General immune dampening is associated with disturbed metabolism at diagnosis of type 1 diabetes

Pediatric Research

Volumn 75, Issue 1, 2014, Pages 45-50

  Rydén, Anna ^a,b,c   Ludvigsson, Johnny ^a   Fredrikson, Mats ^a   Faresjö, Maria ^d,e  

^a LINKÖPING UNIVERSITY   (Sweden)

^b NOVO NORDISK INC   (United States)

^c PACIFIC NORTHWEST RESEARCH INSTITUTE   (United States)

^d JÖNKÖPING UNIVERSITY   (Sweden)

^e RYHOV COUNTY HOSPITAL   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

C PEPTIDE; GAMMA INTERFERON; HEMOGLOBIN A1C; INSULIN; INTERLEUKIN 10; INTERLEUKIN 13; INTERLEUKIN 17; INTERLEUKIN 6; TUMOR NECROSIS FACTOR ALPHA;

ADOLESCENT; ARTICLE; BODY MASS; CHILD; CHILDHOOD DISEASE; CLINICAL FEATURE; CONTROLLED STUDY; CYTOKINE RELEASE; DISEASE COURSE; DRUG MEGADOSE; FEMALE; FLUOROCHROME STAINING; HUMAN; IN VITRO STUDY; INSULIN DEPENDENT DIABETES MELLITUS; KETOACIDOSIS; MAJOR CLINICAL STUDY; MALE; METABOLISM; PRESCHOOL CHILD; PRIORITY JOURNAL; SCHOOL CHILD; TH1 CELL; WEIGHT REDUCTION;

ADOLESCENT; AUTOANTIGENS; C-PEPTIDE; CHILD; CYTOKINES; DIABETES MELLITUS, TYPE 1; HUMANS; KETOSIS; PUBERTY;

EID: 84893256167     PISSN: 00313998     EISSN: 15300447     Source Type: Journal    
DOI: 10.1038/pr.2013.167     Document Type: Article

References (29)

