Requirement of estrogen receptor alpha DNA-binding domain for HPV oncogene-induced cervical carcinogenesis in mice

Carcinogenesis

Volumn 35, Issue 2, 2014, Pages 489-496

  Son, Jieun ^a   Park, Jung Wook ^a,b   Lambert, Paul F ^b   Chung, Sang Hyuk ^b  

^a University of Houston   (United States)

^b UNIVERSITY OF WISCONSIN MADISON   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ESTROGEN RECEPTOR ALPHA; VIRUS DNA;

ALLELE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CARCINOGENESIS; CELL PROLIFERATION; CERVICAL CARCINOGENESIS; CONTROLLED STUDY; DNA BINDING; DNA SYNTHESIS; EPITHELIUM CELL; FEMALE; GENE EXPRESSION; GENE TARGETING; HUMAN PAPILLOMAVIRUS TYPE 16; MOUSE; MUTANT; NONHUMAN; PRIORITY JOURNAL; UTERINE CERVIX CANCER; UTERINE CERVIX EPITHELIUM; VIRUS CARCINOGENESIS; VIRUS ONCOGENE; WILD TYPE;

ANIMALS; CELL PROLIFERATION; CELL TRANSFORMATION, NEOPLASTIC; DNA-BINDING PROTEINS; EPITHELIAL CELLS; ESTROGEN RECEPTOR ALPHA; ESTROGENS; FEMALE; HUMANS; HYPERPLASIA; IMMUNOENZYME TECHNIQUES; MICE; MICE, TRANSGENIC; PAPILLOMAVIRUS E7 PROTEINS; RESPONSE ELEMENTS; STROMAL CELLS; UTERINE CERVICAL NEOPLASMS;

EID: 84893362437     PISSN: 01433334     EISSN: 14602180     Source Type: Journal    
DOI: 10.1093/carcin/bgt350     Document Type: Article

References (42)

