Stress and pancreatic carcinoma - β-adrenergic signaling and tumor biology;Stress und Pankreaskarzinom: β-adrenerge Signaltransduktion und Tumorbiologie

Deutsche Medizinische Wochenschrift

Volumn 139, Issue 7, 2014, Pages 334-338

  Hefner, J ^a   Csef, H ^a   Kunzmann, V ^a  

^a UNIVERSITY HOSPITAL WÜRZBURG   (Germany)

Author keywords

blocker; catecholamines; GABA; pancreatic carcinoma; psycho neuroimmunology

Indexed keywords

BETA ADRENERGIC RECEPTOR;

BIOLOGY; PANCREAS CARCINOMA; REVIEW; SIGNAL TRANSDUCTION; STRESS;

ANIMALS; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; MODELS, BIOLOGICAL; PANCREATIC NEOPLASMS; RECEPTORS, ADRENERGIC, BETA; SIGNAL TRANSDUCTION; STRESS, PSYCHOLOGICAL; TUMOR MICROENVIRONMENT;

EID: 84893528810     PISSN: 00120472     EISSN: 14394413     Source Type: Journal    
DOI: 10.1055/s-0033-1360039     Document Type: Review

References (43)

1. Al-Wadei H. A., Al-Wadei M. H., Schuller H. M. Prevention of pancreatic cancer by the beta-blocker propranolol. Anticancer Drugs: 2009; 20 477 482
2. Al-Wadei H. A., Ullah M. F., Al-Wadei M. GABA (gamma-aminobutyric acid), a non-protein amino acid counters the beta-adrenergic cascadeactivated oncogenic signaling in pancreatic cancer: a review of experimental evidence. Mol Nutr Food Res: 2011; 55 1745 1758
3. Al-Wadei M. H., Al-Wadei H. A., Schuller H. M. Pancreatic cancer cells and normal pancreatic duct epithelial cells express an autocrine catecholamine loop that is activated by nicotinic acetylcholine receptors alpha3, alpha5, and alpha7. Mol Cancer Res: 2012; 10 239 249
4. Almhanna K., Philip P. A. Defining new paradigms for the treatment of pancreatic cancer. Curr Treat Options Oncol: 2011; 12 111 125
5. Antoni M. H., Lutgendorf S. K., Cole S. W. et al. The influence of bio-behavioural factors on tumour biology: pathways and mechanisms. Nat Rev Cancer: 2006; 6 240 248 (Pubitemid 43292567)
6. Chida Y., Hamer M., Wardle J. et al. Do stress-related psychosocial factors contribute to cancer incidence and survival? Nat Clin Pract Oncol: 2008; 5 466 475
7. Clark K. L., Loscalzo M., Trask P. C. et al. Psychological distress in patients with pancreatic cancer - an understudied group. Psychooncology: 2010; 19 1313 1320
8. Cole S. W., Sood A. K. Molecular pathways: beta-adrenergic signaling in cancer. Clin Cancer Res: 2012; 18 1201 1206
9. Conroy T., Desseigne F., Ychou M. et al. FOLFIRINOX versus gemcitabine for metastatic pancreatic cancer. N Engl J Med: 2011; 364 1817 1825
10. Franek M., Vaculin S., Rokyta R. GABA(B) receptor agonist baclofen has non-specific antinociceptive effect in the model of peripheral neuropathy in the rat. Physiol Res: 2004; 53 351 355 (Pubitemid 38797292)
11. Gladkevich A., Korf J., Hakobyan V. P. et al. The peripheral GABAergic system as a target in endocrine disorders. Auton Neurosci: 2006; 124 1 8
12. Guo K., Ma Q., Wang L. et al. Norepinephrine-induced invasion by pancreatic cancer cells is inhibited by propranolol. Oncol Rep: 2009; 22 825 830
13. Hamer M., Chida Y., Molloy G. J. Psychological distress and cancer mortality. J Psychosom Res: 2009; 66 255 258
14. Hefner J., Csef H. Psychoneuroimmunologie und Krebs. Neue Ergebnisse zu psychosozialen Einflüssen auf Tumorerkrankungen. Onkologe: 2011; 9 839 850
15. Herrmann R., Bodoky G., Ruhstaller T. et al. Gemcitabine plus capecitabine compared with gemcitabine alone in advanced pancreatic cancer: a randomized, multicenter, phase III trial of the Swiss Group for Clinical Cancer Research and the Central European Cooperative Oncology Group. J Clin Oncol: 2007; 25 2212 2217 (Pubitemid 46954645)
16. Hidalgo M. Pancreatic cancer. N Engl J Med: 2010; 362 1605 1617
17. Hieble J. P., Bondinell W. E., Ruffolo R. R. Jr. Alpha-and beta-adrenoceptors: from the gene to the clinic. 1. Molecular biology and adrenoceptor subclassification. J Med Chem: 1995; 38 3415 3444
18. Huang X. Y., Wang H. C., Yuan Z. et al. Norepinephrine stimulates pancreatic cancer cell proliferation, migration and invasion via beta-adrenergic receptor-dependent activation of P38/MAPK pathway. Hepatogastroenterology: 2012; 59 889 893
