Nicotine deteriorates the osteogenic differentiation of periodontal ligament stem cells through α7 nicotinic acetylcholine receptor regulating wnt pathway

PLoS ONE

Volumn 8, Issue 12, 2013, Pages

  Zhou, Zhifei ^a   Li, Bei ^a   Dong, Zhiwei ^b   Liu, Fen ^a,c   Zhang, Yu ^a   Yu, Yang ^a   Shang, Fengqing ^a   Wu, Lizheng ^a   Wang, Xiaojing ^a   Jin, Yan ^a  

^a FOURTH MILITARY MEDICAL UNIVERSITY   (China)

^b GENERAL HOSPITAL OF NORTHERN THEATER COMMAND   (China)

^c Maternal and Child Health Hospital of Shaanxi Province   (China)

Author keywords

[No Author keywords available]

Indexed keywords

BETA CATENIN; BUNGAROTOXIN RECEPTOR; NICOTINE; WNT PROTEIN;

ADOLESCENT; ADULT; ARTICLE; CELL DIFFERENTIATION; CHILD; CLINICAL ARTICLE; CONTROLLED STUDY; GENE EXPRESSION; HUMAN; HUMAN CELL; HUMAN TISSUE; MESENCHYMAL STEM CELL; PERIODONTAL LIGAMENT STEM CELL; PROTEIN EXPRESSION; PROTEIN FUNCTION; SIGNAL TRANSDUCTION; STEM CELL;

ADOLESCENT; ALPHA7 NICOTINIC ACETYLCHOLINE RECEPTOR; BETA CATENIN; CELL DIFFERENTIATION; CHILD; DOSE-RESPONSE RELATIONSHIP, DRUG; GENE EXPRESSION REGULATION; HUMANS; NICOTINE; OSTEOGENESIS; PERIODONTAL LIGAMENT; PRIMARY CELL CULTURE; SIGNAL TRANSDUCTION; STEM CELLS; WNT PROTEINS; YOUNG ADULT;

EID: 84893377649     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0083102     Document Type: Article

References (38)

