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Volumn 1, Issue 2, 2012, Pages 153-167

Can ELISPOT be applied to a clinical setting as a diagnostic utility for neuroborreliosis?

Author keywords

Borrelia burgdorferi; Cerebrospinal fluid; Diagnostic test; ELISPOT; Neuroborreliosis; Sensitivity; Specificity

Indexed keywords

AMOXICILLIN; CEFTRIAXONE; DOXYCYCLINE; GAMMA INTERFERON;

EID: 84893606893     PISSN: None     EISSN: 20734409     Source Type: Journal    
DOI: 10.3390/cells1020153     Document Type: Article
Times cited : (19)

References (53)
  • 2
    • 0345282979 scopus 로고    scopus 로고
    • Lyme borreliosis
    • Stanek, G.; Strle, F. Lyme borreliosis. Lancet 2003, 362, 1639-1647.
    • (2003) Lancet , vol.362 , pp. 1639-1647
    • Stanek, G.1    Strle, F.2
  • 4
    • 34547117093 scopus 로고    scopus 로고
    • Clinical usefulness of intrathecal antibody testing in acute lyme neuroborreliosis
    • Ljostad, U.; Skarpaas, T.; Mygland, A. Clinical usefulness of intrathecal antibody testing in acute lyme neuroborreliosis. Eur. J. Neurol. 2007, 14, 873-876.
    • (2007) Eur. J. Neurol. , vol.14 , pp. 873-876
    • Ljostad, U.1    Skarpaas, T.2    Mygland, A.3
  • 5
    • 28844474474 scopus 로고    scopus 로고
    • Epidemiology and diagnosis of lyme borreliosis
    • Wilske, B. Epidemiology and diagnosis of lyme borreliosis. Ann. Med. 2005, 37, 568-579.
    • (2005) Ann. Med. , vol.37 , pp. 568-579
    • Wilske, B.1
  • 8
    • 0027469188 scopus 로고
    • Borrelia burgdorferi-specific intrathecal antibody production in neuroborreliosis: A follow-up study
    • Hammers-Berggren, S.; Hansen, K.; Lebech, A.M.; Karlsson, M. Borrelia burgdorferi-specific intrathecal antibody production in neuroborreliosis: A follow-up study. Neurology 1993, 43, 169-175.
    • (1993) Neurology , vol.43 , pp. 169-175
    • Hammers-Berggren, S.1    Hansen, K.2    Lebech, A.M.3    Karlsson, M.4
  • 9
    • 0024395429 scopus 로고
    • Meningoradiculitis and encephalomyelitis due to borrelia burgdorferi: A follow-up study of 72 patients over 27 years
    • Kruger, H.; Reuss, K.; Pulz, M.; Rohrbach, E.; Pflughaupt, K.W.; Martin, R.; Mertens, H.G. Meningoradiculitis and encephalomyelitis due to borrelia burgdorferi: A follow-up study of 72 patients over 27 years. J. Neurol. 1989, 236, 322-328.
    • (1989) J. Neurol. , vol.236 , pp. 322-328
    • Kruger, H.1    Reuss, K.2    Pulz, M.3    Rohrbach, E.4    Pflughaupt, K.W.5    Martin, R.6    Mertens, H.G.7
  • 10
  • 11
    • 0029396587 scopus 로고
    • Detection of borrelia burgdorferi-specific antigen in antibody-negative cerebrospinal fluid in neurologic lyme disease
    • Coyle, P.K.; Schutzer, S.E.; Deng, Z.; Krupp, L.B.; Belman, A.L.; Benach, J.L.; Luft, B.J. Detection of borrelia burgdorferi-specific antigen in antibody-negative cerebrospinal fluid in neurologic lyme disease. Neurology 1995, 45, 2010-2015.
