Identification of the 5,5-dioxo-7,8-dihydro-6H-thiopyrano[3,2-d]pyrimidine derivatives as highly selective PDE4B inhibitors

Bioorganic and Medicinal Chemistry Letters

Volumn 24, Issue 3, 2014, Pages 893-899

  Goto, Taiji ^a,b   Shiina, Akiko ^a   Murata, Takeshi ^a   Tomii, Masato ^a   Yamazaki, Takanori ^a   Yoshida, Ken Ichi ^a   Yoshino, Toshiharu ^a   Suzuki, Osamu ^a   Sogawa, Yoshitaka ^a   Mizukami, Kiyoshi ^a   Takagi, Nana ^a   Yoshitomi, Tomomi ^a   Etori, Maki ^a   Tsuchida, Hiroshi ^a   Mikkaichi, Tsuyoshi ^a   Nakao, Naoki ^a   Takahashi, Mizuki ^a   Takahashi, Hisashi ^a   Sasaki, Shigeki ^b  

^a DAIICHI SANKYO CO   (Japan)

^b KYUSHU UNIVERSITY   (Japan)

Author keywords

COPD; Full length; PDE4; PDE4B; PDE4D; Selective inhibitor

Indexed keywords

2 (3 CHLORO 4 METHOXY PHENYL) 5,5 DIOXO 7,8 DIHYDRO 6H THIOPYRANO[3,2 D]PYRIMIDINE DERIVATIVE; 5,5 DIOXO 7,8 DIHYDRO 6 H THIOPYRANO[3,2 D]PYRIMIDINE DERIVATIVE; 7,8 DIHYDRO 6 H THIOPYRANO[3,2 D]PYRIMIDINE DERIVATIVE; ANTIINFLAMMATORY AGENT; PHOSPHODIESTERASE IV INHIBITOR; PYRIMIDINE DERIVATIVE; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; CONTROLLED STUDY; CROSS COUPLING REACTION; CYTOKINE PRODUCTION; DRUG CONFORMATION; DRUG HALF LIFE; DRUG HYDROLYSIS; DRUG IDENTIFICATION; DRUG PENETRATION; DRUG SELECTIVITY; DRUG SYNTHESIS; DRUG TARGETING; ENZYME INHIBITION; IC 50; IN VITRO STUDY; IN VIVO STUDY; MAXIMUM PLASMA CONCENTRATION; MOUSE; NONHUMAN; SPLEEN CELL; SUBSTITUTION REACTION;

COPD; FULL LENGTH; PDE4; PDE4B; PDE4D; SELECTIVE INHIBITOR;

BINDING SITES; CYCLIC S-OXIDES; ENZYME INHIBITORS; HUMANS; INHIBITORY CONCENTRATION 50; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PHENYLACETATES; PHOSPHODIESTERASE 4 INHIBITORS;

EID: 84893659559     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2013.12.076     Document Type: Article

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