An Encapsulated Juice Powder Concentrate Improves Markers of Pulmonary Function and Cardiovascular Risk Factors in Heavy Smokers

Journal of the American College of Nutrition

Volumn 32, Issue 1, 2013, Pages 18-25

  Bamonti, Fabrizia ^a   Pellegatta, Marco ^b   Novembrino, Cristina ^a   Vigna, Luisella ^b   De Giuseppe, Rachele ^a   de Liso, Federica ^a   Gregori, Dario ^c   Noce, Cinzia Della ^d   Patrini, Lorenzo ^b   Schiraldi, Gianfranco ^d   Bonara, Paola ^b   Calvelli, Laura ^d   Maiavacca, Rita ^b   Cighetti, Giuliana ^e  

^a UNIVERSITY OF MILAN   (Italy)

^b FONDAZIONE IRCCS CA GRANDA OSPEDALE MAGGIORE POLICLINICO   (Italy)

^c UNIVERSITY OF PADOVA   (Italy)

^d OSPEDALE NIGUARDA CA GRANDA   (Italy)

^e UNIVERSITY OF MILAN   (Italy)

Author keywords

cysteine; folate; homocysteine; nutraceutical; tobacco

Indexed keywords

COTININE; HOMOCYSTEINE; BIOLOGICAL MARKER; CARBON MONOXIDE; CYSTEINE; FOLIC ACID; PLANT MEDICINAL PRODUCT; MICROCAPSULE; POWDER;

ADULT; ARTICLE; BODY MASS; CARDIOVASCULAR RISK; CHEMICAL ANALYSIS; CONTROLLED STUDY; DIET SUPPLEMENTATION; DIETARY INTAKE; FEMALE; FORCED EXPIRATORY FLOW; FORCED EXPIRATORY VOLUME; FORCED VITAL CAPACITY; FRUIT JUICE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; LIFESTYLE MODIFICATION; LUNG FUNCTION; MIDDLE AGED; NORMAL HUMAN; NUTRITIONAL ASSESSMENT; PHYSICAL ACTIVITY; SMOKING; SPIROMETRY; VEGETABLE; BLOOD; BREATHING; CARDIOVASCULAR DISEASE; CONTROLLED CLINICAL TRIAL; DRUG EFFECT; FRUIT; LUNG; MALE; METABOLISM; MICROCAPSULE; PATHOPHYSIOLOGY; POWDER; RANDOMIZED CONTROLLED TRIAL; RISK FACTOR; TOBACCO; CARDIOVASCULAR DISEASES; DRUG EFFECTS; DRUG THERAPY;

ADULT; BIOLOGICAL MARKERS; CAPSULES; CARBON MONOXIDE; CARDIOVASCULAR DISEASES; CYSTEINE; DIETARY SUPPLEMENTS; FEMALE; FOLIC ACID; FRUIT; HOMOCYSTEINE; HUMANS; LUNG; MALE; MIDDLE AGED; PLANT PREPARATIONS; POWDERS; RESPIRATION; RISK FACTORS; SMOKING; TOBACCO PRODUCTS; VEGETABLES;

EID: 84893350199     PISSN: 07315724     EISSN: 15411087     Source Type: Journal    
DOI: 10.1080/07315724.2013.767652     Document Type: Article

References (48)

