Green tea catechins: Proposed mechanisms of action in breast cancer focusing on the interplay between survival and apoptosis

Anti-Cancer Agents in Medicinal Chemistry

Volumn 14, Issue 2, 2014, Pages 290-295

  Yiannakopoulou, Eugenia Ch ^a  

^a UNIVERSITY OF WEST ATTICA   (Greece)

Author keywords

Apoptosis; Breast cancer; Carcinogenesis; EGCG; Green tea catechins; Mechanisms of action

Indexed keywords

ANIMALS; ANTICARCINOGENIC AGENTS; APOPTOSIS; BREAST NEOPLASMS; CATECHIN; CELL CYCLE; CELL SURVIVAL; EPIGENESIS, GENETIC; FEMALE; HUMANS; MOLECULAR CHAPERONES; OXIDATION-REDUCTION; PROTEASOME ENDOPEPTIDASE COMPLEX; SIGNAL TRANSDUCTION; TEA; TELOMERASE;

EID: 84893481901     PISSN: 18715206     EISSN: 18755992     Source Type: Journal    
DOI: 10.2174/18715206113136660339     Document Type: Review

References (29)

1. Cabrera, C.; Artacho, R.; Gimenez, R. Beneficial effects of green tea: A review. J. Am. Coll. Nutr., 2006, 25, 79-99.
2. Yang, C. S.; Wang, H.; Li, G. X.; Yang, Z.; Guan, F.; Jin, H. Cancer prevention by tea: Evidence from laboratory studies. Pharmacol. Res., 2011, 64, 113-122.
3. Yuan, J. M.; Sun, C.; Butler, L. M. Tea and cancer prevention: Epidemiological studies. Pharmacol. Res., 2011, 64, 123-135.
4. Sing, F. M.; Yang, W. S.; Gao, S.; Gao, J.; Xiang, Y. B. Epidemiological studies of the association between tea drinking and primary liver cancer: a meta-analysis. Eur. J. Cancer Prev., 2011, 20, 157-165.
5. Mann, C. D.; Neal, C. P.; Garcea, G.; Manson, M. M.; Dennison, A. R.; Berry, D. P. Phytochemicals as potential chemopreventive and chemotherapeutic agents in hepatocarcinogenesis. Eur. J. Cancer Prev., 2009, 18, 13-25.
6. Ferlay, J.; Shin, H. R.; Bray, F.; Forman, D.; Mathers, C.; Parkin, D. M. Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008. Int. J. Cancer, 2010, 15, 2893-2917.
7. Rathore, K.; Wang, H. C. Mesenchymal and stem-like cell properties targeted in suppression of chronically-induced breastcell carcinogenesis. Cancer Lett., 2013, 333(1), 113-123.
8. Rathore, K.; Choudhary, S.; Odoi, A.; Wang, H. C. Green tea catechin intervention of reactive oxygen species-mediated ERK pathway activation and chronically induced breast cell carcinogenesis. Carcinogenesis, 2012, 33(1), 174-183.
9. Rathore, K.; Wang, H. C. Green tea catechin extract in intervention of chronic breast cell carcinogenesis induced by environmental carcinogens. Mol. Carcinog., 2012, 51, 280-289.
10. Bigelow, R. L.; Cardelli, J. A. The green tea catechins, (-)-Epigallocatechin-3-gallate (EGCG) and (-)-Epicatechin-3-gallate (ECG), inhibit HGF/Met signaling in immortalized and tumorigenic breast epithelial cells. Oncogene, 2006, 25, 1922-1930.
11. Tran, P. L.; Kim, S. A.; Choi, H. S.; Yoon, J. H.; Ahn, S. G. Epigallocatechin-3-gallate suppresses the expression of HSP70 and HSP90 and exhibits anti-tumor activity in vitro and in vivo. BMC Cancer, 2010, 10, 276.
12. Sutherland, B. A.; Rahman, R. M.; Appleton, I. Mechanisms of action of green tea catechins, with a focus on ischemia-induced neurodegeneration. J. Nutr. Biochem., 2006, 17, 291-306.
13. Skrzydlewska, E.; Ostrowska, J.; Farbiszewski, R.; Michalak, K. Protective effect of green tea against lipid peroxidation in the rat liver, blood serum and the brain. Phytomedicine, 2002, 9, 232-238.
14. Kaur, S.; Greaves, P.; Cooke, D. N.; Edwards, R.; Steward, W. P.; Gescher, A. J.; Marczylo, T. H. Breast cancer prevention by green tea catechins and black tea theaflavins in the C3(1) SV40 T, t antigen transgenic mouse model is accompanied by increased apoptosis and a decrease in oxidative DNA adducts. J. Agric. Food Chem., 2007, 55, 3378-3385.
