Use of IRF-3 and/or IRF-7 knockout mice to study viral pathogenesis: Lessons from a murine retrovirus-induced AIDS model

Journal of Virology

Volumn 88, Issue 4, 2014, Pages 2349-2353

  O'Connor, Megan A ^a   Green, William R ^a  

^a DARTMOUTH MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMALS; DISEASE MODELS, ANIMAL; ELECTROPHORESIS; GAMMARETROVIRUS; INTERFERON REGULATORY FACTOR-3; INTERFERON REGULATORY FACTOR-7; INTERFERON TYPE I; MICE; MICE, KNOCKOUT; MURINE ACQUIRED IMMUNODEFICIENCY SYNDROME; PROTEINS; SPECIES SPECIFICITY; STATISTICS, NONPARAMETRIC;

EID: 84893478492     PISSN: 0022538X     EISSN: 10985514     Source Type: Journal    
DOI: 10.1128/JVI.02960-13     Document Type: Article

References (48)

1. Daffis S, Samuel MA, Keller BC, Gale M, Jr, Diamond MS. 2007. Cell-specific IRF-3 responses protect against West Nile virus infection by interferon-dependent and-independent mechanisms. PLoS Pathog. 3:e106. http://dx.doi.org/10.1371/journal.ppat.0030106.
2. Daffis S, Samuel MA, Suthar MS, Keller BC, Gale M, Jr, Diamond MS. 2008. Interferon regulatory factor IRF-7 induces the antiviral alpha interferon response and protects against lethal West Nile virus infection. J. Virol. 82:8465-8475. http://dx.doi.org/10.1128/JVI.00918-08.
3. Daffis S, Suthar MS, Szretter KJ, Gale M, Jr, Diamond MS. 2009. Induction of IFN-beta and the innate antiviral response in myeloid cells occurs through an IPS-1-dependent signal that does not require IRF-3 and IRF-7. PLoS Pathog. 5:e1000607. http://dx.doi.org/10.1371/journal.ppat.1000607.
4. Fu XY, Schindler C, Improta T, Aebersold R, Darnell, Jr, JE. 1992. The proteins of ISGF-3, the interferon alpha-induced transcriptional activator, define a gene family involved in signal transduction. Proc. Natl. Acad. Sci. U.S.A. 89:7840-7843. http://dx.doi.org/10.1073/pnas.89.16.7840.
5. Hiscott J, Pitha P, Genin P, Nguyen H, Heylbroeck C, Mamane Y, Algarte M, Lin R. 1999. Triggering the interferon response: the role of IRF-3 transcription factor. J. Interferon Cytokine Res. 19:1-13. http://dx.doi.org/10.1089/107999099314360.
6. Honda K, Taniguchi T. 2006. IRFs: master regulators of signalling by Toll-like receptors and cytosolic pattern-recognition receptors. Nat. Rev. Immunol. 6:644-658. http://dx.doi.org/10.1038/nri1900.
7. Levy DE, García-Sastre A. 2001. The virus battles: IFN induction of the antiviral state and mechanisms of viral evasion. Cytokine Growth Factor Rev. 12:143-156. http://dx.doi.org/10.1016/S1359-6101(00)00027-7.
8. Lin R, Heylbroeck C, Pitha PM, Hiscott J. 1998. Virus-dependent phosphorylation of the IRF-3 transcription factor regulates nuclear translocation, transactivation potential, and proteasome-mediated degradation. Mol. Cell. Biol. 18:2986-2996.
9. Menachery VD, Leib DA. 2009. Control of herpes simplex virus replication is mediated through an interferon regulatory factor 3-dependent pathway. J. Virol. 83:12399-12406. http://dx.doi.org/10.1128/JVI.00888-09.
10. Murphy AA, Rosato PC, Parker ZM, Khalenkov A, Leib DA. 2013. Synergistic control of herpes simplex virus pathogenesis by IRF-3, and IRF-7 revealed through non-invasive bioluminescence imaging. Virology444:71-79. http://dx.doi.org/10.1016/j.virol.2013.05.034.
11. Reich NC. 2007. STAT dynamics. Cytokine Growth Factor Rev. 18:511-518. http://dx.doi.org/10.1016/j.cytogfr.2007.06.021.
12. Zimmerer JM, Lesinski GB, Radmacher MD, Ruppert A, Carson WE, 3rd. 2007. STAT1-dependent and STAT1-independent gene expression in murine immune cells following stimulation with interferon-alpha. Cancer Immunol. Immunother. 56:1845-1852. http://dx.doi.org/10.1007/s00262-007-0329-9.
13. Honda K, Yanai H, Negishi H, Asagiri M, Sato M, Mizutani T, Shimada N, Ohba Y, Takaoka A, Yoshida N, Taniguchi T. 2005. IRF-7 is the master regulator of type-I interferon-dependent immune responses. Nature 434:772-777. http://dx.doi.org/10.1038/nature03464.