    • (1995) Neurology , vol.45 , pp. 2010-2015
    • Coyle, P.K.1    Schutzer, S.E.2    Deng, Z.3    Krupp, L.B.4    Belman, A.L.5    Benach, J.L.6    Luft, B.J.7
  • 13
    • 0029163481 scopus 로고
    • Antibodies against whole sonicated borrelia burgdorferi spirochetes, 41-kilodalton flagellin, and p39 protein in patients with pcr-or culture-proven late lyme borreliosis
    • Oksi, J.; Uksila, J.; Marjamaki, M.; Nikoskelainen, J.; Viljanen, M.K. Antibodies against whole sonicated borrelia burgdorferi spirochetes, 41-kilodalton flagellin, and p39 protein in patients with pcr-or culture-proven late lyme borreliosis. J. Clin. Microbiol. 1995, 33, 2260-2264.
    • (1995) J. Clin. Microbiol. , vol.33 , pp. 2260-2264
    • Oksi, J.1    Uksila, J.2    Marjamaki, M.3    Nikoskelainen, J.4    Viljanen, M.K.5
  • 14
    • 0025101297 scopus 로고
    • Sequestration of antibody to borrelia burgdorferi in immune complexes in seronegative lyme disease
    • Schutzer, S.E.; Coyle, P.K.; Belman, A.L.; Golightly, M.G.; Drulle, J. Sequestration of antibody to borrelia burgdorferi in immune complexes in seronegative lyme disease. Lancet 1990, 335, 312-315.
    • (1990) Lancet , vol.335 , pp. 312-315
    • Schutzer, S.E.1    Coyle, P.K.2    Belman, A.L.3    Golightly, M.G.4    Drulle, J.5
  • 15
    • 0023736053 scopus 로고
    • Seronegative lyme disease. Dissociation of specific t-and b-lymphocyte responses to borrelia burgdorferi
    • Dattwyler, R.J.; Volkman, D.J.; Luft, B.J.; Halperin, J.J.; Thomas, J.; Golightly, M.G. Seronegative lyme disease. Dissociation of specific t-and b-lymphocyte responses to borrelia burgdorferi. New Engl. J. Med. 1988, 319, 1441-1446.
    • (1988) New Engl. J. Med. , vol.319 , pp. 1441-1446
    • Dattwyler, R.J.1    Volkman, D.J.2    Luft, B.J.3    Halperin, J.J.4    Thomas, J.5    Golightly, M.G.6
  • 17
    • 84869118537 scopus 로고    scopus 로고
    • High frequency of false positive igm immunoblots for borrelia burgdorferi in clinical practic
    • doi: 10.1111/j.1469-0691.2011.03749.x
    • Seriburi, V.; Ndukwe, N.; Chang, Z.; Cox, M.E.; Wormser, G.P. High frequency of false positive igm immunoblots for borrelia burgdorferi in clinical practic. Clin. Microbiol. Infect. 2011, doi: 10.1111/j.1469-0691.2011.03749.x.
    • (2011) Clin. Microbiol. Infect.
    • Seriburi, V.1    Ndukwe, N.2    Chang, Z.3    Cox, M.E.4    Wormser, G.P.5
  • 18
    • 33750132121 scopus 로고    scopus 로고
    • The clinical assessment, treatment, and prevention of lyme disease, human granulocytic anaplasmosis, and babesiosis: Clinical practice guidelines by the infectious diseases society of america
    • Wormser, G.P.; Dattwyler, R.J.; Shapiro, E.D.; Halperin, J.J.; Steere, A.C.; Klempner, M.S.; Krause, P.J.; Bakken, J.S.; Strle, F.; Stanek, G.; et al. The clinical assessment, treatment, and prevention of lyme disease, human granulocytic anaplasmosis, and babesiosis: Clinical practice guidelines by the infectious diseases society of america. Clin. Infect. Dis. 2006, 43, 1089-1134.
    • (2006) Clin. Infect. Dis. , vol.43 , pp. 1089-1134
    • Wormser, G.P.1    Dattwyler, R.J.2    Shapiro, E.D.3    Halperin, J.J.4    Steere, A.C.5    Klempner, M.S.6    Krause, P.J.7    Bakken, J.S.8    Strle, F.9    Stanek, G.10
  • 19
    • 2342468026 scopus 로고    scopus 로고
    • Diagnosis of lyme borreliosis in europe
    • Wilske, B. Diagnosis of lyme borreliosis in europe. Vector Borne Zoonotic Dis. 2003, 3, 215-227.
