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Volumn 15, Issue 5, 2013, Pages 489-496

Endothelin antagonism and its role in the treatment of hypertension

Author keywords

Blood pressure; BP; Chronic kidney disease; CKD; Endothelin 1; ET 1; Hypertension; Metabolic syndrome; Primary hypertension; Resistant hypertension

Indexed keywords

AMBRISENTAN; AMINOTRANSFERASE; BOSENTAN; DARUSENTAN; ENDOTHELIN; ENDOTHELIN 1; ENDOTHELIN 2; ENDOTHELIN 3; ENDOTHELIN A RECEPTOR; ENDOTHELIN B RECEPTOR; ENDOTHELIN CONVERTING ENZYME; ENDOTHELIN RECEPTOR ANTAGONIST;

EID: 84893638697     PISSN: 15226417     EISSN: 15343111     Source Type: Journal    
DOI: 10.1007/s11906-013-0380-1     Document Type: Article
Times cited : (29)

References (67)
  • 1
    • 84871055775 scopus 로고    scopus 로고
    • A comparative risk assessment of burden of disease and injury attributable to 67 risk factors and risk factor clusters in 21 regions, 1990-2010: A systematic analysis for the Global Burden of Disease Study 2010
    • Lim SS, Vos T, Flaxman AD, et al. A comparative risk assessment of burden of disease and injury attributable to 67 risk factors and risk factor clusters in 21 regions, 1990-2010: a systematic analysis for the Global Burden of Disease Study 2010. Lancet. 2012;380:2224-60.
    • (2012) Lancet. , vol.380 , pp. 2224-2260
    • Lim, S.S.1    Vos, T.2    Flaxman, A.D.3
  • 3
    • 84879785194 scopus 로고    scopus 로고
    • Cardiovascular risk factor burden, treatment, and control among adults with chronic kidney disease in the United States
    • doi:10.1016/j.ahj.2013. 03.016
    • Foster MC, Rawlings AM, Marrett E, et al. Cardiovascular risk factor burden, treatment, and control among adults with chronic kidney disease in the United States. Am Heart J. 2013. doi:10.1016/j.ahj.2013. 03.016.
    • (2013) Am Heart J.
    • Foster, M.C.1    Rawlings, A.M.2    Marrett, E.3
  • 4
    • 84876567794 scopus 로고    scopus 로고
    • Hypertension in metabolic syndrome: Vascular pathophysiology
    • doi:10.1155/2013/230868
    • Mendizabal Y, Llorens S, Nava E. Hypertension in metabolic syndrome: vascular pathophysiology. Int J Hyper. 2013. doi:10.1155/2013/230868.
    • (2013) Int J Hyper.
    • Mendizabal, Y.1    Llorens, S.2    Nava, E.3
  • 5
    • 0023859136 scopus 로고
    • A novel potent vasoconstrictor peptide produced by vascular endothelial-cells
    • Yanagisawa M, Kurihara H, Kimura S, et al. A novel potent vasoconstrictor peptide produced by vascular endothelial-cells. Nature. 1988;332:411-5.
    • (1988) Nature. , vol.332 , pp. 411-415
    • Yanagisawa, M.1    Kurihara, H.2    Kimura, S.3
  • 6
    • 0013543367 scopus 로고
    • The human endothelin family - 3 structurally and pharmacologically distinct isopeptides predicted by 3 separate genes
    • Inoue A, Yanagisawa M, Kimura S et al. The human endothelin family - 3 structurally and pharmacologically distinct isopeptides predicted by 3 separate genes. PNAS 1989, 86.
    • (1989) PNAS , pp. 86
    • Inoue, A.1    Yanagisawa, M.2    Kimura, S.3
  • 7
    • 0027983753 scopus 로고
    • Contribution of endogenous generation of endothelin-1 to basal vascular tone
    • Haynes WG, Webb DJ. Contribution of endogenous generation of endothelin-1 to basal vascular tone. Lancet. 1994;344:852-4.
