The serotonin transporter gene polymorphism (5-HTTLPR) and irritable bowel syndrome: A meta-analysis of 25 studies

BMC Gastroenterology

Volumn 14, Issue 1, 2014, Pages

  Zhang, Zhi Feng ^a   Duan, Zhi Jun ^a   Wang, Li Xia ^a   Yang, Dong ^a   Zhao, Gang ^a   Zhang, Lin ^a  

^a DALIAN MEDICAL UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ALLELES; ASIAN CONTINENTAL ANCESTRY GROUP; CASE-CONTROL STUDIES; CONSTIPATION; EUROPEAN CONTINENTAL ANCESTRY GROUP; GENOTYPE; HUMANS; IRRITABLE BOWEL SYNDROME; POLYMORPHISM, GENETIC; SEROTONIN PLASMA MEMBRANE TRANSPORT PROTEINS;

EID: 84893663496     PISSN: None     EISSN: 1471230X     Source Type: Journal    
DOI: 10.1186/1471-230X-14-23     Document Type: Article

References (49)

1. Drossman DA, Camilleri M, Mayer EA, et al. AGA technical review on irritable bowel syndrome. Gastroenterology 2002, 123:2108-2131. 10.1053/gast.2002.37095, 12454866.
2. Guilera M, Balboa A, Mearin F. Bowel habit subtypes and temporal patterns in irritable bowel syndrome: systematic review. Am J Gastroenterol 2005, 100:1174-1184. 10.1111/j.1572-0241.2005.40674.x, 15842596.
3. Longstreth GF, Thompson WG, Chey WD, et al. Functional bowel disorders. Gastroenterology 2006, 130:1480-1491. 10.1053/j.gastro.2005.11.061, 16678561.
4. Wilson S, Roberts L, Roalfe A, et al. Prevalence of irritable bowel syndrome: a community survey. Br J Gen Pract 2004, 54:495-502. 1324800, 15239910.
5. Robin S. Clinical update: Irritable bowel syndrome. Lancet 2007, 369:1586-1588. 10.1016/S0140-6736(07)60726-0, 17499587.
6. Kim DY, Camilleri M. Serotonin: a mediator of the brain-gut connection. Am J Gastroenterol 2000, 95:2698-2709.
7. Atkinson W, Lockhart S, Whorwell PJ, et al. Altered 5-hydroxytryptamine signaling in patients with constipation- and diarrhea-predominant irritable bowel syndrome. Gastroenterology 2006, 130:34-43. 10.1053/j.gastro.2005.09.031, 16401466.
8. Bertrand PP, Bertrand RL. Serotonin release and uptake in the gastrointestinal tract. Auton Neurosci 2010, 153:47-57. 10.1016/j.autneu.2009.08.002, 19729349.
9. Heils A, Teufel A, Petri S, et al. Allelic variation of human serotonin transporter gene expression. J Neurochem 1996, 66:2621-2624.
10. Yeo A, Boyd P, Lumsden S, et al. Association between a functional polymorphism in the serotonin transporter gene and diarrhoea predominant irritable bowel syndrome in women. Gut 2004, 53:1452-1458. 10.1136/gut.2003.035451, 1774243, 15361494.
11. Park JM, Choi MG, Park JA, et al. Serotonin transporter gene polymorphism and irritable bowel syndrome. Neurogastroenterol Motil 2006, 18:995-1000. 10.1111/j.1365-2982.2006.00829.x, 17040410.
12. Kim HJ, Camilleri M, Carlson PJ, et al. Association of distinct alpha(2) adrenoceptor and serotonin transporter polymorphisms with constipation and somatic symptoms in functional gastrointestinal disorders. Gut 2004, 53:829-37. 10.1136/gut.2003.030882, 1774073, 15138209.
13. Van Kerkhoven LA, Laheij RJ, Jansen JB. Meta-analysis: a functional polymorphism in the gene encoding for activity of the serotonin transporter protein is not associated with the irritable bowel syndrome. Aliment Pharmacol Ther 2007, 26:979-986. 10.1111/j.1365-2036.2007.03453.x, 17877505.
14. Dai C, Zheng CQ, Jiang M. Letter: serotonin transporter gene polymorphisms and the irritable bowel syndrome. Aliment Pharmacol Ther 2013, 37(6):657-658. 10.1111/apt.12222, 23406411.
15. Areeshi MY, Haque S, Panda AK, Mandal RK. A serotonin transporter gene (SLC6A4) polymorphism is associated with reduced risk of irritable bowel syndrome in American and Asian population: a meta-analysis. PLoS One 2013, 8(9):e75567. 10.1371/journal.pone.0075567, 3777956, 24069428.
16. Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0 [updated March 2011] The Cochrane Collaboration, Higgins JPT, Green S, Accessed 2011 June 30 http://www.cochrane.org/training/cochrane-handbook.
17. Egger M, Smith GD, Schneider M, et al. Bias in meta-analysis detected by a simple, graphical test. Br Med J 1997, 315:629-634.
18. Sterne JA, Egger M. Funnel plots for detecting bias in meta-analysis: guidelines on choice of axis. J Clin Epidemiol 2001, 54:1046-1055. 10.1016/S0895-4356(01)00377-8, 11576817.
19. Holm S. A simple sequentially rejective bonferroni test procedure. Scand J Stat 1979, 6:65-70.
20. Pata C, Erdal ME, Derici E, et al. Serotonin transporter gene polymorphism in irritable bowel syndrome. Am J Gastroenterol 2002, 97(7):1780-1784. 10.1111/j.1572-0241.2002.05841.x, 12135035.
21. Lee DY, Park H, Kim WH, et al. Serotonin transporter gene polymorphism in healthy adults and patients with irritable bowel syndrome. Korean J Gastroenterol 2004, 43(1):18-22.
22. Wang BM, Wang YM, Zhang WM, et al. Serotonin transporter gene polymorphism in irritable bowel syndrome. Zhonghua Nei Ke Za Zhi 2004, 43(6):439-441.
23. Zhang XM, Lin ZH. Relationship between serotonin transporter gene polymorphism and irritable bowel syndrome. Shijie Huaren Xiaohua Zazhi 2006, 14(18):1790-1794.
24. Whitehead WE, Palsson OS, Thiwan SI, et al. Short-allele serotonin transporter gene polymorphism is associated with elevated serotonin and is less common in IBS with constipation compared to healthy controls. Gastroenterology 2006, 130(4):A513.
25. Li Y, Nie Y, Xie J, et al. The association of serotonin transporter genetic polymorphisms and irritable bowel syndrome and its influence on tegaserod treatment in Chinese patients. Dig Dis Sci 2007, 52(11):2942-2949. 10.1007/s10620-006-9679-y, 17394071.
26. Saito YA, Locke GR, Zimmerman JM, et al. A genetic association study of 5-HTT LPR and GNbeta3 C825T polymorphisms with irritable bowel syndrome. Neurogastroenterol Motil 2007, 19(6):465-470. 10.1111/j.1365-2982.2007.00905.x, 17564628.
27. Camilleri M, Busciglio I, Carlson P, et al. Candidate genes and sensory functions in health and irritable bowel syndrome. Am J Physiol Gastrointest Liver Physiol 2008, 295(2):G219-225. 10.1152/ajpgi.90202.2008, 2519854, 18511740.
28. Kohen R, Jarrett ME, Cain KC, et al. The serotonin transporter polymorphism rs25531 is associated with irritable bowel syndrome. Dig Dis Sci 2009, 54(12):2663-2770. 10.1007/s10620-008-0666-3, 2937164, 19125330.
29. Schmulson M, Farfan-Labone B, Charua-Guindic L, et al. The presence of the short allele in the promoter region of the SERT-P is associated with IBS among females in a Latin population. Neurogastroenterol Motil 2009, 21:S90.
30. Niesler B, Kapeller J, Fell C, et al. 5-HTTLPR and STin2 polymorphisms in the serotonin transporter gene and irritable bowel syndrome: effect of bowel habit and sex. Eur J Gastroenterol Hepatol 2010, 22(7):856-861. 10.1097/MEG.0b013e32832e9d6b, 19561511.
31. Sikander A, Rana SV, Sinha SK, et al. Serotonin transporter promoter variant: Analysis in Indian IBS patients and control population. J Clin Gastroenterol 2009, 43(10):957-961. 10.1097/MCG.0b013e3181b37e8c, 19687750.
32. Markoutsaki T, Karantanos T, Gazouli M, et al. 5-HT2A receptor gene polymorphisms and irritable bowel syndrome. J Clin Gastroenterol 2011, 45(6):514-517. 10.1097/MCG.0b013e318205e13b, 21325954.
33. Jiang ZD, Dupont AW, DuPont HL, et al. Genetic polymorphisms in serotonin transporter and G-protein genes in patients with irritable bowel syndrome. Gastroenterology 2012, 142(5):S562.