    • (2003) Vector Borne Zoonotic Dis. , vol.3 , pp. 215-227
    • Wilske, B.1
  • 21
    • 0025374968 scopus 로고
    • Oligoclonal borrelia burgdorferi-specific igg antibodies in cerebrospinal fluid in lyme neuroborreliosis
    • Hansen, K.; Cruz, M.; Link, H. Oligoclonal borrelia burgdorferi-specific igg antibodies in cerebrospinal fluid in lyme neuroborreliosis. J. Infect. Dis. 1990, 161, 1194-1202.
    • (1990) J. Infect. Dis. , vol.161 , pp. 1194-1202
    • Hansen, K.1    Cruz, M.2    Link, H.3
  • 22
    • 0025286131 scopus 로고
    • Evaluation of the intrathecal antibody response to borrelia burgdorferi as a diagnostic test for lyme neuroborreliosis
    • Steere, A.C.; Berardi, V.P.; Weeks, K.E.; Logigian, E.L.; Ackermann, R. Evaluation of the intrathecal antibody response to borrelia burgdorferi as a diagnostic test for lyme neuroborreliosis. J. Infect. Dis. 1990, 161, 1203-1209.
    • (1990) J. Infect. Dis. , vol.161 , pp. 1203-1209
    • Steere, A.C.1    Berardi, V.P.2    Weeks, K.E.3    Logigian, E.L.4    Ackermann, R.5
  • 23
    • 0021914880 scopus 로고
    • Diagnosis of spirochetal meningitis by enzyme-linked immunosorbent assay and indirect immunofluorescence assay in serum and cerebrospinal fluid
    • Stiernstedt, G.T.; Granstrom, M.; Hederstedt, B.; Skoldenberg, B. Diagnosis of spirochetal meningitis by enzyme-linked immunosorbent assay and indirect immunofluorescence assay in serum and cerebrospinal fluid. J. Clin. Microbiol. 1985, 21, 819-825.
    • (1985) J. Clin. Microbiol. , vol.21 , pp. 819-825
    • Stiernstedt, G.T.1    Granstrom, M.2    Hederstedt, B.3    Skoldenberg, B.4
  • 24
    • 0033749232 scopus 로고    scopus 로고
    • Clinical comparison of immunoblot and antibody index for detection of intrathecal synthesis of specific antibodies in lyme neuroborreliosis
    • Picha, D.; Moravcova, L.; Zdarsky, E.; Benes, J. Clinical comparison of immunoblot and antibody index for detection of intrathecal synthesis of specific antibodies in lyme neuroborreliosis. Eur. J. Clin. Microbiol. Infect. Dis. 2000, 19, 805-806.
    • (2000) Eur. J. Clin. Microbiol. Infect. Dis. , vol.19 , pp. 805-806
    • Picha, D.1    Moravcova, L.2    Zdarsky, E.3    Benes, J.4
  • 25
    • 0028850301 scopus 로고
    • Relevance of cerebrospinal fluid variables for early diagnosis of neuroborreliosis
    • Tumani, H.; Nolker, G.; Reiber, H. Relevance of cerebrospinal fluid variables for early diagnosis of neuroborreliosis. Neurology 1995, 45, 1663-1670.
    • (1995) Neurology , vol.45 , pp. 1663-1670
    • Tumani, H.1    Nolker, G.2    Reiber, H.3
  • 28
    • 0025995457 scopus 로고
    • The t-cell proliferative assay in the diagnosis of lyme disease
    • Dressler, F.; Yoshinari, N.H.; Steere, A.C. The t-cell proliferative assay in the diagnosis of lyme disease. Ann. Intern. Med. 1991, 115, 533-539.
    • (1991) Ann. Intern. Med. , vol.115 , pp. 533-539
    • Dressler, F.1    Yoshinari, N.H.2    Steere, A.C.3
  • 29
    • 0032516796 scopus 로고    scopus 로고
    • Augmented intrathecal secretion of interferon-γ in response to borrelia garinii in neuroborreliosis
    • Ekerfelt, C.; Ernerudh, J.; Forsberg, P.; Bergström, S. Augmented intrathecal secretion of interferon-γ in response to borrelia garinii in neuroborreliosis. J. Neuroimmunol. 1998, 89, 177-181.
