Brain vs behavior: An effect size comparison of neuroimaging and cognitive studies of genetic risk for schizophrenia

Schizophrenia Bulletin

Volumn 39, Issue 3, 2013, Pages 518-526

  Rose, Emma Jane ^a,b   Donohoe, Gary ^a,b  

^a ST JAMES S HOSPITAL   (Ireland)

^b TRINITY COLLEGE DUBLIN   (Ireland)

Author keywords

effect size; endophenotype; imaging genetics; meta analysis; neurocognitive; schizophrenia

Indexed keywords

DISRUPTED IN SCHIZOPHRENIA 1 PROTEIN; DYSBINDIN; RGS4 PROTEIN;

ARTICLE; BEHAVIOR; BRAIN; BRAIN FUNCTION; COGNITION; COMPARATIVE STUDY; DIFFUSION TENSOR IMAGING; EFFECT SIZE; ELECTROENCEPHALOGRAPHY; FUNCTIONAL MAGNETIC RESONANCE IMAGING; GENE FREQUENCY; GENETIC RISK; HUMAN; META ANALYSIS; NEUROIMAGING; PENETRANCE; PRIORITY JOURNAL; PUBLISHING; SAMPLE SIZE; SCHIZOPHRENIA; SYSTEMATIC REVIEW; VOXEL BASED MORPHOMETRY;

BRAIN; COGNITION DISORDERS; ELECTROENCEPHALOGRAPHY; FUNCTIONAL NEUROIMAGING; GENETIC PREDISPOSITION TO DISEASE; HUMANS; MAGNETIC RESONANCE IMAGING; NEUROIMAGING; NEUROPSYCHOLOGICAL TESTS; SCHIZOPHRENIA; SCHIZOPHRENIC PSYCHOLOGY;

EID: 84876561583     PISSN: 05867614     EISSN: 17451701     Source Type: Journal    
DOI: 10.1093/schbul/sbs056     Document Type: Article

References (34)

