Blockade of endothelin ETA, but not thromboxane, receptors offsets the cyclosporine-evoked hypertension and interrelated baroreflex and vascular dysfunctions

European Journal of Pharmacology

Volumn 727, Issue 1, 2014, Pages 52-59

  Nasser, Suzanne A ^a   Elmallah, Ahmed I ^b   Sabra, Ramzi ^c   Khedr, Mohamed M ^b   El Din, Mahmoud M Mohy ^b   El Mas, Mahmoud M ^b  

^a BEIRUT ARAB UNIVERSITY   (Lebanon)

^b Alexandria University Faculty of Pharmacy   (Egypt)

^c AMERICAN UNIVERSITY OF BEIRUT   (Lebanon)

Author keywords

Acetycholine relaxations; Arterial baroreceptors; Cyclosporine; Endothelin receptors; Hypertension; Thromboxane receptors

Indexed keywords

ATRASENTAN; CYCLOSPORIN; ENDOTHELIAL NITRIC OXIDE SYNTHASE; ENDOTHELIN A RECEPTOR; ENDOTHELIN A RECEPTOR ANTAGONIST; NAPHTHALENE DERIVATIVE; NITRIC OXIDE; NOS3 PROTEIN, RAT; PROPIONIC ACID DERIVATIVE; PYRROLIDINE DERIVATIVE; TERUTROBAN; THROMBOXANE RECEPTOR; VASODILATOR AGENT;

ANIMAL; ANTAGONISTS AND INHIBITORS; BLOOD PRESSURE; CHEMICALLY INDUCED; DISEASE MODEL; DOSE RESPONSE; DRUG EFFECTS; HEART RATE; HYPERTENSION; MALE; METABOLISM; PATHOPHYSIOLOGY; SIGNAL TRANSDUCTION; SPRAGUE DAWLEY RAT; TIME; VASODILATATION;

ANIMALS; BLOOD PRESSURE; CYCLOSPORINE; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; ENDOTHELIN A RECEPTOR ANTAGONISTS; HEART RATE; HYPERTENSION; MALE; NAPHTHALENES; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE III; PROPIONATES; PYRROLIDINES; RATS, SPRAGUE-DAWLEY; RECEPTOR, ENDOTHELIN A; RECEPTORS, THROMBOXANE; SIGNAL TRANSDUCTION; TIME FACTORS; VASODILATION; VASODILATOR AGENTS;

EID: 84893657782     PISSN: 00142999     EISSN: 18790712     Source Type: Journal    
DOI: 10.1016/j.ejphar.2014.01.034     Document Type: Article

References (53)

