메뉴 건너뛰기




Volumn 28, Issue 1, 2014, Pages 63-68

Mitochondrial enhancement for neurodegenerative movement disorders: A systematic review of trials involving creatine, coenzyme Q10, idebenone and mitoquinone

Author keywords

[No Author keywords available]

Indexed keywords

8 HYDROXYDEOXYGUANOSINE; CARNITINE; CREATINE; GPI 1485; IDEBENONE; MITOQUINONE; PLACEBO; QUINONE DERIVATIVE; REMACEMIDE; UBIDECARENONE; UNCLASSIFIED DRUG;

EID: 84893517755     PISSN: 11727047     EISSN: 11791934     Source Type: Journal    
DOI: 10.1007/s40263-013-0124-4     Document Type: Review
Times cited : (45)

References (33)
  • 1
    • 57649171115 scopus 로고    scopus 로고
    • Mitochondrial approaches for neuroprotection
    • 1:CAS:528:DC%2BD1MXhsVejsr4%3D 2605644 19076459 10.1196/annals.1427.027
    • Chaturvedi RK, Beal MF. Mitochondrial approaches for neuroprotection. Ann N Y Acad Sci. 2008;1147:395-412.
    • (2008) Ann N y Acad Sci. , vol.1147 , pp. 395-412
    • Chaturvedi, R.K.1    Beal, M.F.2
  • 2
    • 0038336912 scopus 로고    scopus 로고
    • Coenzyme Q induces nigral mitochondrial uncoupling and prevents dopamine cell loss in a primate model of Parkinson's disease
    • 1:CAS:528:DC%2BD3sXkvF2ks7Y%3D 12810526 10.1210/en.2003-0163
    • Horvath TL, Diano S, Leranth C, Garcia-Segura LM, Cowley MA, Shanabrough M, et al. Coenzyme Q induces nigral mitochondrial uncoupling and prevents dopamine cell loss in a primate model of Parkinson's disease. Endocrinology. 2003;144:2757-60.
    • (2003) Endocrinology. , vol.144 , pp. 2757-2760
    • Horvath, T.L.1    Diano, S.2    Leranth, C.3    Garcia-Segura, L.M.4    Cowley, M.A.5    Shanabrough, M.6
  • 3
  • 4
    • 0035834571 scopus 로고    scopus 로고
    • An association between idiopathic Parkinson's disease and polymorphisms of phase II detoxification enzymes: Glutathione S-transferase M1 and quinone oxidoreductase 1 and 2
    • 1:CAS:528:DC%2BD3MXnvFGit7s%3D 11688992 10.1006/bbrc.2001.5868
    • Harada S, Fujii C, Hayashi A, Ohkoshi N. An association between idiopathic Parkinson's disease and polymorphisms of phase II detoxification enzymes: glutathione S-transferase M1 and quinone oxidoreductase 1 and 2. Biochem Biophys Res Commun. 2001;288:887-92.
    • (2001) Biochem Biophys Res Commun. , vol.288 , pp. 887-892
    • Harada, S.1    Fujii, C.2    Hayashi, A.3    Ohkoshi, N.4
  • 5
    • 84655167081 scopus 로고    scopus 로고
    • The effects of idebenone on mitochondrial bioenergetics
    • 1:CAS:528:DC%2BC38XhtlWhsw%3D%3D 3265671 22086148 10.1016/j.bbabio.2011. 10.012
    • Giorgio V, Petronilli V, Ghelli A, Carelli V, Rugolo M, Lenaz G, et al. The effects of idebenone on mitochondrial bioenergetics. Biochim Biophys Acta. 2012;1817:363-9.
    • (2012) Biochim Biophys Acta. , vol.1817 , pp. 363-369
    • Giorgio, V.1    Petronilli, V.2    Ghelli, A.3    Carelli, V.4    Rugolo, M.5    Lenaz, G.6
  • 6
    • 84880440278 scopus 로고    scopus 로고
    • Mutations in COQ2 in familial and sporadic multiple-system atrophy
    • The Multiple-System Atrophy Research Collaboration 10.1056/NEJMoa1212115
    • The Multiple-System Atrophy Research Collaboration. Mutations in COQ2 in familial and sporadic multiple-system atrophy. N Engl J Med. 2013;369:233-44.
