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Volumn 27, Issue 10, 2010, Pages 714-730

The role of opioid receptor antagonists in the treatment of opioid-induced constipation: A review

Author keywords

Constipation; Laxatives; Opioid receptor antagonists; Opioid induced constipation; Opioids; Treatment

Indexed keywords

17 METHYLNALTREXONE; ALVIMOPAN; BISACODYL; BUPRENORPHINE; CODEINE; DIHYDROCODEINE; DOCUSATE SODIUM; DOMPERIDONE; FENTANYL; HYDROMORPHONE; LACTULOSE; LAXATIVE; LIQUID PARAFFIN; MACROGOL; METHADONE; METHYLCELLULOSE; METOCLOPRAMIDE; MORPHINE; NALMEFENE; NALOXONE; NALOXONE PLUS OXYCODONE; NALTREXONE; NARCOTIC ANALGESIC AGENT; OPIATE ANTAGONIST; OXYCODONE; PICOSULFATE SODIUM; PLACEBO; SURFACTANT; TRAMADOL; UNCLASSIFIED DRUG; UNINDEXED DRUG; DRUG DERIVATIVE; NARCOTIC ANTAGONIST; OPIATE RECEPTOR; QUATERNARY AMMONIUM DERIVATIVE;

EID: 79952116743     PISSN: 0741238X     EISSN: 18658652     Source Type: Journal    
DOI: 10.1007/s12325-010-0063-0     Document Type: Review
Times cited : (52)

References (80)
  • 1
    • 0035695398 scopus 로고    scopus 로고
    • Incidence, prevalence, and management of opioid bowel dysfunction
    • Pappagallo M. Incidence, prevalence, and management of opioid bowel dysfunction. Am J Surg. 2001;182:11S-18S.
    • (2001) Am J Surg , vol.182
    • Pappagallo, M.1
  • 2
    • 58149242906 scopus 로고    scopus 로고
    • The management of constipation in palliative care: Clinical practice recommendations
    • Larkin PJ, Sykes NP, Centeno C, et al. The management of constipation in palliative care: clinical practice recommendations. Palliat Med. 2008;22:796-807.
    • (2008) Palliat Med , vol.22 , pp. 796-807
    • Larkin, P.J.1    Sykes, N.P.2    Centeno, C.3
  • 3
    • 33646771321 scopus 로고    scopus 로고
    • The pathogenesis of constipation
    • Sykes N. The pathogenesis of constipation. J Support Oncol. 2006;4:213-218.
    • (2006) J Support Oncol , vol.4 , pp. 213-218
    • Sykes, N.1
  • 4
    • 0031706176 scopus 로고    scopus 로고
    • The relationship between opioid use and laxative use in terminally ill cancer patients
    • DOI 10.1191/026921698674125048
    • Sykes N. The relationship between opioid use and laxative use in terminally ill cancer patients. Palliat Med. 1998;12:375-382. (Pubitemid 28454405)
    • (1998) Palliative Medicine , vol.12 , Issue.5 , pp. 375-382
    • Sykes, N.P.1
  • 5
    • 52149120714 scopus 로고    scopus 로고
    • Objawy ze strony ukladu pokarmowego u chorych z zaawansowana choroba nowotworowa
    • Leppert W, Kozikowska J, Luczak J, Glowacka A, Malinger S. Objawy ze strony ukladu pokarmowego u chorych z zaawansowana choroba nowotworowa. (Gastrointestinal symptoms in patients with advanced cancer). Nowa Med. 2000;97:18-39.
    • (2000) Nowa Med , vol.97 , pp. 18-39
    • Leppert, W.1    Kozikowska, J.2    Luczak, J.3    Glowacka, A.4    Malinger, S.5
  • 6
    • 79958199190 scopus 로고    scopus 로고
    • Postepowanie u chorych z zaparciem stolca w medycynie paliatywnej - Zalecenia Grupy Roboczej Ekspertow Polskiego Towarzystwa Medycyny Paliatywnej
    • Leppert W, Dzierzanowski T, Cialkowska-Rysz A, Jarosz J, Pyszkowska J, Stachowiak A. Postepowanie u chorych z zaparciem stolca w medycynie paliatywnej - zalecenia Grupy Roboczej Ekspertow Polskiego Towarzystwa Medycyny Paliatywnej. (The management of constipation in palliative medicine - recommendations of the Expert Working Group of the Polish Association for Palliative Medicine). Medycyna Paliatywna. 2009;1:1-10.