19. Lin X., Luo K., Lv Z. et al. β-adrenoceptor action on pancreatic cancer cell proliferation and tumor growth in mice. Hepatogastroenterology: 2012; 59 584 588
20. Lowenfels A. B., Maisonneuve P. Risk factors for pancreatic cancer. J Cell Biochem: 2005; 95 649 656 (Pubitemid 41420153)
21. Mancuso A., Calabro F., Sternberg C. N. Current therapies and advances in the treatment of pancreatic cancer. Crit Rev Oncol Hematol: 2006; 58 231 241 (Pubitemid 43796083)
22. McEwen B. S. The neurobiology of stress: from serendipity to clinical relevance. Brain Res: 2000; 886 172 189
23. Moreno-Smith M., Lutgendorf S. K., Sood A. K. Impact of stress on cancer metastasis. Future Oncol: 2010; 6 1863 1881
24. Paez D., Labonte M. J., Lenz H. J. Pancreatic cancer: medical management (novel chemotherapeutics). Gastroenterol Clin North Am: 2012; 41 189 209
25. Parkin D. M., Bray F., Ferlay J. et al. Estimating the world cancer burden: Globocan 2000. Int J Cancer: 2001; 94 153 156 (Pubitemid 32911406)
26. Philip P. A., Benedetti J., Corless C. L. et al. Phase III study comparing gemcitabine plus cetuximab versus gemcitabine in patients with advanced pancreatic adenocarcinoma: Southwest Oncology Group-directed intergroup trial S0205. J Clin Oncol: 2010; 28 3605 10
27. Reddy L. H., Marque P. E., Dubernet C. et al. Preclinical toxicology (subacute and acute) and efficacy of a new squalenoyl gemcitabine anticancer nanomedicine. J Pharmacol Exp Ther: 2008; 325 484 90 (Pubitemid 351574820)
28. Satin J. R., Linden W., Phillips M. J. Depression as a predictor of disease progression and mortality in cancer patients: a meta-analysis. Cancer: 2009; 115 5349 5361
29. Schuller H. M., Al-Wadei H. A., Majidi M. GABA B receptor is a novel drug target for pancreatic cancer. Cancer: 2008; 112 767 778 (Pubitemid 351240570)
30. Schuller H. M., Al-Wadei H. A., Ullah M. F. et al. Regulation of pancreatic cancer by neuropsychological stress responses: a novel target for intervention. Carcinogenesis: 2012; 33 191 196
31. Shan T., Ma Q., Zhang D. et al. β2-adrenoceptor blocker synergizes with gemcitabine to inhibit the proliferation of pancreatic cancer cells via apoptosis induction. Eur J Pharmacol: 2011; 665 1 7
32. Siegel R., Naishadham D., Jemal A. Cancer statistics, 2013. CA Cancer J Clin: 2013; 63 11 30
33. Spiegel D., Giese-Davis J. Depression and cancer: mechanisms and disease progression. Biol Psychiatry: 2003; 54 269 282 (Pubitemid 37267857)
34. Thaker P. H., Han L. Y., Kamat A. A. et al. Chronic stress promotes tumor growth and angiogenesis in a mouse model of ovarian carcinoma. Nat Med: 2006; 12 939 944 (Pubitemid 44175146)
35. Thaker P. H., Lutgendorf S. K., Sood A. K. The neuroendocrine impact of chronic stress on cancer. Cell Cycle: 2007; 6 430 433 (Pubitemid 46393445)
36. Troiani T., Martinelli E., Capasso A. et al. Targeting EGFR in pancreatic cancer treatment. Curr Drug Targets: 2012; 13 802 810
37. Tsigos C., Chrousos G. P. Hypothalamic-pituitary-adrenal axis, neuroendocrine factors and stress. J Psychosom Res: 2002; 53 865 871 (Pubitemid 35282615)
38. Wadler S. Molecular targeting in pancreatic cancer. Rev Recent Clin Trials: 2007; 2 69 75 (Pubitemid 46723189)
39. Weddle D. L., Tithoff P., Williams M. et al. Beta-adrenergic growth regulation of human cancer cell lines derived from pancreatic ductal carcinomas. Carcinogenesis: 2001; 22 473 479 (Pubitemid 32203828)
40. Zabora J., BrintzenhofeSzoc K., Curbow B. et al. The prevalence of psychological distress by cancer site. Psychooncology: 2001; 10 19 28 (Pubitemid 32106774)
41. Zhang D., Ma Q., Shen S. et al. Inhibition of pancreatic cancer cell proliferation by propranolol occurs through apoptosis induction: the study of beta-adrenoceptor antagonist's anticancer effect in pancreatic cancer cell. Pancreas: 2009; 38 94 100
42. Zhang D., Ma Q. Y., Hu H. T. et al. β2-adrenergic antagonists suppress pancreatic cancer cell invasion by inhibiting CREB, NFkappaB and AP-1. Cancer Biol Ther: 2010; 10 19 29
43. Zhang D., Ma Q., Wang Z. et al. β2-adrenoceptor blockage induces G1/S phase arrest and apoptosis in pancreatic cancer cells via Ras/Akt/NFkappaB pathway. Mol Cancer: 2011; 10 146