A structure-based catalytic mechanism for the xanthine oxidase family of molybdenum enzymes

Proceedings of the National Academy of Sciences of the United States of America

Volumn 93, Issue 17, 1996, Pages 8846-8851

  Huber, Robert ^a   Hof, Peter ^a   Duarte, Rui O ^d   Moura, Jose J G ^d   Moura, Isabel ^d   Liu, Ming Yih ^e   LeGall, Jean ^e   Hille, Russ ^f   Archer, Margarida ^b,c   Romão, Maria J ^b,c  

^a MAX PLANCK INSTITUTE OF BIOCHEMISTRY   (Germany)

^b INSTITUTO DE TECNOLOGIA QUÍMICA E BIOLÓGICA   (Portugal)

^c INSTITUTO SUPERIOR TÉCNICO   (Portugal)

^d UNIVERSIDADE NOVA DE LISBOA   (Portugal)

^e University of Georgia   (United States)

^f OHIO STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 PROPANOL; ALDEHYDE DEHYDROGENASE; CARBOXYLIC ACID; CYTOSINE DERIVATIVE; DINUCLEOTIDE; DITHIOL DERIVATIVE; GLUTAMIC ACID; METAL; MOLYBDENUM IRON PROTEIN; WATER; XANTHINE OXIDASE;

AMINO ACID SEQUENCE; ARTICLE; CRYSTAL STRUCTURE; DESULFOVIBRIO; ENZYME INHIBITOR INTERACTION; ENZYME MECHANISM; ENZYME STRUCTURE; ENZYME SUBSTRATE COMPLEX; METAL BINDING; NONHUMAN; OXIDATION REDUCTION POTENTIAL; PRIORITY JOURNAL;

ALDEHYDE OXIDOREDUCTASES; BACTERIAL PROTEINS; CRYSTALLOGRAPHY, X-RAY; CYTOSINE NUCLEOTIDES; DESULFOVIBRIO; MODELS, MOLECULAR; MOLYBDENUM; OXIDATION-REDUCTION; PTERINS; XANTHINE OXIDASE;

BACTERIA (MICROORGANISMS); DESULFOVIBRIO; DESULFOVIBRIO GIGAS; NEGIBACTERIA;

EID: 9444219600     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.93.17.8846     Document Type: Article

References (58)

