Adenylyl cyclase type II activity is regulated by two different mechanisms: Implications for acute and chronic opioid exposure

Neuropharmacology

Volumn 50, Issue 8, 2006, Pages 998-1005

  Schallmach, Ester ^a   Steiner, Debora ^a   Vogel, Zvi ^a  

^a WEIZMANN INSTITUTE OF SCIENCE   (Israel)

Author keywords

Adenylyl cyclase type II; cAMP; G proteins; Opioid receptor; PKC; Superinhibition

Indexed keywords

ADENYLATE CYCLASE; ADENYLATE CYCLASE II; ENKEPHALIN[2 DEXTRO ALANINE 4 METHYLPHENYLALANINE 5 GLYCINE]; GUANINE NUCLEOTIDE BINDING PROTEIN ALPHA SUBUNIT; MORPHINE; NALOXONE; OPIATE; OPIATE AGONIST; PERTUSSIS TOXIN; PHORBOL 13 ACETATE 12 MYRISTATE; PROTEIN KINASE C; PROTEIN SUBUNIT; SCAVENGER; THYROTROPIN; TRANSDUCIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL STRAIN COS7; CONTROLLED STUDY; DRUG EXPOSURE; DRUG MECHANISM; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME ASSAY; ENZYME INHIBITION; ENZYME REGULATION; GENETIC TRANSFECTION; LONG TERM EXPOSURE; NONHUMAN; PRIORITY JOURNAL; REGULATORY MECHANISM; STIMULATION;

ADENINE; ADENYLATE CYCLASE; ANIMALS; CERCOPITHECUS AETHIOPS; COS CELLS; CYCLIC AMP; DRUG ADMINISTRATION SCHEDULE; DRUG INTERACTIONS; ENKEPHALIN, ALA(2)-MEPHE(4)-GLY(5)-; ENZYME ACTIVATION; MORPHINE; NALOXONE; NARCOTIC ANTAGONISTS; NARCOTICS; RECEPTORS, OPIOID, MU; RECEPTORS, THYROTROPIN; TETRADECANOYLPHORBOL ACETATE; THYROTROPIN; TRANSFECTION; TRITIUM;

EID: 33646901336     PISSN: 00283908     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neuropharm.2006.01.004     Document Type: Article

References (32)

