OpdA, a bacterial organophosphorus hydrolase, prevents lethality in rats after poisoning with highly toxic organophosphorus pesticides

Toxicology

Volumn 247, Issue 2-3, 2008, Pages 88-92

  Bird, Steven B ^a   Sutherland, Tara D ^b   Gresham, Chip ^c   Oakeshott, John ^b   Scott, Colin ^b   Eddleston, Michael ^d  

^a UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

^b CSIRO   (Australia)

^c BANNER GOOD SAMARITAN MEDICAL CENTER   (United States)

^d UNIVERSITY OF EDINBURGH   (United Kingdom)

Author keywords

Acetylcholinesterase (AChE); Hydrolase; Organophosphorus (OP); Pralidoxime (2 PAM)

Indexed keywords

ANTIDOTE; ARYLDIALKYLPHOSPHATASE; ORGANOPHOSPHATE PESTICIDE; PARATHION; PRALIDOXIME CHLORIDE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CATALYSIS; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFICACY; ENZYME PURIFICATION; INTOXICATION; LD 50; LETHALITY; MALE; MOLECULAR CLONING; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; RHIZOBIUM RADIOBACTER; SINGLE DRUG DOSE; SURVIVAL;

ANIMALS; ARYLDIALKYLPHOSPHATASE; BACTERIAL PROTEINS; DICHLORVOS; INSECTICIDES; MALE; ORGANOPHOSPHORUS COMPOUNDS; PARATHION; PRALIDOXIME COMPOUNDS; RATS; RATS, WISTAR;

AGROBACTERIUM TUMEFACIENS; BACTERIA (MICROORGANISMS); RATTUS;

EID: 42749086354     PISSN: 0300483X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tox.2008.02.005     Document Type: Article

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