-
1
-
-
33744818232
-
phox) and hemoxygenase-1 in patients with Type 2 diabetes and microangiopathy
-
DOI 10.1111/j.1464-5491.2006.01879.x
-
A. Adaikalakoteswari, M. Balasubramanyam, M. Rema, and V. Mohan Differential gene expression of NADPH oxidase (p22phox) and hemoxygenase-1 in patients with Type 2 diabetes and microangiopathy Diabet. Med. 23 2006 666 674 (Pubitemid 43830069)
-
(2006)
Diabetic Medicine
, vol.23
, Issue.6
, pp. 666-674
-
-
Adaikalakoteswari, A.1
Balasubramanyam, M.2
Rema, M.3
Mohan, V.4
-
2
-
-
0033527374
-
Expression of NADH/NADPH oxidase p22(phox) in human coronary arteries
-
H. Azumi, N. Inoue, S. Takeshita, Y. Rikitake, S. Kawashima, Y. Hayashi, H. Itoh, and M. Yokoyama Expression of NADH/NADPH oxidase p22phox in human coronary arteries Circulation 100 1999 1494 1498 (Pubitemid 29461459)
-
(1999)
Circulation
, vol.100
, Issue.14
, pp. 1494-1498
-
-
Azumi, H.1
Inoue, N.2
Takeshita, S.3
Rikitake, Y.4
Kawashima, S.5
Hayashi, Y.6
Itoh, H.7
Yokoyama, M.8
-
3
-
-
41949138804
-
PPARδ regulates multiple proinflammatory pathways to suppress atherosclerosis
-
DOI 10.1073/pnas.0711875105
-
G.D. Barish, A.R. Atkins, M. Downes, P. Olson, L.W. Chong, M. Nelson, Y. Zou, H. Hwang, H. Kang, L. Curtiss, R.M. Evans, and C.H. Lee PPARdelta regulates multiple proinflammatory pathways to suppress atherosclerosis Proc. Nat. Acad. Sci. U.S.A. 105 2008 4271 4276 (Pubitemid 351754370)
-
(2008)
Proceedings of the National Academy of Sciences of the United States of America
, vol.105
, Issue.11
, pp. 4271-4276
-
-
Barish, G.D.1
Atkins, A.R.2
Downes, M.3
Olson, P.4
Chong, L.-W.5
Nelson, M.6
Zou, Y.7
Hwang, H.8
Kang, H.9
Curtiss, L.10
Evans, R.M.11
Lee, C.-H.12
-
4
-
-
70349111436
-
Emerging roles of peroxisome proliferator-activated receptor-beta/delta in inflammation
-
D. Bishop-Bailey, and J. Bystrom Emerging roles of peroxisome proliferator-activated receptor-beta/delta in inflammation Pharmacol. Ther. 124 2009 141 150
-
(2009)
Pharmacol. Ther.
, vol.124
, pp. 141-150
-
-
Bishop-Bailey, D.1
Bystrom, J.2
-
5
-
-
0030897348
-
Fasting total plasma homocysteine and atherosclerotic peripheral vascular disease
-
DOI 10.1007/s100169900037
-
S.W. Cheng, A.C. Ting, and J. Wong Fasting total plasma homocysteine and atherosclerotic peripheral vascular disease Ann. Vasc. Surg. 11 1997 217 223 (Pubitemid 27188234)
-
(1997)
Annals of Vascular Surgery
, vol.11
, Issue.3
, pp. 217-223
-
-
Cheng, S.W.K.1
Ting, A.C.W.2
Wong, J.3
-
6
-
-
15744368783
-
The expression of the NADPH oxidase subunit p22phox is regulated by a redox-sensitive pathway in endothelial cells
-
DOI 10.1016/j.freeradbiomed.2004.09.036
-
T. Djordjevic, P.A. BelAiba, R.S. Bonello, S. Wotzlaw, C. Acker, H. Hess, and J. Görlach A. The expression of the NADPH oxidase subunit p22phox is regulated by a redox-sensitive pathway in endothelial cells Free Radical Biol. Med. 38 2005 616 630 (Pubitemid 40416858)
-
(2005)
Free Radical Biology and Medicine
, vol.38
, Issue.5
, pp. 616-630
-
-
Djordjevic, T.1
Pogrebniak, A.2
BelAiba, R.S.3
Bonello, S.4
Wotzlaw, C.5
Acker, H.6
Hess, J.7
Gorlach, A.8
-
8
-
-
38949198356
-
Homocysteine stimulates NADPH oxidase-mediated superoxide production leading to endothelial dysfunction in rats
-
V.E.C.W. Edirimanne, Y.L. Woo, G.N. Siow, J.Y. Pierce, and K.O. Xie Homocysteine stimulates NADPH oxidase-mediated superoxide production leading to endothelial dysfunction in rats Can. J. Physiol. Pharmacol. 85 2007 1236 1247
-
(2007)
Can. J. Physiol. Pharmacol.
