IgG subclasses in lyme borreliosis: A study of specific IgG subclass distribution in an interferon-γ-predominated disease

Scandinavian Journal of Immunology

Volumn 47, Issue 6, 1998, Pages 575-581

  Widhe, M ^a   Ekerfelt, C ^a   Forsberg, P ^a   Bergstrom S ^b   Ernerudh, J ^a  

^a LINKÖPING UNIVERSITY HOSPITAL   (Sweden)

^b UMEÅ UNIVERSITY   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

GAMMA INTERFERON; IMMUNOGLOBULIN G1; IMMUNOGLOBULIN G2; IMMUNOGLOBULIN G3; IMMUNOGLOBULIN G4;

ADOLESCENT; ADULT; AGED; ARTICLE; CHILD; CLINICAL ARTICLE; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; HOST RESISTANCE; HUMAN; IMMUNOGLOBULIN PRODUCTION; INTERFERON PRODUCTION; LYME DISEASE; MALE; OPSONIZATION; PRIORITY JOURNAL; T LYMPHOCYTE ACTIVATION;

ADULT; AGED; AGED, 80 AND OVER; BORRELIA BURGDORFERI GROUP; CHILD; CHILD, PRESCHOOL; FEMALE; HUMANS; IMMUNOGLOBULIN G; INTERFERON TYPE II; LYME DISEASE; MALE; MIDDLE AGED;

EID: 0031800694     PISSN: 03009475     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (35)

