure and effects of nebivolol (data from the Study of Effects of Nebivolol Intervention on Outcomes and Rehospitalization in Seniors with heart failure [SENIORS]). Am J Cardiol 2010;106:78-86e1.
21. Kostis JB, Sanders M. The association of heart failure with insulin resistance and the development of type 2 diabetes. Am J Hypertens 2005;18:731-7.
22. Satake M, Ikarashi N, Ichikawa Y, Maniwa A, Toda T, Ito K, et al. The role of renal aquaporin 2 in the alleviation of dehydration associated with diabetic polyuria in KKAy mice. Life Sci 2010;87:475-80.
23. Gao XM, Xu Q, Kiriazis H, Dart AM, Du XJ. Mouse model of post-infarct ventricular rupture: time course, strain- and gender-dependency, tensile strength, and histopathology. Cardiovasc Res 2005;65:469-77.
24. Cavasin MA, Tao ZY, Yu AL, Yang XP. Testosterone enhances early cardiac remodeling after myocardial infarction, causing rupture and degrading cardiac function. Am J Physiol Heart Circ Physiol 2006;290:H2043-50.
25. Anzai T. Post-infarction inflammation and left ventricular remodeling. Circ J 2013;77:580-7.
26. Ertl G, Frantz S. Healing after myocardial infarction. Cardiovasc Res 2005;66:22-32.
27. Ueland T, Aukrust P, Yndestad A, Otterdal K, Froland SS, Dickstein K, et al. Soluble CD40 ligand in acute and chronic heart failure. Eur Heart J 2005;26:1101-7.
28. Cleutjens JP, Verluyten MJ, Smiths JF, Daemen MJ. Collagen remodeling after myocardial infarction in the rat heart. Am J Pathol 1995;147:325-38.
29. Thakker GD, Frangogiannis NG, Bujak M, Zymek P, Gaubatz JW, Reddy AK, et al. Effects of diet-induced obesity on inflammation and remodeling after myocardial infarction. Am J Physiol Heart Circ Physiol 2006;291:H2504-14.
30. Fomovsky GM, Holmes JW. Evolution of scar structure, mechanics, and ventricular function after myocardial infarction in the rat. Am J Physiol Heart Circ Physiol 2010;298:H221-8.