, vol.85
, pp. 1236-1247
-
-
Edirimanne, V.E.C.W.1
Woo, Y.L.2
Siow, G.N.3
Pierce, J.Y.4
Xie, K.O.5
-
9
-
-
57349100410
-
Neuroprotective effects of cannabidiol in endotoxin-induced uveitis: Critical role of p38 MAPK activation
-
A.B. El-Remessy, Y. Tang, G. Zhu, S. Matragoon, Y. Khalifa, E.K. Liu, J.Y. Liu, E. Hanson, S. Mian, N. Fatteh, and G.I. Liou Neuroprotective effects of cannabidiol in endotoxin-induced uveitis: critical role of p38 MAPK activation Mol. Vis. 14 2008 2190 2203
-
(2008)
Mol. Vis.
, vol.14
, pp. 2190-2203
-
-
El-Remessy, A.B.1
Tang, Y.2
Zhu, G.3
Matragoon, S.4
Khalifa, Y.5
Liu, E.K.6
Liu, J.Y.7
Hanson, E.8
Mian, S.9
Fatteh, N.10
Liou, G.I.11
-
10
-
-
38549127422
-
Suppression of pro-inflammatory adhesion molecules by PPAR-δ in human vascular endothelial cells
-
DOI 10.1161/ATVBAHA.107.149815, PII 0004360520080200000018
-
Y. Fan, Y. Wang, Z. Tang, H. Zhang, X. Qin, Y. Zhu, Y. Guan, X. Wang, B. Staels, S. Chien, and N. Wang Suppression of pro-inflammatory adhesion molecules by PPAR-delta in human vascular endothelial cells Arterioscler. Thromb. Vasc. Biol. 28 2008 315 321 (Pubitemid 351161205)
-
(2008)
Arteriosclerosis, Thrombosis, and Vascular Biology
, vol.28
, Issue.2
, pp. 315-321
-
-
Fan, Y.1
Wang, Y.2
Tang, Z.3
Zhang, H.4
Qin, X.5
Zhu, Y.6
Guan, Y.7
Wang, X.8
Staels, B.9
Chien, S.10
Wang, N.11
-
11
-
-
0034633838
-
Functional effect of the C242T polymorphism in the NAD(P)H oxidase p22phox gene on vascular superoxide production in atherosclerosis
-
T.J. Guzik, N.E. West, E. Black, D. McDonald, C. Ratnatunga, R. Pillai, and K.M. Channon Functional effect of the C242T polymorphism in the NAD(P)H oxidase p22phox gene on vascular superoxide production in atherosclerosis Circulation 102 2000 1744 1747
-
(2000)
Circulation
, vol.102
, pp. 1744-1747
-
-
Guzik, T.J.1
West, N.E.2
Black, E.3
McDonald, D.4
Ratnatunga, C.5
Pillai, R.6
Channon, K.M.7
-
12
-
-
0029921114
-
Hyperhomocysteinemia as a risk factor for deep-vein thrombosis
-
DOI 10.1056/NEJM199603213341203
-
M. den Heijer, K.T. Blom, H.J. Bos, G.M. Briet, E. Reitsma, P.H. Vandenbroucke, and J.P. Rosendaal FR. Hyperhomocysteinemia as a risk factor for deep-vein thrombosis N. Engl. J. Med. 334 1996 759 762 (Pubitemid 26089357)
-
(1996)
New England Journal of Medicine
, vol.334
, Issue.12
, pp. 759-762
-
-
Den Heijer, M.1
Koster, T.2
Blom, H.J.3
Bos, G.M.J.4
Briet, E.5
Reitsma, P.H.6
Vandenbroucke, J.P.7
Rosendaal, F.R.8
-
13
-
-
0142116239
-
Transcriptional Repression of Atherogenic Inflammation: Modulation by PPARδ
-
DOI 10.1126/science.1087344
-
C.H. Lee, A. Chawla, N. Urbiztondo, D. Liao, W.A. Boisvert, R.M. Evans, and L.K. Curtiss Transcriptional repression of atherogenic inflammation: modulation by PPARdelta Science 302 2003 453 457 (Pubitemid 37296272)
-
(2003)
Science
, vol.302
, Issue.5644
, pp. 453-457
-
-
Lee, C.-H.1
Chawla, A.2
Urbiztondo, N.3
Liao, D.4
