-
1
-
-
57649171115
-
Mitochondrial approaches for neuroprotection
-
1:CAS:528:DC%2BD1MXhsVejsr4%3D 2605644 19076459 10.1196/annals.1427.027
-
Chaturvedi RK, Beal MF. Mitochondrial approaches for neuroprotection. Ann N Y Acad Sci. 2008;1147:395-412.
-
(2008)
Ann N y Acad Sci.
, vol.1147
, pp. 395-412
-
-
Chaturvedi, R.K.1
Beal, M.F.2
-
2
-
-
0038336912
-
Coenzyme Q induces nigral mitochondrial uncoupling and prevents dopamine cell loss in a primate model of Parkinson's disease
-
1:CAS:528:DC%2BD3sXkvF2ks7Y%3D 12810526 10.1210/en.2003-0163
-
Horvath TL, Diano S, Leranth C, Garcia-Segura LM, Cowley MA, Shanabrough M, et al. Coenzyme Q induces nigral mitochondrial uncoupling and prevents dopamine cell loss in a primate model of Parkinson's disease. Endocrinology. 2003;144:2757-60.
-
(2003)
Endocrinology.
, vol.144
, pp. 2757-2760
-
-
Horvath, T.L.1
Diano, S.2
Leranth, C.3
Garcia-Segura, L.M.4
Cowley, M.A.5
Shanabrough, M.6
-
3
-
-
0032914740
-
Creatine and cyclocreatine attenuate MPTP neurotoxicity
-
1:CAS:528:DyaK1MXis1Klurk%3D 10222117 10.1006/exnr.1999.7049
-
Matthews RT, Ferrante RJ, Klivenyi P, Yang L, Klein AM, Mueller G, et al. Creatine and cyclocreatine attenuate MPTP neurotoxicity. Exp Neurol. 1999;157:142-9.
-
(1999)
Exp Neurol.
, vol.157
, pp. 142-149
-
-
Matthews, R.T.1
Ferrante, R.J.2
Klivenyi, P.3
Yang, L.4
Klein, A.M.5
Mueller, G.6
-
4
-
-
0035834571
-
An association between idiopathic Parkinson's disease and polymorphisms of phase II detoxification enzymes: Glutathione S-transferase M1 and quinone oxidoreductase 1 and 2
-
1:CAS:528:DC%2BD3MXnvFGit7s%3D 11688992 10.1006/bbrc.2001.5868
-
Harada S, Fujii C, Hayashi A, Ohkoshi N. An association between idiopathic Parkinson's disease and polymorphisms of phase II detoxification enzymes: glutathione S-transferase M1 and quinone oxidoreductase 1 and 2. Biochem Biophys Res Commun. 2001;288:887-92.
-
(2001)
Biochem Biophys Res Commun.
, vol.288
, pp. 887-892
-
-
Harada, S.1
Fujii, C.2
Hayashi, A.3
Ohkoshi, N.4
-
5
-
-
84655167081
-
The effects of idebenone on mitochondrial bioenergetics
-
1:CAS:528:DC%2BC38XhtlWhsw%3D%3D 3265671 22086148 10.1016/j.bbabio.2011. 10.012
-
Giorgio V, Petronilli V, Ghelli A, Carelli V, Rugolo M, Lenaz G, et al. The effects of idebenone on mitochondrial bioenergetics. Biochim Biophys Acta. 2012;1817:363-9.
-
(2012)
Biochim Biophys Acta.
, vol.1817
, pp. 363-369
-
-
Giorgio, V.1
Petronilli, V.2
Ghelli, A.3
Carelli, V.4
Rugolo, M.5
Lenaz, G.6
-
6
-
-
84880440278
-
Mutations in COQ2 in familial and sporadic multiple-system atrophy
-
The Multiple-System Atrophy Research Collaboration 10.1056/NEJMoa1212115
-
The Multiple-System Atrophy Research Collaboration. Mutations in COQ2 in familial and sporadic multiple-system atrophy. N Engl J Med. 2013;369:233-44.
-
(2013)
N Engl J Med.