    • (1998) J. Neuroimmunol. , vol.89 , pp. 177-181
    • Ekerfelt, C.1    Ernerudh, J.2    Forsberg, P.3    Bergström, S.4
  • 30
    • 0029131745 scopus 로고
    • The outer surface proteins of lyme disease borrelia spirochetes stimulate t cells to secrete interferon-gamma (ifn-gamma): Diagnostic and pathogenic implications
    • Forsberg, P.; Ernerudh, J.; Ekerfelt, C.; Roberg, M.; Vrethem, M.; Bergstrom, S. The outer surface proteins of lyme disease borrelia spirochetes stimulate t cells to secrete interferon-gamma (ifn-gamma): Diagnostic and pathogenic implications. Clin. Exp. Immunol. 1995, 101, 453-460.
    • (1995) Clin. Exp. Immunol. , vol.101 , pp. 453-460
    • Forsberg, P.1    Ernerudh, J.2    Ekerfelt, C.3    Roberg, M.4    Vrethem, M.5    Bergstrom, S.6
  • 31
    • 0029736634 scopus 로고    scopus 로고
    • Decreased interleukin-4 and increased gamma interferon production by peripheral blood mononuclear cells of patients with lyme borreliosis
    • Oksi, J.; Savolainen, J.; Pène, J.; Bòusquet, J.; Laippala, P.; Viljanen, M.K. Decreased interleukin-4 and increased gamma interferon production by peripheral blood mononuclear cells of patients with lyme borreliosis. Infect. Immun. 1996, 64, 3620-3623.
    • (1996) Infect. Immun. , vol.64 , pp. 3620-3623
    • Oksi, J.1    Savolainen, J.2    Pène, J.3    Bòusquet, J.4    Laippala, P.5    Viljanen, M.K.6
  • 32
    • 0031800694 scopus 로고    scopus 로고
    • Igg subclasses in lyme borreliosis: A study of specific igg subclass distribution in an IFN-γ predominated disease
    • Widhe, M.; Ekerfelt, C.; Forsberg, P.; Bergström, S.; Ernerudh, J. Igg subclasses in lyme borreliosis: A study of specific igg subclass distribution in an IFN-γ predominated disease. Scand. J. Immunol. 1998, 47, 575-581.
    • (1998) Scand. J. Immunol. , vol.47 , pp. 575-581
    • Widhe, M.1    Ekerfelt, C.2    Forsberg, P.3    Bergström, S.4    Ernerudh, J.5
  • 33
    • 2442707597 scopus 로고    scopus 로고
    • Borrelia specific ifn-g and il-4 secretion in blood and csf during the course of human lyme borreliosis: Relation to clinical outcome
    • Widhe, M.; Jarefors, S.; Ekerfelt, C.; Vrethem, M.; Bergström, S.; Forsberg, P.; Ernerudh, J. Borrelia specific ifn-g and il-4 secretion in blood and csf during the course of human lyme borreliosis: Relation to clinical outcome. J. Infect. Dis. 2004, 189, 1881-1891.
    • (2004) J. Infect. Dis. , vol.189 , pp. 1881-1891
    • Widhe, M.1    Jarefors, S.2    Ekerfelt, C.3    Vrethem, M.4    Bergström, S.5    Forsberg, P.6    Ernerudh, J.7
  • 34
    • 0031037620 scopus 로고    scopus 로고
    • T cell cytokine pattern in the joints of patients with lyme arthritis and its regulation by cytokines and anticytokines
    • Yin, Z.; Braun, J.; Neure, L.; Wu, P.; Eggens, U.; Krause, A.; Kamradt, T.; Sieper, J. T cell cytokine pattern in the joints of patients with lyme arthritis and its regulation by cytokines and anticytokines. Arthritis Rheum. 1997, 40, 69-79.