Boisvert, W.A.5
Evans, R.M.6
-
14
-
-
84862201667
-
Activation of PPARdelta counteracts angiotensin II-induced ROS generation by inhibiting rac1 translocation in vascular smooth muscle cells
-
H. Lee, S.A. Ham, M.Y. Kim, J.H. Kim, K.S. Paek, E.S. Kang, H.J. Kim, J.S. Hwang, T. Yoo, C. Park, J.H. Kim, D.S. Lim, C.W. Han, and H.G. Seo Activation of PPARdelta counteracts angiotensin II-induced ROS generation by inhibiting rac1 translocation in vascular smooth muscle cells Free Radical Res. 46 2012 912 919
-
(2012)
Free Radical Res.
, vol.46
, pp. 912-919
-
-
Lee, H.1
Ham, S.A.2
Kim, M.Y.3
Kim, J.H.4
Paek, K.S.5
Kang, E.S.6
Kim, H.J.7
Hwang, J.S.8
Yoo, T.9
Park, C.10
Kim, J.H.11
Lim, D.S.12
Han, C.W.13
Seo, H.G.14
-
15
-
-
65349162821
-
PPARdelta activation inhibits angiotensin II induced cardiomyocyte hypertrophy by suppressing intracellular Ca2+ signaling pathway
-
K.S. Lee, J.H. Park, S. Lee, H.J. Lim, and H.Y. Park PPARdelta activation inhibits angiotensin II induced cardiomyocyte hypertrophy by suppressing intracellular Ca2+ signaling pathway J. Cell Biochem. 106 2009 823 834
-
(2009)
J. Cell Biochem.
, vol.106
, pp. 823-834
-
-
Lee, K.S.1
Park, J.H.2
Lee, S.3
Lim, H.J.4
Park, H.Y.5
-
16
-
-
42149103872
-
AP-1-dependent transcriptional regulation of NADPH oxidase in human aortic smooth muscle cells: Role of p22phox subunit
-
DOI 10.1161/ATVBAHA.108.163592, PII 0004360520080500000016
-
A. Manea, S.A. Manea, A.V. Gafencu, M. Raicu, and M. Simionescu AP-1-dependent transcriptional regulation of NADPH oxidase in human aortic smooth muscle cells: role of p22phox subunit Arterioscler. Thromb. Vasc. Biol. 28 2008 878 885 (Pubitemid 351544102)
-
(2008)
Arteriosclerosis, Thrombosis, and Vascular Biology
, vol.28
, Issue.5
, pp. 878-885
-
-
Manea, A.1
Manea, S.A.2
Gafencu, A.V.3
Raicu, M.4
Simionescu, M.5
-
17
-
-
1842370239
-
Plasma homocysteine levels and mortality in patients with coronary artery disease
-
DOI 10.1056/NEJM199707243370403
-
O. Nygard, J.E. Nordrehaug, H. Refsum, P.M. Ueland, M. Farstad, and S.E. Vollset Plasma homocysteine levels and mortality in patients with coronary artery disease N. Engl. J. Med. 337 1997 230 236 (Pubitemid 27310438)
-
(1997)
New England Journal of Medicine
, vol.337
, Issue.4
, pp. 230-236
-
-
Nygard, O.1
Nordrehaug, J.E.2
Refsum, H.3
Ueland, P.M.4
Farstad, M.5
Vollset, S.E.6
-
18
-
-
1842844951
-
Mild hyperhomocysteinemia is a risk-factor in all etiological subtypes of stroke
-
DOI 10.1007/s10072-004-0219-5
-
L. Parnetti, C.V. Santucci, A. Corea, F. Lanari, A. Floridi, A. Conte, and C. Bottiglieri T. Mild hyperhomocysteinemia is a risk-factor in all etiological subtypes of stroke Neurol. Sci. 25 2004 13 17 (Pubitemid 38489141)
-
(2004)
Neurological Sciences
, vol.25
, Issue.1
, pp. 13-17
-
-
Parnetti, L.1
Caso, V.2
Santucci, A.3
Corea, F.4
Lanari, A.5
Floridi, A.6
Conte, C.7
Bottiglieri, T.8
-
19
-
-