34. Wang YM, Chang Y, Chang YY, et al. Serotonin transporter gene promoter region polymorphisms and serotonin transporter expression in the colonic mucosa of irritable bowel syndrome patients. Neurogastroenterol Motil 2012, 24(6):560-565. 10.1111/j.1365-2982.2012.01902.x, 22435794.
35. Park CS, Uhm JH. Polymorphisms of the serotonin transporter gene and G-protein β3 subunit gene in korean children with irritable bowel syndrome and functional dyspepsia. Gut Liver 2012, 6(2):223-228. 10.5009/gnl.2012.6.2.223, 3343161, 22570752.
36. Zhang ZX, Xie J, Huang CB, et al. Serotonin transporter polymorphism in constipation predominant irritable bowel syndrome and its influence on clinical effect of tegaserod. Shandong Yiyao 2012, 52(25):16-18.
37. Kumar S, Ranjan P, Mittal B, et al. Serotonin transporter gene (SLC6A4) polymorphism in patients with irritable bowel syndrome and healthy controls. J Gastrointestin Liver Dis 2012, 21(1):31-38.
38. Saito YA, Larson JJ, Atkinson EJ, et al. The role of 5-HTT LPR and GNβ3 825C > T polymorphisms and gene-environment interactions in irritable bowel syndrome (IBS). Dig Dis Sci 2012, 57(10):2650-2657. 10.1007/s10620-012-2319-9, 3912694, 22855291.
39. Colucci R, Gambaccini D, Ghisu N, et al. Influence of the serotonin transporter 5HTTLPR polymorphism on symptom severity in irritable bowel syndrome. PLoS ONE 2013, 8(2):e54831. 10.1371/journal.pone.0054831, 3564922, 23393559.
40. Shiotani A, Kusunoki H, Kimura Y, et al. S100A Expression and interleukin-10 polymorphisms Are associated with ulcerative colitis and diarrhea predominant irritable bowel syndrome. Dig Dis Sci 2013, 18. doi:10.1007/s10620-013-2677-y. [Epub ahead of print].
41. Farjadian S, Fakhraei B, Moeini M, et al. Serotonin transporter gene polymorphisms in Southwestern Iranian patients with irritable bowel syndrome. Arab J Gastroenterol 2013, 14(2):59-62. 10.1016/j.ajg.2013.03.001, 23820502.
42. Collins SM, Bercik P. The relationship between intestinal microbiota and the central nervous system in normal gastrointestinal function and disease. Gastroenterology 2009, 136(6):2003-2014. 10.1053/j.gastro.2009.01.075, 19457424.
43. Clarke G, Quigley EM, Cryan JF, et al. Irritable bowel syndrome: towards biomarker identification. Trends Mol Med 2009, 15(10):478-489. 10.1016/j.molmed.2009.08.001, 19811951.
44. Zemlan FP, Murphy AZ, Behbehani MM. 5-HT1A receptors mediate the effect of the bulbospinal serotonin system on spinal dorsal horn nociceptive neurones. Pharmacology 1994, 48:1-10. 10.1159/000139156, 8309982.
45. Arebi N, Gurmany S, Bullas D, et al. Review article: the psychoneuroimmunology of irritable bowel syndrome-an exploration of interactions between psychological, neurological and immunological observations. Aliment Pharmacol Ther 2008, 28(7):830-840. 10.1111/j.1365-2036.2008.03801.x, 18637004.
46. Munafò MR, Brown SM, Hariri AR. Serotonin transporter (5-HTTLPR) genotype and amygdala activation: a meta-analysis. Biol Psychiatry 2008, 63:852-857. 10.1016/j.biopsych.2007.08.016, 2755289, 17949693.
47. Karg K, Burmeister M, Shedden K, et al. The serotonin transporter promoter variant (5-HTTLPR), stress, and depression meta-analysis revisited: evidence of genetic moderation. Arch Gen Psychiatry 2011, 68:444-454. 10.1001/archgenpsychiatry.2010.189, 3740203, 21199959.
48. Lipsky RH, Hu XZ, Goldman D. Additional functional variation at the SLC6 A4 gene. Am J Med Genet B Neuropsychiatr Genet 2009, 150:153.
49. Kanazawa M, Watanabe S, Tana C, Komuro H, Aoki M, Fukudo S. Effect of 5-HT4 receptor agonist mosapride citrate on rectosigmoid sensorimotor function in patients with irritable bowel syndrome. Neurogastroenterol Motil 2011, 23(8):754-e332. 10.1111/j.1365-2982.2011.01732.x, 21615623.