Genomic oncology education: An urgent need, a new approach

Cancer Journal (United States)

Volumn 20, Issue 1, 2014, Pages 91-95

  Haspel, Richard L ^a   Saffitz, Jeffrey E ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

Author keywords

cancer; gene panels; Genomics; medical education; molecular pathology; next generation sequencing; oncology; residency training

Indexed keywords

EPIDERMAL GROWTH FACTOR RECEPTOR KINASE INHIBITOR; PROTEIN RET; TRANSCRIPTOME;

BREAST CANCER; CANCER GENETICS; CANCER PROGNOSIS; CLINICAL PRACTICE; CURRICULUM; EXOME; FLUORESCENCE IN SITU HYBRIDIZATION; GENE EXPRESSION; GENE MUTATION; GENE REARRANGEMENT; GENETIC COUNSELING; GENETIC SCREENING; GENOMICS; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HUMAN; IMMUNOHISTOCHEMISTRY; LUNG NON SMALL CELL CANCER; MEDICAL EDUCATION; MEDICAL GENETICS; MOLECULAR PATHOLOGY; PERSONALIZED MEDICINE; PHARMACOGENOMICS; PHYSICIAN; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROMYELOCYTIC LEUKEMIA; RESIDENCY EDUCATION; REVIEW; UPREGULATION; EDUCATION; ONCOLOGY;

GENOMICS; HUMANS; MEDICAL ONCOLOGY; PATHOLOGY, MOLECULAR;

EID: 84893614512     PISSN: 15289117     EISSN: 1540336X     Source Type: Journal    
DOI: 10.1097/PPO.0000000000000015     Document Type: Review

References (45)