30744460411
-
Peroxisome proliferator-activated receptor δ (PPARδ) activation protects H9c2 cardiomyoblasts from oxidative stress-induced apoptosis
-
DOI 10.1016/j.cardiores.2005.10.019, PII S000863630500492X
-
M. Pesant, S. Sueur, P. Dutartre, M. Tallandier, P.A. Grimaldi, L. Rochette, and J.L. Connat Peroxisome proliferator-activated receptor delta (PPARdelta) activation protects H9c2 cardiomyoblasts from oxidative stress-induced apoptosis Cardiovasc. Res. 69 2006 440 449 (Pubitemid 43098800)
-
(2006)
Cardiovascular Research
, vol.69
, Issue.2
, pp. 440-449
-
-
Pesant, M.1
Sueur, S.2
Dutartre, P.3
Tallandier, M.4
Grimaldi, P.A.5
Rochette, L.6
Connat, J.-L.7
-
20
-
-
84864331653
-
Activation of peroxisome proliferator-activated receptor-beta/-delta (PPARbeta/delta) prevents endothelial dysfunction in type 1 diabetic rats
-
A.M. Quintela, R. Jimenez, M. Gomez-Guzman, M.J. Zarzuelo, P. Galindo, M. Sanchez, F. Vargas, A. Cogolludo, J. Tamargo, F. Perez-Vizcaino, and J. Duarte Activation of peroxisome proliferator-activated receptor-beta/-delta (PPARbeta/delta) prevents endothelial dysfunction in type 1 diabetic rats Free Radical Biol. Med. 53 2012 730 741
-
(2012)
Free Radical Biol. Med.
, vol.53
, pp. 730-741
-
-
Quintela, A.M.1
Jimenez, R.2
Gomez-Guzman, M.3
Zarzuelo, M.J.4
Galindo, P.5
Sanchez, M.6
Vargas, F.7
Cogolludo, A.8
Tamargo, J.9
Perez-Vizcaino, F.10
Duarte, J.11
-
21
-
-
0037168869
-
PPARα and PPARδ activators inhibit cytokine-induced nuclear translocation of NF-κB and expression of VCAM-1 in EAhy926 endothelial cells
-
DOI 10.1016/S0014-2999(01)01589-8, PII S0014299901015898
-
Y. Rival, N. Beneteau, T. Taillandier, M. Pezet, E. Dupont-Passelaigue, J.F. Patoiseau, D. Junquero, F.C. Colpaert, and A. Delhon PPARalpha and PPARdelta activators inhibit cytokine-induced nuclear translocation of NF-kappaB and expression of VCAM-1 in EAhy926 endothelial cells Eur. J. Pharmacol. 435 2002 143 151 (Pubitemid 34131694)
-
(2002)
European Journal of Pharmacology
, vol.435
, Issue.2-3
, pp. 143-151
-
-
Rival, Y.1
Beneteau, N.2
Taillandier, T.3
Pezet, M.4
Dupont-Passelaigue, E.5
Patoiseau, J.-F.6
Junquero, D.7
Colpaert, F.C.8
Delhon, A.9
-
22
-
-
3543011345
-
phox expression and NADPH oxidase activity in hypertension
-
DOI 10.1161/01.HYP.0000134790.02026.e4
-
G. San Jose, M.U. Moreno, S. Olivan, O. Beloqui, A. Fortuno, J. Diez, and G. Zalba Functional effect of the p22phox -930A/G polymorphism on p22phox expression and NADPH oxidase activity in hypertension Hypertension 44 2004 163 169 (Pubitemid 39014233)
-
(2004)
Hypertension
, vol.44
, Issue.2
, pp. 163-169
-
-
San Jose, G.1
Moreno, M.U.2
Olivan, S.3
Beloqui, O.4
Fortuno, A.5
Diez, J.6
Zalba, G.7
-
23
-
-
0037177164
-
Superoxide production and expression of Nox family proteins in human atherosclerosis
-
DOI 10.1161/01.CIR.0000012917.74432.66
-