14. Schilte C, Buckwalter MR, Laird ME, Diamond MS, Schwartz O, Albert ML. 2012. Cutting edge: independent roles for IRF-3 and IRF-7 in hematopoietic and nonhematopoietic cells during host response to Chikungunya infection. J. Immunol. 188:2967-2971. http://dx.doi.org/10.4049/jimmunol.1103185.
15. Steinberg C, Eisenächer K, Gross O, Reindl W, Schmitz F, Ruland J, Krug A. 2009. The IFN regulatory factor 7-dependent type I IFN response is not essential for early resistance against murine cytomegalovirus infection. Eur. J. Immunol. 39:1007-1018. http://dx.doi.org/10.1002/eji.200838814.
16. Thackray LB, Duan E, Lazear HM, Kambal A, Schreiber RD, Diamond MS, Virgin HW. 2012. Critical role for interferon regulatory factor 3 (IRF-3) and IRF-7 in type I interferon-mediated control of murine norovirus replication. J. Virol. 86:13515-13523. http://dx.doi.org/10.1128/JVI.01824-12.
17. Beignon A-S. 2005. Endocytosis of HIV-1 activates plasmacytoid dendritic cells via Toll-like receptor-viral RNA interactions. J. Clin. Invest. 115:3265-3275. http://dx.doi.org/10.1172/JCI26032.
18. Browne EP. 2011. Toll-like receptor 7 controls the anti-retroviral germinal center response. PLoS Pathog. 7:e1002293. http://dx.doi.org/10.1371/journal.ppat.1002293.
19. Browne EP. 2013. Toll-like receptor 7 inhibits early acute retroviral infection through rapid lymphocyte responses. J. Virol. 87:7357-7366. http://dx.doi.org/10.1128/JVI.00788-13.
20. Heil F, Hemmi H, Hochrein H, Ampenberger F, Kirschning C, Akira S, Lipford G, Wagner H, Bauer S. 2004. Species-specific recognition of single-stranded RNA via Toll-like receptor 7 and 8. Science 303:1526-1529. http://dx.doi.org/10.1126/science.1093620.
21. Lee H, Komano J, Saitoh Y, Yamaoka S, Kozaki T, Misawa T, Takahama M, Satoh T, Takeuchi O, Yamamoto N, Matsuura Y, Saitoh T, Akira S. 2013. Zinc-finger antiviral protein mediates retinoic acid inducible gene I-like receptor-independent antiviral response to murine leukemia virus. Proc. Natl. Acad. Sci. U.S.A. 110:12379-12384. http://dx.doi.org/10.1073/pnas.1310604110.
22. Meier A, Alter G, Frahm N, Sidhu H, Li B, Bagchi A, Teigen N, Streeck H, Stellbrink HJ, Hellman J, van Lunzen J, Altfeld M. 2007. MyD88-dependent immune activation mediated by human immunodeficiency virus type 1-encoded Toll-like receptor ligands. J. Virol. 81:8180-8191. http://dx.doi.org/10.1128/JVI.00421-07.
23. Yu P, Lübben W, Slomka H, Gebler J, Konert M, Cai C, Neubrandt L, Prazeres da Costa O, Paul S, Dehnert S, Döhne K, Thanisch M, Storsberg S, Wiegand L, Kaufmann A, Nain M, Quintanilla-Martinez L, Bettio S, Schnierle B, Kolesnikova L, Becker S, Schnare M, Bauer S. 2012. Nucleic acid-sensing Toll-like receptors are essential for the control of endogenous retrovirus viremia and ERV-induced tumors. Immunity 37:867-879. http://dx.doi.org/10.1016/j.immuni.2012.07.018.
24. Cerny A, Hügin AW, Hardy RR, Hayakawa K, Zinkernagel RM, Makino M, Morse HC, III. 1990. B cells are required for induction of T cell abnormalities in a murine retrovirus-induced immunodeficiency syndrome. J. Exp. Med. 171:315-320. http://dx.doi.org/10.1084/jem.171.1.315.
25. Morse HC, III, Yetter RA, Via CS, Hardy RR, Cerny A, Hayakawa K, Hugin AW, Miller MW, Holmes KL, Shearer GM. 1989. Functional and phenotypic alterations in T cell subsets during the course of MAIDS, a murine retrovirus-induced immunodeficiency syndrome. J. Immunol. 143:844-850.
26. Buller RM, Yetter RA, Fredrickson TN, Morse HC, III. 1987. Abrogation of resistance to severe mousepox in C57BL/6 mice infected with LP-BM5 murine leukemia viruses. J. Virol. 61:383-387.
27. Hartley JW, Rowe WP, Huebner RJ. 1970. Host-range restrictions of murine leukemia viruses in mouse embryo cell cultures. J. Virol. 5:221-225.
28. Ho O, Green WR. 2006. Cytolytic CD8+ T cells directed against a cryptic epitope derived from a retroviral alternative reading frame confer disease protection. J. Immunol. 176:2470-2475.