    • (1994) Lancet. , vol.344 , pp. 852-854
    • Haynes, W.G.1    Webb, D.J.2
  • 8
    • 0023765634 scopus 로고
    • Endothelin stimulates c-fos and c-myc expression and proliferation of vascular smooth-muscle cells
    • Komuro I, Kurihara H, Sugiyama T, et al. Endothelin stimulates c-fos and c-myc expression and proliferation of vascular smooth-muscle cells. FEBS Lett. 1988;238:249-52.
    • (1988) FEBS Lett. , vol.238 , pp. 249-252
    • Komuro, I.1    Kurihara, H.2    Sugiyama, T.3
  • 9
    • 0030025731 scopus 로고    scopus 로고
    • Changes in collagen metabolism in response to endothelin-1: Evidence for fibroblast heterogeneity
    • Dawes KE, Cambrey AD, Campa JS, et al. Changes in collagen metabolism in response to endothelin-1: Evidence for fibroblast heterogeneity. Int J Biochem Cell Biol. 1996;28:229-38.
    • (1996) Int J Biochem Cell Biol. , vol.28 , pp. 229-238
    • Dawes, K.E.1    Cambrey, A.D.2    Campa, J.S.3
  • 10
    • 0035941416 scopus 로고    scopus 로고
    • Coronary vasodilation and improvement in endothelial dysfunction with endothelin ETA receptor blockade
    • Halcox J P J, Nour K R A, Zalos G, Quyyumi AA. Coronary vasodilation and improvement in endothelial dysfunction with endothelin ETA receptor blockade. Circ Res. 2001;89:969-76.
    • (2001) Circ Res. , vol.89 , pp. 969-976
    • Halcox, J.P.J.1    Nour, K.R.A.2    Zalos, G.3    Quyyumi, A.A.4
  • 11
    • 0038796565 scopus 로고    scopus 로고
    • Effects of endothelin-1 and endothelin-1 receptor blockade on cardiac output, aortic pressure, and pulse wave velocity in humans
    • Vuurmans T J L, Boer P, Koomans HA. Effects of endothelin-1 and endothelin-1 receptor blockade on cardiac output, aortic pressure, and pulse wave velocity in humans. Hypertension. 2003;41:1253-8.
    • (2003) Hypertension. , vol.41 , pp. 1253-1258
    • Vuurmans, T.J.L.1    Boer, P.2    Koomans, H.A.3
  • 12
    • 1242341961 scopus 로고    scopus 로고
    • Mice with cardiomyocytespecific disruption of the endothelin-1 gene are resistant to hyperthyroid cardiac hypertrophy
    • Shohet RV, Kisanuki YY, Zhao XS, et al. Mice with cardiomyocytespecific disruption of the endothelin-1 gene are resistant to hyperthyroid cardiac hypertrophy. PNAS. 2004;101:2088-93.
    • (2004) PNAS , vol.101 , pp. 2088-2093
    • Shohet, R.V.1    Kisanuki, Y.Y.2    Zhao, X.S.3
  • 13
    • 20044366257 scopus 로고    scopus 로고
    • Endothelin antagonism in pulmonary hypertension, heart failure, and beyond
    • Attina T, Camidge R, Newby DE, Webb DJ. Endothelin antagonism in pulmonary hypertension, heart failure, and beyond. Heart. 2005;91:825-31.
    • (2005) Heart. , vol.91 , pp. 825-831
    • Attina, T.1    Camidge, R.2    Newby, D.E.3    Webb, D.J.4
  • 14
    • 0026698004 scopus 로고
    • Polar secretion of endothelin-1 by cultured endothelial-cells
    • Wagner OF, Christ G, Wojta J, et al. Polar secretion of endothelin-1 by cultured endothelial-cells. J Biol Chem. 1992;267:16066-8.
    • (1992) J Biol Chem. , vol.267 , pp. 16066-16068
    • Wagner, O.F.1    Christ, G.2    Wojta, J.3
  • 15
    • 0025605345 scopus 로고    scopus 로고
    • Cloning and expression of a cDNAencoding an endothelin receptor
    • Arai H, Hori S, Aramori I et al. Cloning and expression of a cDNAencoding an endothelin receptor. Nature 1990, 348.
    • Nature 1990, 348.