D.D. Sorescu, B. Weiss, R.E. Lassegue, K. Clempus, G.P. Szocs, L. Sorescu, M.T. Valppu, J.D. Quinn, J.D. Lambeth, W.R. Vega, K.K. Taylor, and Griendling Superoxide production and expression of nox family proteins in human atherosclerosis Circulation 105 2002 1429 1435 (Pubitemid 34263273)
-
(2002)
Circulation
, vol.105
, Issue.12
, pp. 1429-1435
-
-
Sorescu, D.1
Weiss, D.2
Lassegue, B.3
Clempus, R.E.4
Szocs, K.5
Sorescu, G.P.6
Valppu, L.7
Quinn, M.T.8
Lambeth, J.D.9
Vega, J.D.10
Taylor, W.R.11
Griendling, K.K.12
-
24
-
-
0026684554
-
A prospective study of plasma homocyst(e)ine and risk of myocardial infarction in US physicians
-
M.J. Stampfer, M.R. Malinow, W.C. Willett, L.M. Newcomer, B. Upson, D. Ullmann, P.V. Tishler, and C.H. Hennekens A prospective study of plasma homocyst(e)ine and risk of myocardial infarction in US physicians J. Am. Med. Assoc. 268 1992 877 881
-
(1992)
J. Am. Med. Assoc.
, vol.268
, pp. 877-881
-
-
Stampfer, M.J.1
Malinow, M.R.2
Willett, W.C.3
Newcomer, L.M.4
Upson, B.5
Ullmann, D.6
Tishler, P.V.7
Hennekens, C.H.8
-
25
-
-
41949123156
-
PPARδ-mediated antiinflammatory mechanisms inhibit angiotensin II-accelerated atherosclerosis
-
DOI 10.1073/pnas.0708647105
-
Y. Takata, J. Liu, F. Yin, A.R. Collins, C.J. Lyon, C.H. Lee, A.R. Atkins, M. Downes, G.D. Barish, R.M. Evans, W.A. Hsueh, and R.K. Tangirala PPARdelta-mediated antiinflammatory mechanisms inhibit angiotensin II-accelerated atherosclerosis Proc. Nat. Acad. Sci. U.S.A. 105 2008 4277 4282 (Pubitemid 351754371)
-
(2008)
Proceedings of the National Academy of Sciences of the United States of America
, vol.105
, Issue.11
, pp. 4277-4282
-
-
Takata, Y.1
Liu, J.2
Yin, F.3
Collins, A.R.4
Lyon, C.J.5
Lee, C.-H.6
Atkins, A.R.7
Downes, M.8
Barish, G.D.9
Evans, R.M.10
Hsueh, W.A.11
Tangirala, R.K.12
-
26
-
-
0034541503
-
Plasma homocysteine and severity of thoracic aortic atherosclerosis
-
DOI 10.1378/chest.118.6.1685
-
C.M. Tribouilloy, M. Peltier, M.C. Iannetta Peltier, F. Trojette, M. Andrejak, and J.P. Lesbre Plasma homocysteine and severity of thoracic aortic atherosclerosis Chest 118 2000 1685 1689 (Pubitemid 32001796)
-
(2000)
Chest
, vol.118
, Issue.6
, pp. 1685-1689
-
-
Tribouilloy, C.M.1
Peltier, M.2
Peltier, M.C.I.3
Trojette, F.4
Andrejak, M.5
Lesbre, J.-P.M.6
-
27
-
-
0037339694
-
Increased superoxide production in coronary arteries in hyperhomocysteinemia: Role of tumor necrosis factor-α, NAD(P)H oxidase, and inducible nitric oxide synthase
-
DOI 10.1161/01.ATV.0000061735.85377.40
-
Z. Ungvari, A. Csiszar, J.G. Edwards, P.M. Kaminski, M.S. Wolin, G. Kaley, and A. Koller Increased superoxide production in coronary arteries in hyperhomocysteinemia: role of tumor necrosis factor-alpha, NAD(P)H oxidase, and inducible nitric oxide synthase Arterioscler. Thromb. Vasc. Biol. 23 2003 418 424 (Pubitemid 36337217)
-
(2003)
Arteriosclerosis, Thrombosis, and Vascular Biology
, vol.23
, Issue.3
, pp. 418-424
