Substrate orientation and specificity in xanthine oxidase: Crystal structures of the enzyme in complex with indole-3-acetaldehyde and guanine

Biochemistry

Volumn 53, Issue 3, 2014, Pages 533-541

  Cao, Hongnan ^a,b   Hall, James ^a   Hille, Russ ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b RICE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

8-HYDROXYGUANINE; BOVINE ENZYME; DOMINANT ORIENTATION; ENZYME ACTIVE SITES; ENZYME REDUCTIONS; SUBSTRATE ORIENTATION; UV-VIS SPECTRUM; XANTHINE OXIDASE;

ACETALDEHYDE; ENZYMES; HYDROXYLATION; MAMMALS; MOLYBDENUM; POLYCYCLIC AROMATIC HYDROCARBONS; POSITIVE IONS;

SUBSTRATES;

8 HYDROXYGUANINE; ALDEHYDE; GUANINE; HYPOXANTHINE; INDOLE DERIVATIVE; INDOLEACETALDEHYDE; UNCLASSIFIED DRUG; XANTHINE OXIDASE;

ARTICLE; CATTLE; COMPLEX FORMATION; CRYSTAL STRUCTURE; ENZYME ACTIVE SITE; ENZYME KINETICS; ENZYME PURIFICATION; ENZYME SPECIFICITY; ENZYME STRUCTURE; ENZYME SUBSTRATE; HYDROXYLATION; NONHUMAN; PRIORITY JOURNAL; ULTRAVIOLET SPECTROSCOPY; X RAY CRYSTALLOGRAPHY;

ANIMALS; CATALYTIC DOMAIN; CATTLE; CRYSTALLIZATION; CRYSTALLOGRAPHY, X-RAY; GUANINE; HYDROXYLATION; INDOLES; KINETICS; MOLECULAR CONFORMATION; MOLYBDENUM; SUBSTRATE SPECIFICITY; XANTHINE OXIDASE;

EID: 84893482895     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi401465u     Document Type: Article

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