1. Ferlay,J. et al. (2010) Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008. Int. J. Cancer, 127, 2893-2917.
2. zur Hausen,H. (2002) Papillomaviruses and cancer: from basic studies to clinical application. Nat. Rev. Cancer, 2, 342-350.
3. Schiller,J.T. et al. (2012) Understanding and learning from the success of prophylactic human papillomavirus vaccines. Nat. Rev. Microbiol., 10, 681-692.
4. Quinn,M.A. et al. (2006) Carcinoma of the cervix uteri. FIGO 26th Annual Report on the Results of Treatment in Gynecological Cancer. Int. J. Gynaecol. Obstet., 95 (suppl. 1), S43-103.
5. Arbyn,M. et al. (2008) Perinatal mortality and other severe adverse pregnancy outcomes associated with treatment of cervical intraepithelial neoplasia: meta-analysis. BMJ, 337, a1284.
6. Strati,K. et al. (2008) Human papillomavirus association with head and neck cancers: understanding virus biology and using it in the development of cancer diagnostics. Expert Opin. Med. Diagn., 2, 11-20.
7. Johung,K. et al. (2007) Human papillomavirus E7 repression in cervical carcinoma cells initiates a transcriptional cascade driven by the retinoblastoma family, resulting in senescence. J. Virol., 81, 2102-2116.
8. Jabbar,S.F. et al. (2012) Cervical cancers require the continuous expression of the human papillomavirus type 16 E7 oncoprotein even in the presence of the viral E6 oncoprotein. Cancer Res., 72, 4008-4016.
9. Jabbar,S.F. et al. (2009) Persistence of high-grade cervical dysplasia and cervical cancer requires the continuous expression of the human papillomavirus type 16 E7 oncogene. Cancer Res., 69, 4407-4414.
10. Moreno,V. et al.; International Agency for Research on Cancer. Multicentric Cervical Cancer Study Group. (2002) Effect of oral contraceptives on risk of cervical cancer in women with human papillomavirus infection: the IARC multicentric case-control study. Lancet, 359, 1085-1092.
11. Rinaldi,S. et al. (2011) Endogenous sex steroids and risk of cervical carcinoma: results from the EPIC study. Cancer Epidemiol. Biomarkers Prev., 20, 2532-2540.
12. Elson,D.A. et al. (2000) Sensitivity of the cervical transformation zone to estrogen-induced squamous carcinogenesis. Cancer Res., 60, 1267-1275.
13. Riley,R.R. et al. (2003) Dissection of human papillomavirus E6 and E7 function in transgenic mouse models of cervical carcinogenesis. Cancer Res., 63, 4862-4871.
14. Brake,T. et al. (2003) Comparative analysis of cervical cancer in women and in a human papillomavirus-transgenic mouse model: identification of minichromosome maintenance protein 7 as an informative biomarker for human cervical cancer. Cancer Res., 63, 8173-8180.
15. Chung,S.H. et al. (2009) Prevention and treatment of cervical cancer in mice using estrogen receptor antagonists. Proc. Natl Acad. Sci. USA, 106, 19467-19472.
16. Chung,S.H. et al. (2008) Requirement for estrogen receptor alpha in a mouse model for human papillomavirus-associated cervical cancer. Cancer Res., 68, 9928-9934.
17. Chung,S.H. et al. (2010) Estrogen and ERalpha: culprits in cervical cancer? Trends Endocrinol. Metab., 21, 504-511.
18. Jakacka,M. et al. (2002) An estrogen receptor (ER)alpha deoxyribonucleic acid-binding domain knock-in mutation provides evidence for nonclassical ER pathway signaling in vivo. Mol. Endocrinol., 16, 2188-2201.
19. Syed,F.A. et al. (2005) Skeletal effects of estrogen are mediated by opposing actions of classical and nonclassical estrogen receptor pathways. J. Bone Miner. Res., 20, 1992-2001.
20. Chokalingam,K. et al. (2012) Examination of ERa signaling pathways in bone of mutant mouse models reveals the importance of ERE-dependent signaling. Endocrinology, 153, 5325-5333.
21. Herber,R. et al. (1996) Squamous epithelial hyperplasia and carcinoma in mice transgenic for the human papillomavirus type 16 E7 oncogene. J. Virol., 70, 1873-1881.
22. Winuthayanon,W. et al. (2010) Uterine epithelial estrogen receptor a is dispensable for proliferation but essential for complete biological and biochemical responses. Proc. Natl Acad. Sci. USA, 107, 19272-19277.
23. Hayashi,S. et al. (2002) Efficient recombination in diverse tissues by a tamoxifen-inducible form of Cre: a tool for temporally regulated gene activation/inactivation in the mouse. Dev. Biol., 244, 305-318.
24. Lubahn,D.B. et al. (1993) Alteration of reproductive function but not prenatal sexual development after insertional disruption of the mouse estrogen receptor gene. Proc. Natl Acad. Sci. USA, 90, 11162-11166.
25. Shin,M.K. et al. (2012) Inactivating all three rb family pocket proteins is insufficient to initiate cervical cancer. Cancer Res., 72, 5418-5427.
26. Chung,S.H. et al. (2013) Requirement for stromal estrogen receptor alpha in cervical neoplasia. Horm. Cancer, 4, 50-59.
27. Shin,M.K. et al. (2009) Human papillomavirus E7 oncoprotein overrides the tumor suppressor activity of p21Cip1 in cervical carcinogenesis. Cancer Res., 69, 5656-5663.
28. Strati,K. et al. (2006) Identification of biomarkers that distinguish human papillomavirus (HPV)-positive versus HPV-negative head and neck cancers in a mouse model. Proc. Natl Acad. Sci. USA, 103, 14152-14157.
29. Jozwik,K.M. et al. (2012) Pioneer factors in hormone-dependent cancers. Nat. Rev. Cancer, 12, 381-385.
30. DeNardo,D.G. et al. (2007) Estrogen receptor DNA binding is not required for estrogen-induced breast cell growth. Mol. Cell. Endocrinol., 277, 13-25.
31. Wang,L.H. et al. (2006) Disruption of estrogen receptor DNA-binding domain and related intramolecular communication restores tamoxifen sensitivity in resistant breast cancer. Cancer Cell, 10, 487-499.
32. Thomas,C. et al. (2011) The different roles of ER subtypes in cancer biology and therapy. Nat. Rev. Cancer, 11, 597-608.
33. Zhai,Y. et al. (2010) Loss of estrogen receptor 1 enhances cervical cancer invasion. Am. J. Pathol., 177, 884-895.
34. Kwasniewska,A. et al. (2011) Estrogen and progesterone receptor expression in HPV-positive and HPV-negative cervical carcinomas. Oncol. Rep., 26, 153-160.
35. Hewitt,S.C. et al. (2010) Estrogen-mediated regulation of Igf1 transcription and uterine growth involves direct binding of estrogen receptor alpha to estrogen-responsive elements. J. Biol. Chem., 285, 2676-2685.
36. Wu,X. et al. (2003) Serum levels of insulin-like growth factor I and risk of squamous intraepithelial lesions of the cervix. Clin. Cancer Res., 9, 3356-3361.
37. Bourdeau,V. et al. (2004) Genome-wide identification of high-affinity estrogen response elements in human and mouse. Mol. Endocrinol., 18, 1411-1427.
38. Kawase,R. et al. (2010) Expression of fibroblast growth factor receptor 2 IIIc in human uterine cervical intraepithelial neoplasia and cervical cancer. Int. J. Oncol., 36, 331-340.
39. Zheng,J. et al. (1995) Keratinocyte growth factor is a bifunctional regulator of HPV16 DNA-immortalized cervical epithelial cells. J. Cell Biol., 129, 843-851.
40. Bulut,G. et al. (2011) Beta-catenin accelerates human papilloma virus type-16 mediated cervical carcinogenesis in transgenic mice. PLoS One, 6, e27243.
41. Hewitt,S.C. et al. (2009) Selective disruption of ER{alpha} DNA-binding activity alters uterine responsiveness to estradiol. Mol. Endocrinol., 23, 2111-2116.
42. Jordan,V.C. (2007) Chemoprevention of breast cancer with selective oestrogen-receptor modulators. Nat. Rev. Cancer, 7, 46-53.