    • Arai, H.1    Hori, S.2    Aramori, I.3
  • 17
    • 0028987030 scopus 로고
    • Endothelin ETA and ETB messenger-rna and receptors expressed by smooth-muscle in the human vasculature - Majority of the ETA sub-type
    • Davenport AP, Oreilly G, Kuc RE. Endothelin ETA and ETB messenger-rna and receptors expressed by smooth-muscle in the human vasculature - majority of the ETA sub-type. Br J Pharmacol. 1995;114:1110-6.
    • (1995) Br J Pharmacol. , vol.114 , pp. 1110-1116
    • Davenport, A.P.1    Oreilly, G.2    Kuc, R.E.3
  • 18
    • 0027253153 scopus 로고
    • Novel ligands BQ123 and BQ3020 characterize endothelin receptor subtypes ETA and ETB in human kidney
    • Karet FE, Kuc RE, Davenport AP. Novel ligands BQ123 and BQ3020 characterize endothelin receptor subtypes ETA and ETB in human kidney. Kidney Int. 1993;44:36-42.
    • (1993) Kidney Int. , vol.44 , pp. 36-42
    • Karet, F.E.1    Kuc, R.E.2    Davenport, A.P.3
  • 19
    • 3242663549 scopus 로고    scopus 로고
    • Endothelin stimulates endothelial nitric oxide synthase expression in the thick ascending limb
    • Herrera M, Garvin JL. Endothelin stimulates endothelial nitric oxide synthase expression in the thick ascending limb. Am J Physiol. 2004;287:F231-5.
    • (2004) Am J Physiol. , vol.287
    • Herrera, M.1    Garvin, J.L.2
  • 20
    • 13244287739 scopus 로고    scopus 로고
    • Positron emission tomography using F-18-labelled endothelin-1 reveals prevention of binding to cardiac receptors owing to tissue-specific clearance by ETB receptors in vivo
    • Johnstrom P, Fryer TD, Richards HK, et al. Positron emission tomography using F-18-labelled endothelin-1 reveals prevention of binding to cardiac receptors owing to tissue-specific clearance by ETB receptors in vivo. Br J Pharmacol. 2005;144:115-22.
    • (2005) Br J Pharmacol. , vol.144 , pp. 115-122
    • Johnstrom, P.1    Fryer, T.D.2    Richards, H.K.3
  • 21
    • 84867582858 scopus 로고    scopus 로고
    • Defining the affinity and receptor sub-type selectivity of four classes of endothelin antagonists in clinically relevant human cardiovascular tissues
    • Maguire JJ, Kuc RE, Davenport AP. Defining the affinity and receptor sub-type selectivity of four classes of endothelin antagonists in clinically relevant human cardiovascular tissues. Life Sci. 2012;91:681-6.
    • (2012) Life Sci. , vol.91 , pp. 681-686
    • Maguire, J.J.1    Kuc, R.E.2    Davenport, A.P.3
  • 22
    • 18244416362 scopus 로고    scopus 로고
    • Endothelin antagonists and hypertension: A question of dose?
    • Goddard J, Webb DJ. Endothelin antagonists and hypertension: A question of dose? Hypertension. 2002;40:E1-2.
    • (2002) Hypertension. , vol.40
    • Goddard, J.1    Webb, D.J.2
  • 23
    • 20444488435 scopus 로고    scopus 로고
    • Vascular endothelin in hypertension
    • Schiffrin EL. Vascular endothelin in hypertension. Vasc Pharmacol 2005, 43.
    • (2005) Vasc Pharmacol , pp. 43
    • Schiffrin, E.L.1
  • 25
    • 0034803324 scopus 로고    scopus 로고
    • Evidence for endothelin involvement in the response to high salt
    • Pollock DM, Pollock JS. Evidence for endothelin involvement in the response to high salt. Am J Physiol. 2001;281:F144-50.
    • (2001) Am J Physiol. , vol.281
    • Pollock, D.M.1    Pollock, J.S.2
  • 26
    • 0026566042 scopus 로고
    • Salt-dependency of endothelin-induced, chronic hypertension in conscious rats
    • Mortensen LH, Fink GD. Salt-dependency of endothelin-induced, chronic hypertension in conscious rats. Hypertension. 1992;19:549-54.
