Synthesis of novel 1,2,3-triazole tagged pyrazolo[3,4-b]pyridine derivatives and their cytotoxic activity

Bioorganic and Medicinal Chemistry Letters

Volumn 24, Issue 3, 2014, Pages 746-749

  Kurumurthy, Chavva ^a   Veeraswamy, Banda ^a   Sambasiva Rao, Pillalamarri ^a   Santhosh Kumar, Gautham ^a   Shanthan Rao, Pamulaparthy ^a   Loka Reddy, Velaturu ^a   Venkateswara Rao, Janapala ^a   Narsaiah, Banda ^a  

^a INDIAN INSTITUTE OF CHEMICAL TECHNOLOGY   (India)

Author keywords

1,2,3 Triazoles; Cytotoxic activity; Propargylation; Pyrazolo 3,4 b pyridine; Sharpless conditions

Indexed keywords

1,2,3 TRIAZOLE DERIVATIVE; ANTINEOPLASTIC AGENT; ETOPOSIDE; PYRAZOLO[3,4 B]PYRIDINE DERIVATIVE;

ANIMAL CELL; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL CULTURE; COMPARATIVE STUDY; CONTROLLED STUDY; CYCLOADDITION; DRUG CYTOTOXICITY; DRUG IDENTIFICATION; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; IC 50; IN VITRO STUDY; LEUKEMIA CELL; MELANOMA CELL; MOUSE; NONHUMAN; STRUCTURE ACTIVITY RELATION;

1,2,3-TRIAZOLES; CYTOTOXIC ACTIVITY; PROPARGYLATION; PYRAZOLO[3,4-B]PYRIDINE; SHARPLESS CONDITIONS;

ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; INHIBITORY CONCENTRATION 50; MOLECULAR STRUCTURE; PYRAZOLES; PYRIDINES; TRIAZOLES;

EID: 84893662962     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2013.12.107     Document Type: Article

References (28)

1. A. Jemal, R. Siegel, E. Ward, T. Murray, and J. Xu CA Cancer J. Clin. 57 2007 51
2. P. Anand, A.B. Kunnumakara, C. Sundaram, K.B. Harikumar, S.T. Tharakan, O.S. Lai, B. Sung, and B.B. Aggarwal Pharm. Res. 25 2008 2097
3. M.H. Elnagdi, N. Al-Awadi, A.W. Erian In, A.R. Katritzky, C.W. Rees, and E.F.V. Scriven Comprehensive Heterocyclic Chem II 1996 Pergamon Oxford Vol. 4, pp 431
4. S.M. Desenko, S.A. Komykhov, V.D. Orlov, and H. Meier J. Heterocycl. Chem. 35 1998 989
5. J. Quiroga, B. Insuashy, S. Craz, P. Hernandez, A. Bolafios, R. Moreno, A. Homoza, and R.H. de Almedias J. Heterocycl. Chem. 35 1998 333
6. M.S. Mohamed, Y.E. El-Deen Awad, S.M. El-Hallouty, and m. El-Araby Open J. Med. Chem. 2 2012 78
7. J. Witherington, V. Bordas, A. Gaiba, N.S. Garton, A. Naylor, A.D. Rawlings, B.P. Slingsby, D.G. Smith, A.K. Takle, and R.W. Ward Bioorg. Med. Chem. Lett. 13 2003 3055
8. T. Sado, and A. Inoue Chem. Abstr. 113 1990 78422k
9. K. Imaizumi, and T. Sado Chem. Abstr. 121 1994 91797w
10. A. Akahane, S. Kuroda, I. Itani, S. Tabuchi, Y. Sato, N. Matsuoka, M. Tada, H. Matsuoka, T. Oku, and A. Tanaka Chem. Abstr. 135 2001 33489a
11. A. Akahane, and A. Tanaka Chem. Abstr. 138 2003 24732a
12. F. Takabe, A. Shibayama, M. Yamaguchi, M. Yamaji, R. Hanai, and H. Sadohara Chem. Abstr. 126 1997 277477a
13. R.M. Abdel-Rahman Pharmazie 56 2001 275
14. Z. El-Gendy, J.M. Morsy, H.A. Allimony, W.R. Abdel-Monem, and R.M. Abdel-Rahman Phosphorus, Sulfur Silicon Relat. Elem. 178 2003 2055
15. T.E. Ali Phosphorus, Sulfur Silicon Relat. Elem. 182 2007 1717
16. T.E. Ali, and W.R. Abdel-Monem Int. J. Chem. 17 2007 303
17. T.E. Ali, S.A. Abdel-Aziz, H.M. El-Shaaer, F.I. Hanafy, and A.Z. El-Fauomy Phosphorus, Sulfur Silicon Relat. Elem. 183 2008 2139
18. F. El-Mariah, M. Hosny, and A. Deeb Phosphorus, Sulfur Silicon Relat. Elem. 181 2006 2505
19. K. Pericherla, P. Khedar, B.M. Khungar, and A. Kumar Tetrahedron Lett. 53 2012 6761
20. K. Slamova, P. Marhol, K. Bezouska, L. Lindkvist, S. Hansen, V. Kren, and H. Jensen Bioorg. Med. Chem. Lett. 20 2010 4263
21. P. Mani Chandrika, T. Yakaiah, G. Gayatri, K. Pranay Kumar, B. Narsaiah, U.S.N. Murthy, and A. RaghuRam Rao Eur. J. Med. Chem. 45 2010 78
22. B. Sirisha, B. Narsaiah, T. Yakaiah, G. Gayatri, G. Narahari Sastry, M. Raghu Prasad, and A. RaghuramRao Eur. J. Med. Chem. 45 2010 1739
23. C. Kurumurthy, P. Sambasiva Rao, B. Veeraswamy, G. Santhosh Kumar, P. Shanthan Rao, B. Narsaiah, L.R. Velatooru, R. Pamanji, and J. Venkateswara Rao Eur. J. Med. Chem. 46 2011 3462
24. A. Chandra Sheker Reddy, B. Narsaiah, and R.V. Venkataratnam J. Fluorine Chem. 86 1997 127
25. C.W. Tornoe, C. Christensen, and M. Medals J. Org. Chem. 67 2002 3057
26. F. Himo, T. Lovell, R. Hilgraf, V.V. Rostovtsev, L. Noodleman, K.B. Sharpless, and V.V. Fokin J. Am. Chem. Soc. 127 2005 210
27. R. Srinivasan, U. Mahesh, and S.Q. Yao Org. Lett. 8 2006 713
28. T. Mosmann J. Immunol. Methods 65 1983 55