, vol.369
, pp. 233-244
-
-
-
7
-
-
63149125653
-
Pharmacotherapy for Friedreich ataxia
-
1:CAS:528:DC%2BD1MXlsVajt7g%3D 19320530 10.2165/00023210-200923030-00003
-
Tsou AY, Friedman LS, Wilson RB, Lynch DR. Pharmacotherapy for Friedreich ataxia. CNS Drugs. 2009;23:213-23.
-
(2009)
CNS Drugs.
, vol.23
, pp. 213-223
-
-
Tsou, A.Y.1
Friedman, L.S.2
Wilson, R.B.3
Lynch, D.R.4
-
9
-
-
33749835508
-
Creatine supplementation in Parkinson disease: A placebo-controlled randomized pilot trial
-
1:CAS:528:DC%2BD28XhtFyqtLfF 17030762 10.1212/01.wnl.0000238518.34389.12
-
Bender A, Koch W, Elstner M, Schombacher Y, Bender J, Moeschl M, et al. Creatine supplementation in Parkinson disease: a placebo-controlled randomized pilot trial. Neurology. 2006;67:1262-4.
-
(2006)
Neurology.
, vol.67
, pp. 1262-1264
-
-
Bender, A.1
Koch, W.2
Elstner, M.3
Schombacher, Y.4
Bender, J.5
Moeschl, M.6
-
10
-
-
33846948238
-
Resistance training with creatine monohydrate improves upper-body strength in patients with Parkinson disease: A randomized trial
-
17312085 10.1177/1545968306293449
-
Hass CJ, Collins MA, Juncos JL. Resistance training with creatine monohydrate improves upper-body strength in patients with Parkinson disease: a randomized trial. Neurorehabil Neural Repair. 2007;21:107-15.
-
(2007)
Neurorehabil Neural Repair.
, vol.21
, pp. 107-115
-
-
Hass, C.J.1
Collins, M.A.2
Juncos, J.L.3
-
11
-
-
0037426566
-
Coenzyme Q10 supplementation provides mild symptomatic benefit in patients with Parkinson's disease
-
12697283 10.1016/S0304-3940(03)00185-X
-
Müller T, Buttner T, Gholipour AF, Kuhn W. Coenzyme Q10 supplementation provides mild symptomatic benefit in patients with Parkinson's disease. Neurosci Lett. 2003;341:201-4.
-
(2003)
Neurosci Lett.
, vol.341
, pp. 201-204
-
-
Müller, T.1
Buttner, T.2
Gholipour, A.F.3
Kuhn, W.4
-
12
-
-
33645894705
-
A randomized, double-blind, futility clinical trial of creatine and minocycline in early Parkinson disease
-
The NINDS NET-PD Investigators 10.1212/01.wnl.0000201252.57661.e1
-
The NINDS NET-PD Investigators. A randomized, double-blind, futility clinical trial of creatine and minocycline in early Parkinson disease. Neurology. 2006;66:664-71.
-
(2006)
Neurology.
, vol.66
, pp. 664-671
-
-
-
13
-
-
33846115045
-
A randomized clinical trial of coenzyme Q10 and GPI-1485 in early Parkinson disease
-
The NINDS NET-PD Investigators 10.1212/01.wnl.0000250355.28474.8e
-
The NINDS NET-PD Investigators. A randomized clinical trial of coenzyme Q10 and GPI-1485 in early Parkinson disease. Neurology. 2007;68:20-8.
-
(2007)
Neurology.
, vol.68
, pp. 20-28
-
-
-
14
-
-
0036771852
-
Effects of coenzyme Q10 in early Parkinson disease: Evidence of slowing of the functional decline
-
12374491 10.1001/archneur.59.10.1541
-
Shults CW, Oakes D, Kieburtz K, Beal MF, Haas R, Plumb S, et al. Effects of coenzyme Q10 in early Parkinson disease: evidence of slowing of the functional decline. Arch Neurol. 2002;59:1541-50.
-
(2002)
Arch Neurol.
, vol.59
, pp. 1541-1550
-
-
Shults, C.W.1
Oakes, D.2
Kieburtz, K.3
Beal, M.F.4
Haas, R.5
Plumb, S.6
-
15
-
-
77955792985
-
A double-blind, placebo-controlled study to assess the mitochondria-targeted antioxidant MitoQ as a disease-modifying therapy in Parkinson's disease
-
20568096 10.1002/mds.23148
-
Snow BJ, Rolfe FL, Lockhart MM, Frampton CM, O'Sullivan JD, Fung V, et al. A double-blind, placebo-controlled study to assess the mitochondria-targeted antioxidant MitoQ as a disease-modifying therapy in Parkinson's disease. Mov Disord. 2010;25:1670-4.