    • (1992) Hypertension. , vol.19 , pp. 549-554
    • Mortensen, L.H.1    Fink, G.D.2
  • 27
    • 0032167360 scopus 로고    scopus 로고
    • Endothelin in hypertension: A role for receptor antagonists?
    • Moreau P. Endothelin in hypertension: A role for receptor antagonists? Cardiovasc Res. 1998;39:534-42.
    • (1998) Cardiovasc Res. , vol.39 , pp. 534-542
    • Moreau, P.1
  • 29
    • 0026544193 scopus 로고    scopus 로고
    • Plasma endothelin correlates with the extent of pulmonary-hypertension in patients with chronic congestive-heart-failure
    • Cody RJ, Haas GJ, Binkley PF et al. Plasma endothelin correlates with the extent of pulmonary-hypertension in patients with chronic congestive-heart- failure. Circulation 1992, 85.
    • Circulation 1992, 85.
    • Cody, R.J.1    Haas, G.J.2    Binkley, P.F.3
  • 30
    • 0025181868 scopus 로고
    • A sensitive radioimmunoassay measuring endothelin-like immunoreactivity in human plasma - Comparison of levels in patients with essential-hypertension and normotensive control subjects
    • Davenport AP, Ashby MJ, Easton P, et al. A sensitive radioimmunoassay measuring endothelin-like immunoreactivity in human plasma - comparison of levels in patients with essential-hypertension and normotensive control subjects. Clin Sci. 1990;78:261-4.
    • (1990) Clin Sci. , vol.78 , pp. 261-264
    • Davenport, A.P.1    Ashby, M.J.2    Easton, P.3
  • 31
    • 0025825226 scopus 로고
    • Plasma endothelin in human essentialhypertension
    • Schiffrin EL, Thibault G. Plasma endothelin in human essentialhypertension. Am J Hyper. 1991;4:303-8.
    • (1991) Am J Hyper. , vol.4 , pp. 303-308
    • Schiffrin, E.L.1    Thibault, G.2
  • 33
    • 0032999576 scopus 로고    scopus 로고
    • Role of endothelin in the increased vascular tone of patients with essential hypertension
    • Cardillo C, Kilcoyne CM, Waclawiw M, et al. Role of endothelin in the increased vascular tone of patients with essential hypertension. Hypertension. 1999;33:753-8.
    • (1999) Hypertension. , vol.33 , pp. 753-758
    • Cardillo, C.1    Kilcoyne, C.M.2    Waclawiw, M.3
  • 34
    • 0036201208 scopus 로고    scopus 로고
    • Effect of endothelin blockade on basal and stimulated forearm blood flow in patients with essential hypertension
    • Martin P, Ninio D, Krum H. Effect of endothelin blockade on basal and stimulated forearm blood flow in patients with essential hypertension. Hypertension. 2002;39:821-4.
    • (2002) Hypertension. , vol.39 , pp. 821-824
    • Martin, P.1    Ninio, D.2    Krum, H.3
  • 35
    • 0032546259 scopus 로고    scopus 로고
    • The effect of an endothelinreceptor antagonist, bosentan, on blood pressure in patients with essential hypertension
    • Krum H, Viskoper RJ, Lacourciere Y, et al. The effect of an endothelinreceptor antagonist, bosentan, on blood pressure in patients with essential hypertension. New Engl J Med. 1998;338:784-90.
    • (1998) New Engl J Med. , vol.338 , pp. 784-790
    • Krum, H.1    Viskoper, R.J.2    Lacourciere, Y.3
  • 36
    • 0032455523 scopus 로고    scopus 로고
    • Pharmacology of the endothelin A receptor antagonist: LU 135252
    • Rohmeiss P, Birck R, Braun C, et al. Pharmacology of the endothelin A receptor antagonist: LU 135252. Cardiovasc Drug Rev. 1998;16:391-412.