15. Hsuuw, Y. D.; Chan, W. H. Epigallocatechin gallate dose-dependently induces apoptosis or necrosis in human MCF-7 cells. Ann. NY Acad. Sci., 2007, 1095, 428-440.
16. Mittal, A.; Pate, M. S.; Wylie, R. C.; Tollefsbol, T. O.; Katiyar, S. K. EGCG down-regulates telomerase in human breast carcinoma MCF-7 cells, leading to suppression of cell viability and induction of apoptosis. Int. J. Oncol., 2004, 24, 703-710.
17. Berletch, J. B.; Liu, C.; Love, W. K.; Andrews, L. G.; Katiyar, S. K.; Tollefsbol, T. O. Epigenetic and genetic mechanisms contribute to telomerase inhibition by EGCG. J. Cell Biochem., 2008, 103, 509-519.
18. Meeran, S. M.; Patel, S. N.; Chan, T. H.; Tollefsbol, T. O. A novel prodrug of epigallocatechin-3-gallate: differential epigenetic hTERT repression in human breast cancer cells. Cancer Prev. Res. (Phila), 2011, 4, 1243-1254.
19. Alshatwi, A. A. Catechin hydrate suppresses MCF-7 proliferation through TP53/Caspase-mediated apoptosis. J. Exp. Clin. Cancer Res., 2010, 29, 167.
20. Roy, A. M.; Baliga, M. S.; Katiyar, S. K. Epigallocatechin-3-gallate induces apoptosis in estrogen receptor-negative human breast carcinoma cells via modulation in protein expression of p53 and Bax and caspase-3 activation. Mol. Cancer Ther., 2005, 4, 81-90.
21. Vergote, D.; Cren-Olivé, C.; Chopin, V.; Toillon, R. A.; Rolando, C.; Hondermarck, H.; Le Bourhis, X. (-)-Epigallocatechin (EGC) of green tea induces apoptosis of human breast cancer cells but not of their normal counterparts. Breast Cancer Res. Treat., 2002, 76, 195-201.
22. Landis-Piwowar, K. R.; Huo, C.; Chen, D.; Milacic, V.; Shi, G.; Chan, T. H.; Dou, Q. P. A novel prodrug of the green tea polyphenol (-)-epigallocatechin-3-gallate as a potential anticancer agent. Cancer Res., 2007, 67, 4303-4310.
23. Thangapazham, R. L.; Singh, A. K.; Sharma, A.; Warren, J.; Gaddipati, J. P.; Maheshwari, R. K. Green tea polyphenols and its constituent epigallocatechin gallate inhibits proliferation of human breast cancer cells in vitro and in vivo. Cancer Lett., 2007, 245, 232-241.
24. Friedman, M.; Mackey, B. E.; Kim, H. J.; Lee, I. S.; Lee, K. R.; Lee, S. U.; Kozukue, E.; Kozukue, N. Structure-activity relationships of tea compounds against human cancer cells. J. Agric. Food Chem., 2007, 55, 243-253.
25. Zhao, X.; Tian, H.; Ma, X.; Li, L. Epigallocatechin gallate, the main ingredient of green tea induces apoptosis in breast cancer cells. Front. Biosci., 2006, 11, 2428-2433.
26. Valcic, S.; Timmermann, B. N.; Alberts, D. S.; Wächter, G. A.; Krutzsch, M.; Wymer, J.; Guillén, J. M. Inhibitory effect of six green tea catechins and caffeine on the growth of four selected human tumor cell lines. Anticancer Drugs, 1996, 7, 461-468.
27. Beltz, L. A.; Bayer, D. K.; Moss, A. L.; Simet, I. M. Mechanisms of cancer prevention by green and black tea polyphenols. Anticancer Agents Med. Chem., 2006, 6, 389-406.
28. Yiannakopoulou, E. Targeting oxidative stress response by green tea polyphenols: clinical implications. Free Radic. Res., 2013, 47(9), 667-671.
29. Crew, K. D.; Brown, P.; Greenlee, H.; Bevers, T. B.; Arun, B.; Hudis, C.; McArthur, H. L.; Chang, J.; Rimawi, M.; Vornik, L.; Cornelison, T. L.; Wang, A.; Hibshoosh, H.; Ahmed, A.; Terry, M. B.; Santella, R. M.; Lippman, S. M.; Hershman, D. L. Phase IB randomized, double-blinded, placebo-controlled, dose escalation study of polyphenon E in women with hormone receptor-negative breast cancer. Cancer Prev. Res. (Phila), 2012, 5, 1144-1154.