Vivo imaging of brain aromatase in female baboons: [11C]Vorozole kinetics and effect of the menstrual cycle

Molecular Imaging

Volumn 12, Issue 8, 2013, Pages

  Pareto, Deborah ^a,b   Biegon, Anat ^a,b   Alexoff, David ^a,b   Carter, Pauline ^a,b   Shea, Coreen ^a,b   Muench, Lisa ^a,b   Xu, Youwen ^a,b   Fowler, Joanna S ^a,b   Kim, Sunny W ^a,b   Logan, Jean ^c  

^a HOSPITAL UNIVERSITARI VALL D HEBRON   (Spain)

^b BIOMATERIALES Y NANOMEDICINA CIBER BBN   (Spain)

^c BROOKHAVEN NATIONAL LABORATORY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COMPARTMENT MODEL; CORTICAL AREAS; DISTRIBUTION VOLUME; GRAPHICAL METHODS; GRAPHICAL MODEL; HORMONE LEVELS; MENSTRUAL CYCLE; QUANTIFICATION METHODS;

ESTIMATION; GRAPHIC METHODS; POSITRON EMISSION TOMOGRAPHY; TISSUE;

BRAIN;

EID: 84893348689     PISSN: 15353508     EISSN: None     Source Type: Journal    
DOI: 10.2310/7290.2013.00068     Document Type: Article

References (19)

1. Naftolin F, Ryan KJ, Petro Z. Aromatization of androstenedione by limbic system tissue from human foetuses. J Endocrinol 1971;51: 795-6, doi:10.1677/joe.0.0510795
2. Lephart ED. A review of brain aromatase cytochrome P450. Brain Res Rev 1996;22:1-26, doi:10.1016/0165-0173(96)00002-1
3. Garcia-Segura LM, Veiga S, Sierra A, et al. Aromatase: a neuroprotective enzyme. Prog Neurobiol 2003;71:31-41, doi:10. 1016/j.pneurobio.2003.09.005
4. Ishunina TA, van Beurden D, van der Meulen G, et al. Diminished aromatase immunoreactivity in the hypothalamus, but not in the basal forebrain nuclei in Alzheimer's disease. Neurobiol Aging 2005;26:173-94, doi:10.1016/j. neurobiolaging.2004.03.010
5. Roselli CE, Resko JA. Cytochrome P450 aromatase (CYP19) in the non-human primate brain: distribution, regulation, and functional significance. J Steroid Biochem Mol Biol 2001;79:247-53, doi:10.1016/S0960-0760(01)00141-8
6. Yague JG, Wang AC, Janssen WG, et al. Aromatase distribution in the monkey temporal neocortex and hippocampus. Brain Res 2008;1209:115-27.
7. Wouters W, Snoeck E, DeCoster R. Vorozole, a specific nonsteroidal aromatase inhibitor. Breast Cancer Res Treat 1994;30:89- 94, doi:10.1007/BF00682743
8. Plourde PV, Dyroff M, Dowsett M, et al. ARIMIDEX: a new oral, once-a-day aromatase inhibitor. J Steroid Biochem Mol Biol 1995; 53:175-9, doi:10.1016/0960-0760(95)00045-2
9. Dowsett M, Jones A, Johnston SR, et al. In vivo measurement of aromatase inhibition by letrozole (CGS 20267) in postmenopausal patients with breast cancer. Clin Cancer Res 1995;1:1511-5
10. Handelsman DJ. Indirect androgen doping by oestrogen blockade in sports. Br J Pharmacol 2008;154:598-605, doi:10.1038/ bjp.2008.150.
11. Decoster R, Vanginckel RF, Callens MJL, et al. Antitumoral and endocrine effects of (+)-vorozole in rats bearing dimethylbenzanthracene- induced mammary tumors. Cancer Res 1992;52: 1240-4
12. Lidstrom P, Bonasera TA, Kirilovas D, et al. Synthesis, in vivo rhesus monkey biodistribution and in vitro evaluation of a C-11- labelled potent aromatase inhibitor: [N-methyl-C-11]vorozole. Nucl Med Biol 1998;25:497-501, doi:10.1016/S0969-8051(98)00 009-2
13. Takahashi K, Bergström M, Frändberg P, et al. Imaging of aromatase distribution in rat and rhesus monkey brains with [11C]vorozole. Nucl Med Biol 2006;33:599-605, doi:10.1016/ j.nucmedbio.2006.03.009
14. Kim SW, Biegon A, Katsamanis Z, et al. Reinvestigation of the synthesis and evaluation of [N-methyl-11C]vorozole, a radiotracer targeting cytochrome P450 aromatase. Nucl Med Biol 2009; 36:323-34
15. Logan J, Fowler JS, Volkow ND, et al. Graphical analysis of reversible radioligand binding from time-activity measurements applied to [N-11C-methyl]-(-)-cocaine PET studies in human subjects. J Cereb Blood Flow Metab 1990;10:740-7, doi:10.1038/ jcbfm.1990.127
16. Greer PJ, Villemagne VL, Ruszkiewicz J, et al. MR atlas of the baboon brain for functional neuroimaging. Brain Res Bull 2002;58: 429-38, doi:10.1016/S0361-9230(02)00810-9
17. Holthoff VA, Koeppe RA, Frey KA, et al. Differentiation of radioligand delivery and binding in the brain: validation of a two-compartment model for [11C]flumazenil. J Cereb Blood Flow Metab 1991;11:745-52, doi:10.1038/jcbfm. 1991.131
18. Abdelgadir SE, Roselli CE, Choate JVA, Resko JA. Distribution of aromatase cytochrome P450 messenger ribonucleic acid in adult rhesus monkey brains. Biol Reprod 1997;57:772-7, doi:10.1095/ biolreprod57.4.772.
19. Österlund MK, Yasmin L, Hurd YL. Estrogen receptors in the human forebrain and the relation to neuropsychiatric disorders. Progress in Neurobiology 2001;64:251-267, Available at: http:// www.sciencedirect.com/ science/journal/03010082 (accessed Dec 16,2013)