    • (1998) Cardiovasc Drug Rev. , vol.16 , pp. 391-412
    • Rohmeiss, P.1    Birck, R.2    Braun, C.3
  • 37
    • 0036634351 scopus 로고    scopus 로고
    • Darusentan: An effective endothelin A receptor antagonist for treatment of hypertension
    • Nakov R, Pfarr E, Eberle S, Investigators H. Darusentan: An effective endothelin A receptor antagonist for treatment of hypertension. Am J Hyper. 2002;15:583-9.
    • (2002) Am J Hyper. , vol.15 , pp. 583-589
    • Nakov, R.1    Pfarr, E.2    Eberle, S.3    Investigators, H.4
  • 38
    • 43049099531 scopus 로고    scopus 로고
    • Efficacy and safety of darusentan in patients with resistant hypertension: Results from a randomized, double-blind, placebo-controlled dose-ranging study
    • Black HR, Bakris GL, Weber MA, et al. Efficacy and safety of darusentan in patients with resistant hypertension: results from a randomized, double-blind, placebo-controlled dose-ranging study. J Clin Hyper. 2007;9:760-9.
    • (2007) J Clin Hyper. , vol.9 , pp. 760-769
    • Black, H.R.1    Bakris, G.L.2    Weber, M.A.3
  • 39
    • 70350133404 scopus 로고    scopus 로고
    • A selective endothelin-receptor antagonist to reduce blood pressure in patients with treatmentresistant hypertension: A randomised, double-blind, placebocontrolled trial
    • Weber MA, Black H, Bakris G, et al. A selective endothelin-receptor antagonist to reduce blood pressure in patients with treatmentresistant hypertension: a randomised, double-blind, placebocontrolled trial. Lancet. 2009;374:1423-31.
    • (2009) Lancet. , vol.374 , pp. 1423-1431
    • Weber, M.A.1    Black, H.2    Bakris, G.3
  • 40
    • 78149244260 scopus 로고    scopus 로고
    • Divergent results using clinic and ambulatory blood pressures report of a darusentan-resistant hypertension trial
    • Bakris GL, Lindholm LH, Black HR, et al. Divergent results using clinic and ambulatory blood pressures report of a darusentan-resistant hypertension trial. Hypertension. 2010;56:824-30. A large clincal trial where the decrease in BP with an ETAR selective antagonist was similar to placebo. This result terminated any future studies.
    • (2010) Hypertension. , vol.56 , pp. 824-830
    • Bakris, G.L.1    Lindholm, L.H.2    Black, H.R.3
  • 41
    • 78149237594 scopus 로고    scopus 로고
    • DORADO: Opportunity postponed lessons from studies of endothelin receptor antagonists in treatment-resistant hypertension
    • Webb DJ. DORADO: opportunity postponed lessons from studies of endothelin receptor antagonists in treatment-resistant hypertension. Hypertension. 2010;56:806-7.
    • (2010) Hypertension. , vol.56 , pp. 806-807
    • Webb, D.J.1
  • 42
    • 0035912555 scopus 로고    scopus 로고
    • Progression, remission, regression of chronic renal diseases
    • Ruggenenti P, Schieppati A, Remuzzi G. Progression, remission, regression of chronic renal diseases. Lancet. 2001;357:1601-8.
    • (2001) Lancet. , vol.357 , pp. 1601-1608
    • Ruggenenti, P.1    Schieppati, A.2    Remuzzi, G.3
  • 43
    • 33644638520 scopus 로고    scopus 로고
    • Early endothelin-A receptor blockade decreases blood pressure and ameliorates end-organ damage in homozygous Ren-2 rats
    • Vaneckova I, Kramer HJ, Backer A, et al. Early endothelin-A receptor blockade decreases blood pressure and ameliorates end-organ damage in homozygous Ren-2 rats. Hypertension. 2005;46:969-74.
    • (2005) Hypertension. , vol.46 , pp. 969-974
    • Vaneckova, I.1    Kramer, H.J.2    Backer, A.3
  • 44
    • 0024553261 scopus 로고
    • Plasma endothelin levels in patients with uremia
    • Koyama H, Nishzawa Y, Morii H, et al. Plasma endothelin levels in patients with uremia. Lancet. 1989;1:991-2.
