Serotonin Transporter Gene (SLC6A4) Polymorphism in Patients with Irritable Bowel Syndrome and Healthy Controls

Journal of Gastrointestinal and Liver Diseases

Volumn 21, Issue 1, 2012, Pages 31-38

  Kumar, Sunil ^a   Ranjan, Prabhat ^a   Mittal, Balraj ^a   Ghoshal, Uday C ^a  

^a SANJAY GANDHI POSTGRADUATE INSTITUTE OF MEDICAL SCIENCES   (India)

Author keywords

Functional gastrointestinal disorders; Gastroenteritis; Gastrointestinal infection; Genetic polymorphism; Post infectious IBS; Serotonin receptor

Indexed keywords

SEROTONIN; SEROTONIN TRANSPORTER;

ABDOMINAL DISCOMFORT; ABDOMINAL DISTENSION; ABDOMINAL PAIN; ADULT; ARTICLE; BLOATING; CONSTIPATION; CONTROLLED STUDY; DIARRHEA; DISEASE ASSOCIATION; DISEASE CLASSIFICATION; DNA POLYMORPHISM; FEMALE; GASTROENTERITIS; GENE DELETION; GENE FREQUENCY; GENE INSERTION; GENOTYPE; HUMAN; HUMAN TISSUE; IRRITABLE COLON; MAJOR CLINICAL STUDY; MALE; RECTUM BIOPSY; RECTUM MUCOSA;

ADULT; BASE SEQUENCE; BIOLOGICAL MARKERS; CASE-CONTROL STUDIES; FEMALE; GENETIC MARKERS; GENOTYPING TECHNIQUES; HUMANS; INTESTINAL MUCOSA; IRRITABLE BOWEL SYNDROME; LOGISTIC MODELS; MALE; MIDDLE AGED; POLYMORPHISM, GENETIC; RECTUM; SEQUENCE DELETION; SEROTONIN; SEROTONIN PLASMA MEMBRANE TRANSPORT PROTEINS;

EID: 84863375638     PISSN: 18418724     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (47)