    • (2009) Medycyna Paliatywna , vol.1 , pp. 1-10
    • Leppert, W.1    Dzierzanowski, T.2    Cialkowska-Rysz, A.3    Jarosz, J.4    Pyszkowska, J.5    Stachowiak, A.6
  • 7
    • 27344455677 scopus 로고    scopus 로고
    • Constipation and diarrhoea
    • Doyle D, Hanks G, Cherny N, Calman K, eds. Oxford: Oxford University Press
    • Sykes NP. Constipation and diarrhoea. In: Doyle D, Hanks G, Cherny N, Calman K, eds. Oxford Textbook of Palliative Medicine. Oxford: Oxford University Press; 2004: 483-496.
    • (2004) Oxford Textbook of Palliative Medicine , pp. 483-496
    • Sykes, N.P.1
  • 8
    • 79958231812 scopus 로고    scopus 로고
    • Diarrhoea and constipation: Supportive oncology management
    • Ettinger DS, ed. New York: Humana Press
    • Benson AB, Stein R. Diarrhoea and constipation: supportive oncology management. In: Ettinger DS, ed. Supportive Care in Cancer Therapy. New York: Humana Press; 2009:213-225.
    • (2009) Supportive Care in Cancer Therapy , pp. 213-225
    • Benson, A.B.1    Stein, R.2
  • 10
    • 32844474925 scopus 로고    scopus 로고
    • Validation of the PAC-SYM questionnaire for opioid-induced constipation in patients with chronic low back pain
    • DOI 10.1016/j.ejpain.2005.03.008, PII S1090380105000431
    • Slappendel R, Simpson K, Dubois D, Keininger DL. Validation of the PAC-SYM questionnaire for opioid-induced constipation in patients with chronic low back pain. Eur J Pain. 2006;10:209-217. (Pubitemid 43255207)
    • (2006) European Journal of Pain , vol.10 , Issue.3 , pp. 209-217
    • Slappendel, R.1    Simpson, K.2    Dubois, D.3    Keininger, D.L.4
  • 11
    • 58149178876 scopus 로고    scopus 로고
    • A randomised controlled trial with prolonged-release oral oxycodone and naloxone to prevent and reverse opioid-induced constipation
    • Meissner W, Leyendecker P, Meuller-Lissner S, et al. A randomised controlled trial with prolonged-release oral oxycodone and naloxone to prevent and reverse opioid-induced constipation. Eur J Pain. 2009;13:56-64.
    • (2009) Eur J Pain , vol.13 , pp. 56-64
    • Meissner, W.1    Leyendecker, P.2    Meuller-Lissner, S.3
  • 13
    • 58749084861 scopus 로고    scopus 로고
    • Ocena analgezji i objawow niepozadanych tramadolu i dihydrokodeiny o kontrolowanym uwalnianiu u chorych z bolem nowotworowym - Na podstawie zmodyfikowanej skali ESAS
    • Leppert W, Majkowicz M. Ocena analgezji i objawow niepozadanych tramadolu i dihydrokodeiny o kontrolowanym uwalnianiu u chorych z bolem nowotworowym - na podstawie zmodyfikowanej skali ESAS. (Assessment of analgesia and adverse effects of controlled release tramadol and dihydrocodeine in patients with cancer pain - based on a modified ESAS). Wspolcz Onkol. 2008;12:246-254.
    • (2008) Wspolcz Onkol , vol.12 , pp. 246-254
    • Leppert, W.1    Majkowicz, M.2
  • 14
    • 34250625200 scopus 로고    scopus 로고
    • Opioid-induced constipation - A frequent and distressing side effect in daily practice affecting oral and transdermal opioid applications
    • Ueberral MA, Mueller-Schwefe G. Opioid-induced constipation - a frequent and distressing side effect in daily practice affecting oral and transdermal opioid applications. Eur J Pain. 2006;10:S172.
    • (2006) Eur J Pain , vol.10
    • Ueberral, M.A.1    Mueller-Schwefe, G.2
  • 15
    • 54849430090 scopus 로고    scopus 로고
    • Meeting the challenges of opioid-induced constipation in chronic pain management - A novel approach
    • Reimer K, Hopp M, Zenz M, et al. Meeting the challenges of opioid-induced constipation in chronic pain management - a novel approach. Pharmacology. 2009;83:10-17.
    • (2009) Pharmacology , vol.83 , pp. 10-17
    • Reimer, K.1    Hopp, M.2    Zenz, M.3
  • 16
    • 33947240432 scopus 로고    scopus 로고
    • The opioid bowel syndrome: A review of pathophysiology and treatment
    • Davis MP. The opioid bowel syndrome: a review of pathophysiology and treatment. J Opioid Manage. 2005;1:153-161.