-
-
Ungvari, Z.1
Csiszar, A.2
Edwards, J.G.3
Kaminski, P.M.4
Wolin, M.S.5
Kaley, G.6
Koller, A.7
-
28
-
-
0345258511
-
Redox Regulation of Reactive Oxygen Species-Induced p38 MAP Kinase Activation and Barrier Dysfunction in Lung Microvascular Endothelial Cells
-
P.V. Usatyuk, S. Vepa, T. Watkins, D. He, N.L. Parinandi, and V. Natarajan Redox regulation of reactive oxygen species-induced p38 MAP kinase activation and barrier dysfunction in lung microvascular endothelial cells Antioxid. Redox Signal. 5 2003 723 730 (Pubitemid 37462055)
-
(2003)
Antioxidants and Redox Signaling
, vol.5
, Issue.6
, pp. 723-730
-
-
Usatyuk, P.V.1
Vepa, S.2
Watkins, T.3
He, D.4
Parinandi, N.L.5
Natarajan, V.6
-
29
-
-
14044276314
-
Mechanisms of increased vascular oxidant stress in hyperhomocysteinemia and its impact on endothelial function
-
DOI 10.2174/1389200052997357
-
N. Weiss Mechanisms of increased vascular oxidant stress in hyperhomocys-teinemia and its impact on endothelial function Curr. Drug Metab. 6 2005 27 36 (Pubitemid 40277879)
-
(2005)
Current Drug Metabolism
, vol.6
, Issue.1
, pp. 27-36
-
-
Weiss, N.1
-
30
-
-
22144478334
-
phox gene in hypertension
-
DOI 10.1089/ars.2005.7.1327
-
G. Zalba, G. San Jose, M.U. Moreno, A. Fortuno, and J. Diez NADPH oxidase-mediated oxidative stress: genetic studies of the p22(phox) gene in hypertension Antioxid. Redox Signal. 7 2005 1327 1336 (Pubitemid 41232530)
-
(2005)
Antioxidants and Redox Signaling
, vol.7
, Issue.9-10
, pp. 1327-1336
-
-
Zalba, G.1
San Jose, G.2
Moreno, M.U.3
Fortuno, A.4
Diez, J.5
-
31
-
-
80053575772
-
Antihypertensive effects of peroxisome proliferator-activated receptor-beta activation in spontaneously hypertensive rats
-
M.J. Zarzuelo, R. Jimenez, P. Galindo, M. Sanchez, A. Nieto, M. Romero, A.M. Quintela, R. Lopez-Sepulveda, M. Gomez-Guzman, E. Bailon, I. Rodriguez-Gomez, A. Zarzuelo, J. Galvez, J. Tamargo, F. Perez-Vizcaino, and J. Duarte Antihypertensive effects of peroxisome proliferator-activated receptor-beta activation in spontaneously hypertensive rats Hypertension 58 2011 733 743
-
(2011)
Hypertension
, vol.58
, pp. 733-743
-
-
Zarzuelo, M.J.1
Jimenez, R.2
Galindo, P.3
Sanchez, M.4
Nieto, A.5
Romero, M.6
Quintela, A.M.7
Lopez-Sepulveda, R.8
Gomez-Guzman, M.9
Bailon, E.10
Rodriguez-Gomez, I.11
Zarzuelo, A.12
Galvez, J.13
Tamargo, J.14
Perez-Vizcaino, F.15
Duarte, J.16
-
32
-
-
0042878460
-
Homocysteine mediated expression and secretion of monocyte chemoattractant protein-1 and interleukin-8 in human monocytes
-
DOI 10.1161/01.RES.0000087642.01082.E4
-
X. Zeng, J. Dai, D.G. Remick, and X. Wang Homocysteine mediated expression and secretion of monocyte chemoattractant protein-1 and interleukin-8 in human monocytes Circ. Res. 93 2003 311 320 (Pubitemid 37048243)
-
(2003)
Circulation Research
, vol.93
, Issue.4
, pp. 311-320
-
-
Zeng, X.1
Dai, J.2
Remick, D.G.3
Wang, X.4
|