1. B. Bartholomeusz, K.J. Hardy, A.S. Nelson, and P.A. Phillips Bosentan ameliorates cyclosporin A-induced hypertension in rats and primates Hypertension 27 1996 1341 1345 (Pubitemid 26165641)
2. A. Bischoff, V. Limmroth, and M.C. Michel Indomethacin inhibits the natriuretic effects of neuropeptide Y in anesthetized rats J. Pharmacol. Exp. Ther. 286 1998 704 708 (Pubitemid 29003459)
3. D. Bokemeyer, U. Friedrichs, A. Baecker, S. Drechsler, H.J. Kramer, and H. Meyer-Lehnert Atrial natriuretic peptide inhibits cyclosporine-A induced endothelin production and calcium accumulation in rat vascular smooth muscle cells Clin. Sci. 87 1994 383 387 (Pubitemid 24323928)
4. S.L. Bourque, S.T. Davidge, and M.A. Adams The interaction between endothelin-1 and nitric oxide in the vasculature: new perspectives Am. J. Physiol. Regul. Integr. Comp. Physiol. 300 2011 R1288 R1295
5. R.M. Bryan Jr., J. You, E.M. Golding, and S.P. Marrelli Endothelium-derived hyperpolarizing factor: a cousin to nitric oxide and prostacyclin Anesthesiology 102 2005 1261 1277 (Pubitemid 40745846)
6. G.J. Cai, C.Y. Miao, H.H. Xie, L.H. Lu, and D.F. Su Arterial baroreflex dysfunction promotes atherosclerosis in rats Atherosclerosis 183 2005 41 47
7. P.R. Câmara, G.J. Ferraz, L.A. Velloso, J.M. Zeitune, F.A. Suassuna, and J.G. Ferraz Endothelin and neonatal capsaicin regulate gastric resistance to injury in BDL rats World J. Gastrointest. Pathophysiol. 3 2012 85 91
8. R.L. Cauduro, C. Costa, F. Lhulier, R.G. Garcia, R.D. Cabral, L.F. Gonçalves, and R.C. Manfro Endothelin-1 plasma levels and hypertension in cyclosporine-treated renal transplant patients Clin. Transplant. 19 2005 470 474 (Pubitemid 40990655)
9. M.W. Chapleau, G. Hajduczok, and F.M. Abboud Suppression of baroreceptor discharge by endothelin at high carotid sinus pressure Am. J. Physiol. 263 1992 R103 R108
10. O.J. David, and A. Johnston Limited sampling strategies for estimating area under the concentration-time curve: review of current algorithms Ther. Drug Monit. 23 2001 100 114 (Pubitemid 32240136)
11. G.M. De Ferrari, A. Sanzo, A. Bertoletti, G. Specchia, E. Vanoli, and P.J. Schwartz Baroreflex sensitivity predicts long-term cardiovascular mortality after myocardial infarction even in patients with preserved left ventricular function J. Am. Coll. Cardiol. 50 2007 2285 2290 (Pubitemid 350192103)
12. J.P. De La Cruz, N. Jebrouni, J.A. López-Villodres, J. Muñoz-Marín, A. Guerrero, and J.A. González-Correa Effects of terutroban, a thromboxane/prostaglandin endoperoxide receptor antagonist, on retinal vascularity in diabetic rats Diabetes Metab. Res. Rev. 28 2012 132 138
13. N. Dhaun, J. Goddard, D.E. Kohan, D.M. Pollock, E.L. Schiffrin, and D.J. Webb Role of endothelin-1 in clinical hypertension: 20 years on Hypertension 52 2008 452 459
14. S.E. DiCarlo, and V.S. Bishop Central baroreflex resetting as a means of increasing and decreasing sympathetic outflow and arterial pressure Ann. N. Y. Acad. Sci. 940 2001 324 337 (Pubitemid 32623405)
15. Z. Ebrahim, D.M. Yellon, and G.F. Baxter Bradykinin elicits "second window" myocardial protection in rat heart through an NO-dependent mechanism Am. J. Physiol. Heart Circ. Physiol. 281 2001 H1458 H1464
16. M.M. El-Mas, and A.A. Abdel-Rahman Role of the sympathetic control of vascular resistance in ethanol-clonidine hemodynamic interaction in SHRs J. Cardiovasc. Pharmacol. 34 1999 589 596 (Pubitemid 29446929)
17. 1-adrenoceptor reactivity in rat aortic smooth muscle Eur. J. Pharmacol. 322 1997 201 210 (Pubitemid 27122894)
18. 1-adrenoceptors following aortic barodenervation Eur. J. Pharmacol. 337 1997 235 243 (Pubitemid 27507789)
