Kinetics and efficacy of an organophosphorus hydrolase in a rodent model of methylparathion poisoning

Academic Emergency Medicine

Volumn 17, Issue 7, 2010, Pages 736-740

  Gresham, Chip ^a   Rosenbaum, Christopher ^b   Gaspari, Romolo J ^b   Jackson, Colin J ^c   Bird, Steven B ^b  

^a MIDDLEMORE HOSPITAL   (New Zealand)

^b UNIVERSITY OF MASSACHUSETTS   (United States)

^c CSIRO   (Australia)

Author keywords

Hydrolase; Organophosphate; Pesticide

Indexed keywords

ARYLDIALKYLPHOSPHATASE; PARATHION METHYL; PLACEBO;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DRUG EFFICACY; DRUG HALF LIFE; FLUOROMETRY; INTOXICATION; LETHAL DOSE; LETHALITY; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; SINGLE DRUG DOSE; SURVIVAL;

ANIMALS; ARYLDIALKYLPHOSPHATASE; DISEASE MODELS, ANIMAL; HALF-LIFE; LETHAL DOSE 50; METHYL PARATHION; RATS; RATS, WISTAR;

EID: 77955893754     PISSN: 10696563     EISSN: 15532712     Source Type: Journal    
DOI: 10.1111/j.1553-2712.2010.00798.x     Document Type: Article

References (20)

1. Jeyaratnam J. Acute pesticide poisoning: a major global health problem. World Health Stat Q. 1990;43:139-44.
2. Sidell FR. Clinical effects of organophosphorus cholinesterase inhibitors. J Appl Toxicol. 1994;14:111-3.
3. Thiermann H, Szinicz L, Eyer P, Zilker T, Worek F. Correlation between red blood cell acetylcholinesterase activity and neuromuscular transmission in organophosphate poisoning. Chem Biol Interact. 2005; 157-158, 345-7.
4. Bird SB, Gaspari RJ, Dickson EW. Early death due to severe organophosphate poisoning is a centrally mediated process. Acad Emerg Med. 2003;10:295-8.
5. Eddleston M, Singh S, Buckley N. Organophosphorus poisoning (acute). Clin Evid (BMJ). 2005;13:1744-55.
6. Eyer F, Meischner V, Kiderlen D, et al. Human parathion poisoning. A toxicokinetic analysis. Toxicol Rev. 2003;22:143-63.
7. Jokanovic M. Biotransformation of organophosphorus compounds. Toxicology. 2001;166:139-60.
8. Horne I, Sutherland TD, Harcourt RL, Russell RJ, Oakeshott JG. Identification of an opd (organophosphate degradation) gene in an Agrobacterium isolate. Appl Environ Microbiol. 2002;68:3371-6.
9. Sogorb MA, Vilanova E. Enzymes involved in the detoxification of organophosphorus, carbamate and pyrethroid insecticides through hydrolysis. Toxicol Lett. 2002;128:215-28.
10. Vilanova E, Sogorb MA. The role of phosphotriesterases in the detoxication of organophosphorus compounds. Crit Rev Toxicol. 1999;29:21-57.
11. Sutherland TD, Horne I, Weir KM, et al. Enzymatic bioremediation: from enzyme discovery to applications. Clin Exp Pharmacol Physiol. 2004;31:817-21.
12. Bird SB, Dawson A, Ollis D. Enzymes and bioscavengers for prophylaxis and treatment of organophosphate poisoning. Front Biosci. 2010; S 2:209-20.
13. Sogorb MA, Vilanova E, Carrera V. Future applications of phosphotriesterases in the prophylaxis and treatment of organophosporus insecticide and nerve agent poisonings. Toxicol Lett. 2004;151:219-33.
14. Raushel FM. Bacterial detoxification of organophosphate nerve agents. Curr Opin Microbiol. 2002;5:288-95.
15. Yang H, Carr PD, McLoughlin SY, et al. Evolution of an organophosphate-degrading enzyme: a comparison of natural and directed evolution. Protein Eng. 2003;16:135-45.
16. Jackson CJ, Foo JL, Tokuriki N, et al. Conformational sampling, catalysis, and evolution of the bacterial phosphotriesterase. Proc Natl Acad Sci U S A. 2009;106:21631-6.
17. Harcourt RL, Horne I, Sutherland TD, Hammock BD, Russell RJ, Oakeshott JG. Development of a simple and sensitive fluorimetric method for isolation of coumaphos-hydrolysing bacteria. Lett Appl Microbiol. 2002;34:263-8.
18. Jackson CJ, Weir K, Herlt A, et al. Structure-based rational design of a phosphotriesterase. Appl Environ Microbiol. 2009;75:5153-6.
19. Dawson RM, Pantelidis S, Rose HR, Kotsonis SE. Degradation of nerve agents by an organophosphate-degrading agent (OpdA). J Hazard Mater. 2008;157:308-14.
20. Eddleston M, Eyer P, Worek F, Sheriff MH, Buckley NA. Predicting outcome using butyrylcholinesterase activity in organophosphorus pesticide self-poisoning. QJM. 2008;101:467-74.