1. Gershon MD. Review article: roles played by 5-hydroxytryptamine in the physiology of the bowel. Aliment Pharmacol Ther 1999;13 Suppl 2:15-30.
2. De Ponti F. Pharmacology of serotonin: what a clinician should know. Gut 2004;53:1520-1535.
3. Houghton LA, Atkinson W, Whitaker RP, Whorwell PJ, Rimmer MJ. Increased platelet depleted plasma 5-hydroxytryptamine concentration following meal ingestion in symptomatic female subjects with diarrhoea predominant irritable bowel syndrome. Gut 2003;52:663-670.
4. Atkinson W, Lockhart S, Whorwell PJ, Keevil B, Houghton LA. Altered 5-hydroxytryptamine signaling in patients with constipation- and diarrhea-predominant irritable bowel syndrome. Gastroenterology 2006;130:34-43.
5. Brea J, Rodrigo J, Carrieri A, et al. New serotonin 5-HT(2A), 5-HT(2B), and 5-HT(2C) receptor antagonists: synthesis, pharmacology, 3D-QSAR, and molecular modeling of (aminoalkyl)benzo and heterocycloalkanones. J Med Chem 2002;45:54-71.
6. Kim YS, Choi SC, Park JM, et al. The effect of tegaserod on symptoms and quality of life in korean women with irritable bowel syndrome with constipation. J Neurogastroenterol Motil 2010;16:61-70.
7. Walstab J, Rappold G, Niesler B. 5-HT(3) receptors: role in disease and target of drugs. Pharmacol Ther 2010;128:146-169.
8. Margoob MA, Mushtaq D, Murtza I, Mushtaq H, Ali A. Serotonin transporter gene polymorphism and treatment response to serotonin reuptake inhibitor (escitalopram) in depression: An open pilot study. Indian J Psychiatry 2008;50:47-50.
9. Bertrand PP, Bertrand RL. Serotonin release and uptake in the gastrointestinal tract. Auton Neurosci 2010;153:47-57.
10. Wise L. The signifcance of serotonin in the gastrointestinal tract: clinical notes. Surgery 1973;74:452-455.
11. Heils A, Teufel A, Petri S, et al. Allelic variation of human serotonin transporter gene expression. J Neurochem 1996;66:2621-2624.
12. Pata C, Erdal ME, Derici E, Yazar A, Kanik A, Ulu O. Serotonin transporter gene polymorphism in irritable bowel syndrome. Am J Gastroenterol 2002;97:1780-1784.
13. Yeo A, Boyd P, Lumsden S, et al. Association between a functional polymorphism in the serotonin transporter gene and diarrhoea predominant irritable bowel syndrome in women. Gut 2004;53:1452-1458.
14. Kim HJ, Camilleri M, Carlson PJ, et al. Association of distinct alpha(2) adrenoceptor and serotonin transporter polymorphisms with constipation and somatic symptoms in functional gastrointestinal disorders. Gut 2004;53:829-837.
15. Lee DY, Park H, Kim WH, Lee SI, Seo YJ, Choi YC. Serotonin transporter gene polymorphism in healthy adults and patients with irritable bowel syndrome. Korean J Gastroenterol 2004;43:18-22.
16. Hattori T, Fukudo S. Use of Rome III criteria for diagnosing irritable bowel syndrome. Nihon Rinsho 2006;64:1425-1428.
17. DuPont AW. Postinfectious irritable bowel syndrome. Clin Infect Dis 2008;46:594-599.
18. Lesch KP, Bengel D, Heils A, et al. Association of anxiety-related traits with a polymorphism in the serotonin transporter gene regulatory region. Science 1996;274:1527-1531.
19. Chen JJ, Li Z, Pan H, et al. Maintenance of serotonin in the intestinal mucosa and ganglia of mice that lack the high-affn\ity serotonin transporter: Abnormal intestinal motility and the expression of cation transporters. J Neurosci 2001;21:6348-6361.
20. Park JM, Choi MG, Park JA, et al. Serotonin transporter gene polymorphism and irritable bowel syndrome. Neurogastroenterol Motil 2006;18:995-1000.
21. Li Y, Nie Y, Xie J, et al. The association of serotonin transporter genetic polymorphisms and irritable bowel syndrome and its infuence on tegaserod treatment in Chinese patients. Dig Dis Sci 2007;52:2942-2949.
22. Li Y Y, Nie YQ, Xie J, Tan HZ, Zhou YJ, Wang H. Serotonin transporter gene polymorphisms in irritable bowel syndrome and their impact on tegaserod treatment. Zhonghua Nei Ke Za Zhi 2006;45:552-555.
23. Wang BM, Wang YM, Zhang WM, et al. Serotonin transporter gene polymorphism in irritable bowel syndrome. Zhonghua Nei Ke Za Zhi 2004;43:439-441.
24. Sikander A, Rana S V, Sinha SK, et al. Serotonin transporter promoter variant: Analysis in Indian IBS patients and control population. J Clin Gastroenterol 2009;43:957-961.
25. Makharia GK, Verma AK, Amarchand R, et al. Prevalence of irritable bowel syndrome: a community based study from northern India. J Neurogastroenterol Motil 2011;17:82-87.