    • (2005) J Opioid Manage , vol.1 , pp. 153-161
    • Davis, M.P.1
  • 17
    • 33846782895 scopus 로고    scopus 로고
    • Treatment of opioid-induced gut dysfunction
    • DOI 10.1517/13543784.16.2.181
    • Holzer P. Treatment of opioid-induced gut dysfunction. Expert Opin Investig Drugs. 2007;16:181-194. (Pubitemid 46206632)
    • (2007) Expert Opinion on Investigational Drugs , vol.16 , Issue.2 , pp. 181-194
    • Holzer, P.1
  • 18
    • 2342594524 scopus 로고    scopus 로고
    • Opioids and opioid receptors in the enteric nervous system: From a problem in opioid analgesia to a possible new prokinetic therapy in humans
    • DOI 10.1016/j.neulet.2003.12.004, PII S0304394003013843
    • Holzer P. Opioids and opioid receptors in the myenteric nervous system: from a problem in opioid analgesia to a possible new prokinetic therapy in humans. Neurosci Lett. 2004;361: 192-195. (Pubitemid 38609249)
    • (2004) Neuroscience Letters , vol.361 , Issue.1-3 , pp. 192-195
    • Holzer, P.1
  • 20
    • 0020640892 scopus 로고
    • Ketazocines and morphine: Effects on gastrointestinal transit after central and peripheral administration
    • Porecca F, Cowan A, Raffa RB, Tallarida RJ. Ketazocines and morphine: effects on gastrointestinal transit after central and peripheral administration. Life Sci. 1983;32:1785-1790. (Pubitemid 13122673)
    • (1983) Life Sciences , vol.32 , Issue.15 , pp. 1785-1790
    • Porreca, F.1    Cowan, A.2    Raffa, R.B.3    Tallarida, R.J.4
  • 21
    • 0017716935 scopus 로고
    • Effect of intracerebroventricular administration of morphine upon intestinal motility in rat and its antagonism with naloxone
    • Parolado D, Sala M, Gori E. Effect of intracerebroventricular administration of morphine upon intestinal motility in rat and its antagonism with naloxone. Eur J Pharmacol. 1977;46:329-338. (Pubitemid 8240486)
    • (1977) European Journal of Pharmacology , vol.46 , Issue.4 , pp. 329-338
    • Parolaro, D.1    Sala, M.2    Gori, E.3
  • 25
    • 64849097928 scopus 로고    scopus 로고
    • Methylnaltrexone for treatment of opioid-induced constipation in advanced illness patients
    • Slatkin N, Thomas J, Lipman AG, et al. Methylnaltrexone for treatment of opioid-induced constipation in advanced illness patients. J Support Oncol. 2009;7:39-46.
    • (2009) J Support Oncol , vol.7 , pp. 39-46
    • Slatkin, N.1    Thomas, J.2    Lipman, A.G.3
  • 26
    • 7944230640 scopus 로고    scopus 로고
    • Function of opioids in the enteric nervous system
    • Wood JD, Galligan JJ. Function of opioids in the enteric nervous system. Neurogastroenterol Motil. 2004;16(suppl. 2):181-194.
    • (2004) Neurogastroenterol Motil , vol.16 , Issue.SUPPL. 2 , pp. 181-194
    • Wood, J.D.1    Galligan, J.J.2
  • 27
    • 0242496957 scopus 로고    scopus 로고
    • Constipation - Modern laxative therapy
    • DOI 10.1007/s00520-003-0525-x
    • Klaschik E, Nauck F, Ostgathe C. Constipation - modern laxative therapy. Support Care Cancer. 2003;11:679-685. (Pubitemid 37432623)
    • (2003) Supportive Care in Cancer , vol.11 , Issue.11 , pp. 679-685
    • Klaschik, E.1    Nauck, F.2    Ostgathe, C.3
  • 28
    • 0023502264 scopus 로고
    • Continuous Sc infusion of metoclopramide for treatment of narcotic bowel syndrome
    • Bruera E, Brenneis C, Michand M, MacDonald N. Continuous subcutaneous infusion of metoclopramide for treatment of narcotic bowel syndrome. Cancer Treat Rep. 1987;71:1121-1122. (Pubitemid 18002237)
    • (1987) Cancer Treatment Reports , vol.71 , Issue.11 , pp. 1121-1122
    • Bruera, E.1    Brenneis, C.2    Michaud, M.3    MacDonald, N.4
  • 31
    • 4243459506 scopus 로고
    • Can high fibre diets improve the bowel function in patients on radiotherapy ward?
