Zolpidem and restoration of consciousness

American Journal of Physical Medicine and Rehabilitation

Volumn 93, Issue 2, 2014, Pages 101-113

  Whyte, John ^a   Rajan, Riya ^a   Rosenbaum, Amy ^b   Katz, Douglas ^c,d   Kalmar, Kathleen ^e   Seel, Ron ^f   Greenwald, Brian ^g   Zafonte, Ross ^h   Demarest, David ⁱ   Brunner, Robert ^j   Kaelin, Darryl ^k  

^a MOSS REHABILITATION RESEARCH INSTITUTE   (United States)

^b Park Terrace Care Center ^*  (United States)

^c BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d Braintree Rehabilitation Hospital   (United States)

^e JFK JOHNSON REHABILITATION INSTITUTE   (United States)

^f SHEPHERD CENTER   (United States)

^g MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^h and Red Sox Foundation and Massachusetts General Hospital Home Base Program   (United States)

ⁱ On with Life   (United States)

^j University of Alabama at Birmingham   (United States)

^k University of Louisville School of Medicine   (United States)

more..

Author keywords

Brain Injuries; Consciousness Disorders; Minimally Conscious State; Vegetative State; Zolpidem

Indexed keywords

HYPNOTIC SEDATIVE AGENT; PYRIDINE DERIVATIVE; ZOLPIDEM;

ADULT; AGED; ARTICLE; CONSCIOUSNESS DISORDER; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CONVALESCENCE; CROSSOVER PROCEDURE; DOUBLE BLIND PROCEDURE; FEMALE; HUMAN; MALE; MIDDLE AGED; MULTICENTER STUDY; PROSPECTIVE STUDY; TREATMENT OUTCOME; YOUNG ADULT;

ADULT; AGED; CONSCIOUSNESS DISORDERS; CROSS-OVER STUDIES; DOUBLE-BLIND METHOD; FEMALE; HUMANS; HYPNOTICS AND SEDATIVES; MALE; MIDDLE AGED; PROSPECTIVE STUDIES; PYRIDINES; RECOVERY OF FUNCTION; TREATMENT OUTCOME; YOUNG ADULT;

EID: 84893295775     PISSN: 08949115     EISSN: 15377385     Source Type: Journal    
DOI: 10.1097/PHM.0000000000000069     Document Type: Article

References (29)

1. Plum F, Posner J: The Pathologic Physiology of Signs and Symptoms of Coma. The Diagnosis of Stupor and Coma, ed 3. Philadelphia, PA, FA Davis, 1982
2. American Academy of Neurology Quality Standards Subcommittee: Practice parameter: Assessment and management of persons in the persistent vegetative state. Neurology 1995;45: 1015-8
3. Giacino J, Ashwal S, Childs N, et al: The minimally conscious state: Definition and diagnostic criteria. Neurology 2002;58: 349-53
4. Seel RT, Sherer M, Whyte J, et al: Assessment scales for disorders of consciousness: Evidence-based recommendations for clinical practice and research. Arch Phys Med Rehabil 2010;91: 1795-813
5. The Multi-Society Task Force Report on PVS: Medical aspects of the persistent vegetative state. N Engl J Med 1994;330:1499-508, 572-9
6. Giacino JT, Zasler ND: Outcome after severe traumatic brain injury: Coma, the vegetative state, and the minimally responsive state. J Head Trauma Rehabil 1995;10: 40-56
7. Bernat JL: Chronic consciousness disorders. Annu Rev Med 2009;60: 381-92
8. Giacino J, Whyte J, Bagiella E, et al: Placebo-controlled trial of amantadine for severe traumatic brain injury. N Engl J Med 2012;366: 819-26
9. Clauss RP, Guldenpfennig WM, Nel HW, et al: Extraordinary arousal from semi-comatose state on zolpidem. A case report. S Afr Med J 2000;90: 68-72
10. Clauss R, Nel W: Drug induced arousal from the permanent vegetative state. NeuroRehabilitation 2006; 21: 23-8
11. Shames JL, Ring H: Transient reversal of anoxic brain injuryYrelated minimally conscious state after zolpidem administration: A case report. Arch Phys Med Rehabil 2008;89: 386-8
12. Cohen L, Chaaban B, Habert MO: Transient improvement of aphasia with zolpidem. N Engl J Med 2004;350: 949-50
13. Machado C, Estevez M, Perez-Nellar J, et al: Autonomic, EEG, and behavioral arousal signs in a PVS case after Zolipdem intake. Can J Neurol Sci 2011;38: 341-4
14. Singh R, McDonald C, Dawson K, et al: Zolpidem in a minimally conscious state. Brain Inj 2008;22: 103-6
15. Snyman N, Egan JR, London K, et al: Zolpidem for persistent vegetative stateVA placebo-controlled trial in pediatrics. Neuropediatrics 2010;41: 223-7
16. Berlin I, Warot D, Hergueta T, et al: Comparison of the effects of zolpidem and triazolam on memory functions, psychomotor performances, and postural sway in healthy subjects. J Clin Psychopharm 1992; 13: 100-6
17. Whyte J, Myers R: Incidence of clinically significant responses to zolpidem among patients with disorders of consciousness: A preliminary placebo controlled trial. Am J Phys Med Rehabil 2009;88: 410-8
18. Rappaport M, Hall KM, Hopkins K, et al: Disability Rating Scale for severe head trauma: Coma to community. Arch Phys Med Rehabil 1982;63: 118-23
19. Giacino JT, Kalmar K, Whyte J, et al: Coma Recovery ScaleYRevised: Measurement characteristics and diagnostic utility. Arch Phys Med Rehabil 2004;85: 2020-9
20. Cohen S, Duong T: Increased arousal in a patient with anoxic brain injury after administration of zolpidem. Am J Phys Med Rehabil 2008;87: 229-31
21. Clauss RP: Neurotransmitters in coma, vegetative and minimally conscious states. Med Hypotheses 2010;75: 287-90
22. Brown EN, Lydic R, Schiff ND: General anesthesia, sleep, and coma. N Engl J Med 2010;363: 2638-50
23. Churchill L, Bourdelais A, Austin M, et al: Gammaamino butyric acid and mu-opoid receptor localization and adaptation in the basal forebrain. Adv Exp Med Biol 1991;295: 101-17
24. Schiff ND, Posner JB: Another "Awakenings". Ann Neurol 2007;62: 5-7
25. Schiff ND: Recovery of consciousness after brain injury: A mesocircuit hypothesis. Trends Neurosci 2010; 1: 1-9
26. Brefel-Courbon C, Payoux P, Fabierine O, et al: Clinical and imaging evidence of zolpidem effect in hypoxic encephalopathy. Ann Neurol 2007;62: 102-5
27. van Lier H, Drinkenburg WH, van Eeten YJ, et al: Effects of diazepam and zolpidem on EEG beta frequencies are behavior-specific in rats. Neuropharmacology 2004;47: 163-74
28. Patat A, Trocherie S, Thebault JJ, et al: EEG profile of intravenous zolpidem in healthy volunteers. Psychopharmacology 1994;114: 138-46
29. Galson S, U.S. Food and Drug Administration: Drug Safety/Drug Approval Process. Available at: http:// www.fda.gov/newsevents/testimony/ucm161673.htm. Accessed December 25, 2013