26. Chang F Y, Lu CL, Chen TS. The current prevalence of irritable bowel syndrome in Asia. J Neurogastroenterol Motil 2010;16:389-400.
27. Lee O Y. Prevalence and risk factors of irritable bowel syndrome in Asia. J Neurogastroenterol Motil 2010;16:5-7.
28. Ghoshal UC, Abraham P, Bhatt C, et al. Epidemiological and clinical profile of irritable bowel syndrome in India: report of the Indian Society of Gastroenterology Task Force. Indian J Gastroenterol 2008;27:22-28.
29. Gelernter J, Kranzler H, Cubells JF. Serotonin transporter protein (SLC6A4) allele and haplotype frequencies and linkage disequilibria in African- and European-American and Japanese populations and in alcohol-dependent subjects. Hum Genet 1997;101:243-246.
30. Kim WK, Kim HS, Kim WJ, et al. Serotonin transporter gene polymorphism and migraine in the Korean population. Headache 2005;45:1056-1060.
31. Kweon YS, Lee HK, Lee CT, Lee KU, Pae CU. Association of the serotonin transporter gene polymorphism with Korean male alcoholics. J Psychiatr Res 2005;39:371-376.
32. Kotani K, Shimomura T, Shimomura F, Ikawa S, Nanba E. A polymorphism in the serotonin transporter gene regulatory region and frequency of migraine attacks. Headache 2002;42:893-895.
33. Saito YA, Locke 3rd GR, Zimmerman JM, et al. A genetic association study of 5-HTT LPR and GNbeta3 C825T polymorphisms with irritable bowel syndrome. Neurogastroenterol Motil 2007;19:465-470.
34. Niesler B, Kapeller J, Fell C, et al. 5-HTTLPR and STin2 polymorphisms in the serotonin transporter gene and irritable bowel syndrome: effect of bowel habit and sex. Eur J Gastroenterol Hepatol 2010;22:856-861.
35. Houghton LA, Atkinson W, Lockhart C, Whorwell PJ, Keevil B. Sigmoid-colonic motility in health and irritable bowel syndrome: a role for 5-hydroxytryptamine. Neurogastroenterol Motil 2007;19:724-731.
36. Cremon C, Carini G, Wang B, et al. Intestinal serotonin release, sensory neuron activation, and abdominal pain in irritable bowel syndrome. Am J Gastroenterol 2011;106:1290-1298.
37. Faure C, Patey N, Gauthier C, Brooks EM, Mawe GM. Serotonin signaling is altered in irritable bowel syndrome with diarrhea but not in functional dyspepsia in pediatric age patients. Gastroenterology 2010;139:249-258.
38. Coates MD, Mahoney CR, Linden DR, et al. Molecular defects in mucosal serotonin content and decreased serotonin reuptake transporter in ulcerative colitis and irritable bowel syndrome. Gastroenterology 2004;126:1657-1664.
39. Dunlop SP, Jenkins D, Neal KR, Spiller RC. Relative importance of enterochromaffn cell hyperplasia, anxiety, and depression in postinfectious IBS. Gastroenterology 2003;125:1651-1659.
40. Kim HS, Lim JH, Park H, Lee SI. Increased immunoendocrine cells in intestinal mucosa of postinfectious irritable bowel syndrome patients 3 years after acute Shigella infection--an observation in a small case control study. Yonsei Med J 2010;51:45-51.
41. Costedio MM, Hyman N, Mawe GM. Serotonin and its role in colonic function and in gastrointestinal disorders. Dis Colon Rectum 2007;50:376-388.
42. Dunlop SP, Coleman NS, Blackshaw E, et al. Abnormalities of 5-hydroxytryptamine metabolism in irritable bowel syndrome. Clin Gastroenterol Hepatol 2005;3:349-357.
43. Faure C, Patey N, Gauthier C, Brooks EM, Mawe GM. Serotonin signaling is altered in irritable bowel syndrome with diarrhea but not in functional dyspepsia in pediatric age patients. Gastroenterology 2010;139:249-258.
44. Coleman NS, Foley S, Dunlop SP, et al. Abnormalities of serotonin metabolism and their relation to symptoms in untreated celiac disease. Clin Gastroenterol Hepatol 2006;4:874-881.
45. Minderhoud IM, Oldenburg B, Schipper ME, Linde JJ, Samsom M. Serotonin synthesis and uptake in symptomatic patients with Crohn's disease in remission. Clin Gastroenterol Hepatol 2007;5:714-720.
46. Linden DR, Chen JX, Gershon MD, Sharkey KA, Mawe GM. Serotonin availability is increased in mucosa of guinea pigs with TNBS-induced colitis. Am J Physiol Gastrointest Liver Physiol 2003;285:G207-216.
47. Wheatcroft J, Wakelin D, Smith A, Mahoney CR, Mawe G, Spiller R. Enterochromaffin cell hyperplasia and decreased serotonin transporter in a mouse model of post infectious bowel dysfunction. Neurogastroenterol Motil 2005;17:863-870.