Respiratory and behavioral dysfunction following loss of the GABAA receptor α4 subunit

Brain and Behavior

Volumn 3, Issue 2, 2013, Pages 104-113

  Loria, C Jean ^a   Stevens, Ashley M ^a   Crummy, Ellen ^a   Casadesus, Gemma ^a   Jacono, Frank J ^a,b   Dick, Thomas E ^a   Siegel, Ruth E ^a  

^a CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b LOUIS STOKES CLEVELAND VA MEDICAL CENTER   (United States)

Author keywords

Control of breathing; GABAA receptor subunits; Pons; Ventilatory response

Indexed keywords

4 AMINOBUTYRIC ACID A RECEPTOR; 4 AMINOBUTYRIC ACID A RECEPTOR ALPHA4; 4 AMINOBUTYRIC ACID A RECEPTOR ALPHA6; 4 AMINOBUTYRIC ACID A RECEPTOR DELTA; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANXIETY; ARTICLE; BEHAVIOR DISORDER; BREATHING PATTERN; CONTROLLED STUDY; FEMALE; HYPOXIA; MALE; MOTOR PERFORMANCE; MOUSE; NONHUMAN; PONS; PRIORITY JOURNAL; PROTEIN DEPLETION; PROTEIN EXPRESSION; RESPIRATORY FAILURE; RESPIRATORY FUNCTION;

EID: 84893507164     PISSN: None     EISSN: 21623279     Source Type: Journal    
DOI: 10.1002/brb3.122     Document Type: Article

References (50)