    • (1989) Lancet. , vol.1 , pp. 991-992
    • Koyama, H.1    Nishzawa, Y.2    Morii, H.3
  • 45
    • 36048946080 scopus 로고    scopus 로고
    • Fractional urinary excretion of endothelin-1 is reduced by acute ETB receptor blockade
    • Goddard J, Johnston NR, Cumming AD, Webb DJ. Fractional urinary excretion of endothelin-1 is reduced by acute ETB receptor blockade. Am J Physiol. 2007;293:F1433-8.
    • (2007) Am J Physiol. , vol.293
    • Goddard, J.1    Johnston, N.R.2    Cumming, A.D.3    Webb, D.J.4
  • 46
    • 0027160523 scopus 로고
    • Renal endothelin gene-expression is increased in remnant kidney and correlates with disease progression
    • Orisio S, Benigni A, Bruzzi I, et al. Renal endothelin gene-expression is increased in remnant kidney and correlates with disease progression. Kidney Int. 1993;43:354-8.
    • (1993) Kidney Int. , vol.43 , pp. 354-358
    • Orisio, S.1    Benigni, A.2    Bruzzi, I.3
  • 47
    • 1542514709 scopus 로고    scopus 로고
    • Endothelin-A receptor antagonism reduces blood pressure and increases renal blood flow in hypertensive patients with chronic renal failure - A comparison of selective and combined endothelin receptor blockade
    • Goddard J, Johnston NR, Hand MF, et al. Endothelin-A receptor antagonism reduces blood pressure and increases renal blood flow in hypertensive patients with chronic renal failure - A comparison of selective and combined endothelin receptor blockade. Circulation. 2004;109:1186-93.
    • (2004) Circulation. , vol.109 , pp. 1186-1193
    • Goddard, J.1    Johnston, N.R.2    Hand, M.F.3
  • 48
    • 67649859521 scopus 로고    scopus 로고
    • Blood pressureindependent reduction in proteinuria and arterial stiffness after acute endothelin-A receptor antagonism in chronic kidney disease
    • Dhaun N, MacIntyre IM, Melville V, et al. Blood pressureindependent reduction in proteinuria and arterial stiffness after acute endothelin-A receptor antagonism in chronic kidney disease. Hypertension. 2009;54:U113-U71.
    • (2009) Hypertension. , vol.54
    • Dhaun, N.1    MacIntyre, I.M.2    Melville, V.3
  • 49
    • 0030943903 scopus 로고    scopus 로고
    • Discovery of TBC11251, a potent, long acting, orally active endothelin receptor-A selective antagonist
    • Wu CD, Chan MF, Stavros F, et al. Discovery of TBC11251, a potent, long acting, orally active endothelin receptor-A selective antagonist. J Med Chem. 1997;40:1690-7.
    • (1997) J Med Chem. , vol.40 , pp. 1690-1697
    • Wu, C.D.1    Chan, M.F.2    Stavros, F.3
  • 50
    • 79953213661 scopus 로고    scopus 로고
    • Selective endothelin-A receptor antagonism reduces proteinuria, blood pressure, and arterial stiffness in chronic proteinuric kidney disease
    • Dhaun N, MacIntyre IM, Kerr D, et al. Selective endothelin-A receptor antagonism reduces proteinuria, blood pressure, and arterial stiffness in chronic proteinuric kidney disease. Hypertension. 2011;57:772. Reduction in blood pressure and cardiovascular risk factors with chronic ETAR selective antagonism in CKD.
    • (2011) Hypertension. , vol.57 , pp. 772
    • Dhaun, N.1    MacIntyre, I.M.2    Kerr, D.3
  • 51
    • 33847005092 scopus 로고    scopus 로고
    • Review: Insulin and endothelin: An interplay contributing to hypertension development?
    • Sarafidis PA, Bakris GL. Review: Insulin and endothelin: An interplay contributing to hypertension development? J Clin Endocrin Metabol. 2007;92:379-85.
