Synthesis and theoretical studies on energetics of novel N- and O- perfluoroalkyl triazole tagged thienopyrimidines - Their potential as adenosine receptor ligands

European Journal of Medicinal Chemistry

Volumn 45, Issue 5, 2010, Pages 1739-1745

  Sirisha, B ^a   Narsaiah, B ^a   Yakaiah, T ^a   Gayatri, G ^a   Sastry, G Narahari ^a   Prasad, M Raghu ^b   Rao, A Raghuram ^c  

^a INDIAN INSTITUTE OF CHEMICAL TECHNOLOGY   (India)

^b SHRI VISHNU COLLEGE OF PHARMACY   (India)

^c PANJAB UNIVERSITY   (India)

Author keywords

Cycloaddition; Perfluoroalkyl triazole; Propargyl bromide; Regioisomers; Sharpless conditions; Thienopyrimidines

Indexed keywords

2 (4 FLUOROBENZYL) 3 PROP 2 YN 1 YL 3,5,6,7 TETRAHYDRO 4H CYCLOPENTA[4,5]THIENO[2,3 D]PYRIMIDIN 4 ONE; 2 (4 FLUOROBENZYL) 3 PROP 2 YN 1 YL 5,6,7,8 TETRAHYDRO[1]BENZOTHIENO[2,3 D]PYRIMIDIN 4(3H)ONE; 2 (4 FLUOROBENZYL) 4 (PROP 2 YN 1 YLOXY) 5,6,7,8 TETRAHYDRO[1]BENZOTHIENO[2,3 D]PYRIMIDINE; 2 (4 FLUOROBENZYL) 4 (PROP 2 YN 1 YLOXY) 6,7 DIHYDRO 5H CYCLOPENTA[4,5]THIENO[2,3 D]PYRIMIDINE; 2 (4 FLUOROBENZYL) 5,6 DIMETHYL 3 PROP 2 YN 1 YLTHIENO[2,3 D]PYRIMIDIN 4(3H)ONE; 2 (4 FLUOROBENZYL) 5,6 DIMETHYL 4 (PROP 2 YN 1 YLOXY)THIENO[2,3 D]PYRIMIDINE; 2 METHYL 3 PROP 2 YN 1 YL 3,5,6, TETRAHYDRO 4H CYCLOPENTA[4,5]THIENO[2,3 D]PYRIMIDIN 4 ONE; 2 METHYL 3 PROP 2 YN 1 YL 5,6,7,8 TETRAHYDRO[1]BENZOTHIENO[2,3 D]PYRIMIDIN 4(3H)ONE; 2 METHYL 4 (PROP 2 YN 1 YLOXY) 5,6,7,8 TETRAHYDRO[1]BENZOTHIENO[2,3 D]PYRIMIDINE; 2 METHYL 4 (PROP 2 YN 1 YLOXY) 6,7 DIHYDRO 5H CYCLOPENTA[4,5]THIENO[2,3 D]PYRIMIDINE; 2 PHENYL 3 PROP 2 YN 1 YL 3,5,6,7 TETRAHYDRO 4H CYCLOPENTA[4,5]THIENO[2,3 D]PYRIMIDINE 4 ONE; 2 PHENYL 3 PROP 2 YN 1 YL 5,6,7,8 TETRAHYDRO[1]BENZOTHIENO[2,3 D]PYRIMIDIN 4(3H)ONE; 2 PHENYL 4 (PROP 2 YN 1 YLOXY) 5,6,7,8 TETRAHYDRO[1]BENZOTHIENO[2,3 D]PYRIMIDINE; 2 PHENYL 4 (PROP 2 YN 1 YLOXY) 6,7 DIHYDRO 5H CYCLOPENTA[4,5]THIENO[2,3 D]PYRIMIDINE; 2,5,6 TRIMETHYL 3 PROP 2 YN 1 YLTHIENO[2,3 D]PYRIMIDIN 4 (3H)ONE; 2,5,6 TRIMETHYL 4 (PROP 2 YN 1 YLOXY)THIENO[2,3 D]PYRIMIDINE; 4 PYRIMIDINONE DERIVATIVE; 5,6 DIMETHYL 2 PHENYL 3 PROP 2 YN 1 YLTHIENO[2, 3 D]PYRIMIDIN 4 (3H)ONE; 5,6 DIMETHYL 2 PHENYL 4 (PROP 2 YN 1 YLOXY)THIENO[2,3 D]PYRIMIDINE; ADENOSINE A1 RECEPTOR; ADENOSINE A2A RECEPTOR; ADENOSINE RECEPTOR; AZIDE; LIGAND; PYRIMIDINE DERIVATIVE; THIENO[2,3 D]PYRIMIDIN 4 (3H)ONE DERIVATIVE; THIOPHENE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; CHEMICAL REACTION; CYCLOADDITION; DRUG SYNTHESIS; ENERGY TRANSFER; ISOMER; NONHUMAN; RAT; SHARPLESS EPOXIDATION; THEORETICAL STUDY;

ANIMALS; BINDING SITES; COMPUTER SIMULATION; CYCLIZATION; DRUG DESIGN; LIGANDS; MODELS, MOLECULAR; PYRIMIDINES; RATS; RECEPTORS, PURINERGIC P1; STRUCTURE-ACTIVITY RELATIONSHIP; THERMODYNAMICS; TRIAZOLES;

EID: 77949492766     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2009.12.075     Document Type: Article

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