1. Abelson, J. L., S. Khan, and N. Giardino, 2010. HPA axis, respiration and the airways in stress - a review in search of intersections. Biol. Psychol. 84:57-65.
2. Alheid, G. F., W. K. Milsom, and D. R. McCrimmon, 2004. Pontine influences on breathing: an overview. Respir. Physiol. Neurobiol. 143:105-114.
3. Brennan, M., M. Palaniswami, and P. Kamen, 2002. Poincare plot interpretation using a physiological model of HRV based on a network of oscillators. Am. J. Physiol. Heart Circ. Physiol. 283:H1873-H1886.
4. A receptors suggest differential targeting of receptor subtypes. J. Neurosci. 19:2960-2973.
5. Bruce, E. N. 1997. Chemoreflex and vagal afferent mechanisms enhance breath to breath variability of breathing. Respir. Physiol. 110:237-244.
6. Chamberlin, N. L. 2004. Functional organization of the parabrachial complex and intertrigeminal region in the control of breathing. Respir. Physiol. Neurobiol. 143:115-125.
7. A receptor alpha 4 subunits mediate extrasynaptic inhibition in thalamus and dentate gyrus and the action of gaboxadol. Proc. Natl. Acad. Sci. USA 103:15230-15235.
8. A receptor alpha 4 subunit knockout mice. Alcohol. Clin. Exp. Res. 32:10-18.
9. Dubois, D. W., A. Perlegas, D. W. Floyd, J. L. Weiner, and B. A. McCool, 2006. Distinct functional characteristics of the lateral/basolateral amygdala GABAergic system in C57BL/6J and DBA/2J mice. J. Pharmacol. Exp. Ther. 318:629-640.
10. Eldridge, F. L., D. Paydarfar, P. G. Wagner, and R. T. Dowell, 1989. Phase resetting of respiratory rhythm: effect of changing respiratory "drive". Am. J. Physiol. 257:R271-R277.
11. Farrant, M., and Z. Nusser, 2005. Variations on an inhibitory theme: phasic and tonic activation of GABA(A) receptors. Nat. Rev. Neurosci. 6:215-229.
12. Fishman, M., F. J. Jacono, S. Park, R. Jamasebi, A. Thungtong, K. A. Loparo, et al. 2012. A method for analyzing temporal patterns of variability of a time series from Poincare plots. J. Appl. Physiol. 113:297-306.
13. Frazao, R., M. I. Nogueira, and H. Wassle, 2007. Colocalization of synaptic GABA(C)-receptors with GABA (A)-receptors and glycine-receptors in the rodent central nervous system. Cell Tissue Res. 330:1-15.
14. Fritschy, J. M., R. J. Harvey, and G. Schwarz, 2008. Gephyrin: where do we stand, where do we go? Trends Neurosci. 31:257-264.
15. Gonsenhauser, I., C. G. Wilson, F. Han, K. P. Strohl, and T. E. Dick, 2004. Strain differences in murine ventilatory behavior persist after urethane anesthesia. J. Appl. Physiol. 97:888-894.
16. Guthmann, A., J. M. Fritschy, O. P. Ottersen, R. Torp, and H. Herbert, 1998. GABA, GABA transporters, GABA(A) receptor subunits, and GAD mRNAs in the rat parabrachial and Kolliker-Fuse nuclei. J. Comp. Neurol. 400:229-243.
17. Hedner, J., T. Hedner, J. Jonason, and D. Lundberg, 1981. GABA-ergic mechanisms in central respiratory control in the anesthetized rat. Naunyn Schmiedebergs Arch. Pharmacol. 317:315-320.
18. Hsieh, Y. H., R. E. Siegel, and T. E. Dick, 2004. Pontine GABAergic pathways: role and plasticity in the hypoxic ventilatory response. Respir. Physiol. Neurobiol. 143:141-153.
19. Hsieh, Y. H., T. E. Dick, and R. E. Siegel, 2008. Adaptation to hypobaric hypoxia involves GABAA receptors in the pons. Am. J. Physiol. Regul. Integr. Comp. Physiol. 294:R549-R557.
20. Huang, Z. J. 2009. Activity-dependent development of inhibitory synapses and innervation pattern: role of GABA signalling and beyond. J. Physiol. 587:1881-1888.
21. Jacono, F. J., M. A. de Georgia, C. G. Wilson, T. E. Dick, and K. A. Loparo, 2010. Data acquisition and complex systems analysis in critical care: developing the intensive care unit of the future. J. Healthc. Eng. 1:337-356.
22. A receptor a subunit is expressed only in cerebellar granule cells. J. Mol. Biol. 214:619-624.
23. Kaufman, D. L., C. R. Houser, and A. J. Tobin, 1991. Two forms of the gamma-aminobutyric acid synthetic enzyme glutamate decarboxylase have distinct intraneuronal distributions and cofactor interactions. J. Neurochem. 56:720-723.
24. Kneussel, M., and S. Loebrich, 2007. Trafficking and synaptic anchoring of ionotropic inhibitory neurotransmitter receptors. Biol. Cell 99:297-309.
25. A receptor alpha 4 subunit deletion on synaptic and extrasynaptic currents in mouse dentate granule cells. Alcohol. Clin. Exp. Res. 32:19-26.
26. Livak, K. J., and T. D. Schmittgen, 2001. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-delta delta C(T)) method. Methods 25:402-408.
27. A receptor selective for a behavioural alcohol antagonist. Nature 346:648-651.
28. Masaoka, Y., and I. Homma, 2000. The source generator of respiratory-related anxiety potential in the human brain. Neurosci. Lett. 283:21-24.
29. Masaoka, Y., and I. Homma, 2004. Amygdala and emotional breathing in humans. Adv. Exp. Med. Biol. 551:9-14.
30. McCrimmon, D. R., W. K. Milsom, and G. F. Alheid, 2004. The rhombencephalon and breathing: a view from the pons. Respir. Physiol. Neurobiol. 143:103-104.
31. Mody, I. 2001. Distinguishing between GABA(A) receptors responsible for tonic and phasic conductances. Neurochem. Res. 26:907-913.
32. Mozhui, K., R. M. Karlsson, T. L. Kash, J. Ihne, M. Norcross, S. Patel, et al. 2010. Strain differences in stress responsivity are associated with divergent amygdala gene expression and glutamate-mediated neuronal excitability. J. Neurosci. 30:5357-5367.
33. Nardi, A. E., R. C. Freire, and W. A. Zin, 2009. Panic disorder and control of breathing. Respir. Physiol. Neurobiol. 167:133-143.
34. Nehrenberg, D. L., R. M. Rodriguiz, M. Cyr, X. Zhang, J. M. Lauder, J. L. Gariepy, et al. 2009. An anxiety-like phenotype in mice selectively bred for aggression. Behav. Brain Res. 201:179-191.
35. A receptors to synaptic and extrasynaptic membranes of cerebellar granule cells. J. Neurosci. 18:1693-1703.
36. A receptor subtypes in the cerebellum of alpha1-subunit-deficient mice. J. Neurochem. 96:136-147.
37. A receptors: subtypes provide diversity of function and pharmacology. Neuropharmacology 56:141-148.
38. Papandreou, I., A. Powell, A. L. Lim, and N. Denko, 2005. Cellular reaction to hypoxia: sensing and responding to an adverse environment. Mutat. Res. 569:87-100.
39. Renner, M., C. G. Specht, and A. Triller, 2008. Molecular dynamics of postsynaptic receptors and scaffold proteins. Curr. Opin. Neurobiol. 18:532-540.
40. Sammon, M. P., and E. N. Bruce, 1991. Vagal afferent activity increases dynamical dimension of respiration in rats. J. Appl. Physiol. 70:1748-1762.
41. A receptor subtypes. Adv. Pharmacol. 54:231-263.
42. Smith, J. C., A. P. Abdala, I. A. Rybak, and J. F. Paton, 2009. Structural and functional architecture of respiratory networks in the mammalian brainstem. Philos. Trans. R. Soc. Lond. B Biol. Sci. 364:2577-2587.
43. Storz, J. F., G. R. Scott, and Z. A. Cheviron, 2010. Phenotypic plasticity and genetic adaptation to high-altitude hypoxia in vertebrates. J. Exp. Biol. 213:4125-4136.
44. Tretter, V., and S. J. Moss, 2008. GABA(A) receptor dynamics and constructing GABAergic synapses. Front. Mol. Neurosci. 1:7.
45. Tretter, V., T. C. Jacob, J. Mukherjee, J. M. Fritschy, M. N. Pangalos, and S. J. Moss, 2008. The clustering of GABA(A) receptor subtypes at inhibitory synapses is facilitated via the direct binding of receptor alpha 2 subunits to gephyrin. J. Neurosci. 28:1356-1365.
46. Tulppo, M. P., T. H. Makikallio, T. E. Takala, T. Seppanen, and H. V. Huikuri, 1996. Quantitative beat-to-beat analysis of heart rate dynamics during exercise. Am. J. Physiol. 271:H244-H252.
47. A receptor subunit expression by pharmacological agents. Pharmacol. Rev. 62:97-135.
48. Waldvogel, H. J., K. Baer, E. Eady, K. L. Allen, R. T. Gilbert, H. Mohler, et al. 2010. Differential localization of gamma-aminobutyric acid type A and glycine receptor subunits and gephyrin in the human pons, medulla oblongata and uppermost cervical segment of the spinal cord: an immunohistochemical study. J. Comp. Neurol. 518:305-328.
49. Walker, M. C., and A. Semyanov, 2008. Regulation of excitability by extrasynaptic GABA(A) receptors. Results Probl. Cell Differ. 44:29-48.
50. Zuperku, E. J., and D. R. McCrimmon, 2002. Gain modulation of respiratory neurons. Respir. Physiol. Neurobiol. 131:121-133.