    • (2007) J Clin Endocrin Metabol. , vol.92 , pp. 379-385
    • Sarafidis, P.A.1    Bakris, G.L.2
  • 52
    • 33746581658 scopus 로고    scopus 로고
    • Dehydroepiandrosterone mimics acute actions of insulin to stimulate production of both nitric oxide and endothelin 1 via distinct phosphatidylinositol 3-kinase- and mitogen-activated protein kinase-dependent pathways in vascular endothelium
    • Formoso G, Chen H, Kim JA, et al. Dehydroepiandrosterone mimics acute actions of insulin to stimulate production of both nitric oxide and endothelin 1 via distinct phosphatidylinositol 3-kinase- and mitogen-activated protein kinase-dependent pathways in vascular endothelium. Mol Endocrinol. 2006;20:1153-63.
    • (2006) Mol Endocrinol. , vol.20 , pp. 1153-1163
    • Formoso, G.1    Chen, H.2    Kim, J.A.3
  • 53
    • 40749132624 scopus 로고    scopus 로고
    • Vascular peptide endothelin-1 links fat accumulation with alterations of visceral adipocyte lipolysis
    • Van Harmelen V, Eriksson A, Astrom G, et al. Vascular peptide endothelin-1 links fat accumulation with alterations of visceral adipocyte lipolysis. Diabetes. 2008;57:378-86.
    • (2008) Diabetes. , vol.57 , pp. 378-386
    • Van Harmelen, V.1    Eriksson, A.2    Astrom, G.3
  • 55
    • 6044230923 scopus 로고    scopus 로고
    • Insulin infusion induces endothelin-1-dependent hypertension in rats
    • Juan CC, Shen YW, Chien Y, et al. Insulin infusion induces endothelin-1-dependent hypertension in rats. Am J Physiol. 2004;287:E948-54.
    • (2004) Am J Physiol. , vol.287
    • Juan, C.C.1    Shen, Y.W.2    Chien, Y.3
  • 56
    • 0036789361 scopus 로고    scopus 로고
    • Increased activity of endogenous endothelin in patients with type II diabetes mellitus
    • Cardillo C, Campia U, Bryant MB, Panza JA. Increased activity of endogenous endothelin in patients with type II diabetes mellitus. Circulation. 2002;106:1783-7.
    • (2002) Circulation. , vol.106 , pp. 1783-1787
    • Cardillo, C.1    Campia, U.2    Bryant, M.B.3    Panza, J.A.4
  • 57
    • 33745685243 scopus 로고    scopus 로고
    • Enhanced endotheliumdependent vasodilatation by dual endothelin receptor blockade in individuals with insulin resistance
    • Shemyakin A, Bohm F, Wagner H, et al. Enhanced endotheliumdependent vasodilatation by dual endothelin receptor blockade in individuals with insulin resistance. J Cardiovasc Pharmacol. 2006;47:385-90.
    • (2006) J Cardiovasc Pharmacol. , vol.47 , pp. 385-390
    • Shemyakin, A.1    Bohm, F.2    Wagner, H.3
  • 58
    • 5644247979 scopus 로고    scopus 로고
    • Endothelium-restricted overexpression of human endothelin-1 causes vascular remodeling and endothelial dysfunction
    • Amiri F, Virdis A, Neves MF, et al. Endothelium-restricted overexpression of human endothelin-1 causes vascular remodeling and endothelial dysfunction. Circulation. 2004;110:2233-40.
    • (2004) Circulation. , vol.110 , pp. 2233-2240
    • Amiri, F.1    Virdis, A.2    Neves, M.F.3
  • 59
    • 78149277201 scopus 로고    scopus 로고
    • Endothelin-1 increases glomerular permeability and inflammation independent of blood pressure in the rat
    • Saleh MA, Boesen EI, Pollock JS, et al. Endothelin-1 increases glomerular permeability and inflammation independent of blood pressure in the rat. Hypertension. 2010;56:U942-427.
    • (2010) Hypertension. , vol.56
    • Saleh, M.A.1    Boesen, E.I.2    Pollock, J.S.3
  • 60
    • 0032564279 scopus 로고    scopus 로고
    • Endothelin ETA receptor blockade restores NO-mediated endothelial function and inhibits atherosclerosis in apolipoprotein E-deficient mice
    • Barton M, Haudenschild CC, D'Uscio LV, et al. Endothelin ETA receptor blockade restores NO-mediated endothelial function and inhibits atherosclerosis in apolipoprotein E-deficient mice. PNAS. 1998;95:14367-72.
