Zolpidem for persistent vegetative state - A placebo-controlled trial in pediatrics

Neuropediatrics

Volumn 41, Issue 5, 2010, Pages 223-227

  Snyman, N ^a,c   Egan, J R ^a,d   London, K ^a   Howman Giles, R ^a,d   Gill, D ^a   Gillis, J ^a,d   Scheinberg, A ^a,b  

^a CHILDREN S HOSPITAL AT WESTMEAD   (Australia)

^b ROYAL CHILDREN'S HOSPITAL   (Australia)

^c UNIVERSITY OF NEW SOUTH WALES   (Australia)

^d UNIVERSITY OF SYDNEY   (Australia)

Author keywords

pediatrics; persistent vegetative state; positron emission tomography; zolpidem

Indexed keywords

FLUORODEOXYGLUCOSE F 18; ZOLPIDEM;

ADOLESCENT; ARTICLE; BRAIN BLOOD FLOW; BRAIN PERFUSION; CHILD; CLINICAL TRIAL; COGNITION; COMA; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; HUMAN; MALE; PERSISTENT VEGETATIVE STATE; POSITRON EMISSION TOMOGRAPHY; PRESCHOOL CHILD; PRIORITY JOURNAL; PROSPECTIVE STUDY; RANCHO LOS AMIGOS SCALE; RANDOMIZED CONTROLLED TRIAL; RATING SCALE; REGIONAL PERFUSION;

ADOLESCENT; BRAIN; CEREBROVASCULAR CIRCULATION; CHILD; CHILD, PRESCHOOL; DOUBLE-BLIND METHOD; GABA-A RECEPTOR ANTAGONISTS; HUMANS; MALE; PERSISTENT VEGETATIVE STATE; PROSPECTIVE STUDIES; PYRIDINES; TREATMENT OUTCOME;

EID: 78650982327     PISSN: 0174304X     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-0030-1269893     Document Type: Article

References (22)

1. Annas G. Medical aspects of the persistent vegetative state (2). The Multi-Society Task Force on PVS. N Engl J Med 1994 330 1572-1579
2. Ashwal S. Recovery of consciousness and life expectancy of children in a vegetative state. Neuropsychol Rehabil 2005 15 190-197
3. BBC. Pill reverses' vegetative state. BBC http://news.bbc.co.uk/go/pr/fr/ -/2/hi/health/5008744.stm 2006
4. Bernat JL. Chronic disorders of consciousness. Lancet 2006 367 9517 1181-1192
5. Beuthien-Baumann B, Holthoff VA, Rudolf J. Functional imaging of vegetative state applying single photon emission tomography and positron emission tomography. Neuropsychol Rehabil 2005 15 276-282
6. Clauss RP, Nel WH. Effect of zolpidem on brain injury and diaschisis as detected by 99 mTc HMPAO brain SPECT in humans. Arzneimittelforschung 2004 54 641-646
7. Clauss RP, Nel WH. Drug induced arousal from the permanent vegetative state. NeuroRehabilitation 2006 21 23-28
8. Colle M, Rosenzweig P, Bianchetti G, etal. Nocturnal profile of growth hormone secretion during sleep induced by zolpidem: a double-blind study in young adults and children. Horm Res 1991 35 30-34
9. Crowe L, Babl F, Anderson V, etal. The epidemiology of pediatric head injuries: Data from a referral centre in Victoria, Australia. J Paediatr Child Health 2009; May 28
10. Egan J, Snyman N, Scheinberg N, etal. Zolpidem for persistent vegetative state: a placebo controlled trial in pediatrics. Minerva Anesthesiologica 2009 75 Supp 2 241
11. Fortune N, Wen X. The definition, incidence and prevalence of acquired brain injury in Australia. In: Welfare AIoHa, editor. Canberra 1999
12. Hagen C, Malkmus D, Durham P. Levels of cognitive functioning. In: Rehabilitation of the Head Injured Adult: Comprehensive Physical Management. Downey, CA Professional Staff Association of Rancho Los Amigos Hospital 1979
13. Hall C. Now tests begin on the miracle' drug. Telegraph. http://www.telegraph.co.uk/news/uknews/1534727/Now-tests-begin-on-the-miracle- drug.html 2006
14. Juengling FD, Kassubek J, Huppertz HJ, etal. Separating functional and structural damage in persistent vegetative state using combined voxel-based analysis of 3-D MRI and FDG-PET. J Neurol Sci 2005 228 179-184
15. Kurta DL, Myers LB, Krenzelok EP. Zolpidem (Ambien): a pediatric case series. J Toxicol Clin Toxicol 1997 35 453-457
16. Lister S. Sleeping pill that brought a coma victim back to life. The Times. http://www.timesonline.co.uk/tol/news/uk/article727295.ece 2006
17. Mancini J, Thirion X, Masut A, etal. Anxiolytics, hypnotics, and antidepressants dispensed to adolescents in a French region in 2002. Pharmacoepidemiol Drug Saf 2006 15 494-503
18. Pidd H. Reborn. Guardian. 2006 June http:www.guardian.co.uk/science/2006/ sep/12/health.healthandwellbeing 2008
19. Rappaport M. The disability rating and coma/near-coma scales in evaluating severe head injury. Neuropsychol Rehabil 2005 15 442-453
20. Schiff ND. Multimodal neuroimaging approaches to disorders of consciousness. J Head Trauma Rehabil 2006 21 388-397
21. Teasdale G, Jennett B. Assessment of coma and impaired consciousness. A practical scale. Lancet 1974 2 7872 81-84
22. Wikimedia Foundation. Persistent vegetative state. [cited 2009 January]; Available from: http://en.wikipedia.org/wiki/Persistent-vegetative-state 2009