    • Twycross RG, Lack SA, eds. Edinburgh: Churchill Livingstone
    • Mumford SP. Can high fibre diets improve the bowel function in patients on radiotherapy ward? In: Twycross RG, Lack SA, eds. Control of Alimentary Symptoms in Far Advanced Cancer. Edinburgh: Churchill Livingstone; 1986:183.
    • (1986) Control of Alimentary Symptoms in Far Advanced Cancer , pp. 183
    • Mumford, S.P.1
  • 32
    • 0028062730 scopus 로고
    • Current approaches to the management of constipation
    • Sykes NP. Current approaches to the management of constipation. Cancer Surv. 1994;21:137-146. (Pubitemid 24355818)
    • (1994) Cancer Surveys , vol.21 , pp. 137-146
    • Sykes, N.P.1
  • 33
    • 0031871290 scopus 로고    scopus 로고
    • Constipation in advanced cancer patients
    • DOI 10.1007/s005200050177
    • Mancini I, Bruera E. Constipation in advanced cancer patients. Support Care Cancer. 1998;6:356-364. (Pubitemid 28337126)
    • (1998) Supportive Care in Cancer , vol.6 , Issue.4 , pp. 356-364
    • Mancini, I.1    Bruera, E.2
  • 34
    • 84970155935 scopus 로고
    • A clinical comparison of laxatives in a hospice
    • Sykes NP. A clinical comparison of laxatives in a hospice. Palliat Med. 1991;5:307-314.
    • (1991) Palliat Med , vol.5 , pp. 307-314
    • Sykes, N.P.1
  • 36
    • 68349121437 scopus 로고    scopus 로고
    • Opioid-induced bowel dysfunction in cancer-related pain: Causes, consequences, and a novel approach for its management
    • Holzer P, Ahmedzai SH, Niederle N, et al. Opioid-induced bowel dysfunction in cancer-related pain: causes, consequences, and a novel approach for its management. J Opioid Manage. 2009;5:145-195.
    • (2009) J Opioid Manage , vol.5 , pp. 145-195
    • Holzer, P.1    Ahmedzai, S.H.2    Niederle, N.3
  • 37
    • 33746925643 scopus 로고    scopus 로고
    • Opioid switching: A systematic and critical review
    • DOI 10.1016/j.ctrv.2006.03.001, PII S0305737206000533
    • Mercadante S, Bruera E. Opioid switching: a systematic and critical review. Cancer Treat Rev. 2006;32:304-315. (Pubitemid 44502005)
    • (2006) Cancer Treatment Reviews , vol.32 , Issue.4 , pp. 304-315
    • Mercadante, S.1    Bruera, E.2
  • 38
    • 67149133225 scopus 로고    scopus 로고
    • Postepy w leczeniu farmakologicznym bolu nowotworowego analgetykami opioidowymi
    • Leppert W. Postepy w leczeniu farmakologicznym bolu nowotworowego analgetykami opioidowymi. (Progress in pharmacological pain treatment with opioid analgesics). Wspolcz Onkol. 2009;13: 66-73.
    • (2009) Wspolcz Onkol , vol.13 , pp. 66-73
    • Leppert, W.1
  • 39
    • 0030909704 scopus 로고    scopus 로고
    • Transdermal fentanyl versus sustained-release oral morphine in cancer pain: Preference, efficacy, and quality of life
    • DOI 10.1016/S0885-3924(97)00082-1, PII S0885392497000821
    • Ahmedzai S, Brooks D. Transdermal fentanyl versus sustained-release oral morphine in cancer pain: preference, efficacy and quality of life. J Pain Symptom Manage. 1997;13:254-261. (Pubitemid 27240678)
    • (1997) Journal of Pain and Symptom Management , vol.13 , Issue.5 , pp. 254-261
    • Ahmedzai, S.1    Brooks, D.2
  • 40
    • 0033009480 scopus 로고    scopus 로고
    • The constipation-inducing potential of morphine and transdermal fentanyl
    • DOI 10.1016/S1090-3801(99)90170-2
    • Haazen L, Noorduin H, Megens A, Meert T. The constipation-inducing potential of morphine and transdermal fentanyl. Eur J Pain. 1999; 3(suppl. A):9-15. (Pubitemid 29292685)
    • (1999) European Journal of Pain , vol.3 , Issue.SUPPL. A , pp. 9-15
    • Haazen, L.1    Noorduin, H.2    Megens, A.3    Meert, T.4
  • 41
    • 0032819163 scopus 로고    scopus 로고
    • A comparison of subcutaneous morphine and fentanyl in hospice cancer patients
    • DOI 10.1016/S0885-3924(99)00051-2, PII S0885392499000512
    • Hunt R, Fazekas B, Thorne D, Brooksbank M. A comparison of subcutaneous morphine and fentanyl in hospice cancer patients. J Pain Symptom Manage. 1999;18:111-119. (Pubitemid 29409439)
    • (1999) Journal of Pain and Symptom Management , vol.18 , Issue.2 , pp. 111-119
    • Hunt, R.1    Fazekas, B.2    Thorne, D.3    Brooksbank, M.4
  • 42
    • 41149155227 scopus 로고    scopus 로고
    • Adverse effects of transdermal opiates treating moderate-severe cancer pain in comparison to long-acting morphine: A meta-analysis and systematic review of the literature
    • Tassinari D, Sartori S, Tamburini E, et al. Adverse effects of transdermal opiates treating moderate-severe cancer pain in comparison to long-acting morphine: a meta-analysis and systematic review of the literature. J Palliat Med. 2008;11:492-502.
