Increased Plasma Endothelin Level in Patients with Essential Hypertension

New England Journal of Medicine

Volumn 322, Issue 3, 1990, Pages 205-

  Saito, Yoshihiko ^a   Nakao, Kazuwa ^a   Mukoyama, Masashi ^a   Imura, Hiroo ^a  

^a KYOTO UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ENDOTHELIN;

ESSENTIAL HYPERTENSION; HUMAN; LETTER; PRIORITY JOURNAL;

ENDOTHELINS; ENDOTHELIUM, VASCULAR; HUMAN; HYPERTENSION; MIDDLE AGE; PEPTIDES;

EID: 0025057374     PISSN: 00284793     EISSN: 15334406     Source Type: Journal    
DOI: 10.1056/NEJM199001183220315     Document Type: Letter

References (4)

1. Yanagisawa M, Kurihara H, Kimura S, et al. A novel potent vasoconstrictor peptide produced by vascular endothelial cells. Nature 1988; 332: 411–5.
2. Yanagisawa M, Inoue A, Ishikawa T, et al. Primary structure, synthesis, and biological activity of rat endothelin, an endothelium-derived vasoconstrictor peptide. Proc Natl Acad Sci U S A 1988; 85: 6964–7.
3. Inoue A, Yanagisawa M, Kimura S, et al. The human endothelin family: three structurally and pharmacologically distinct isopeptides predicted by three separate genes. Proc Natl Acad Sci U S A 1989; 86: 2863–7.
4. Saito Y, Nakao K, Itoh H, et al. Endothelin in human plasma and culture medium of aortic endothelial cells: detection and characterization with radioimmunoassay using monoclonal antibody. Biochem Biophys Res Commun 1989; 161: 320–6.