29. Khan IA, Green WR, Kasper LH, Green KA, Schwartzman JD. 1999. Immune CD8(+) T cells prevent reactivation of Toxoplasma gondii infection in the immunocompromised host. Infect. Immun. 67:5869-5876.
30. Klinman DM, Morse HC, III. 1989. Characteristics of B cell proliferation and activation in murine AIDS. J. Immunol. 142:1144-1149.
31. Klinken SP, Fredrickson TN, Hartley JW, Yetter RA, Morse HC, III. 1988. Evolution of B cell lineage lymphomas in mice with a retrovirusinduced immunodeficiency syndrome, MAIDS. J. Immunol. 140:1123-1131.
32. Mayrand SM, Schwarz DA, Green WR. 1998. An alternative translational reading frame encodes an immunodominant retroviral CTL determinant expressed by an immunodeficiency-causing retrovirus. J. Immunol. 160: 39-50.
33. Mosier DE, Yetter RA, Morse HC, III. 1985. Retroviral induction of acute lymphoproliferative disease and profound immunosuppression in adult C57BL/6 mice. J. Exp. Med. 161:766-784. http://dx.doi.org/10.1084/jem.161.4.766.
34. Mosier DE, Yetter RA, Morse HC, III. 1987. Functional T lymphocytes are required for a murine retrovirus-induced immunodeficiency disease (MAIDS). J. Exp. Med. 165:1737-1742. http://dx.doi.org/10.1084/jem.165.6.1737.
35. Sato M, Suemori H, Hata N, Asagiri M, Ogasawara K, Nakao K, Nakaya T, Katsuki M, Noguchi S, Tanaka N, Taniguchi T. 2000. Distinct and essential roles of transcription factors IRF-3 and IRF-7 in response to viruses for IFN-alpha/beta gene induction. Immunity 13:539-548. http://dx.doi.org/10.1016/S1074-7613(00)00053-4.
36. Green KA, Noelle RJ, Green WR. 1998. Evidence for a continued requirement for CD40/CD40 ligand (CD154) interactions in the progression of LP-BM5 retrovirus-induced murine AIDS. Virology 241:260-268. http://dx.doi.org/10.1006/viro.1997.8970.
37. O'Connor MA, Green WR. 2013. The role of indoleamine 2,3-dioxygenase in LP-BM5 murine retroviral disease progression. Virol. J. 10:154. http://dx.doi.org/10.1186/1743-422X-10-154.
38. Rutkowski MR, Ho O, Green WR. 2009. Defining the mechanism(s) of protection by cytolytic CD8 T cells against a cryptic epitope derived from a retroviral alternative reading frame. Virology 390:228-238. http://dx.doi.org/10.1016/j.virol.2009.05.003.
39. Rutkowski MR, Stevens CA, Green WR. 2011. Impaired memory CD8 T cell responses against an immunodominant retroviral cryptic epitope. Virology 412:256-268. http://dx.doi.org/10.1016/j.virol.2010.11.013.
40. Pincus T, Hartley JW, Rowe WP. 1971. A major genetic locus affecting resistance to infection with murine leukemia viruses. I. Tissue culture studies of naturally occurring viruses. J. Exp. Med. 133:1219-1233.
41. Steeves R, Lilly F. 1977. Interactions between host and viral genomes in mouse leukemia. Annu. Rev. Genet. 11:277-296. http://dx.doi.org/10.1146/annurev.ge.11.120177.001425.
42. Trask H, Tomlinson C, Fiering S, Gorham JD, Muirhead K. 2010. Introducing DartMouse: the mouse speed congenic facility at Dartmouth Medical School. J. Biomol. Tech. 21:S70.
43. Stoye JP. 1998. Fv1, the mouse retrovirus resistance gene. Rev. Sci. Tech. 17:269-277.
44. Pincus T, Hartley JW, Rowe WP. 1975. A major genetic locus affecting resistance to infection with murine leukemia viruses. IV. Dose-response relationships in Fv-1-sensitive and resistant cell cultures. Virology 65:333-342.
45. Hartley JW, Fredrickson TN, Yetter RA, Makino M, Morse HC, III. 1989. Retrovirus-induced murine acquired immunodeficiency syndrome: natural history of infection and differing susceptibility of inbred mouse strains. J. Virol. 63:1223-1231.
46. Kozak CA. 1985. Analysis of wild-derived mice for Fv-1 and Fv-2 murine leukemia virus restriction loci: a novel wild mouse Fv-1 allele responsible for lack of host range restriction. J. Virol. 55:281-285.
47. Rowe WP, Sato H. 1973. Genetic mapping of the Fv-1 locus of the mouse. Science 180:640-641. http://dx.doi.org/10.1126/science.180.4086.640.
48. Taylor BA, Bedigian HG, Meier H. 1977. Genetic studies of the Fv-1 locus of mice: linkage with Gpd-1 in recombinant inbred lines. J. Virol. 23:106-109.