-
(2010)
Mov Disord.
, vol.25
, pp. 1670-1674
-
-
Snow, B.J.1
Rolfe, F.L.2
Lockhart, M.M.3
Frampton, C.M.4
O'Sullivan, J.D.5
Fung, V.6
-
16
-
-
34447252358
-
Randomized, double-blind, placebo-controlled trial on symptomatic effects of coenzyme Q(10) in Parkinson disease
-
17502459 10.1001/archneur.64.7.nct60005
-
Storch A, Jost WH, Vieregge P, Spiegel J, Greulich W, Durner J, et al. Randomized, double-blind, placebo-controlled trial on symptomatic effects of coenzyme Q(10) in Parkinson disease. Arch Neurol. 2007;64:938-44.
-
(2007)
Arch Neurol.
, vol.64
, pp. 938-944
-
-
Storch, A.1
Jost, W.H.2
Vieregge, P.3
Spiegel, J.4
Greulich, W.5
Durner, J.6
-
17
-
-
49249087500
-
Short-term effects of coenzyme Q10 in progressive supranuclear palsy: A randomized, placebo-controlled trial
-
18464278 10.1002/mds.22023
-
Stamelou M, Reuss A, Pilatus U, Magerkurth J, Niklowitz P, Eggert KM, et al. Short-term effects of coenzyme Q10 in progressive supranuclear palsy: a randomized, placebo-controlled trial. Mov Disord. 2008;23:942-9.
-
(2008)
Mov Disord.
, vol.23
, pp. 942-949
-
-
Stamelou, M.1
Reuss, A.2
Pilatus, U.3
Magerkurth, J.4
Niklowitz, P.5
Eggert, K.M.6
-
18
-
-
33644927838
-
Creatine in Huntington disease is safe, tolerable, bioavailable in brain and reduces serum 8OH2'dG
-
1:CAS:528:DC%2BD28XpsFGj 16434666 10.1212/01.wnl.0000194318.74946.b6
-
Hersch SM, Gevorkian S, Marder K, Moskowitz C, Feigin A, Cox M, et al. Creatine in Huntington disease is safe, tolerable, bioavailable in brain and reduces serum 8OH2'dG. Neurology. 2006;66:250-2.
-
(2006)
Neurology.
, vol.66
, pp. 250-252
-
-
Hersch, S.M.1
Gevorkian, S.2
Marder, K.3
Moskowitz, C.4
Feigin, A.5
Cox, M.6
-
19
-
-
85009226418
-
A randomized, placebo-controlled trial of coenzyme Q10 and remacemide in Huntington's disease
-
The Huntington Study Group
-
The Huntington Study Group. A randomized, placebo-controlled trial of coenzyme Q10 and remacemide in Huntington's disease. Neurology. 2001;57:397-404.
-
(2001)
Neurology.
, vol.57
, pp. 397-404
-
-
-
20
-
-
9544255791
-
A controlled trial of idebenone in Huntington's disease
-
1:STN:280:DyaK2s%2FitVSnsA%3D%3D 8866496 10.1002/mds.870110510
-
Ranen NG, Peyser CE, Coyle JT, Bylsma FW, Sherr M, Day L, et al. A controlled trial of idebenone in Huntington's disease. Mov Disord. 1996;11:549-54.
-
(1996)
Mov Disord.
, vol.11
, pp. 549-554
-
-
Ranen, N.G.1
Peyser, C.E.2
Coyle, J.T.3
Bylsma, F.W.4
Sherr, M.5
Day, L.6
-
21
-
-
34548606803
-
Neurological effects of high-dose idebenone in patients with Friedreich's ataxia: A randomized, placebo-controlled trial
-
17826341 10.1016/S1474-4422(07)70220-X
-
Di Prospero NA, Baker A, Jeffries N, Fischbeck KH. Neurological effects of high-dose idebenone in patients with Friedreich's ataxia: a randomized, placebo-controlled trial. Lancet Neurol. 2007;6:878-86.