19. M.M. El-Mas, E.A. Afify, A.G. Omar, and F.M. Sharabi Cyclosporine adversely affects baroreflexes via inhibition of testosterone modulation of cardiac vagal control J. Pharmacol. Exp. Ther. 301 2002 346 354 (Pubitemid 34250313)
20. M.M. El-Mas, E.A. Afify, A.G. Omar, M.M. Mohy El-Din, and F.M. Sharabi Testosterone depletion contributes to cyclosporine-induced chronic impairment of acetylcholine renovascular relaxations Eur. J. Pharmacol. 468 2003 217 224 (Pubitemid 36712902)
21. M.M. El-Mas, M. Rekik, A.A. Abdel-Rahman, and S.J. Mustafa Chronic ethanol feeding potentiates alpha1-adrenoceptor responsiveness in SHR aortas Clin. Exp. Hypertens. 25 2003 381 393 (Pubitemid 36993242)
22. M.M. El-Mas, M.M. Mohy El-Din, S.M. El-gowilly, and F.M. Sharabi Relative roles of endothelial relaxing factors in cyclosporine-induced impairment of cholinergic and b-adrenergic renalvasodilations Eur. J. Pharmacol. 487 2004 149 158 (Pubitemid 38368992)
23. M.M. El-Mas, M. Fan, and A.A. Abdel-Rahman Endotoxemia-mediated induction of cardiac inducible nitric-oxide synthase expression accounts for the hypotensive effect of ethanol in female rats J. Pharmacol. Exp. Ther. 324 2008 368 375 (Pubitemid 350294155)
24. M.M. El-Mas, M. Fan, and A.A. Abdel-Rahman Upregulation of cardiac NOS due to endotoxemia and vagal overactivity contributes to the hypotensive effect of chronic ethanol in female rats Eur. J. Pharmacol. 650 2011 317 323
25. M.M. El-Mas, A.G. Omar, M.M. Helmy, and M.M. Mohy El-Din Crosstalk between central pathways of nitric oxide and carbon monoxide in the hypertensive action of cyclosporine Neuropharmacology 62 2012 1890 1896
26. S.M. El-gowilly, A.M. Ghazal, E.Y. Gohar, and M.M. El-Mas Exacerbation by nicotine of the cyclosporine A-induced impairment of β-adrenoceptor- mediated renal vasodilation in rats Clin. Exp. Pharmacol. Physiol. 35 2008 1164 1171
27. N.M. Fardin, L.M. Oyama, and R.R. Campos Changes in baroreflex control of renal sympathetic nerve activity in high-fat-fed rats as a predictor of hypertension Obesity 20 2012 1591 1597
28. D. Fischer, S. Rossa, U. Landmesser, S. Spiekermann, N. Engberding, B. Hornig, and H. Drexler Endothelial dysfunction in patients with chronic heart failure is independently associated with increased incidence of hospitalization, cardiac transplantation, or death Eur. Heart J. 26 2005 65 69 (Pubitemid 40221125)
29. U. Gerhardt, M. Riedasch, and H. Hohage Cyclosporine A modulates baroreceptor function in kidney transplant recipients Int. J. Cardiol. 68 1999 203 208 (Pubitemid 29083471)
30. J.B. Glen, and W.N. Scott Carbon dioxide euthanasia of cats Br. Vet. J. 129 1973 471 479
31. D.S. Goldstein Arterial baroreflex sensitivity, plasma catecholamines and pressor responsiveness in essential hypertension Circulation 68 1983 234 240
32. F.J. Gordon, and A.L. Mark Impaired baroreflex control of vascular resistance in prehypertensive Dahl S rats Am. J. Physiol. 245 1983 H210 H217 (Heart Circ. Physiol., vol. 14)
33. G. Hardy, F. Stanke-Labesque, G. Deveaux, P. Devillier, C. Sessa, and G. Bessard Cyclosporine A and cremophor EL induce contractions of human saphenous vein: involvement of thromboxane A2 receptor-dependent pathway J. Cardiovasc. Pharmacol. 36 2000 693 698
34. E.J. Hoorn, S.B. Walsh, J.A. McCormick, R. Zietse, R.J. Unwin, and D.H. Ellison Pathogenesis of calcineurin inhibitor-induced hypertension J. Nephrol. 25 2012 269 275
35. M.F. Jarvis, J.L. Wessale, C.Z. Zhu, J.J. Lynch, B.D. Dayton, S.V. Calzadilla, R.J. Padley, T.J. Opgenorth, and E.A. Kowaluk ABT-627, an endothelin ET(A) receptor-selective antagonist, attenuates tactile allodynia in a diabetic rat model of neuropathic pain Eur. J. Pharmacol. 388 2000 29 35 (Pubitemid 30066434)