1. Nocton JJ, Steere AC. Lyme Disease. Adv Intern Med 1995;40:69-117.
2. Steere AC, Schoen RT, Taylor E. The clinical evolution of Lyme arthritis. Ann Intern Med 1987;107:725-31.
3. Asch ES, Bujak DI, Weiss M, Peterson MGE, Weinstein A. Lyme Disease: An infectious and postinfectious syndrome. J Rheumatol 1994;21:454-61.
4. Barthold SW, Bockenstedt LK. Passive immunizing activity of sera from mice infected with Borrelia burgdorferi. Infect Immun 1993;61:4696-702.
5. Mosmann TR, Sad S. The expanding universe of T-cell subsets: Th1, Th2 and more. Immunol Today 1996;17:138-46.
6. Matyniak JE, Reiner SL. T helper phenotype and genetic susceptibility in experimental Lyme Disease. J Exp Med 1994;181: 1251-4.
7. Keane-Myers A, Nickell SP. Role of IL-4 and IFN-γ in modulation of immunity to Borrelia burgdorferi in mice. J Immunol 1995;155:2020-8.
8. Forsberg P, Ernerudh J, Ekerfelt C, Roberg M, Vrethem M, Bergström S. The outer surface proteins of Lyme disease borrelia spirochetes stimulate T cells to secrete interferon-γ: diagnostic and pathogenic implications. Clin Exp Immunol 1995;101:453-60.
9. Wang W-Z, Fredrikson S, Sun J-B, Link H. Lyme neuroborreliosis: Evidence for persistent up-regulation of Borrelia burgdorferi-reactive cells secreting Interferon-γ. Scand J Immunol 1995;42:694-700.
10. Oksi J, Savolainen J, Pene J, Bousquet J, Laippala P, Viljanen M. Decreased interleukin-4 and increased gamma interferon production by peripheral blood mononuclear cells of patients with Lyme borreliosis. Infect Immun 1996;64:3620-3.
11. Ekerfelt C, Ernerudh J, Bunikis J et al. Compartmentalization of antigen specific cytokine responses to the central nervous system in CNS borreliosis; secretion of IFN-γ predominates over IL-4 secretion in responses to outer surface proteins of Lyme disease Borrelia spirochetes. J Neuroimmunol 1997;79:155-62.
12. Bergström S, Sjöstedt A, Dotevall L et al. Diagnosis of Lyme Borreliosis by an enzyme immunoassay detecting immunoglobulin G reactive to purified Borrelia burgdorferi cell components. Eur J Microbiol Infect Dis 1991;10:422-7.
13. Magnarelli LA, Anderson JF, Barbour AG. Enzyme-linked immunosorbent assay for Lyme disease: Reactivity of subunits of Borrelia burgdorferi. J Infect Dis 1989;159:43-9.
14. Olsson I, Hammarström L, Smith CIE, Hovmark A, Åsbrink E. IgG subclasses of specific antibodies in Ixodes ricinus-borne borreliosis. Clin Exp Immunol 1987;69:618-23.
15. Hechemy KE, Harris HL, Duerr MJ, Benach JL, Reimer CB. Immunoglobulin G subclasses specific to Borrelia burgdorferi in patients with Lyme Disease. Ann NY Acad Sci 1988;539:162-9.
16. Lundgren M, Persson U, Larsson P et al. Interleukin 4 induces synthesis of IgE and IgG4 in human B cells. Eur J Immunol 1989;19:1311-15.
17. Fujieda S, Zhang K, Saxon A. IL-4 plus CD40 monoclonal antibody induces human B cells γ subclass-specific isotype switch: switching to γ1, γ3, and γ4, but not γ2. J Immunol 1995;155:2318-28.
18. Collins JT, Dunnick WA. Germline transcripts of the murine immunoglobulin γ2a gene: Structure and induction by IFN-γ. Int Immunol 1993;5:885-91.
19. Inoue R, Kondo K, Kobayshi Y, Fukutomi O, Orii T. IgG2 deficiency associated with defects in production of interferon-gamma; comparison with common variable immunodeficiency. Scand J Immunol 1995;41:130-4.
20. Kitani A, Strober W. Regulation of Cγ subclass germ-line transcripts in human peripheral blood B cells. J Immunol 1993;151:3478-88.
21. Kawano Y, Noma T, Yata J. Regulation of human IgG subclass production by cytokines - IFN-γ and IL-4 act antagonistically in the induction of human IgG1 but additively in the induction of IgG2. J Immunol 1994;153:4948-58.
22. Kawano Y, Noma T. Role of interleukin-2 and interferon-γ in inducing production of IgG subclasses in lymphocytes of human newborns. Immunology 1996;88:40-8.
23. Janeway CA, Travers P. Immunobiology, 2nd edn. London/New York: Current Biology Ltd/Garland Publishing Inc, 1996.
24. Röcken M, Racke M, Shevach EM. IL-4 induced immune deviation as antigen-specific therapy for inflammatory autoimmune disease. Immunol Today 1996;17:225-31.
25. Romagnani S. Understanding the role of Th1/Th2 cells in infection. Trends Microbiol 1996;4:470-3.
26. Baughn R, Jorizzo J, Adams C et al. Ig class and IgG subclass responses to Treponema pallidum in patients with syphilis. J Clin Immunol 1988;8:128-39.
27. Voorhis Wv, Barrett L, Koelle D, Nasio J, Plummer F, Lukehart S. Primary and secondary syphilis lesions contain mRNA for Th1 cytokines. J Infect Dis 1996;173:491-5.
28. Linde G. Subclass distribution of rubella virus-specific immunoglobulin G. J Clin Microbiol 1985;21:117-21.
29. Nakayama T, Urano T, Osano M et al. Evaluation of live trivalent vaccine of measles AIK-C strain, mumps Hoshino strain and rubella Takahashi strain, by virus-specific interferon-gamma production and antibody response. Microbiol Immunol 1990;34:497-508.
30. Linde G, Granström M, Orvell C. Immunoglobulin class and immunoglobulin G subclass enzyme-linked immunosorbent assays compared with microneutralization assay for serodiagnosis of mumps infection and determination of immunity. J Clin Microbiol 1987;25:1653-8.
31. Martin R, Vallbracht A, Kreth H. Interferon-gamma secretion by in vivo activated cytotoxic T lymphocytes from the blood and cerebrospinal fluid during mumps meningitis. J Neuroimmunol 1991;33:191-8.
32. Hornsleth A, Bech-Thomsen N, Friis B. Detection by ELISA of IgG-subclass-specific antibodies in primary respiratory syncytial virus infections. J Med Virol 1985;16:321-8.
33. Andersson L, Tsou C, Potter C et al. Cytokine response to respiratory syncytial virus stimulation of human peripheral blood mononuclear cells. J Infect Dis 1994;170:1201-8.
34. Schmitz JL, Schell RF, Callister SM et al. Immunoglobulin G2 confers protection against Borrelia burgdorferi infection in hamsters. Infect Immun 1992;60:2677-82.
35. Aydintug MK, Go Y, Philipp MT. Borrelia burgdorferi antigens that are targeted by antibody-dependent, complement-mediated killing in the Rhesus monkey. Infect Immun 1994;62:4929-37.