Use of OpdA, an organophosphorus (OP) hydrolase, prevents lethality in an African green monkey model of acute OP poisoning

Toxicology

Volumn 317, Issue 1, 2014, Pages 1-5

  Jackson, Colin J ^a   Carville, Angela ^b   Ward, Jeanine ^c   Mansfield, Keith ^b,e   Ollis, David L ^a   Khurana, Tejvir ^d   Bird, Steven B ^c  

^a AUSTRALIAN NATIONAL UNIVERSITY   (Australia)

^b HARVARD MEDICAL SCHOOL   (United States)

^c UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

^d UNIVERSITY OF PENNSYLVANIA   (United States)

^e NOVARTIS INSTITUTES FOR BIOMEDICAL RESEARCH   (United States)

Author keywords

Dichlorvos; Hydrolysis; Monkey; Organophosphorus; Pesticide

Indexed keywords

ACETYLCHOLINESTERASE; ARYLDIALKYLPHOSPHATASE; DICHLORVOS; OPDA ENZYME; ORGANOPHOSPHATE PESTICIDE; RECOMBINANT ENZYME; RECOMBINANT OPDA ENZYME; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; APNEA; ARTICLE; BRADYCARDIA; BREATHING; BREATHING RATE; CHLOROCEBUS AETHIOPS; CONTROLLED STUDY; DRUG BLOOD LEVEL; ENZYME ACTIVITY; ENZYME BLOOD LEVEL; GENE EXPRESSION; HEART RATE; LETHALITY; MALE; NONHUMAN; NUCLEOTIDE SEQUENCE; ORGANOPHOSPHATE POISONING; PRIMATE; PRIORITY JOURNAL;

DICHLORVOS; HYDROLYSIS; MONKEY; ORGANOPHOSPHORUS; PESTICIDE;

ACETYLCHOLINESTERASE; AGROBACTERIUM; ANIMALS; ANTIDOTES; BACTERIAL PROTEINS; CERCOPITHECUS AETHIOPS; CHOLINESTERASE INHIBITORS; DEPRESSION, CHEMICAL; DICHLORVOS; DISEASE MODELS, ANIMAL; ERYTHROCYTES; HEART RATE; HYDROLASES; HYDROLYSIS; MALE; ORGANOPHOSPHATE POISONING; PESTICIDES; RECOMBINANT PROTEINS; RESPIRATORY RATE; SEVERITY OF ILLNESS INDEX; SUBSTRATE SPECIFICITY; SURVIVAL ANALYSIS;

EID: 84893451121     PISSN: 0300483X     EISSN: 18793185     Source Type: Journal    
DOI: 10.1016/j.tox.2014.01.003     Document Type: Article

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