    • (2013) N Engl J Med. , vol.369 , pp. 233-244
  • 7
    • 63149125653 scopus 로고    scopus 로고
    • Pharmacotherapy for Friedreich ataxia
    • 1:CAS:528:DC%2BD1MXlsVajt7g%3D 19320530 10.2165/00023210-200923030-00003
    • Tsou AY, Friedman LS, Wilson RB, Lynch DR. Pharmacotherapy for Friedreich ataxia. CNS Drugs. 2009;23:213-23.
    • (2009) CNS Drugs. , vol.23 , pp. 213-223
    • Tsou, A.Y.1    Friedman, L.S.2    Wilson, R.B.3    Lynch, D.R.4
  • 9
    • 33749835508 scopus 로고    scopus 로고
    • Creatine supplementation in Parkinson disease: A placebo-controlled randomized pilot trial
    • 1:CAS:528:DC%2BD28XhtFyqtLfF 17030762 10.1212/01.wnl.0000238518.34389.12
    • Bender A, Koch W, Elstner M, Schombacher Y, Bender J, Moeschl M, et al. Creatine supplementation in Parkinson disease: a placebo-controlled randomized pilot trial. Neurology. 2006;67:1262-4.
    • (2006) Neurology. , vol.67 , pp. 1262-1264
    • Bender, A.1    Koch, W.2    Elstner, M.3    Schombacher, Y.4    Bender, J.5    Moeschl, M.6
  • 10
    • 33846948238 scopus 로고    scopus 로고
    • Resistance training with creatine monohydrate improves upper-body strength in patients with Parkinson disease: A randomized trial
    • 17312085 10.1177/1545968306293449
    • Hass CJ, Collins MA, Juncos JL. Resistance training with creatine monohydrate improves upper-body strength in patients with Parkinson disease: a randomized trial. Neurorehabil Neural Repair. 2007;21:107-15.
    • (2007) Neurorehabil Neural Repair. , vol.21 , pp. 107-115
    • Hass, C.J.1    Collins, M.A.2    Juncos, J.L.3
  • 11
    • 0037426566 scopus 로고    scopus 로고
    • Coenzyme Q10 supplementation provides mild symptomatic benefit in patients with Parkinson's disease
    • 12697283 10.1016/S0304-3940(03)00185-X
    • Müller T, Buttner T, Gholipour AF, Kuhn W. Coenzyme Q10 supplementation provides mild symptomatic benefit in patients with Parkinson's disease. Neurosci Lett. 2003;341:201-4.
    • (2003) Neurosci Lett. , vol.341 , pp. 201-204
    • Müller, T.1    Buttner, T.2    Gholipour, A.F.3    Kuhn, W.4
  • 12
    • 33645894705 scopus 로고    scopus 로고
    • A randomized, double-blind, futility clinical trial of creatine and minocycline in early Parkinson disease
    • The NINDS NET-PD Investigators 10.1212/01.wnl.0000201252.57661.e1
    • The NINDS NET-PD Investigators. A randomized, double-blind, futility clinical trial of creatine and minocycline in early Parkinson disease. Neurology. 2006;66:664-71.
    • (2006) Neurology. , vol.66 , pp. 664-671
  • 13
    • 33846115045 scopus 로고    scopus 로고
    • A randomized clinical trial of coenzyme Q10 and GPI-1485 in early Parkinson disease
    • The NINDS NET-PD Investigators 10.1212/01.wnl.0000250355.28474.8e
    • The NINDS NET-PD Investigators. A randomized clinical trial of coenzyme Q10 and GPI-1485 in early Parkinson disease. Neurology. 2007;68:20-8.
    • (2007) Neurology. , vol.68 , pp. 20-28
  • 14
    • 0036771852 scopus 로고    scopus 로고
    • Effects of coenzyme Q10 in early Parkinson disease: Evidence of slowing of the functional decline
    • 12374491 10.1001/archneur.59.10.1541
    • Shults CW, Oakes D, Kieburtz K, Beal MF, Haas R, Plumb S, et al. Effects of coenzyme Q10 in early Parkinson disease: evidence of slowing of the functional decline. Arch Neurol. 2002;59:1541-50.