    • (1997) Arthritis Rheum. , vol.40 , pp. 69-79
    • Yin, Z.1    Braun, J.2    Neure, L.3    Wu, P.4    Eggens, U.5    Krause, A.6    Kamradt, T.7    Sieper, J.8
  • 35
    • 0030810233 scopus 로고    scopus 로고
    • Compartmentalization of antigen specific cytokine responses to the central nervous system in cns borreliosis: Secretion of ifn-gamma predominates over il-4 secretion in response to outer surface proteins of lyme disease borrelia spirochetes
    • Ekerfelt, C.; Ernerudh, J.; Bunikis, J.; Vrethem, M.; Aagesen, J.; Roberg, M.; Bergstrom, S.; Forsberg, P. Compartmentalization of antigen specific cytokine responses to the central nervous system in cns borreliosis: Secretion of ifn-gamma predominates over il-4 secretion in response to outer surface proteins of lyme disease borrelia spirochetes. J. Neuroimmunol. 1997, 79, 155-162.
    • (1997) J. Neuroimmunol. , vol.79 , pp. 155-162
    • Ekerfelt, C.1    Ernerudh, J.2    Bunikis, J.3    Vrethem, M.4    Aagesen, J.5    Roberg, M.6    Bergstrom, S.7    Forsberg, P.8
  • 36
    • 34548537013 scopus 로고    scopus 로고
    • Borrelios/lyme disease-Serologi/diagnostik
    • Granström, M. Borrelios/lyme disease-Serologi/diagnostik. Inf. från Läkemedelsverket 1998, 9, 98.
    • (1998) Inf. från Läkemedelsverket , vol.9 , pp. 98
    • Granström, M.1
  • 37
    • 0031964715 scopus 로고    scopus 로고
    • T helper 1 response is dominant and localized to the synovial fluid in patients with lyme arthritis
    • Gross, D.M.; Steere, A.C.; Huber, B.T. T helper 1 response is dominant and localized to the synovial fluid in patients with lyme arthritis. J. Immunol. 1998, 160, 1022-1028.
    • (1998) J. Immunol. , vol.160 , pp. 1022-1028
    • Gross, D.M.1    Steere, A.C.2    Huber, B.T.3
  • 38
    • 0036789981 scopus 로고    scopus 로고
    • Increased expression of the th1-inducing cytokines interleukin-12 and interleukin-18 in cerebrospinal fluid but not in sera from patients with lyme neuroborreliosis
    • Grusell, M.; Widhe, M.; Ekerfelt, C. Increased expression of the th1-inducing cytokines interleukin-12 and interleukin-18 in cerebrospinal fluid but not in sera from patients with lyme neuroborreliosis. J. Neuroimmunol. 2002, 131, 173-178.
    • (2002) J. Neuroimmunol. , vol.131 , pp. 173-178
    • Grusell, M.1    Widhe, M.2    Ekerfelt, C.3
  • 39
    • 0029563646 scopus 로고
    • Lyme neuroborreliosis: Evidence for persistent up-regulation of borrelia burgdorferi-reactive cells secreting interferon-γ
    • Wang, W.-Z.; Fredriksson, S.; Sun, J.-B.; Link, H. Lyme neuroborreliosis: Evidence for persistent up-regulation of borrelia burgdorferi-reactive cells secreting interferon-γ. Scand. J. Immunol. 1995, 42, 694-700.
    • (1995) Scand. J. Immunol. , vol.42 , pp. 694-700
    • Wang, W.-Z.1    Fredriksson, S.2    Sun, J.-B.3    Link, H.4
  • 40
    • 76249122064 scopus 로고    scopus 로고
    • Advances in the diagnosis of tuberculosis
    • Lange, C.; Mori, T. Advances in the diagnosis of tuberculosis. Respirology 2010, 15, 220-240.
    • (2010) Respirology , vol.15 , pp. 220-240
    • Lange, C.1    Mori, T.2
  • 41
  • 42
    • 2142814678 scopus 로고    scopus 로고
    • Finland's National institute for health and welfare, R.o. D, Available online, (accessed on 9 May 2012)
    • Finland's National institute for health and welfare, R.o.D., Statistical Database. Available online: http://www3.ktl.fi/stat/ (accessed on 9 May 2012).