    • (1998) PNAS , vol.95 , pp. 14367-14372
    • Barton, M.1    Haudenschild, C.C.2    D'Uscio, L.V.3
  • 61
    • 0027998055 scopus 로고
    • Role of endothelin in the maintenance of blood-pressure in conscious rats with chronic heartfailure-acute effects of the endothelin receptor antagonist RO-47-0203 (bosentan)
    • Teerlink JR, Loffler BM, Hess P, et al. Role of endothelin in the maintenance of blood-pressure in conscious rats with chronic heartfailure-acute effects of the endothelin receptor antagonist RO-47-0203 (bosentan). Circulation. 1994;90:2510-8.
    • (1994) Circulation. , vol.90 , pp. 2510-2518
    • Teerlink, J.R.1    Loffler, B.M.2    Hess, P.3
  • 62
    • 34547558919 scopus 로고    scopus 로고
    • Results of european postmarketing surveillance of bosentan in pulmonary hypertension
    • Humbert M, Segal ES, Kiely DG, et al. Results of european postmarketing surveillance of bosentan in pulmonary hypertension. Eur Resp J. 2007;30:338-44.
    • (2007) Eur Resp J. , vol.30 , pp. 338-344
    • Humbert, M.1    Segal, E.S.2    Kiely, D.G.3
  • 63
    • 84862896499 scopus 로고    scopus 로고
    • Long-term hepatic safety of ambrisentan in patients with pulmonary arterial hypertension
    • Ben-Yehuda O, Pizzuti D, Brown A, et al. Long-term hepatic safety of ambrisentan in patients with pulmonary arterial hypertension. J Am Coll Cardiol. 2012;60:80-1.
    • (2012) J Am Coll Cardiol. , vol.60 , pp. 80-81
    • Ben-Yehuda, O.1    Pizzuti, D.2    Brown, A.3
  • 64
    • 10744230817 scopus 로고    scopus 로고
    • Sitaxsentan therapy for pulmonary arterial hypertension
    • Barst RJ, Langleben D, Frost A, et al. Sitaxsentan therapy for pulmonary arterial hypertension. Am J Resp Crit Care Med. 2004;169:441-7.
    • (2004) Am J Resp Crit Care Med. , vol.169 , pp. 441-447
    • Barst, R.J.1    Langleben, D.2    Frost, A.3
  • 65
    • 84893646675 scopus 로고    scopus 로고
    • Identification of the site of endothelin a receptor antagonist-induced fluid retention
    • Kohan D, Strait K, Stricklett P et al. Identification of the site of endothelin a receptor antagonist-induced fluid retention. Hypertension 2011, 58:E155-E.
    • (2011) Hypertension , vol.58
    • Kohan, D.1    Strait, K.2    Stricklett, P.3
  • 66
    • 84866663087 scopus 로고    scopus 로고
    • Effect of endothelin receptor antagonist bosentan on chronic hypoxia-induced inflammation and chemoafferent neuron adaptation in rat carotid body
    • Liu X, He L, Dinger B, et al. Effect of endothelin receptor antagonist bosentan on chronic hypoxia-induced inflammation and chemoafferent neuron adaptation in rat carotid body. HighAltMed Biol. 2012;13:209-16.
    • (2012) HighAltMed Biol. , vol.13 , pp. 209-216
    • Liu, X.1    He, L.2    Dinger, B.3
  • 67
    • 0028292620 scopus 로고
    • Pharmacological characterization of bosentan, a new potent orally-active nonpeptide endothelin receptor antagonist
    • Clozel M, Breu V, Gray GA, et al. Pharmacological characterization of bosentan, a new potent orally-active nonpeptide endothelin receptor antagonist. J Pharmaocl Exp Ther. 1994;270:228-35.
    • (1994) J Pharmaocl Exp Ther. , vol.270 , pp. 228-235
    • Clozel, M.1    Breu, V.2    Gray, G.A.3


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