    • (2002) Arch Neurol. , vol.59 , pp. 1541-1550
    • Shults, C.W.1    Oakes, D.2    Kieburtz, K.3    Beal, M.F.4    Haas, R.5    Plumb, S.6
  • 15
    • 77955792985 scopus 로고    scopus 로고
    • A double-blind, placebo-controlled study to assess the mitochondria-targeted antioxidant MitoQ as a disease-modifying therapy in Parkinson's disease
    • 20568096 10.1002/mds.23148
    • Snow BJ, Rolfe FL, Lockhart MM, Frampton CM, O'Sullivan JD, Fung V, et al. A double-blind, placebo-controlled study to assess the mitochondria-targeted antioxidant MitoQ as a disease-modifying therapy in Parkinson's disease. Mov Disord. 2010;25:1670-4.
    • (2010) Mov Disord. , vol.25 , pp. 1670-1674
    • Snow, B.J.1    Rolfe, F.L.2    Lockhart, M.M.3    Frampton, C.M.4    O'Sullivan, J.D.5    Fung, V.6
  • 16
    • 34447252358 scopus 로고    scopus 로고
    • Randomized, double-blind, placebo-controlled trial on symptomatic effects of coenzyme Q(10) in Parkinson disease
    • 17502459 10.1001/archneur.64.7.nct60005
    • Storch A, Jost WH, Vieregge P, Spiegel J, Greulich W, Durner J, et al. Randomized, double-blind, placebo-controlled trial on symptomatic effects of coenzyme Q(10) in Parkinson disease. Arch Neurol. 2007;64:938-44.
    • (2007) Arch Neurol. , vol.64 , pp. 938-944
    • Storch, A.1    Jost, W.H.2    Vieregge, P.3    Spiegel, J.4    Greulich, W.5    Durner, J.6
  • 17
    • 49249087500 scopus 로고    scopus 로고
    • Short-term effects of coenzyme Q10 in progressive supranuclear palsy: A randomized, placebo-controlled trial
    • 18464278 10.1002/mds.22023
    • Stamelou M, Reuss A, Pilatus U, Magerkurth J, Niklowitz P, Eggert KM, et al. Short-term effects of coenzyme Q10 in progressive supranuclear palsy: a randomized, placebo-controlled trial. Mov Disord. 2008;23:942-9.
    • (2008) Mov Disord. , vol.23 , pp. 942-949
    • Stamelou, M.1    Reuss, A.2    Pilatus, U.3    Magerkurth, J.4    Niklowitz, P.5    Eggert, K.M.6
  • 18
    • 33644927838 scopus 로고    scopus 로고
    • Creatine in Huntington disease is safe, tolerable, bioavailable in brain and reduces serum 8OH2'dG
    • 1:CAS:528:DC%2BD28XpsFGj 16434666 10.1212/01.wnl.0000194318.74946.b6
    • Hersch SM, Gevorkian S, Marder K, Moskowitz C, Feigin A, Cox M, et al. Creatine in Huntington disease is safe, tolerable, bioavailable in brain and reduces serum 8OH2'dG. Neurology. 2006;66:250-2.
    • (2006) Neurology. , vol.66 , pp. 250-252
    • Hersch, S.M.1    Gevorkian, S.2    Marder, K.3    Moskowitz, C.4    Feigin, A.5    Cox, M.6
  • 19
    • 85009226418 scopus 로고    scopus 로고
    • A randomized, placebo-controlled trial of coenzyme Q10 and remacemide in Huntington's disease
    • The Huntington Study Group
    • The Huntington Study Group. A randomized, placebo-controlled trial of coenzyme Q10 and remacemide in Huntington's disease. Neurology. 2001;57:397-404.
    • (2001) Neurology. , vol.57 , pp. 397-404
  • 20
    • 9544255791 scopus 로고    scopus 로고
    • A controlled trial of idebenone in Huntington's disease
    • 1:STN:280:DyaK2s%2FitVSnsA%3D%3D 8866496 10.1002/mds.870110510
    • Ranen NG, Peyser CE, Coyle JT, Bylsma FW, Sherr M, Day L, et al. A controlled trial of idebenone in Huntington's disease. Mov Disord. 1996;11:549-54.