1. Carnevali, S, Petruzzelli, S, Longoni, B, Vanacore, R, Barale, R, Cipollini, M, Scatena, F, Paggiaro, P, Celi, A and Giuntini, C. 2003. Cigarette smoke extract induces oxidative stress and apoptosis in human lung fibroblasts. Am J Physiol Lung Cell, 284: L955 - L963.
2. Okumura, K and Tsukamoto, H. 2011. Folate in smokers. Clin Chim Acta, 412: 521 - 526.
3. Chavez, J, Cano, C, Souki, A, Bermúdez, V, Medina, M, Ciszek, A, Amell, A, Vargas, M E, Reyna, N, Toledo, A, Cano, R, Suárez, G, Contreras, F, Israili, Z H, Hernández-Hernández, R and Valasco, M. 2007. Effect of cigarette smoking on the oxidant/antioxidant balance in healthy subjects. Am J Ther, 14: 189 - 193.
4. Yanbaeva, D G, Dentener, M A, Creutzberg, E C, Wesseling, G and Wouters, E F. 2007. Systemic effects of smoking. Chest, 131: 1557 - 1566.
5. Kelly, G. 2002. The interaction of cigarette smoking and antioxidants. Part I: Diet and carotenoids. Altern Med Rev, 7: 370 - 388.
6. Unverdorben, M, Mostert, A, Munjal, S, van der Bijl, A, Potgieter, L, Venter, C, Liang, Q, Meyer, B and Roethig, H J. 2010. Acute effects of cigarette smoking on pulmonary function. Regul Toxicol Pharmacol, 57: 241 - 246.
7. Sobczak, A, Wardas, W, Zielinska-Danch, W and Pawlicki, K. 2004. The influence of smoking on plasma homocysteine and cysteine levels in passive and active smokers. Clin Chem Lab Med, 42: 408 - 414.
8. Cintra, F, Tufik, S, D'Almeida, V, Calegare, B F, de Paola, A, Oliveira, W, Rizzi, C, Roizenblatt, S and Poyares, D. 2011. Cysteine: A potential biomarker for obstructive sleep apnea. Chest, 139: 246 - 252.
9. Pryor, W A and Stone, K. 1993. Oxidants in cigarette smoke. Radicals, hydrogen peroxide, peroxynitrate and peroxynitrite. Ann N Y Acad Sci, 686: 12 - 29.
10. Ozkan, Y, Ozkan, E and Simsek, B. 2002. Plasma total homocysteine and cysteine as cardiovascular risk factors in coronary heart disease. Int J Cardiol, 82: 269 - 277.
11. El-Khairy, L, Ueland, P M, Refsum, H, Graham, I M and Vollset, S E. 2001. European Concerted Action Project: Plasma total cysteine as risk factor for vascular disease. Circulation, 103: 2544 - 2549.
12. Mansoor, M A, Svardal, A M and Ueland, P M. 1992. Determination of the in vivo redox status of cysteine cysteinylglycine homocysteine and glutathione in human plasma. Anal Biochem, 200: 218 - 229.
13. Palaniappan, U, Jacobs Starkey, L, O'Loughlin, J and Gray-Donald, K. 2001. Fruit and vegetable consumption is lower and saturated fat intake is higher among Canadians reporting smoking. J Nutr, 131: 1952 - 1958.
14. Chang, J L, Chen, G, Ulrich, C M, Bigler, J, King, I B, Schwarz, Y, Li, S, Li, L, Potter, J D and Lampe, J W. 2010. DNA damage and repair: Fruit and vegetable effects in a feeding trial. Nutr Cancer, 62: 329 - 335.
15. Walda, I C, Tabak, C, Smit, H A, Räsänen, L, Fidanza, F, Menotti, A, Nissinen, A, Feskens, E J and Kromhout, D. 2002. Diet and 20-year chronic obstructive pulmonary disease mortality in middle-aged men from three European countries. Eur J Clin Nutr, 56: 638 - 643.
16. Samman, S, Sivarajah, G, Man, J C, Ahmad, Z I, Petocz, P and Caterson, I D. 2003. A mixed fruit and vegetable concentrate increases plasma antioxidant vitamins and folate and lowers plasma homocysteine in men. J Nutr, 133: 2188 - 2193.
17. Kiefer, I, Prock, P, Lawrence, C, Wise, J, Bieger, W, Bayer, P, Rathmanner, T, Kunze, M and Rieder, A. 2004. Supplementation with mixed fruit and vegetable juice concentrates increased serum antioxidants and folate in healthy adults. J Am Coll Nutr, 23: 205 - 211.