1. National Human Genome Research Institute. The human genome project completion: frequently asked questions. 2010. Available at: http://www.genome. gov/11006943 Accessed September 26, 2013.
2. Roychowdhury S, Iyer MK, Robinson DR, et al. Personalized oncology through integrative high-throughput sequencing: a pilot study. Sci Transl Med. 2011;3:111ra121.
3. Bombard Y, Robson M, Offit K. Revealing the incidentalome when targeting the tumor genome. JAMA. 2013;310:795-796.
4. Azim HA Jr, Michiels S, Zagouri F, et al. Utility of prognostic genomic tests in breast cancer practice: the IMPAKT 2012 Working Group Consensus Statement. Ann Oncol. 2013;24:647-654.
5. Sequist LV, Heist RS, Shaw AT, et al. Implementing multiplexed genotyping of nonYsmall-cell lung cancers into routine clinical practice. Ann Oncol. 2011;22:2616-2624.
6. Welch JS, Westervelt P, Ding L, et al. Use of whole-genome sequencing to diagnose a cryptic fusion oncogene. JAMA. 2011;305:1577-1584.
7. Jones SJM, Laskin J, Li YY, et al. Evolution of an adenocarcinoma in response to selection by targeted kinase inhibitors. Genome Biol. 2010; 11:R82.
8. Giardiello FM, Brensinger JD, Petersen GM, et al. The use and interpretation of commercial APC gene testing for familial adenomatous polyposis. N Engl J Med. 1997;336:823-827.
9. ARUP Laboratories. Value of genetic counselors in the laboratory. 2011. Available at: http://www.aruplab.com/files/resources/genetics/White-paper-1- value-of-GCs-in-lab.pdf. Accessed September 26, 2013.
10. Klitzman R, Chung W, Marder K, et al. Attitudes and practices among internists concerning genetic testing. J Genet Couns. 2013;22:90-100.
11. Laedtke AL, O'Neill SM, Rubinstein WS, et al. Family physicians' awareness and knowledge of the Genetic Information Non-discrimination Act (GINA). J Genet Couns. 2012;21:345-352.
12. Thurston VC, Wales PS, Bell MA, et al. The current status of medical genetics instruction in U.S. and Canadian medical schools. Acad Med. 2007;82:441-445.
13. Telner D, Carroll JC, Talbot Y. Genetics education in medical school: a qualitative study exploring educational experiences and needs. Med Teach. 2008;30:192-198.
14. Guttmacher AE, Porteous ME, McInerney JD. Educating health-care professionals about genetics and genomics. Nat Rev Genet. 2007;8: 151-157.
15. Salari K. The dawning era of personalized medicine exposes a gap in medical education. PLoS Med. 2009;6:e1000138.
16. Nelson EA, McGuire AL. The need for medical education reform: genomics and the changing nature of health information. Genome Med. 2010;2:18.
17. Feero WG, Green ED. Genomics education for health care professionals in the 21st century. JAMA. 2011;306:989-990.
18. Salari K, Pizzo PA, Prober CG. Commentary: to genotype or not to genotype? Addressing the debate through the development of a genomics and personalized medicine curriculum. Acad Med. 2011;86:925-927.
19. Dhar SU, Alford RL, Nelson EA, et al. Enhancing exposure to genetics and genomics through an innovative medical school curriculum. Genet Med. 2012;14:163-167.
20. Walt DR, Kuhlik A, Epstein SK, et al. Lessons learned from the introduction of personalized genotyping into a medical school curriculum. Genet Med. 2011;13:63-66.
21. Wiener CM, Thomas PA, Goodspeed E, et al. Genes to society Vthe logic and process of the new curriculum for The Johns Hopkins University School of Medicine. Acad Med. 2010;85:498-506.
22. Skirton H, Lewis C, Kent A, et al. Genetic education and the challenge of genomic medicine: development of core competences to support preparation of health professionals in Europe. Eur J Hum Genet. 2010;18:972-977.
23. Patay BA, Topol EJ. The unmet need of education in genomic medicine. Am J Med. 2012;125:5-6.
24. Accreditation Council for Graduate Medical Education (ACGME). Pathology program requirements. 2013. Available at: http://www.acgme.org/acgmeweb/tabid/ 142/ProgramandInstitutionalGuidelines/HospitalBased Accreditation/Pathology. aspx. Accessed September 26, 2013.
25. Haspel RL, Atkinson JB, Barr FG, et al. TRIG on track: educating pathology residents in genomic medicine. Personal Med. 2012;9:287-293.
26. Tonellato PJ, Crawford JM, Boguski MS, et al. A national agenda for the future of pathology in personalized medicine: report of the proceedings of a meeting at the Banbury Conference Center on genome-era pathology, precision diagnostics, and preemptive care: a stakeholder summit. Am J Clin Pathol. 2011;135:668-672.
27. Ross JS. Next-generation pathology. Am J Clin Pathol. 2011;135:663-665.
28. Intersociety Council for Pathology Information. Career opportunities in pathology. 2013. Available at: http://www.pathologytraining.org/trainees/ documents/recruit.ppt. Accessed September 26, 2013.
29. Haspel RL, Arnaout R, Briere L, et al. A call to action: training pathology residents in genomics and personalized medicine. Am J Clin Pathol. 2010;133:832-834.
30. Haspel RL, Arnaout R, Briere L, et al. A curriculum in genomics and personalized medicine for pathology residents. Am J Clin Pathol. 2010;133: online supplement. Available at: http://ajcp.ascpjournals.org/site/misc/pdf/ Haspel-online.pdf. Accessed September 26, 2013.
31. Kern DE, Thomas PA, Howard DM, et al. Curriculum Development for Medical Education: A Six Step Approach. Baltimore, MD: The Johns Hopkins University Press; 1998.
32. Callier SL. Swabbing students: should universities be allowed to facilitate educational DNA testing? Am J Bioeth. 2012;12:32-40.
33. Grenzen JR, Krasowski MD. Resident training in clinical chemistry. Clin Lab Med. 2007;27:343-358.
34. Knowles MS, Holton EF III, Swanson RA. The Adult Learner. 6th ed. Burlington, MA: Elsevier; 2005.
35. Elliott R, Jacobs WC. Multiple sclerosis. 2010. Available at: http://genomicmedicineinitiative.org/wp-content/uploads/2010/03/Multiple- Sclerosis.pdf. Accessed September 26, 2013.
36. Schrijver I, Natkunam Y, Galli S, et al. Integration of genomic medicine into pathology residency training: the Stanford Open Curriculum. J Mol Diagn. 2013;15:141-148.
37. Stanford University Pathology Faculty. Stanford open curriculum in genomic medicine. 2012. Available at: http://www.youtube.com/playlist?list= PLfTljtR5bxMcTg8hgQp9sA4YQwicpSAQv. Accessed September 26, 2013.
38. Talbert ML, Dunn ST, Hunt J, et al. Competency-based education for the molecular genetic pathology fellow: a report of the association for molecular pathology training and education committee. J Mol Diagn. 2009;11:497-507.
39. Smith BR, Wells A, Alexander CB, et al. Curriculum content and evaluation of resident competency in clinical pathology (laboratory medicine): a proposal. Am J Clin Pathol. 2006;125(suppl):S3-S37.
40. TRIG Working Group Website. 2013. Available at: ascp.org/TRIG. Accessed September 6, 2013.
41. Haspel RL. How can we teach genomic medicine to pathology professionals? Crit Values. 2013;6:19.
42. Haspel RL. Teaching residents genomic pathology: a novel approach for new technology. Adv Anat Pathol. 2013;20:125-129.
43. Rinder HM, Grimes MM, Wagner J, et al. Senior pathology Resident In-Service Examination (RISE) scores correlate with outcomes of the American Board of Pathology (ABP) certifying examinations. Am J Clin Pathol. 2011;136:499-506.
44. Accreditation Council for Graduate Medical Education (ACGME). The pathology milestone project. 2013. Available at: http://www.acgme.org/acgmeweb/ Portals/0/PDFs/Milestones/PathologyMilestones.pdf. Accessed December 3, 2013.
45. American Board of Pathology. Description of examinations-primary. 2011. Available at: http://www.abpath.org/DescriptionOfExamsAPCP.pdf. Accessed September 26, 2013.