    • (2008) J Palliat Med , vol.11 , pp. 492-502
    • Tassinari, D.1    Sartori, S.2    Tamburini, E.3
  • 43
    • 0025873263 scopus 로고
    • Buprenorphine and sustained release oral morphine - Effect and side-effects in chronic use
    • Bach V, Kamp-Jensen M, Jensen N-H, Eriksen J. Buprenorphine and sustained release oral morphine - effect and side-effects in chronic use. Pain Clin. 1991;4:87-93.
    • (1991) Pain Clin , vol.4 , pp. 87-93
    • Bach, V.1    Kamp-Jensen, M.2    Jensen, N.-H.3    Eriksen, J.4
  • 44
    • 0034026529 scopus 로고    scopus 로고
    • Opioid type and other clinical predictors of laxative dose in advanced cancer patients: A retrospective study
    • Mancini IL, Hanson J, Neumann CM, Bruera E. Opioid type and other clinical predictors of laxative dose in advanced cancer patients: a retrospective study. J Palliat Med. 2000;3:49-56. (Pubitemid 30262887)
    • (2000) Journal of Palliative Medicine , vol.3 , Issue.1 , pp. 49-56
    • Mancini, I.L.1    Hanson, J.2    Neumann, C.M.3    Bruera, E.D.4
  • 45
    • 0032854716 scopus 로고    scopus 로고
    • Reduction in constipation and laxative requirements following opioid rotation to methadone: A report of four cases
    • DOI 10.1016/S0885-3924(99)00086-X, PII S088539249900086X
    • Daeninck PJ, Bruera E. Reduction in constipation and laxative requirements following opioid rotation to methadone: a report of four cases. J Pain Symptom Manage. 1999;18:303-309. (Pubitemid 29469709)
    • (1999) Journal of Pain and Symptom Management , vol.18 , Issue.4 , pp. 303-309
    • Daeninck, P.J.1    Bruera, E.2
  • 48
    • 0028785119 scopus 로고
    • The cost of constipation in morphine patients and the economic possibilities with tramadol
    • Duggan AK. The cost of constipation in morphine patients and the economic possibilities with tramadol. Br J Med Econom. 1995;9:21-29.
    • (1995) Br J Med Econom , vol.9 , pp. 21-29
    • Duggan, A.K.1
  • 49
    • 0034789723 scopus 로고    scopus 로고
    • Analgesic efficacy and side effects of oral tramadol and morphine administered orally in the treatment of cancer pain
    • Leppert W. Analgesic efficacy and side effects of oral tramadol and morphine administered orally in the treatment of cancer pain. Nowotwory. 2001;51:257-266. (Pubitemid 32937401)
    • (2001) Nowotwory , vol.51 , Issue.3 , pp. 257-266
    • Leppert, W.1
  • 50
    • 67649395727 scopus 로고    scopus 로고
    • Gastrointestinal symptoms under opioid therapy: A prospective comparison of oral sustained-release hydromorphone, transdermal fentanyl, and transdermal buprenorphine
    • Wirz S, Witmmann M, Schenk M, et al. Gastrointestinal symptoms under opioid therapy: a prospective comparison of oral sustained-release hydromorphone, transdermal fentanyl, and transdermal buprenorphine. Eur J Pain. 2009;13:737-743.