36. T. Lyson, D.M. McMullan, L.D. Ermel, B.J. Morgan, and R.G. Victor Mechanism of cyclosporine-induced sympathetic activation and acute hypertension in rats Hypertension 23 1994 667 675 (Pubitemid 24129364)
37. P. Mathieu, R. Cartier, M. Carrier, and L.C. Pelletier Effect of cyclosporin A on the reactivity of the pulmonary vascular network in dogs Ann. Chir. 50 1996 682 688
38. P.A. Munch Endothelium-mediated and direct actions of acetylcholine on rabbit aortic baroreceptors Circ. Res. 74 1994 422 433 (Pubitemid 24064192)
39. N. Nakahata Thromboxane A2: physiology/pathophysiology, cellular signal transduction and pharmacology Pharmacol. Ther. 118 2008 18 35
40. A. Nishiyama, H. Kobori, T. Fukui, G.X. Zhang, L. Yao, M. Rahman, H. Hitomi, H. Kiyomoto, T. Shokoji, S. Kimura, M. Kohno, and Y. Abe Role of angiotensin II and reactive oxygen species in cyclosporine A-dependent hypertension Hypertension 42 2003 754 760 (Pubitemid 37237321)
41. G.K. Oriji Role of metoprolol, b1-adrenoceptor antagonist, thromboxane A2 and nitric oxide in CsA-induced hypertension Prostaglandins Leukot. Essent. Fatty Acids 68 2003 233 238 (Pubitemid 36241267)
42. N. Perico, A. Benigni, C. Zoja, F. Delaini, and G. Remuzzi Functional significance of exaggerated renal thromboxane A2 synthesis induced by cyclosporine A Am. J. Physiol. 251 1986 F581 F587
43. P.A. Phillips, K.A. Rolls, L.M. Burrell, D. Casley, K.L. Aldred, and K.J. Hardy Vascular endothelin responsiveness and receptor characteristics in vitro and effects of endothelin receptor blockade in vivo in cyclosporin hypertension Clin. Exp. Pharmacol. Physiol. 21 1994 223 226 (Pubitemid 24154528)
44. D. Ramzy, V. Rao, L.C. Tumiati, N. Xu, S. Miriuka, D. Delgado, and H.J. Ross Role of endothelin-1 and nitric oxide bioavailability in transplant-related vascular injury: comparative effects of rapamycin and cyclosporine Circulation 114 2006 I214 I219
45. M.C. Salgado, S.V. Justo, L.F. Joaquim, R. Fazan Jr., and H.C. Salgado Role of nitric oxide and prostanoids in attenuation of rapid baroreceptor resetting Am. J. Physiol. Heart Circ. Physiol. 290 2006 H1059 H1063
46. K. Sebeková, T. Eifert, A. Klassen, A. Heidland, and K. Amann Renal effects of S18886 (Terutroban), a TP receptor antagonist, in an experimental model of type 2 diabetes Diabetes 56 2007 968 974 (Pubitemid 46525071)
47. M.M. Sellers, and J.N. Stallone Sympathy for the devil: the role of thromboxane in the regulation of vascular tone and blood pressure Am. J. Physiol. Heart Circ. Physiol. 294 2008 H1978 H1986
48. M. Singh, G.A. Mensah, and G. Bakris Pathogenesis and clinical physiology of hypertension Cardiol. Clin. 28 2010 545 559
49. H.C. Souza, G.C. Terzini, V.J. da Silva, M.C. Martins-Pinge, H.C. Salgado, and M.C. Salgado Increased cardiac sympathetic drive and reduced vagal modulation following endothelin receptor antagonism in healthy conscious rats Clin. Exp. Pharmacol. Physiol. 35 2008 751 756 (Pubitemid 351728054)
50. L.E. Spieker, R. Corti, C. Binggeli, T.F. Lüscher, and G. Noll Baroreceptor dysfunction induced by nitric oxide synthase inhibition in humans J. Am. Coll. Cardiol. 36 2000 213 218 (Pubitemid 30466136)
51. M. Sykora, J. Diedler, P. Turcani, W. Hacke, and T. Steiner Baroreflex: a new therapeutic target in human stroke? Stroke 40 2009 e678 e688
52. E. Thorin, and D.J. Webb Endothelium-derived endothelin-1 Pflugers Arch. 459 2010 951 958
53. J.J. Tresham, J.A. Whitworth, B.A. Scoggins, and W.M. Bennett Cyclosporine-induced hypertension in sheep. The role of thromboxanes Transplantation 49 1990 144 148 (Pubitemid 20051604)