1. Armitage GC (2004) Periodontal diagnoses and classification of periodontal diseases. Periodontol 2000 34: 9-21.
2. Seo BM, Miura M, Gronthos S, Bartold PM, Batouli S, et al. (2004) Investigation of multipotent postnatal stem cells from human periodontal ligament. Lancet 364: 149-155. (Pubitemid 38891686)
3. Ivanovski S, Gronthos S, Shi S, Bartold PM (2006) Stem cells in the periodontal ligament. Oral Dis 12: 358-363. (Pubitemid 43926812)
4. Calsina G, Ramon JM, Echeverria JJ (2002) Effects of smoking on periodontal tissues. J Clin Periodontol 29: 771-776. (Pubitemid 41697819)
5. Bergstrom J (2004) Tobacco smoking and chronic destructive periodontal disease. Odontology 92: 1-8.
6. Kashiwagi Y, Yanagita M, Kojima Y, Shimabukuro Y, Murakami S (2012) Nicotine up-regulates IL-8 expression in human gingival epithelial cells following stimulation with IL-1β or P. gingivalis lipopolysaccharide via nicotinic acetylcholine receptor signalling. Arch Oral Biol 57: 483-490.
7. Artis D (2008) Epithelial-cell recognition of commensal bacteria and maintenance of immune homeostasis in the gut. Nat Rev Immunol 8: 411-420.
8. Tanaka H, Tanabe N, Suzuki N, Shoji M, Torigoe H, et al. (2005) Nicotine affects mineralized nodule formation by the human osteosarcoma cell line Saos-2. Life Sci 77: 2273-2284. (Pubitemid 41169962)
9. Wang XJ, Liu YF, Wang QY, Tsuruoka M, Ohta K, et al. (2010) Functional expression of alpha 7 nicotinic acetylcholine receptors in human periodontal ligament fibroblasts and rat periodontal tissues. Cell Tissue Res 340: 347-355.
10. Grando SA, Kawashima K, Wessler I (2003) Introduction: the non-neuronal cholinergic system in humans. Life Sci 72: 2009-2012. (Pubitemid 36298941)
11. Sakurai R, Cerny L, Torday J, Rehan V (2011) Mechanism for nicotine-induced up regulation of wnt signaling in human alveolar interstitial fibroblasts. Exp Lung Res 37: 144-154.
12. Liu N, Shi S, Deng M, Tang L, Zhang G, et al. (2011) High levels of b-Catenin signaling reduce osteogenic differentiation of stem cells in inflammatory microenvironments through inhibition of the noncanonical wnt pathway. Journal of Bone and Mineral Research 26: 2082-2095.
13. Chen X, Hu C, Wang G, Li L, Kong X, et al. (2013) Nuclear factor-κB modulates osteogenesis of periodontal ligament stem cells through competition with β-catenin signaling in inflammatory microenvironments. Cell Death and Disease 4: e510.
14. Kong X, Liu Y, Ye R, Zhu B, Zhu Y, et al. (2013) GSK3b is a checkpoint for TNF-α-mediated impaired osteogenic differentiation of mesenchymal stem cells in inflammatory microenvironments. Biochim Biophys Acta 1830: 5119-5129.
15. Yang Z, Jin F, Zhang X, Ma D, Han C, et al. (2009) Tissue engineering of cementum/periodontal-ligament complex using a novel three-dimensional pellet cultivation system for human periodontal ligament stem cells. Tissue Eng Part C Methods 15: 571-581.
16. Liu Y, Liu W, Hu C, Xue Z, Wang G, et al. (2011) MiR-17 modulates osteogenic differentiation through a coherent feed-forward loop in mesenchymal stem cells isolated from periodontal ligaments of patients with periodontitis. Stem Cells 29: 1804-1816.
17. Wang L, Shen H, Zheng W, Tang L, Yang Z, et al. (2011) Characterization of stem cells from alveolar periodontal ligament. Tissue Eng Part A 17: 1015-1026.
18. Zhang J, An Y, Gao LN, Zhang YJ, Jin Y, et al. (2012) The effect of aging on the pluripotential capacity and regenerative potential of human periodontal ligament stem cells. Biomaterials 33: 6974-6986.
19. Chen SC, Marino V, Gronthos S, Bartold PM (2006) Location of putative stem cells in human periodontal ligament. J Periodontal Res 41: 547-553. (Pubitemid 44656931)
20. Gronthos S, Mrozik K, Shi S, Bartold PM (2006) Ovine periodontal ligament stem cells: isolation, characterization, and differentiation potential. Calcif Tissue Int 79: 310-317. (Pubitemid 44900154)
21. Wada N, Menicanin D, Shi S, Bartold PM, Gronthos S (2009) Immunomodulatory properties of human periodontal ligament stem cells. J Cell Physiol 219: 667-676.
22. Li B, Qu C, Chen C, Liu Y, Akiyama K, et al. (2012) Basic fibroblast growth factor inhibits osteogenic differentiation of stem cells from human exfoliated deciduous teeth through ERK signaling. Oral Dis 18: 285-292.
23. Liu C, Li Y, Semenov M, Han C, Baeg GH, et al. (2008) Control of beta-catenin phosphorylation/degradation by a dual kinase mechanism. Cell 108: 837-847.
24. World Health Organization (2005) Governments celebrate five years of anti-tobacco convention. Available: http://www.who.int/fctc/press.pdf. Accessed 2013 Jun 12.
25. Luzzi LI, Greghi SL, Passanezi E, Santana AC, Lauris JR, et al. (2007) Evaluation of clinical periodontal conditions in smokers and non-smokers. J Appl Oral Sci 15: 512-517.
26. Tomar SL, Asma S (2000) Smoking-atributable Periodontitis in the United States: findings from NHANES III. National Health and Nutrition Examination Survey. J Periodontol 71: 743-751.
27. Chambrone L, Chambrone D, Lima LA (2010) Predictors of tooth loss during long-term periodontal maintenance: a systematic review of observational studies. J Clin Periodontol 37: 675-684.
28. Wan CP, Leung WK, Wong MC, Wong RM, Wan P, et al. (2009) Effects of smoking on healing response to non-surgical periodontal therapy: a multilevel modeling analysis. J Clin Periodontol 36: 229-239.
29. Iho S, Tanaka Y, Takauji R, Kobayashi C, Muramatsu I, et al. (2003) Nicotine induces human neutrophils to produce IL-8 through the generation of peroxynitrite and subsequent activation of NF-kappaB. J Leukoc Biol 74: 942-951. (Pubitemid 38040371)
30. Makino A, Yamada S, Okuda K, Kato T (2008) Nicotine involved in periodontal disease through influence on cytokine levels. FEMS Immunol Med Microbiol 52: 282-286. (Pubitemid 351248433)
31. Liu Y, Zheng Y, Ding G, Fang D, Zhang C, et al. (2008) Periodontal ligament stem cell mediated treatment for periodontitis in Miniature Swine. Stem Cells 26: 1065-1073.
32. Sonoyama W, Liu Y, Fang D, Yamaza T, Seo BM, et al. (2006) Mesenchymal stem cell mediated functional tooth regeneration in Swine. PLoS One 20(1): e79.
33. Zhang W, Abukawa H, Troulis MJ, Kaban LB, Vacanti JP, et al. (2009) Tissue engineered hybrid tooth-bone constructs. Methods 47(2): 122-128.
34. Ma Z, Li S, Song Y, Tang L, Ma D, et al. (2008) The biological effect of dentin noncollagenous proteins (DNCPs) on the human periodontal ligament stem cells (HPDLSCs) in vitro and in vivo. Tissue Eng Part A 14: 2059-2068.
35. Hamano R, Takahashi HK, Iwagaki H, Yoshino T, Nishibori M, et al. (2006) Stimulation of alpha7 nicotinic acetyl-choline receptor inhibits CD14 and the toll-like receptor 4 expression in human monocytes. Shock 26: 358-364. (Pubitemid 44402020)
36. Tracey KJ (2007) Physiology and immunology of the cholinergic anti-inflammatory pathway. J Clin Invest 117: 289-296.
37. Yoshikawa H, Kurokawa M, Ozaki N, Nara K, Atou K, et al. (2006) Nicotine inhibits the production of proinflammatory mediators in human monocytes by suppression of I-kappaB phosphorylation and nuclear factor-kappaB transcriptional activity through nicotinic acetylcholine receptor alpha 7. Clin Exp Immunol 146: 116-123. (Pubitemid 44393846)
38. Liu YF, Wu LA, Wang J, Wen LY, Wang XJ (2010) Micro-computerized tomography analysis of alveolar bone loss in ligature- and nicotine-induced experimental periodontitis in rats. J Periodontal Res 45: 714-719.