-
(2007)
Lancet Neurol.
, vol.6
, pp. 878-886
-
-
Di Prospero, N.A.1
Baker, A.2
Jeffries, N.3
Fischbeck, K.H.4
-
22
-
-
77955450939
-
A phase 3, double-blind, placebo-controlled trial of idebenone in friedreich ataxia
-
20697044 10.1001/archneurol.2010.168
-
Lynch DR, Perlman SL, Meier T. A phase 3, double-blind, placebo-controlled trial of idebenone in friedreich ataxia. Arch Neurol. 2010;67:941-7.
-
(2010)
Arch Neurol.
, vol.67
, pp. 941-947
-
-
Lynch, D.R.1
Perlman, S.L.2
Meier, T.3
-
23
-
-
0037849955
-
Idebenone treatment in Friedreich patients: One-year-long randomized placebo-controlled trial
-
1:CAS:528:DC%2BD3sXjsVOqtLk%3D 12771264 10.1212/01.WNL.0000055872.50364. FC
-
Mariotti C, Solari A, Torta D, Marano L, Fiorentini C, Di Donato S. Idebenone treatment in Friedreich patients: one-year-long randomized placebo-controlled trial. Neurology. 2003;60:1676-9.
-
(2003)
Neurology.
, vol.60
, pp. 1676-1679
-
-
Mariotti, C.1
Solari, A.2
Torta, D.3
Marano, L.4
Fiorentini, C.5
Di Donato, S.6
-
24
-
-
20844443983
-
L-carnitine and creatine in Friedreich's ataxia: A randomized, placebo-controlled crossover trial
-
15480852 10.1007/s00702-004-0216-x
-
Schöls L, Zange J, Abele M, Schillings M, Skipka G, Kuntz-Hehner S, et al. L-carnitine and creatine in Friedreich's ataxia: a randomized, placebo-controlled crossover trial. J Neural Transm. 2005;112:789-96.
-
(2005)
J Neural Transm.
, vol.112
, pp. 789-796
-
-
Schöls, L.1
Zange, J.2
Abele, M.3
Schillings, M.4
Skipka, G.5
Kuntz-Hehner, S.6
-
25
-
-
79952451186
-
Idebenone in Friedreich ataxia cardiomyopathy: Results from a 6-month phase III study (IONIA)
-
21392622
-
Lagedrost SJ, Sutton MS, Cohen MS, Satou GM, Kaufman BD, Perlman SL, et al. Idebenone in Friedreich ataxia cardiomyopathy: results from a 6-month phase III study (IONIA). Am Heart J. 2011;161(639-645):e1.
-
(2011)
Am Heart J.
, vol.161
, Issue.639-645
, pp. 1
-
-
Lagedrost, S.J.1
Sutton, M.S.2
Cohen, M.S.3
Satou, G.M.4
Kaufman, B.D.5
Perlman, S.L.6
-
26
-
-
0033962637
-
Serum levels of coenzyme Q10 in patients with Parkinson's disease
-
10847558 10.1007/s007020050015
-
Jiménez-Jiménez FJ, Molina JA, de Bustos F, García-Redondo A, Gómez-Escalonilla C, Martínez-Salio A, et al. Serum levels of coenzyme Q10 in patients with Parkinson's disease. J Neural Transm. 2000;107:177-81.
-
(2000)
J Neural Transm.
, vol.107
, pp. 177-181
-
-
Jiménez-Jiménez, F.J.1
Molina, J.A.2
De Bustos, F.3
García-Redondo, A.4
Gómez-Escalonilla, C.5
Martínez-Salio, A.6
-
27
-
-
84861639638
-
Coenzyme Q10 deficiency in patients with Parkinson's disease
-
1:CAS:528:DC%2BC38XmtlSqtbk%3D 3366011 22542608 10.1016/j.jns.2012.03.023
-
Mischley LK, Allen J, Bradley R. Coenzyme Q10 deficiency in patients with Parkinson's disease. J Neurol Sci. 2012;318:72-5.
-
(2012)
J Neurol Sci.