    • (2009) Eur J Pain , vol.13 , pp. 737-743
    • Wirz, S.1    Witmmann, M.2    Schenk, M.3
  • 51
    • 2942586206 scopus 로고    scopus 로고
    • Clinical status of methylnaltrexone, a new agent to prevent and manage opioid-induced side effects
    • Yuan CS. Clinical status of methylnaltrexone, a new agent to prevent and manage opioid-induced side effects. J Support Oncol. 2004;2:111-122.
    • (2004) J Support Oncol , vol.2 , pp. 111-122
    • Yuan, C.S.1
  • 52
    • 0029878393 scopus 로고    scopus 로고
    • An investigation of the ability of oral naloxone to correct opioid-related constipation in patients with advanced cancer
    • Sykes NP. An investigation of the ability of oral naloxone to correct opioid-related constipation in patients with advanced cancer. Palliat Med. 1996;10:135-144. (Pubitemid 26110994)
    • (1996) Palliative Medicine , vol.10 , Issue.2 , pp. 135-144
    • Sykes, N.P.1
  • 53
    • 0036153676 scopus 로고    scopus 로고
    • Low-dose oral naloxone reverses opioid-induced constipation and analgesia
    • DOI 10.1016/S0885-3924(01)00369-4, PII S0885392401003694
    • Liu M, Wittbrodt E. Low-dose oral naloxone reverses opioid-induced constipation and analgesia. J Pain Symptom Manage. 2002;23:48-53. (Pubitemid 34093880)
    • (2002) Journal of Pain and Symptom Management , vol.23 , Issue.1 , pp. 48-53
    • Liu, M.1    Wittbrodt, E.2
  • 54
    • 0033991826 scopus 로고    scopus 로고
    • Oral naloxone reverses opioid-induced constipation
    • Meissner W, Schimdt U, Hartmann M, et al. Oral naloxone reverses opioid-induced constipation. Pain. 2000;84:105-109.
    • (2000) Pain , vol.84 , pp. 105-109
    • Meissner, W.1    Schimdt, U.2    Hartmann, M.3
  • 55
    • 0028221009 scopus 로고
    • Comparison of potency and duration of action of nalmefene and naloxone
    • Glass PS, Jhaveri RM, Smith LR. Comparison of potency and duration of action of nalmefene and naloxone. Anesth Analg. 1994;78:536-541. (Pubitemid 24079380)
    • (1994) Anesthesia and Analgesia , vol.78 , Issue.3 , pp. 536-541
    • Glass, P.S.A.1    Jhaveri, R.M.2    Smith, L.R.3
  • 56
    • 0029047480 scopus 로고
    • Assessment of nalmefene glucuronide as a selective gut opioid antagonist
    • Cheskin LJ, Chami TN, Johnson RE, et al. Assessment of nalmefene glucuronide as a selective gut opioid antagonist. Drug Alcohol Depend. 1995;39:151-154.
    • (1995) Drug Alcohol Depend , vol.39 , pp. 151-154
    • Cheskin, L.J.1    Chami, T.N.2    Johnson, R.E.3
  • 58
    • 84868361093 scopus 로고    scopus 로고
    • Oxycodone/naloxone prolonged release tablets, questions and answers
    • Anon. London: Haymarket Medical Imprint, 174 Hammersmith Road, W6 7JP, UK; (Feb): Available at Item code UK/TAR-08053
    • Anon. Oxycodone/naloxone prolonged release tablets, questions and answers. In: Paineurope supplement. London: Haymarket Medical Imprint, 174 Hammersmith Road, W6 7JP, UK; 2009 (Feb): 3-10. Available at: www.paineurope.com. Item code UK/TAR-08053.
    • (2009) Paineurope Supplement , pp. 3-10
  • 60
    • 33748440757 scopus 로고    scopus 로고
    • Oxycodone controlled release in cancer pain management
    • Biancofiore G. Oxycodone controlled release in cancer pain management. Therap Clinic Risk Manage. 2006;2:228-234.
    • (2006) Therap Clinic Risk Manage , vol.2 , pp. 228-234
    • Biancofiore, G.1
  • 61
    • 0015758661 scopus 로고
    • Disposition of naloxone-7,8-3H in normal and narcotic-dependent men
    • Fishman J, Roffwarg H, Helman L. Disposition of naloxone-7,8-3H in normal and narcotic-dependent men. J Pharmacol Exp Ther. 1973;187:575-580.