1. Nordwall M, Ludvigsson J. Clinical manifestations and beta cell function in Swedish diabetic children have remained unchanged during the last 25 years. Diabetes Metab Res Rev 2008;24:472-9.
2. American Diabetes Association. Diagnosis and classification of diabetes mellitus. Diabetes Care 2008;31:Suppl 1:S55-60.
3. Steffes MW, Sibley S, Jackson M, Thomas W. Beta-cell function and the development of diabetes-related complications in the diabetes control and complications trial. Diabetes Care 2003;26:832-6.
4. Scalia R, Coyle KM, Levine BJ, Booth G, Lefer AM. C-peptide inhibits leukocyte-endothelium interaction in the microcirculation during acute endothelial dysfunction. FASEB J 2000;14:2357-64.
5. Leslie RD, Atkinson MA, Notkins AL. Autoantigens IA-2 and GAD in Type I (insulin-dependent) diabetes. Diabetologia 1999;42:3-14.
6. Elias D, Prigozin H, Polak N, Rapoport M, Lohse AW, Cohen IR. Autoimmune diabetes induced by the beta-cell toxin STZ. Immunity to the 60-kDa heat shock protein and to insulin. Diabetes 1994;43: 992-8.
7. Wenzlau JM, Juhl K, Yu L, et al. The cation efflux transporter ZnT8 (Slc30A8) is a major autoantigen in human type 1 diabetes. Proc Natl Acad Sci USA 2007;104:17040-5.
8. Christen U, von Herrath MG. Manipulating the type 1 vs type 2 balance in type 1 diabetes. Immunol Res 2004;30:309-25.
9. Eisenbarth GS. Type I diabetes mellitus. A chronic autoimmune disease. N Engl J Med 1986;314:1360-8.
10. Castano L, Eisenbarth GS. Type-I diabetes: A chronic autoimmune disease of human, mouse, and rat. Annu Rev Immunol 1990;8:647-79.
11. Bradley LM, Asensio VC, Schioetz LK, et al. Islet-specific Th1, but not Th2, cells secrete multiple chemokines and promote rapid induction of autoimmune diabetes. J Immunol 1999;162:2511-20.
12. Honkanen J, Nieminen JK, Gao R, et al. IL-17 immunity in human type 1 diabetes. J Immunol 2010;185:1959-67.
13. Berman MA, Sandborg CI, Wang Z, et al. Decreased IL-4 production in new onset type I insulin-dependent diabetes mellitus. J Immunol 1996;157:4690-6.
14. Karlsson MG, Lawesson SS, Ludvigsson J. Th1-like dominance in high-risk first-degree relatives of type I diabetic patients. Diabetologia 2000;43:742-9.
15. Halminen M, Simell O, Knip M, Ilonen J. Cytokine expression in unstimulated PBMC of children with type 1 diabetes and subjects positive for diabetes-associated autoantibodies. Scand J Immunol 2001;53:510-3.
16. Taylor A, Verhagen J, Blaser K, Akdis M, Akdis CA. Mechanisms of immune suppression by interleukin-10 and transforming growth factorbeta: The role of T regulatory cells. Immunology 2006;117:433-42.
17. Ludvigsson J, Heding LG. C-peptide in children with juvenile diabetes. A preliminary report. Diabetologia 1976;12:627-30.
18. Hedman M, Ludvigsson J, Faresjo MK. Nicotinamide reduces high secretion of IFN-gamma in high-risk relatives even though it does not prevent type 1 diabetes. J Interferon Cytokine Res 2006;26:207-13.
19. Karlsson Faresjo MG, Ernerudh J, Ludvigsson J. Cytokine profile in children during the first 3 months after the diagnosis of type 1 diabetes. Scand J Immunol 2004;59:517-26.
20. Stechova K, Bohmova K, Vrabelova Z, et al. High T-helper-1 cytokines but low T-helper-3 cytokines, inflammatory cytokines and chemokines in children with high risk of developing type 1 diabetes. Diabetes Metab Res Rev 2007;23:462-71.
21. Ryden A, Stechova K, Durilova M, Faresjo M. Switch from a dominant Th1-associated immune profile during the pre-diabetic phase in favour of a temporary increase of a Th3-associated and inflammatory immune profile at the onset of type 1 diabetes. Diabetes Metab Res Rev 2009;25:335-43.
22. Torn C, Landin-Olsson M, Lernmark A, et al. Prognostic factors for the course of beta cell function in autoimmune diabetes. J Clin Endocrinol Metab 2000;85:4619-23.
23. Hyoty H, Hiltunen M, Knip M, et al. A prospective study of the role of coxsackie B and other enterovirus infections in the pathogenesis of IDDM. Childhood Diabetes in Finland (DiMe) Study Group. Diabetes 1995;44:652-7.
24. Haidet J, Cifarelli V, Trucco M, Luppi P. C-peptide reduces pro-inflammatory cytokine secretion in LPS-stimulated U937 monocytes in condition of hyperglycemia. Inflamm Res 2012;61:27-35.
25. Elfaitouri A, Berg AK, Frisk G, Yin H, Tuvemo T, Blomberg J. Recent enterovirus infection in type 1 diabetes: Evidence with a novel IgM method. J Med Virol 2007;79:1861-7.
26. Hoffman WH, Burek CL, Waller JL, Fisher LE, Khichi M, Mellick LB. Cytokine response to diabetic ketoacidosis and its treatment. Clin Immunol 2003;108:175-81.
27. Karavanaki K, Karanika E, Georga S, et al. Cytokine response to diabetic ketoacidosis (DKA) in children with type 1 diabetes (T1DM). Endocr J 2011;58:1045-53.
28. Karavanaki K, Kakleas K, Georga S, et al. Plasma high sensitivity C-reactive protein and its relationship with cytokine levels in children with newly diagnosed type 1 diabetes and ketoacidosis. Clin Biochem 2012;45:1383-8.
29. Curran-Everett D. Multiple comparisons: Philosophies and illustrations. Am J Physiol Regul Integr Comp Physiol 2000;279:R1-8.