, vol.318
, pp. 72-75
-
-
Mischley, L.K.1
Allen, J.2
Bradley, R.3
-
28
-
-
84863883001
-
Creatine and guanidinoacetate transport at blood-brain and blood-cerebrospinal fluid barriers
-
1:CAS:528:DC%2BC38XpvVyrsrw%3D 22252611 10.1007/s10545-011-9433-2
-
Braissant O. Creatine and guanidinoacetate transport at blood-brain and blood-cerebrospinal fluid barriers. J Inherit Metab Dis. 2012;35:655-64.
-
(2012)
J Inherit Metab Dis.
, vol.35
, pp. 655-664
-
-
Braissant, O.1
-
29
-
-
20444392739
-
Interactions of mitochondria-targeted and untargeted ubiquinones with the mitochondrial respiratory chain and reactive oxygen species. Implications for the use of exogenous ubiquinones as therapies and experimental tools
-
1:CAS:528:DC%2BD2MXks1elsLo%3D 15788391 10.1074/jbc.M501527200
-
James AM, Cochemé HM, Smith RA, Murphy MP. Interactions of mitochondria-targeted and untargeted ubiquinones with the mitochondrial respiratory chain and reactive oxygen species. Implications for the use of exogenous ubiquinones as therapies and experimental tools. J Biol Chem. 2005;280:21295-312.
-
(2005)
J Biol Chem.
, vol.280
, pp. 21295-21312
-
-
James, A.M.1
Cochemé, H.M.2
Smith, R.A.3
Murphy, M.P.4
-
30
-
-
0000701926
-
The interaction of Q analogs, particularly hydroxydecyl benzoquinone (idebenone), with the respiratory complexes of heart mitochondria
-
1:STN:280:DyaK283jvFWmtA%3D%3D 8660670 10.1006/abbi.1996.0267
-
Esposti MD, Ngo A, Ghelli A, Benelli B, Carelli V, McLennan H, et al. The interaction of Q analogs, particularly hydroxydecyl benzoquinone (idebenone), with the respiratory complexes of heart mitochondria. Arch Biochem Biophys. 1996;330:395-400.
-
(1996)
Arch Biochem Biophys.
, vol.330
, pp. 395-400
-
-
Esposti, M.D.1
Ngo, A.2
Ghelli, A.3
Benelli, B.4
Carelli, V.5
McLennan, H.6
-
31
-
-
80053896954
-
Idebenone induces apoptotic cell death in the human dopaminergic neuroblastoma SHSY-5Y cells
-
1:CAS:528:DC%2BC3MXhtF2jtLjK 21547417 10.1007/s12640-011-9245-z
-
Tai KK, Pham L, Truong DD. Idebenone induces apoptotic cell death in the human dopaminergic neuroblastoma SHSY-5Y cells. Neurotox Res. 2011;20:321-8.
-
(2011)
Neurotox Res.
, vol.20
, pp. 321-328
-
-
Tai, K.K.1
Pham, L.2
Truong, D.D.3
-
32
-
-
84879097833
-
8OHdG is not a biomarker for Huntington disease state or progression
-
1:CAS:528:DC%2BC3sXotVSltrs%3D 23616162 10.1212/WNL.0b013e318293e1a1
-
Borowsky B, Warner J, Leavitt BR, Tabrizi SJ, Roos RA, Durr A, et al. 8OHdG is not a biomarker for Huntington disease state or progression. Neurology. 2013;80:1934-41.
-
(2013)
Neurology.
, vol.80
, pp. 1934-1941
-
-
Borowsky, B.1
Warner, J.2
Leavitt, B.R.3
Tabrizi, S.J.4
Roos, R.A.5
Durr, A.6
-
33
-
-
2142640816
-
Neuroprotective strategies for Parkinson's disease: Conceptual limits of animal models and clinical trials
-
1:CAS:528:DC%2BD2cXjs1Cnurc%3D 15120490 10.1016/j.tips.2004.03.003
-
Meissner W, Hill MP, Tison F, Gross CE, Bezard E. Neuroprotective strategies for Parkinson's disease: conceptual limits of animal models and clinical trials. Trends Pharmacol Sci. 2004;25:249-53.
-
(2004)
Trends Pharmacol Sci.
, vol.25
, pp. 249-253
-
-
Meissner, W.1
Hill, M.P.2
Tison, F.3
Gross, C.E.4
Bezard, E.5
|