1. Stiefel, E. I. (1993) ACS Symp. 535, 1-22.
2. Hilie, R. (1993) ACS Symp. 535, 22-38.
3. Enemark, J. H. & Young, C. G. (1993) Adv. Inorg. Chem. 40, 1-88.
4. Thoenes, U., Flores, O. L., Neves, A., Devreese, B., VanBeumen, J. J., Huber, R., Romao, M. J., LeGall, J., Moura, J. J. G. & Rodrigues-Pousada, C. (1994) Eur. J. Biochem. 220, 901-910.
5. Romão, M. J., Archer, M., Moura, I., Moura, J. J. G., LeGall, J., Engh, R., Schneider, M., Hof, P. & Huber, R. (1995) Science 270, 1170-1176.
6. Romão, M. J., Barata, B. A. S., Archer, M., Lobeck, K., Moura, I., Carrondo, M. A., LeGall, J., Lottspeich, F., Huber, R. & Moura, J. J. G. (1993) Eur. J. Biochem. 215, 729-732.
7. Leslie, A. G. W. (1990) MOSFLM Program (Crystallographic Computing School, Bischenberg, Germany).
8. Collaborative Computational Project No. 4 (1994) Acta Crystallogr. D 50, 760-763.
9. Brünger, A. T. (1990) X-PLOR Version 2.1 Manual (Yale Unív. Press, New Haven, CT).
10. Engh, R. & Huber, R. (1991) Acta Crystallogr. A 47, 392-400.
11. Jones, T.A. (1978) J. Appl. Crystallogr. 11, 268-272.
12. Barata, B. A. S., LeGall, J. & Moura, J. J. G. (1993) Biochemistry 32, 11559-11568.
13. Malthouse, J. P. G. & Bray, R. C. (1980) Biochem. J. 191, 265-267.
14. Massey, V. & Edmondson, D. (1970) J. Biol. Chem. 245, 6595-6598.
15. Wahl, R. C. & Rajagopalan, K. V. (1982) J. Biol. Chem. 257, 1354-1359.
16. Morpeth, F. F. & Bray, R. C (1984) Biochemistry 23, 1332-1338.
17. Turner, N., Barata, B., Bray, R., C., Deistung, J., LeGall, J. & Moura, J. G. (1987) Biochem. J. 243, 755-761.
18. Barata, B. A. S., Liang, J., Moura, I., LeGall, J., Moura, J. J. G. & Hanh Huynh, B. (1992) Eur. J. Biochem. 204, 773-778.
19. Hille, R. George, G. N., Eidsness, M. K. & Cramer, S. P. (1989) Inorg. Chem. 28, 4018-4022.
20. Turner, N. A., Bray, R. C. & Diakun, G. P. (1989) Biochem J. 260,563-571.
21. Stiefel, E. I., Miller, K. F., Bruce, A. E., Corbin, J. L., Berg, J. M. & Hodgson, K. O. (1980) J. Am. Chem. Soc. 102, 3624-3626.
22. Greenwood, R. J., Wilson, G. L., Pilbrow, J. R. & Wedd, A. G. (1993) J. Am. Chem. Soc. 115, 5385-5392.
23. Oertling, T. A. & Hille R. (1990) J. Biol. Chem. 265, 17446-17450.
24. Hille, R. & Sprecher, H. (1987) J. Biol. Chem. 262, 10914-10917
25. Bray, R. C. (1980) in Biological Magnetic Resonance, eds. Reuben, J. & Berliner, L. J. (Plenum, New York), Vol. 2, pp. 45-84.
26. Tanner, S. J. & Bray, R. C. (1978) Biochem. Soc. Trans. 6, 1331-1333.
27. Pick, F. M., McGartoll, M. A. & Bray, R. C. (1971) Eur. J. Biochem. 18, 65-72.
28. Hille, R., Jong, H. K. & Hemann, C. (1993) Biochemistry 32, 3973-3980.
29. Hille, R. & Stewart, R. C. (1984) J. Biol. Chem. 259, 1570-1576.
30. Cramer, S. P. & Hille, R. (1985) J. Am. Chem. Soc. 105, 8164-8169.
31. Hille, R. & Massey, V. (1985) in Molybdenum Enzymes, ed. Spiro, T. G. (Wiley, New York), pp. 443-518.
32. Bray, R. C. & George, G. N. (1985) Biochem. Soc. Trans. 13, 560-567.
33. Gutteridge, S., Tanner, S. J. & Bray, R. C. (1978) Biochem. J. 175, 869-878.
34. Gutteridge, S., Tanner, S. J. & Bray, R. C. (1978) Biochem. J. 175, 887-897.
35. Bray, R. C. & Gutteridge, S. (1982) Biochemistry 21, 5992-5999.
36. Bray, R. C. (1980) in Biological Magnetic Resonance, eds. Berliner, L. J. & Reuben, J. (Plenum, New York), Vol. 2, pp. 45-84.
37. Carducci, M. D., Brown, C., Solomon, E. I. & Enemark, J. H. (1994) J. Am. Chem. Soc. 116, 11856-11868.
38. Howes, B. D., Bennet, B., Bray, R. C., Richards, R. L. & Lowe, D. J. (1994) J. Am. Chem. Soc. 116, 11624-11625
39. Oertling, W. A. & Hille, R. J. (1990) J. Biol. Chem. 265, 17446-17450.
40. Skibo, E. B., Gilchrist, J. H. & Chang, H. L. (1987) Biochemistry 26, 3032-3037.
41. Hofste, B. H. J. (1955) J. Biol. Chem. 216, 235-244.
42. D'Ardenne, S. C. & Edmondson, D. E. (1990) Biochemistry 29, 9046-9052
43. Hille, R. & Stewart, R. C. (1984) J. Biol. Chem. 259, 1570-1576.
44. Davis, M. D., Olsen, J. S. & Palmer G. (1984) J. Biol. Chem. 259, 3526-3533.
45. Morpeth, F. F. (1983) Biochim. Biophys. Acta 744, 328-334.
46. Okamoto, K. & Nishino, T. J. (1995) J. Biol. Chem. 270, 7816-7821.
47. Howes, B. D., Bray, R. C., Ricards, R. L., Turner, N. A., Bennet, B. & Lowe, D. J. (1996) Biochemistry 35, 1432-1443.
48. Bray, R. C. (1988) Q. Rev. Biophys. 21, 299-329.
49. Jong, H. K. & Hille, R. (1993) J. Biol. Chem. 268, 44-51.
50. Hille, R., Jong, H. K. & Hemann, C. (1993) Biochemistry 32, 3973-3980.
51. Cramer, S. P. & Hille, R. (1985) J. Am. Chem. Soc. 107, 8164-8169.
52. George, G. N. & Bray, R. C. (1983) Biochemistry 22, 1013-1021.
53. Hille, R., Stewart, R. C., Fee, J. A. & Massey, V. (1983) J. Biol. Chem. 258, 4849-4851.
54. Howes, B. D., Pinhal, N. M.,Turner, N. A., Bray, R. C., Anger, G., Ehrenberg, A., Raynor, J. B. & Lowe, D. J. (1990) Biochemistry 29, 6120-6127.
55. Guasch, A., Coll, M., Aviles, F. X. & Huber, R. (1992) J. Mol. Biol. 224, 141-157.
56. Phillips, M. A., Fletterick, R. & Rutter, W. J. (1990) J. Biol. Chem. 265, 20692-20698.
57. Grams, F., Reinemer, P., Powers, J. C., Kleine, T., Pieper, M., Tschesche, H., Huber, R. & Bode, W. (1995) Eur. J. Biochem. 228, 830-841.
58. Nar, H., Huber, R., Auerbach, G., Fischer, R., Hösl, C., Ritz, H., Bracher, A., Meining, W., Eberhardt, S. & Bacher, A.(1995) Proc. Natl. Acad. Sci. USA 92, 12120-12125.