Agonistic anti-TIGIT treatment inhibits T cell responses in LDLr deficient mice without affecting atherosclerotic lesion development

PLoS ONE

Volumn 8, Issue 12, 2013, Pages

  Foks, Amanda C ^a   Ran, Ingrid A ^a   Frodermann, Vanessa ^a   Bot, Ilze ^a   Van Santbrink, Peter J ^a   Kuiper, Johan ^a   Van Puijvelde, Gijs H M ^a  

^a LEIDEN UNIVERSITY   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

IMMUNOLOGIC AGENT; INTERLEUKIN 10; INTERLEUKIN 2; LOW DENSITY LIPOPROTEIN RECEPTOR; MEMBRANE PROTEIN; TIGIT ANTIBODY; TIGIT PROTEIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ATHEROSCLEROSIS; CD3+ T LYMPHOCYTE; CD4+ T LYMPHOCYTE; CELLULAR IMMUNITY; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; DENDRITIC CELL; FEMALE; HYPERCHOLESTEROLEMIA; LYMPHOCYTE PROLIFERATION; MOUSE; NONHUMAN; SPLEEN CELL; T LYMPHOCYTE ACTIVATION; UPREGULATION;

ANIMALS; ANTIBODIES; ATHEROSCLEROSIS; CD4-POSITIVE T-LYMPHOCYTES; CELL PROLIFERATION; CRICETULUS; DENDRITIC CELLS; FEMALE; IMMUNOGLOBULIN G; INTERLEUKIN-10; LYMPHOCYTE ACTIVATION; MICE; MICE, KNOCKOUT; RECEPTORS, IMMUNOLOGIC; RECEPTORS, LDL; SPLEEN;

EID: 84893410091     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0083134     Document Type: Article

References (17)

1. Fuchs A, Colonna M (2006) The role of NK cell recognition of nectin and nectin-like proteins in tumor immunosurveillance. Seminars in cancer biology 16: 359-366. (Pubitemid 44311500)
2. Sakisaka T, Takai Y (2004) Biology and pathology of nectins and nectin-like molecules. Current opinion in cell biology 16: 513-521. (Pubitemid 39201235)
3. Levin SD, Taft DW, Brandt CS, Bucher C, Howard ED, et al. (2011) Vstm3 is a member of the CD28 family and an important modulator of T-cell function. European journal of immunology 41: 902-915.
4. Joller N, Hafler JP, Brynedal B, Kassam N, Spoerl S, et al. (2011) Cutting edge: TIGIT has T cell-intrinsic inhibitory functions. Journal of immunology 186: 1338-1342.
5. Yu X, Harden K, Gonzalez LC, Francesco M, Chiang E, et al. (2009) The surface protein TIGIT suppresses T cell activation by promoting the generation of mature immunoregulatory dendritic cells. Nature immunology 10: 48-57.
6. Dardalhon V, Schubart AS, Reddy J, Meyers JH, Monney L, et al. (2005) CD226 is specifically expressed on the surface of Th1 cells and regulates their expansion and effector functions. Journal of immunology 175: 1558-1565. (Pubitemid 41023057)
7. Shibuya K, Shirakawa J, Kameyama T, Honda S, Tahara-Hanaoka S, et al. (2003) CD226 (DNAM-1) is involved in lymphocyte function-associated antigen 1 costimulatory signal for naive T cell differentiation and proliferation. The Journal of experimental medicine 198: 1829-1839. (Pubitemid 38032116)
8. Hafler JP, Maier LM, Cooper JD, Plagnol V, Hinks A, et al. (2009) CD226 Gly307Ser association with multiple autoimmune diseases. Genes and immunity 10: 5-10.
9. Lozano E, Dominguez-Villar M, Kuchroo V, Hafler DA (2012) The TIGIT/CD226 axis regulates human T cell function. Journal of immunology 188: 3869-3875.
10. van Wanrooij EJ, van Puijvelde GH, de Vos P, Yagita H, van Berkel TJ, et al. (2007) Interruption of the Tnfrsf4/Tnfsf4 (OX40/OX40L) pathway attenuates atherogenesis in low-density lipoprotein receptor-deficient mice. Arteriosclerosis, thrombosis, and vascular biology 27: 204-210. (Pubitemid 46360400)
11. Hansson GK (2009) Inflammatory mechanisms in atherosclerosis. Journal of thrombosis and haemostasis: JTH 7 Suppl 1: 328-331.
12. Shah PK (2003) Mechanisms of plaque vulnerability and rupture. Journal of the American College of Cardiology 41: 15S-22S.
13. Elhage R, Gourdy P, Brouchet L, Jawien J, Fouque MJ, et al. (2004) Deleting TCR alpha beta+ or CD4+ T lymphocytes leads to opposite effects on site-specific atherosclerosis in female apolipoprotein E-deficient mice. The American journal of pathology 165: 2013-2018. (Pubitemid 39578379)
14. Galkina E, Ley K (2009) Immune and inflammatory mechanisms of atherosclerosis (*). Annual review of immunology 27: 165-197.
15. Manthey HD, Zernecke A (2011) Dendritic cells in atherosclerosis: functions in immune regulation and beyond. Thrombosis and haemostasis 106: 772-778.
16. Wu H, Gower RM, Wang H, Perrard XY, Ma R, et al. (2009) Functional role of CD11c+ monocytes in atherogenesis associated with hypercholesterolemia. Circulation 119: 2708-2717.
17. Paulson KE, Zhu SN, Chen M, Nurmohamed S, Jongstra-Bilen J, et al. (2010) Resident intimal dendritic cells accumulate lipid and contribute to the initiation of atherosclerosis. Circulation research 106: 383-390.