    • (1996) Mov Disord. , vol.11 , pp. 549-554
    • Ranen, N.G.1    Peyser, C.E.2    Coyle, J.T.3    Bylsma, F.W.4    Sherr, M.5    Day, L.6
  • 21
    • 34548606803 scopus 로고    scopus 로고
    • Neurological effects of high-dose idebenone in patients with Friedreich's ataxia: A randomized, placebo-controlled trial
    • 17826341 10.1016/S1474-4422(07)70220-X
    • Di Prospero NA, Baker A, Jeffries N, Fischbeck KH. Neurological effects of high-dose idebenone in patients with Friedreich's ataxia: a randomized, placebo-controlled trial. Lancet Neurol. 2007;6:878-86.
    • (2007) Lancet Neurol. , vol.6 , pp. 878-886
    • Di Prospero, N.A.1    Baker, A.2    Jeffries, N.3    Fischbeck, K.H.4
  • 22
    • 77955450939 scopus 로고    scopus 로고
    • A phase 3, double-blind, placebo-controlled trial of idebenone in friedreich ataxia
    • 20697044 10.1001/archneurol.2010.168
    • Lynch DR, Perlman SL, Meier T. A phase 3, double-blind, placebo-controlled trial of idebenone in friedreich ataxia. Arch Neurol. 2010;67:941-7.
    • (2010) Arch Neurol. , vol.67 , pp. 941-947
    • Lynch, D.R.1    Perlman, S.L.2    Meier, T.3
  • 23
    • 0037849955 scopus 로고    scopus 로고
    • Idebenone treatment in Friedreich patients: One-year-long randomized placebo-controlled trial
    • 1:CAS:528:DC%2BD3sXjsVOqtLk%3D 12771264 10.1212/01.WNL.0000055872.50364. FC
    • Mariotti C, Solari A, Torta D, Marano L, Fiorentini C, Di Donato S. Idebenone treatment in Friedreich patients: one-year-long randomized placebo-controlled trial. Neurology. 2003;60:1676-9.
    • (2003) Neurology. , vol.60 , pp. 1676-1679
    • Mariotti, C.1    Solari, A.2    Torta, D.3    Marano, L.4    Fiorentini, C.5    Di Donato, S.6
  • 24
    • 20844443983 scopus 로고    scopus 로고
    • L-carnitine and creatine in Friedreich's ataxia: A randomized, placebo-controlled crossover trial
    • 15480852 10.1007/s00702-004-0216-x
    • Schöls L, Zange J, Abele M, Schillings M, Skipka G, Kuntz-Hehner S, et al. L-carnitine and creatine in Friedreich's ataxia: a randomized, placebo-controlled crossover trial. J Neural Transm. 2005;112:789-96.
    • (2005) J Neural Transm. , vol.112 , pp. 789-796
    • Schöls, L.1    Zange, J.2    Abele, M.3    Schillings, M.4    Skipka, G.5    Kuntz-Hehner, S.6
  • 25
    • 79952451186 scopus 로고    scopus 로고
    • Idebenone in Friedreich ataxia cardiomyopathy: Results from a 6-month phase III study (IONIA)
    • 21392622
    • Lagedrost SJ, Sutton MS, Cohen MS, Satou GM, Kaufman BD, Perlman SL, et al. Idebenone in Friedreich ataxia cardiomyopathy: results from a 6-month phase III study (IONIA). Am Heart J. 2011;161(639-645):e1.
    • (2011) Am Heart J. , vol.161 , Issue.639-645 , pp. 1
    • Lagedrost, S.J.1    Sutton, M.S.2    Cohen, M.S.3    Satou, G.M.4    Kaufman, B.D.5    Perlman, S.L.6
  • 27
    • 84861639638 scopus 로고    scopus 로고
    • Coenzyme Q10 deficiency in patients with Parkinson's disease
    • 1:CAS:528:DC%2BC38XmtlSqtbk%3D 3366011 22542608 10.1016/j.jns.2012.03.023
    • Mischley LK, Allen J, Bradley R. Coenzyme Q10 deficiency in patients with Parkinson's disease. J Neurol Sci. 2012;318:72-5.
    • (2012) J Neurol Sci. , vol.318 , pp. 72-75
    • Mischley, L.K.1    Allen, J.2    Bradley, R.3
  • 28
    • 84863883001 scopus 로고    scopus 로고
    • Creatine and guanidinoacetate transport at blood-brain and blood-cerebrospinal fluid barriers
    • 1:CAS:528:DC%2BC38XpvVyrsrw%3D 22252611 10.1007/s10545-011-9433-2
    • Braissant O. Creatine and guanidinoacetate transport at blood-brain and blood-cerebrospinal fluid barriers. J Inherit Metab Dis. 2012;35:655-64.