    • (1973) J Pharmacol Exp Ther , vol.187 , pp. 575-580
    • Fishman, J.1    Roffwarg, H.2    Helman, L.3
  • 62
    • 44649196037 scopus 로고    scopus 로고
    • Oral prolonged release (PR) oxycodone/naloxone combination reduces opioid-induced bowel dysfunction (OIBD) in patients with severe chronic pain
    • Abstract 189
    • Müller-Lissner S, Leyendecker P, Hopp M, Ruckes C, Fleischer W, Reimer K. Oral prolonged release (PR) oxycodone/naloxone combination reduces opioid-induced bowel dysfunction (OIBD) in patients with severe chronic pain. Eur J Pain. 2007;11:Abstract 189.
    • (2007) Eur J Pain , vol.11
    • Müller-Lissner, S.1    Leyendecker, P.2    Hopp, M.3    Ruckes, C.4    Fleischer, W.5    Reimer, K.6
  • 63
    • 56349136276 scopus 로고    scopus 로고
    • Analgesic efficacy and safety of oxycodone in combination with naloxone as prolonged release tablets in patients with moderate to severe chronic pain
    • Vondrackova D, Leyendecker P, Meissner W, et al. Analgesic efficacy and safety of oxycodone in combination with naloxone as prolonged release tablets in patients with moderate to severe chronic pain. J Pain. 2008;9:1144-1154.
    • (2008) J Pain , vol.9 , pp. 1144-1154
    • Vondrackova, D.1    Leyendecker, P.2    Meissner, W.3
  • 64
    • 62349085314 scopus 로고    scopus 로고
    • Fixed-ratio combination oxycodone/naloxone compared with oxycodone alone for the relief of opioid-induced constipation in moderate-to-severe noncancer pain
    • Simpson K, Leyendecker P, Hopp M, et al. Fixed-ratio combination oxycodone/naloxone compared with oxycodone alone for the relief of opioid-induced constipation in moderate-to-severe noncancer pain. Curr Med Res Opin. 2008;24: 3503-3512.
    • (2008) Curr Med Res Opin , vol.24 , pp. 3503-3512
    • Simpson, K.1    Leyendecker, P.2    Hopp, M.3
  • 65
    • 77950641718 scopus 로고    scopus 로고
    • Long-term efficacy and safety of combined prolonged-release oxycodone and naloxone in the management of non-cancer chronic pain
    • Sandner-Kiesling A, Leyendecker P, Hopp M, et al. Long-term efficacy and safety of combined prolonged-release oxycodone and naloxone in the management of non-cancer chronic pain. Int J Clin Pract. 2010;64:763-774.
    • (2010) Int J Clin Pract , vol.64 , pp. 763-774
    • Sandner-Kiesling, A.1    Leyendecker, P.2    Hopp, M.3
  • 66
    • 65649126026 scopus 로고    scopus 로고
    • Combined prolonged release oxycodone and naloxone improves bowel function in patients receiving opioids for moderate-to-severe nonmalignant chronic pain: A randomized controlled trial
    • Löwenstein O, Leyendecker P, Hopp M, et al. Combined prolonged release oxycodone and naloxone improves bowel function in patients receiving opioids for moderate-to-severe nonmalignant chronic pain: a randomized controlled trial. Expert Opin Pharmacother. 2009;10:531-453.
    • (2009) Expert Opin Pharmacother , vol.10 , pp. 531-1453
    • Löwenstein, O.1    Leyendecker, P.2    Hopp, M.3
  • 67
    • 0021804061 scopus 로고
    • Beneficial effects of Naloxone in a patient with intestinal pseudoobstruction
    • Schang JC, Devroede G. Beneficial effects of naloxone in a patient with intestinal pseudoobstruction. Am J Gastroenterol. 1985;80:407-411. (Pubitemid 15080755)
    • (1985) American Journal of Gastroenterology , vol.80 , Issue.6 , pp. 407-411
    • Schang, J.C.1    Devroede, G.2
  • 68
    • 34249732634 scopus 로고    scopus 로고
    • A review of methylnaltrexone, a peripheral opioid receptor antagonist, and its role in opioid-induced constipation
    • Shaiova L, Rim F, Friedman D, Jahdi M. A review of methylnaltrexone, a peripheral opioid receptor antagonist, and its role in opioid-induced constipation. Palliat Support Care. 2007;5: 161-166.