18. Kawashima, A, Madarame, T, Koike, H, Komatsu, Y and Wise, J A. 2007. Four week supplementation with mixed fruit and vegetable juice concentrates increased protective serum antioxidants and folate and decreased plasma homocysteine in Japanese subjects. Asia Pac J Clin Nutr, 16: 411 - 421.
19. Panunzio, M F, Pisano, A, Antoniciello, A, Di Martino, V, Frisoli, L, Cipriani, V, Mongelli, M A and Bronzetti, G. 2003. Supplementation with fruit and vegetable concentrate decrease plasma homocystine levels in a dietary controlled trial. Nutr Res, 23: 1221 - 1228.
20. Bamonti, F, Novembrino, C, Ippolito, S, Soresi, E, Ciani, A, Lonati, S, Scurati-Manzoni, E and Cighetti, G. 2006. Increased free malondialdehyde concentrations in smokers normalise with a mixed fruit and vegetable juice concentrate: A pilot study. Clin Chem Lab Med, 44: 391 - 395.
21. Nantz, M P, Rowe, C A, Nieves, C J and Percival, S S. 2006. Immunity and antioxidant capacity in humans is enhanced by consumption of a dried, encapsulated fruit and vegetable juice concentrate. J Nutr, 136: 2606 - 2610.
22. Lamprecht, M, Oettl, K, Schwaberger, G, Hofmann, P and Greilberger, J F. 2007. Several indicators of oxidative stress, immunity, and illness improved in trained men consuming an encapsulated juice powder concentrate for 28 weeks. J Nutr, 137: 2737 - 2741.
23. Novembrino, C, Cighetti, G, De Giuseppe, R, Vigna, L, de Liso, F, Pellegatta, M, Gregori, D, Maiavacca, R and Bamonti, F. 2011. Effects of encapsulated fruit and vegetable juice powder concentrates on oxidative status in heavy smokers. J Am Coll Nutr, 30: 49 - 56.
24. Cighetti, G, Debiasi, S, Paroni, R and Allevi, P. 1999. Free and total malondialdehyde assessment in biological matrices by gas chromatography-mass spectrometry: What is needed for an accurate detection. Anal Biochem, 266: 222 - 229.
25. Jin, Y, Cui, X, Singh, U P, Chumanevich, A A, Harmon, B, Cavicchia, P, Hofseth, A B, Kotakadi, V, Stroud, B, Volate, S R, Hurley, T G, Hebert, J R and Hofseth, L J. 2010. Systemic inflammatory load in humans is suppressed by consumption of two formulations of dried, encapsulated juice concentrate. 54: 1 - 9. Mol Nutr Food Res
26. Calvelli, L, Accinni, R, Gregori, D, Della Noce, C, Bamonti, F, Vigna, L, Schiraldi, G, Novembrino, C, Cossovich, A, Chiericozzi, M, Scala, E and Allegra, L. 2011. A quick and effective questionnaire to value dietary intakes and oxidative stress related to food in pneumological patients. Progr Nutr, 13: 55 - 64.
27. Miller, M R, Hankinson, J, Brusasco, V, Burgos, F, Casaburi, R, Coates, A, Crapo, R, Enright, P, van der Grinten, C P, Gustafsson, P, Jensen, R, Johnson, D C, MacIntyre, N, McKay, R, Navajas, D, Pedersen, O F, Pellegrino, R, Viegi, G and Wanger, J. 2005. Standardisation of spirometry. Eur Respir J, 26: 319 - 338.
28. Franssen, F ME, Spruit, M A and Wouters, E FM. 2011. Determinants of polypharmacy and compliance with GOLD guidelines in patients with chronic obstructive pulmonary disease. Int J Chron Obstruct Pulmon Dis, 6: 493 - 501.
29. 12: A rapid, automated assay for holotranscobalamin on the Abbott AxSYM analyzer. Clin Chem, 54: 567 - 573.
30. 12 assay: Cut-off point evaluation in the clinical laboratory. Clin Chem Lab Med, 48: 249 - 253.