    • (2012) J Inherit Metab Dis. , vol.35 , pp. 655-664
    • Braissant, O.1
  • 29
    • 20444392739 scopus 로고    scopus 로고
    • Interactions of mitochondria-targeted and untargeted ubiquinones with the mitochondrial respiratory chain and reactive oxygen species. Implications for the use of exogenous ubiquinones as therapies and experimental tools
    • 1:CAS:528:DC%2BD2MXks1elsLo%3D 15788391 10.1074/jbc.M501527200
    • James AM, Cochemé HM, Smith RA, Murphy MP. Interactions of mitochondria-targeted and untargeted ubiquinones with the mitochondrial respiratory chain and reactive oxygen species. Implications for the use of exogenous ubiquinones as therapies and experimental tools. J Biol Chem. 2005;280:21295-312.
    • (2005) J Biol Chem. , vol.280 , pp. 21295-21312
    • James, A.M.1    Cochemé, H.M.2    Smith, R.A.3    Murphy, M.P.4
  • 30
    • 0000701926 scopus 로고    scopus 로고
    • The interaction of Q analogs, particularly hydroxydecyl benzoquinone (idebenone), with the respiratory complexes of heart mitochondria
    • 1:STN:280:DyaK283jvFWmtA%3D%3D 8660670 10.1006/abbi.1996.0267
    • Esposti MD, Ngo A, Ghelli A, Benelli B, Carelli V, McLennan H, et al. The interaction of Q analogs, particularly hydroxydecyl benzoquinone (idebenone), with the respiratory complexes of heart mitochondria. Arch Biochem Biophys. 1996;330:395-400.
    • (1996) Arch Biochem Biophys. , vol.330 , pp. 395-400
    • Esposti, M.D.1    Ngo, A.2    Ghelli, A.3    Benelli, B.4    Carelli, V.5    McLennan, H.6
  • 31
    • 80053896954 scopus 로고    scopus 로고
    • Idebenone induces apoptotic cell death in the human dopaminergic neuroblastoma SHSY-5Y cells
    • 1:CAS:528:DC%2BC3MXhtF2jtLjK 21547417 10.1007/s12640-011-9245-z
    • Tai KK, Pham L, Truong DD. Idebenone induces apoptotic cell death in the human dopaminergic neuroblastoma SHSY-5Y cells. Neurotox Res. 2011;20:321-8.
    • (2011) Neurotox Res. , vol.20 , pp. 321-328
    • Tai, K.K.1    Pham, L.2    Truong, D.D.3
  • 32
    • 84879097833 scopus 로고    scopus 로고
    • 8OHdG is not a biomarker for Huntington disease state or progression
    • 1:CAS:528:DC%2BC3sXotVSltrs%3D 23616162 10.1212/WNL.0b013e318293e1a1
    • Borowsky B, Warner J, Leavitt BR, Tabrizi SJ, Roos RA, Durr A, et al. 8OHdG is not a biomarker for Huntington disease state or progression. Neurology. 2013;80:1934-41.
    • (2013) Neurology. , vol.80 , pp. 1934-1941
    • Borowsky, B.1    Warner, J.2    Leavitt, B.R.3    Tabrizi, S.J.4    Roos, R.A.5    Durr, A.6
  • 33
    • 2142640816 scopus 로고    scopus 로고
    • Neuroprotective strategies for Parkinson's disease: Conceptual limits of animal models and clinical trials
    • 1:CAS:528:DC%2BD2cXjs1Cnurc%3D 15120490 10.1016/j.tips.2004.03.003
    • Meissner W, Hill MP, Tison F, Gross CE, Bezard E. Neuroprotective strategies for Parkinson's disease: conceptual limits of animal models and clinical trials. Trends Pharmacol Sci. 2004;25:249-53.
    • (2004) Trends Pharmacol Sci. , vol.25 , pp. 249-253
    • Meissner, W.1    Hill, M.P.2    Tison, F.3    Gross, C.E.4    Bezard, E.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.