Relationship between serotonin transporter gene polymorphism and irritable bowel syndrome

World Chinese Journal of Digestology

Volumn 14, Issue 18, 2006, Pages 1790-1794

  Zhang, Xiao Min ^a,b   Lin, Zhi Hui ^a  

^a FUJIAN MEDICAL UNIVERSITY   (China)

^b FUJIAN PROVINCIAL HOSPITAL   (China)

Author keywords

Gene polymorphism; Irritable bowel syndrome; Serotonin transporter

Indexed keywords

SEROTONIN TRANSPORTER;

5 HTTLPR GENE; ARTICLE; CONTROLLED STUDY; DNA POLYMORPHISM; GENE; GENE FREQUENCY; GENOTYPE; HUMAN; IRRITABLE COLON; MAJOR CLINICAL STUDY; PHENOTYPE; POLYMERASE CHAIN REACTION; VARIABLE NUMBER OF TANDEM REPEAT;

EID: 33749003096     PISSN: 10093079     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (15)

1. Coates MD, Mahoney CR, Linden DR, Sampson JE, Chen J, Blaszyk H, Crowell MD, Sharkey KA, Gershon MD, Mawe GM, Moses PL. Molecular defects in mucosal serotonin content and decreased serotonin reuptake transporter in ulcerative colitis and irritable bowel syndrome. Gastroenterology 2004; 126: 1657-1664
2. Ogilvie AD, Battersby S, Bubb VJ, Fink G, Harmar AJ, Goodwim GM, Smith CA. Polymorphism in serotonin transporter gene associated with susceptibility to major depression. Lancet 1996; 347: 731-733
3. Wang BM, Wang YM, Zhang WM, Zhang QY, Liu WT, Jiang K, Zhang J. Serotonin transporter gene polymorphism in irritable bowel syndrome. Zhonghua Neike Zazhi 2004; 43: 439-441
4. Zhao AL, Su LY, Zhang YH, Tang BS, Luo XR, Huang CX, Su QR. Association analysis of serotonin transporter promoter gene polymorphism with ADHD and related symptomatology. Int J Neurosci 2005; 115: 1183-1191
5. Lesch KP, Bengel D, Heils A, Sabol SZ, Greenberg BD, Petri S, Benjamin J, Muller CR, Hamer DH, Murphy DL. Association of anxiety-related traits with a polymorphism in the serotonin transporter gene regulatory region. Science 1996; 274: 1527-1531
6. Delbruck SJ, Wendel B, Grunewald I, Sander T, Morris-Rosendahl D, Crocq MA, Berrettini WH, Hoehe MR. A novel allelic variant of the human serotonin transporter gene regulatory polymorphism. Cytogenet Cell Genet 1997; 79: 214-220
7. Gelernter J, Kranzler H, Cubells JF. Serotonin transporter protein (SLC6A4) allele and haplotype frequencies and linkage disequilibria in African-and European-American and Japanese populations and in alcohol-dependent subjects. Hum Genet 1997; 101: 243-246
8. Pata C, Erdal ME, Derici E, Yazar A, Kanik A, Ulu O. Serotonin transporter gene polymorphism in irritable bowel syndrome. Am J Gastroenterol 2002; 97: 1780-1784
9. Kim HJ, Camilleri M, Carlson PJ, Cremonini F, Ferber I, Stephens D, McKinzie S, Zinsmeister AR, Urrutia R. Association of distinct alpha(2) adrenoceptor and serotonin transporter polymorphisms with constipation and somatic symptoms in functional gastrointestinal disorders. Gut 2004; 53: 829-837
10. Lee DY, Park H, Kim WH, Lee SI, Seo YJ, Choi YC. Serotonin transporter gene polymorphism in healthy adults and patients with irritable bowel syndrome. Korean J Gastroenterol 2004; 43: 18-22
11. Yeo A, Boyd P, Lumsden S, Saunders T, Handley A, Stubbins M, Knaggs A, Asquith S, Taylor I, Bahari B, Crocker N, Rallan R, Varsani S, Montgomery D, Alpers DH, Dukes GE, Purvis I, Hicks GA. Association between a functional polymorphism in the serotonin transporter gene and diarrhoea predominant irritable bowel syndrome in women. Gut 2004; 53: 1452-1458
12. Keating E, Lemos C, Monteiro R, Azevedo I, Martel F. The effect of a series of organic cations upon the plasmalemmal serotonin transporter, SERT. Life Sci 2004; 76: 103-119
13. Smulevich AB, Rappoport SI, Syrkin AL, Ovcharenko SI, Ivanov SV, Drobizhev MIu, Ishchenko EN, Baturin KA. Visceral neuroses: clinical approaches to the problem. Zh Nevrol Psikhiatr Im S S Korsakova 2002; 102: 15-21
14. Hudson JI, Mangweth B, Pope HG Jr, De Col C, Hausmann A, Gutweniger S, Laird NM, Biebl W, Tsuang MT. Family study of affective spectrum disorder. Arch Gen Psychiatry 2003; 60: 170-177