1. βγ. J. Biol. Chem. 271 (1996) 21309-21315
2. Avidor-Reiss T., Nevo I., Saya D., Bayewitch M., and Vogel Z. Opiate-induced adenylyl cyclase superactivation is isozyme specific. J. Biol. Chem. 272 (1997) 5040-5047
3. Bayewitch M., Nevo I., Avidor-Reiss T., Levy R., Simonds W.F., and Vogel Z. Alterations in detergent solubility of heterotrimeric G proteins after chronic activation of G(i/o)-coupled receptors: changes in detergent solubility are in correlation with onset of adenylyl cyclase superactivation. Mol. Pharmacol. 57 (2000) 820-825
4. Beazely M.A., Alan J.K., and Watts V.J. Protein kinase C and epidermal growth factor stimulation of Raf1 potentiates adenylyl cyclase type 6 activation in intact cells. Mol. Pharmacol. 67 (2005) 250-259
5. s-coupled receptor signaling pathways. J. Biol. Chem. 277 (2002) 21080-21085
6. Chakrabarti S., Oppermann M., and Gintzler A.R. Chronic morphine induces the concomitant phosphorylation and altered association of multiple signaling proteins: a novel mechanism for modulating cell signaling. Proc. Natl. Acad. Sci. U.S.A. 98 (2001) 4209-4214
7. βγ stimulation of adenylyl cyclase activity. Brain Res. Mol. Brain Res. 119 (2003) 144-151
8. Federman A.D., Conklin B.R., Schrader K.A., Reed R.R., and Bourne H.R. Hormonal stimulation of adenylyl cyclase through Gi-protein βγ subunits. Nature 356 (1992) 159-161
9. Feinstein P.G., Schrader K.A., Bakalyar H.A., Tang W.J., Krupinski J., Gilman A.G., and Reed R.R. Molecular cloning and characterization of a Ca2+/calmodulin-insensitive adenylyl cyclase from rat brain. Proc. Natl. Acad. Sci. U.S.A. 88 (1991) 10173-10177
10. Jacobowitz O., and Iyengar R. Phorbol ester-induced stimulation and phosphorylation of adenylyl cyclase 2. Proc. Natl. Acad. Sci. U.S.A. 91 (1994) 10630-10634
11. Kramer H.K., and Simon E.J. Role of protein kinase C (PKC) in agonist-induced mu-opioid receptor down-regulation: I. PKC translocation to the membrane of SH-SY5Y neuroblastoma cells is induced by mu-opioid agonists. J. Neurochem. 72 (1999) 585-593
12. Lee E., Taussig R., and Gilman A.G. The G226A mutant of Gs alpha highlights the requirement for dissociation of G protein subunits. J. Biol. Chem. 267 (1992) 1212-1218
13. q. J. Biol. Chem. 268 (1993) 13900-13905
14. Mons N., and Cooper D. Adenylate cyclases: critical foci in neuronal signaling. Trends Neurosci. 18 (1995) 536-542
15. β in human neuroblastoma SH-SY5Y cells: correlation with onset of adenylate cyclase sensitization. Mol. Pharmacol. 68 (2005) 467-476
16. o proteins in modulation of adenylyl cyclase type-2 activity. J. Neurochem. 83 (2002) 1252-1261
17. Nevo I., Avidor-Reiss T., Levy R., Bayewitch M., Heldman E., and Vogel Z. Regulation of adenylyl cyclase isozymes upon acute and chronic activation of inhibitory receptors. Mol. Pharmacol. 54 (1998) 419-426
18. Rhee M.-H., Bayewitch M.L., Avidor-Reiss T., Levy R., and Vogel Z. Cannabinoid receptor activation differentially regulates the various adenylyl cyclase isozymes. J. Neurochem. 71 (1998) 1525-1534
19. 1 cannabinoid receptor. Mol. Pharmacol. 57 (2000) 746-752
20. 3H]cAMP in cell monolayers, cell suspensions, and tissue slices. Methods Enzymol 195 (1991) 22-28
21. Simonds W.F. G protein regulation of adenylate cyclase. Trends Pharmacol. Sci. 20 (1999) 66-73
22. Steiner D., Avidor-Reiss T., Schallmach E., Butovsky E., Lev N., and Vogel Z. Regulation of adenylyl cyclase type VIII splice variants by acute and chronic Gi/o-coupled receptor activation. Biochem. J. 386 (2005) 341-348
23. Sunahara R.K., and Taussig R. Isoforms of mammalian adenylyl cyclase: multiplicities of signaling. Mol. Interv. 2 (2002) 168-184
24. sα and forskolin. Science 268 (1995) 1769-1772
25. iα. Science 261 (1993) 218-221
26. Taussig R., Tang W.J., Hepler J.R., and Gilman A.G. Distinct patterns of bidirectional regulation of mammalian adenylyl cyclases. J. Biol. Chem. 269 (1994) 6093-6100
27. Tsu R.C., Chan J.S.C., and Wong Y.H. Regulation of multiple effectors by the cloned δ-opioid receptor: stimulation of phospholipase C and type II adenylyl cyclase. J. Neurochem. 64 (1995) 2700-2707
28. Tsu R.C., and Wong Y.H. Gi-mediated stimulation of type II adenylyl cyclase is augmented by Gq-coupled receptor activation and phorbol ester treatment. J. Neurosci. 16 (1996) 1317-1323
29. Vogel Z., Barg J., Levy R., Saya D., Heldman E., and Mechoulam R. Anandamide, a brain endogenous compound, interacts specifically with cannabinoid receptors and inhibits adenylate cyclase. J. Neurochem. 61 (1993) 352-355
30. Yoshimura M., and Cooper D.M. Type-specific stimulation of adenylylcyclase by protein kinase C. J. Biol. Chem. 268 (1993) 4604-4607
31. Watts V.J., and Neve K.A. Sensitization of adenylate cyclase by Gαi/o-coupled receptors. Pharmacol. Ther. 106 (2005) 405-421
32. Zimmermann G., and Taussig R. Protein kinase C alters the responsiveness of adenylyl cyclases to G protein α and βγ subunits. J. Biol. Chem. 271 (1996) 27161-27166