    • (2007) Palliat Support Care , vol.5 , pp. 161-166
    • Shaiova, L.1    Rim, F.2    Friedman, D.3    Jahdi, M.4
  • 69
    • 0030897506 scopus 로고    scopus 로고
    • The safety and efficacy of oral methylnaltrexone in preventing morphine-induced delay in oral-cecal transit time
    • Yuan CS, Foss JF, Osinski J, Toledano A, Roizen MF, Moss J. The safety and efficacy of oral clinical methylnaltrexone in preventing morphine-induced delay in oral-cecal transit time. Clin Pharmacol Ther. 1997;61:467-475. (Pubitemid 27195949)
    • (1997) Clinical Pharmacology and Therapeutics , vol.61 , Issue.4 , pp. 467-475
    • Yuan, C.-S.1    Foss, J.F.2    Osinski, J.3    Toledano, A.4    Roizen, M.F.5    Moss, J.6
  • 70
    • 0034015051 scopus 로고    scopus 로고
    • Effects of enteric-coated methylnaltrexone in preventing opioid-induced delay in oral-cecal transit time
    • Yuan CS, Foss JF, O'Connor M J, Toledano A, Roizen MF, Moss J. Effects of enteric-coated methylnaltrexone in preventing opioid-induced delay in oral-cecal transit time. Clin Pharmacol Ther. 2000;67:388-404.
    • (2000) Clin Pharmacol Ther , vol.67 , pp. 388-404
    • Yuan, C.S.1    Foss, J.F.2    O'Connor, M.J.3    Toledano, A.4    Roizen, M.F.5    Moss, J.6
  • 72
    • 42649091132 scopus 로고    scopus 로고
    • Subcutaneous Methylnaltrexone for the Treatment of Opioid-Induced Constipation in Patients with Advanced Illness: A Double-Blind, Randomized, Parallel Group, Dose-Ranging Study
    • DOI 10.1016/j.jpainsymman.2007.12.005, PII S0885392408000936
    • Portenoy RK, Thomas J, Moehl Boathwright ML, et al. Subcutaneous methylnaltrexone for the treatment of opioid-induced constipation in patients with advanced illness: a double-blind, randomized, parallel group, dose-ranging study. J Pain Symptom Manage. 2008;35:458-468. (Pubitemid 351601995)
    • (2008) Journal of Pain and Symptom Management , vol.35 , Issue.5 , pp. 458-468
    • Portenoy, R.K.1    Thomas, J.2    Moehl, B.M.L.3    Tran, D.4    Galasso, F.L.5    Stambler, N.6    Von Gunten, C.F.7    Israel, R.J.8
  • 73
    • 70350528606 scopus 로고    scopus 로고
    • Methylnaltrexone treatment of opioid-induced constipation in patients with advanced illness
    • Chamberlain BH, Cross K, Winston JL, et al. Methylnaltrexone treatment of opioid-induced constipation in patients with advanced illness. J Pain Symptom Manage. 2009;38:683-690.
    • (2009) J Pain Symptom Manage , vol.38 , pp. 683-690
    • Chamberlain, B.H.1    Cross, K.2    Winston, J.L.3
  • 74
    • 35548962696 scopus 로고    scopus 로고
    • Peripherally Acting Opioid Antagonists in the Treatment of Opiate-Related Constipation: A Systematic Review
    • DOI 10.1016/j.jpainsymman.2006.12.018, PII S088539240700509X
    • Becker G, Galandi D, Blum HE. Peripherally acting opioid antagonists in the treatment of opiate-related constipation: a systematic review. J Pain Symptom Manage. 2007;34:547-565. (Pubitemid 350001379)
    • (2007) Journal of Pain and Symptom Management , vol.34 , Issue.5 , pp. 547-565
    • Becker, G.1    Galandi, D.2    Blum, H.E.3
  • 75
    • 34250192178 scopus 로고    scopus 로고
    • Methylnaltrexone mechanisms of action and effects on opioid bowel dysfunction and other opioid adverse effects
    • Yuan CS. Methylnaltrexone mechanisms of action and effects on opioid bowel dysfunction and other opioid adverse effects. Ann Pharmacother. 2007;41:984-993.
    • (2007) Ann Pharmacother , vol.41 , pp. 984-993
    • Yuan, C.S.1
  • 79
    • 50249107478 scopus 로고    scopus 로고
    • Efficacy and safety of mu-opioid antagonists in the treatment of opioid-induced bowel dysfunction: Systematic review and meta-analysis of randomized controlled trials
    • McNicol E, Boyce DB, Schumann R, Carr D. Efficacy and safety of mu-opioid antagonists in the treatment of opioid-induced bowel dysfunction: systematic review and meta-analysis of randomized controlled trials. Pain Med. 2008;9:634-659.
    • (2008) Pain Med , vol.9 , pp. 634-659
    • McNicol, E.1    Boyce, D.B.2    Schumann, R.3    Carr, D.4


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