Augmented intrathecal secretion of interferon-γ in response to Borrelia garinii in neuroborreliosis

Journal of Neuroimmunology

Volumn 89, Issue 1-2, 1998, Pages 177-181

  Ekerfelt, C ^a,b   Ernerudh, J ^a,b,c   Forsberg, P ^c   Bergstrom S ^d  

^a Fac Hlth Sci   (Sweden)

^b LINKÖPING UNIVERSITY HOSPITAL   (Sweden)

^c Fac Hlth S   (Sweden)

^d UMEÅ UNIVERSITY   (Sweden)

Author keywords

Borrelia garinii; Interferon ; Neuroborreliosis

Indexed keywords

BACTERIAL PROTEIN; CYTOKINE; GAMMA INTERFERON; IMMUNOGLOBULIN G ANTIBODY; IMMUNOGLOBULIN M ANTIBODY; OUTER MEMBRANE PROTEIN;

ADULT; AGED; ARTICLE; BORRELIA GARINII; BORRELIA INFECTION; CENTRAL NERVOUS SYSTEM INFECTION; CEREBROSPINAL FLUID ANALYSIS; CHILD; CLINICAL ARTICLE; FEMALE; HUMAN; IMMUNE RESPONSE; MALE; PRIORITY JOURNAL; SPIROCHETE;

ADULT; AGED; AGED, 80 AND OVER; ANTIGENS, BACTERIAL; BORRELIA; BORRELIA INFECTIONS; CEREBROSPINAL FLUID; CHILD; FEMALE; HUMANS; IMMUNOASSAY; INTERFERON TYPE II; LYMPHOCYTES; MALE; MIDDLE AGED; NERVOUS SYSTEM DISEASES;

EID: 0032516796     PISSN: 01655728     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0165-5728(98)00136-2     Document Type: Article

References (21)

1. Anthonissen F.M., DeKesel M., Hoet P.P., Bigaignon G.H. Evidence for the involvement of different genospecies of Borrelia in the clinical outcome of Lyme disease in Belgium. Res. Microbiol. 145:1994;327-331.
2. Baig S., Olsson T., Link H. Predominance of Borrelia burgdorferi specific B cells in cerebrospinal fluid in neuroborreliosis. Lancet. II:1989;71-74.
3. Balmelli T., Piffaretti J.-C. Association between different clinical manifestations of Lyme disease and different species of Borrelia burgdorferi sensu lato. Res. Microbiol. 146:1995;329-340.
4. Berglund J., Eitrem R., Ornstein K., Lindberg A., Ringnér Å., Elmrud H., Carlsson M., Runehagen A., Svanborg C., Norrby R. An epidemiologic study of Lyme disease in southern Sweden. New Engl. J. Med. 333:1995;1319-1324.
5. Bergström S., Sjöstedt A., Dotevall L., Kaijser B., Ekstrand-Hammarström B., Wallberg C., Skogman G., Barbour A.G. Diagnosis of Lyme borreliosis by an enzyme immunoassay detecting immunoglobulin G reactive to purified Borrelia burgdorferi cell components. Eur. J. Clin. Microbiol. Infect. Dis. 10:1991;422-427.
6. Boerlin P., Péter O., Bretz A.G., Postic D., Baranton G., Piffaretti J.-C. Population genetics of Borrelia burgdorferi isolates by multilocus enzyme electrophoresis. Infect. Immun. 60:1992;1677-1683.
7. Cadavid D., Pennington P., Kerentseva T.A., Bergström S., Barbour A.G. Immunologic and genetic analyses of VmpA of a neurotropic strain of Borrelia turicatae. Infect. Immun. 65:1997;3352-3360.
8. Ciesielski C.A., Markowitz L.E., Horsley R., Hightower A.W., Russel A.W., Broome C.V. Lyme disease surveillance in the United States, 1983-1986. Rev. Infect. Dis. 11:1989;1435-1441.
9. Demaerschalck I., BenMessaoud A., DeKesel M., Hoyois B., Lobet Y., Hoet P., Bigaignon G., Bollen A., Godfroid E. Simultaneous presence of different Borrelia burgdorferi genospecies in biological fluids of Lyme disease patients. J. Clin. Microbiol. 33:1995;602-608.
10. Ekerfelt C., Ernerudh J., Bunikis J., Vrethem M., Aagesen J., Roberg M., Bergström S., Forsberg P. Compartmentalization of antigen specific cytokine responses to the central nervous system in CNS borreliosis: Secretion of IFN-γ predominates over IL-4 secretion in response to outer surface proteins of Lyme disease Borrelia spirochetes. J. Neuroimmunol. 79:1997;155-162.
11. Forsberg P., Ernerudh J., Ekerfelt C., Roberg M., Vrethem M., Bergström S. The outer surface proteins of Lyme disease Borrelia spirochetes stimulate T cells to secrete interferon-gamma (IFN-gamma): diagnostic and pathogenic implications. Clin. Exp. Immunol. 101:1995;453-460.
12. Garcia-Monco J.C., Villar B.F., Alen J.C., Benach J.L. Borrelia burgdorferi in the central nervous system: experimental and clinical evidence for early invasion. J. Infect. Dis. 161:1990;1187-1193.
13. Hansen K., Lebech A.-M. Lyme Neuroborreliosis: A new sensitive diagnostic assay for intrathecal Synthesis of Borrelia Burgdorferi-specific Immunoglobulin G, A and M. Ann. Neurol. 30:1991;197-205.
14. Ishii N., Isogai E., Isogai H., Kimura K., Nishikawa T., Fujii N., Nakajima H. T cell response to Borrelia garinii, Borrelia afzelii and Borrelia japonica in various congenic mouse strains. Microbiol. Immunol. 39:1995;929-935.
15. Isogai E., Isogai H., Kimura K., Hayashi S., Kubota T., Nishikawa T., Nakane A., Fujii N. Cytokines in the serum and brain in mice infected with distinct species of Lyme disease Borrelia. Microb. Pathog. 21:1996;413-419.
16. Jonsson M., Noppa L., Barbour A.G., Bergström S. Heterogeneity of outer membrane proteins in Borrelia burgdorferi: comparison of osp operons of three isolates of different geographic origins. Infect. Immun. 60:1992;1845-1853.
17. Olsén B., Jaenson T.G.T., Bergström S. Prevalence of Borrelia burgdorferi sensu lato infected ticks on migrating birds. Appl. Environ. Microbiol. 61:1995;3082-3087.
18. Steere A.C., Malawista S.E., Hardin J.A., Ruddy S., Askenase P.W., Andiman W.A. Erythema chronicum migrans and Lyme arthritis: the enlarging clinical spectrum. Ann. Intern. Med. 86:1977;685-698.
19. Stiernstedt G.T., Gustafsson R., Karlsson M., Svenungsson B., Sköldenberg B. Clinical manifestation and diagnosis of neuroborreliosis. Ann. NY Acad. Sci. 539:1988;46-55.
20. vanDam A., Kuiper H., Vos K., Widjojokusumo A., deJongh B., Spanjaard L., Ramselaar A., Kramer M., Dankert J. Different genospecies of Borrelia burgdorferi are associated with different clinical manifestations of Lyme borreliosis. Clin. Infect. Dis. 17:1993;708-717.
21. Wang W.-Z., Fredriksson S., Sun J.-B., Link H. Lyme neuroborreliosis: evidence for persistent up-regulation of Borrelia burgdorferi-reactive cells secreting interferon-γ Scand. J. Immunol. 42:1995;694-700.