1. Owen MJ, O'Donovan MC, Gottesman II. Schizophrenia. In: McGuffin P, Owen MJ, Gottesman II, eds. Psychiatric Genetics and Genomics. Oxford, UK: Oxford University Press; 2002:247-266.
2. Risch N. Linkage strategies for genetically complex traits. II. The power of affected relative pairs. Am J Hum Genet. 1990;46:229-241.
3. Tan HY, Callicott JH, Weinberger DR. Intermediate phenotypes in schizophrenia genetics redux: is it a no brainer? Mol Psychiatry. 2008;13:233-238. (Pubitemid 351272661)
4. Gottesman II, Gould TD. The endophenotype concept in psychiatry: etymology and strategic intentions. Am J Psychiatry. 2003;160:636-645. (Pubitemid 41079594)
5. Berrettini WH. Genetic bases for endophenotypes in psychiatric disorders. Dialogues Clin Neurosci. 2005;7:95-101. (Pubitemid 40961530)
6. Green MF, Kern RS, Heaton RK. Longitudinal studies of cognition and functional outcome in schizophrenia: implications for MATRICS. Schizophr Res. 2004;72:41-51. (Pubitemid 39452904)
7. Toulopoulou T, Picchioni M, Rijsdijk F, et al. Substantial genetic overlap between neurocognition and schizophrenia-genetic modeling in twin samples. Arch Gen Psychiatry. 2007;64:1348-1355. (Pubitemid 350223552)
8. Bartley AJ, Jones DW, Weinberger DR. Genetic variability of human brain size and cortical gyral patterns. Brain. 1997;120:257-269. (Pubitemid 27107659)
9. O'Donovan MC, Craddock N, Owen MJ. Schizophrenia: complex genetics, not fairy tales. Psychol Med. 2008;38:1697-1699; discussion 1818-1820.
10. Rasetti R, Weinberger DR. Intermediate phenotypes in psychiatric disorders. Curr Opin Genet Dev. 2011;21:340-348.
11. Porteous DJ, Thomson P, Brandon NJ, Millar JK. The genetics and biology of DISC1-An emerging role in psychosis and cognition. Biol Psychiatry. 2006;60:123-131.
12. Blackwood DHR, Fordyce A, Walker MT, St Clair DM, Porteous DJ, Muir WJ. Schizophrenia and affective disorders-cosegregation with a translocation at chromosome 1q42 that directly disrupts brain-expressed genes: clinical and P300 findings in a family. Am J Hum Genet. 2001;69:428-433. (Pubitemid 32695214)
13. Funke B, Finn CT, Plocik AM, et al. Association of the DTNBP1 locus with schizophrenia in a U.S. population. Am J Hum Genet. 2004;75:891-898. (Pubitemid 39390497)
14. Riley B, Kendler KS. Molecular genetic studies of schizophrenia. Eur J Hum Genet. 2006;14:669-680. (Pubitemid 43797264)
15. Sun J, Kuo PH, Riley BP, Kendler KS, Zhao Z. Candidate genes for schizophrenia: a survey of association studies and gene ranking. Am J Med Genet B Neuropsychiatr Genet. 2008;147B:1173-1181.
16. Tosato S, Ruggeri M, Bonetto C, et al. Association study of dysbindin gene with clinical and outcome measures in a representative cohort of Italian schizophrenic patients. Am J Med Genet B Neuropsychiatr Genet. 2007;144B:647-659. (Pubitemid 47077150)
17. Hall J, Whalley HC, Job DE, et al. A neuregulin 1 variant associated with abnormal cortical function and psychotic symptoms. Nat Neurosci. 2006;9:1477-1478. (Pubitemid 44862654)
18. Stefansson H, Sigurdsson E, Steinthorsdottir V, et al. Neuregulin 1 and susceptibility to schizophrenia. Am J Hum Genet. 2002;71:110.
19. Harrison PJ, Weinberger DR. Schizophrenia genes, gene expression, and neuropathology: on the matter of their convergence. Mol Psychiatry. 2005;10:40-68. (Pubitemid 40139588)
20. Brzustowicz LM, Hodgkinson KA, Chow EW, Honer WG, Bassett AS. Location of a major susceptibility locus for familial schizophrenia on chromosome 1q21-q22. Science. 2000; 288:678-682. (Pubitemid 30241572)
21. Detera-Wadleigh SD, McMahon FJ. G72/G30 in schizophrenia and bipolar disorder: review and meta-analysis. Biol Psychiatry. 2006;60:106-114. (Pubitemid 44026593)
22. O'Donovan MC, Craddock N, Norton N, et al. Identification of loci associated with schizophrenia by genome-wide association and follow-up. Nat Genet. 2008;40:1053-1055.
23. Stefansson H, Ophoff RA, Steinberg S, et al. Common variants conferring risk of schizophrenia. Nature. 2009;460:744-747.
24. Green EK, Grozeva D, Jones I, et al. The bipolar disorder risk allele at CACNA1C also confers risk of recurrent major depression and of schizophrenia. Mol Psychiatry. 2010;15:1016-1022.
25. ClinTools Software for Windows: Version 4 [computer program]. Psytek Ltd; 2005. http://www.clintools.com. Accessed August 29, 2011.
26. Cohen J. Statistical Power Analysis for the Behavioral Sciences. 2nd ed. Hillsdale, NJ: Lawrence Erlbaum Associates; 1988.
27. Sterne JA, Harbord RM. Funnel plots in meta-analysis. Stata J. 2004;4:127-141.
28. Sterne JA, Egger M. Funnel plots for detecting bias in metaanalysis: guidelines on choice of axis. J Clin Epidemiol. 2001;54:1046-1055. (Pubitemid 32888370)
29. Egger M, Davey Smith G, Schneider M, Minder C. Bias in meta-analysis detected by a simple, graphical test. BMJ. 1997;315:629-634. (Pubitemid 27387172)
30. Meyer-Lindenberg A, Nicodemus KK, Egan MF, Callicott JH, Mattay V, Weinberger DR. False positives in imaging genetics. Neuroimage. 2008;40:655-661.
31. Stefanis NC, Trikalinos TA, Avramopoulos D, et al. Impact of schizophrenia candidate genes on schizotypy and cognitive endophenotypes at the population level. Biol Psychiatry. 2007;62:784-792. (Pubitemid 47374644)
32. Alfimova MV, Monakhov MV, Abramova LI, Golubev SA, Golimbet VE. Polymorphism of serotonin receptor genes (5-HTR2A) and Dysbindin (DTNBP1) and individual components of short-term verbal memory processes in Schizophrenia. Neurosci Behav Physiol. 2010;40:934-940.
33. Walters JT, Owen MJ. Endophenotypes in psychiatric genetics. Mol Psychiatry. 2007;12:886-890. (Pubitemid 47482705)
34. Kendler KS, Neale MC. Endophenotype: a conceptual analysis. Mol Psychiatry. 2010;15:789-797.