31. De Vecchi, A F, Novembrino, C, Patrosso, C, Cresseri, D, Ippolito, S, Rosina, M, Colucci, P, Lando, G and Bamonti-Catena, F. 2003. Effect of incremental doses of folate on homocysteine and metabolically related vitamin concentrations in nondiabetic patients on peritoneal dialysis. ASAIO J, 49: 655 - 659.
32. Accinni, R and Parodi, O. 2001. " Determination of plasma homocysteine ". In "Atherosclerosis: Experimental Methods and Protocols", Edited by: Drew, A F. Vol. 52, 77 - 103. Totowa: Humana Press.
33. Barnes, P J. 2000. Chronic obstructive pulmonary disease. N Engl J Med, 343: 269 - 280.
34. Simmons, M S, Connett, J E, Nides, M A, Lindgren, P G, Kleerup, E C, Murray, R P, Bjornson, W M and Tashkin, D P. 2005. Smoking reduction and the rate of decline in FEV1: results from the lung health study. Eur Respir J, 25: 1011 - 1017.
35. Swanney, M P, Ruppel, G, Enright, P L, Pedersen, O F, Crapo, R O, Miller, M R, Jensen, R L, Falaschetti, E, Schouten, J P, Hankinson, J L, Stocks, J and Quanjer, P H. 2008. Using the lower limit of normal for the FEV1/FVC ratio reduces the misclassification of airway obstruction. Thorax, 63: 1046 - 1051.
36. Roll, S, Noco, M and Willich, N. 2011. Reduction of common cold symptoms by encapsulated juice powder concentrate of fruits and vegetables: A randomised, double-blind, placebo-controlled trial. Br J Nutr, 105: 118 - 122.
37. Demirkol, O, Adams, C and Ercal, N. 2004. Biologically important thiols in various vegetables and fruits. J Agric Food Chem, 52: 8151 - 8154.
38. Laughton, M J, Evans, P J, Moroney, M A, Hoult, J RS and Halliwell, B. 1991. Inhibition of mammalian 5-lipoxygenase and cyclo-oxygenase by flavonoids and phenolic dietary additives. Biochem Pharmacol, 42: 1673 - 1681.
39. Tabak, C, Arts, I CW, Smit, H A, Heederik, D and Kromhout, D. 2001. Chronic obstructive pulmonary disease and intake of catechins, flavonols, and flavones. Am J Respir Crit Care Med, 164: 61 - 64.
40. Tungtrongchitr, R, Pongpaew, P, Soonthornruengyot, M, Viroonudomphol, D, Vudhivai, N, Tungtrongchitr, A, Phonrat, B, Pooudong, S and Schelp, F P. 2003. Relationship of tobacco smoking with serum vitamin B12, folic acid and haematological indices in healthy adults. Public Health Nutr, 6: 675 - 681.
41. Valera-Moreiras, G, Murphy, M M and Scott, J M. 2009. Cobalamin, folic acid, and homocysteine. Nutr Rev, 67: S69 - S72.
42. Pitkin, R M. 2007. Folate and neural tube defects. Am J Clin Nutr, 85: 285S - 288S.
43. Kronenberg, G, Colla, M and Endres, M. 2009. Folic acid, neurodegenerative and neuropsychiatric disease. Curr Mol Med, 9: 315 - 323.
44. Bamonti-Catena, F, Buccianti, G, Porcella, A, Valenti, G, Como, G, Finazzi, S and Maiolo, A T. 1999. Folate measurements in patients on regular hemodialysis treatment. Am J Kidney Dis, 33: 492 - 497.
45. De Vecchi, A F, Bamonti-Catena, F, Finazzi, S, Campolo, J, Taioli, E, Novembrino, C, Colucci, P, Accinni, R, De Franceschi, M, Fasano, M A and Maiolo, A T. 2000. Homocysteine, vitamin B12, serum and erythrocyte folate in peritoneal dialysis and hemodialysis patients. Perit Dial Int, 20: 169 - 173.
46. 12 and folate coenzymes by butyl nitrite as observed by NMR: Implications on one-carbon transfer mechanism. Biochem Biophys Res Commun, 135: 201 - 207.
47. O'Callaghan, P, Meleady, R, Fitzgerald, T and Graham, I. 2002. European COMAC group. Smoking and plasma homocysteine. Eur Heart J, 23: 1580 - 1586.
48. Dekhuijzen, P NR. 2004. Antioxidant properties of N-acetylcysteine: Their relevance in relation to chronic obstructive pulmonary disease. Eur Respir J, 23: 629 - 636.