    • Statistical Database
  • 44
    • 0035175580 scopus 로고    scopus 로고
    • Antibodies and t-cell reactivity to borrelia burgdorferi in an asymptomatic population: A study of healthy blood donors in an inland town district in the south-east of sweden
    • Ekerfelt, C.; Masreliez, C.; Svenvik, M.; Ernerudh, J.; Roberg, M.; Forsberg, P. Antibodies and t-cell reactivity to borrelia burgdorferi in an asymptomatic population: A study of healthy blood donors in an inland town district in the south-east of sweden. Scand. J. Infect. Dis. 2001, 33, 806-808.
    • (2001) Scand. J. Infect. Dis. , vol.33 , pp. 806-808
    • Ekerfelt, C.1    Masreliez, C.2    Svenvik, M.3    Ernerudh, J.4    Roberg, M.5    Forsberg, P.6
  • 46
    • 0035885047 scopus 로고    scopus 로고
    • Persistence of immunoglobulin m or immunoglobulin g antibody responses to borrelia burgdorferi 10-20 years after active lyme disease
    • Kalish, R.A.; McHugh, G.; Granquist, J.; Shea, B.; Ruthazer, R.; Steere, A.C. Persistence of immunoglobulin m or immunoglobulin g antibody responses to borrelia burgdorferi 10-20 years after active lyme disease. Clin. Infect. Dis. 2001, 33, 780-785.
    • (2001) Clin. Infect. Dis. , vol.33 , pp. 780-785
    • Kalish, R.A.1    McHugh, G.2    Granquist, J.3    Shea, B.4    Ruthazer, R.5    Steere, A.C.6
  • 48
    • 0032516796 scopus 로고    scopus 로고
    • Augmented intrathecal secretion of interferon-gamma in response to borrelia garinii in neuroborreliosis
    • Ekerfelt, C.; Ernerudh, J.; Forsberg, P.; Bergstrom, S. Augmented intrathecal secretion of interferon-gamma in response to borrelia garinii in neuroborreliosis. J. Neuroimmunol. 1998, 89, 177-181.
    • (1998) J. Neuroimmunol. , vol.89 , pp. 177-181
    • Ekerfelt, C.1    Ernerudh, J.2    Forsberg, P.3    Bergstrom, S.4
  • 49
    • 2442707597 scopus 로고    scopus 로고
    • Borrelia-specific interferon-gamma and interleukin-4 secretion in cerebrospinal fluid and blood during lyme borreliosis in humans: Association with clinical outcome
    • Widhe, M.; Jarefors, S.; Ekerfelt, C.; Vrethem, M.; Bergstrom, S.; Forsberg, P.; Ernerudh, J. Borrelia-specific interferon-gamma and interleukin-4 secretion in cerebrospinal fluid and blood during lyme borreliosis in humans: Association with clinical outcome. J. Infect. Dis. 2004, 189, 1881-1891.
    • (2004) J. Infect. Dis. , vol.189 , pp. 1881-1891
    • Widhe, M.1    Jarefors, S.2    Ekerfelt, C.3    Vrethem, M.4    Bergstrom, S.5    Forsberg, P.6    Ernerudh, J.7
  • 51
    • 0028269876 scopus 로고
    • Flow rate of cerebrospinal fluid (csf)-A concept common to normal blood-csf barrier function and to dysfunction in neurological diseases
    • Reiber, H. Flow rate of cerebrospinal fluid (csf)-A concept common to normal blood-csf barrier function and to dysfunction in neurological diseases. J. Neurol. Sci. 1994, 122, 189-203.
    • (1994) J. Neurol. Sci. , vol.122 , pp. 189-203
    • Reiber, H.1
  • 53
    • 0019559193 scopus 로고
    • Selection and interpretation of diagnostic tests and procedures. Principles and applications
    • Griner, P.F.; Mayewski, R.J.; Mushlin, A.I.; Greenland, P. Selection and interpretation of diagnostic tests and procedures. Principles and applications. Ann. Intern. Med. 1981, 94, 557-592.
    • (1981) Ann. Intern. Med. , vol.94 , pp. 557-592
    • Griner, P.F.1    Mayewski, R.J.2    Mushlin, A.I.3    Greenland, P.4


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